Oligopeptide nourishing powder for improving memory and sleep and preparation method thereof

Abstract

The application discloses a kind of oligopeptide wisdom-aiding sleep nutritional product and preparation method thereof.The wisdom-aiding sleep nutritional product of the application is prepared from 50kg of jujube seed, 40kg of poria cocos, 40kg of lily, 25kg of longan, 25kg of medlar, 20kg of eucommia leaf, 15kg of gastrodia elata, 25kg of red date, 25kg of millet, 5kg of corn oligopeptide, 2.25kg of chrysanthemum powder, 2.5kg of malt dextrin, 75g of stevia sugar and 150g of sodium citrate.The nutritional powder is organically matched using homologous medicinal and edible materials, takes into account traditional Chinese medicine regulating concept and modern food processing technology, realizes heart-liver-spleen-kidney homodyne, treats both symptoms and root causes, and has high safety, suitable taste and good solubility, can effectively improve sleep quality, improve memory, supplement nutrition and resist fatigue.

Description

Technical Field

[0001] This invention belongs to the field of health and nutrition food technology, specifically relating to an oligopeptide brain-boosting and sleep-aiding nutritional powder and its preparation method. Background Technology

[0003] Currently, there are many types of health products on the market that promote intelligence and sleep, but most of them suffer from problems such as single function, unreasonable combination of ingredients, and poor effect: some products only focus on calming the mind and lack overall conditioning of the internal organs, making it difficult to improve sleep problems from the root and easily leading to dependence or rebound; some products use pure Western medicine ingredients, which may have a quick effect in the short term, but have certain side effects with long-term use; and some products that are both food and medicine have an overly rich and greasy combination of ingredients, which can easily lead to an increased burden on the spleen and stomach, causing discomfort such as bloating and indigestion, and the effective ingredients are not fully extracted, resulting in low bioavailability and failing to fully exert their health benefits.

[0004] Traditional Chinese medicine believes that insomnia, forgetfulness, and other problems are often related to deficiency of heart and liver blood, insufficiency of spleen and kidney, and hyperactivity of liver yang. These conditions require a holistic approach, addressing both the root cause and symptoms by regulating multiple organs, including the heart, liver, spleen, and kidney. Based on this understanding, and combining modern food processing technology, the development of a nutritional product with a scientifically formulated composition, mild medicinal properties, safety without side effects, high utilization rate of active ingredients, and multiple benefits including nourishing the heart and calming the mind, improving intelligence and brain function, and strengthening the spleen and kidney is urgently needed in the current health food industry. Summary of the Invention

[0005] To address the shortcomings of existing brain-boosting and sleep-aiding health products, such as limited functionality, unreasonable formulation, low utilization of effective ingredients, and susceptibility to side effects or discomfort, this invention provides an oligopeptide brain-boosting and sleep-aiding nutritional powder and its preparation method. This nutritional powder uses organically formulated medicinal and edible raw materials, combining traditional Chinese medicine conditioning concepts with modern food processing technology to achieve simultaneous regulation of the heart, liver, spleen, and kidneys, addressing both the symptoms and the root cause. It is also highly safe, has a pleasant taste, and good solubility, effectively improving sleep quality, enhancing memory, supplementing nutrition, and combating fatigue.

[0006] To achieve the above objectives, the present invention adopts the following technical solution: An oligopeptide-based nutritional powder for improving intelligence and aiding sleep, by weight, comprises the following ingredients: 40.0-60.0 kg of jujube seed, 30.0-50.0 kg of Poria cocos, 30.0-50.0 kg of lily bulb, 15.0-35.0 kg of longan, 15.0-35.0 kg of wolfberry, 15.0-25.0 kg of Eucommia ulmoides leaf, 10.0-20.0 kg of Gastrodia elata, 15.0-35.0 kg of red dates, 15.0-35.0 kg of millet, 3.0-7.0 kg of corn oligopeptide, 1.75-2.75 kg of inulin, 1.5-3.5 kg of maltodextrin, 55-95 g of stevia, and 120-180 g of sodium citrate.

[0007] Furthermore, the preferred proportions of the raw material formulation are as follows: 50 kg of jujube seed, 40 kg of poria cocos, 40 kg of lily bulb, 25 kg of longan, 25 kg of wolfberry, 20 kg of eucommia leaf, 15 kg of gastrodia elata, 25 kg of red dates, 25 kg of millet, 5 kg of corn oligopeptide, 2.25 kg of inulin, 2.5 kg of maltodextrin, 75 g of stevia, and 150 g of sodium citrate. This formulation has been optimized through multiple experiments, resulting in the best synergistic effect of each raw material, the most significant health benefits, and optimal taste and solubility.

[0008] Furthermore, the nutritional powder can be made into fine granules for easy mixing and drinking; or it can be directly bottled as an oral liquid for easy carrying and consumption, meeting the needs of different groups of people.

[0009] This invention also provides a method for preparing the above-mentioned Eucommia ulmoides leaf, Ziziphus jujuba seed, and Gastrodia elata oligopeptide nutritional powder for improving intelligence and aiding sleep, comprising the following steps: (1) Raw material pretreatment and extraction: After pulverizing and sieving the jujube seed, gastrodia elata and other mixed raw materials, the extract was obtained by a segmented extraction process, specifically as follows: ① Jujube seed extraction: Crush jujube seeds, pass through a 10-mesh sieve, add 75% edible alcohol at a material-to-liquid ratio of 1:15, reflux at 85℃ for 2 hours, and coarsely filter. Add purified water to the residue at a material-to-liquid ratio of 1:10, boil at 85℃ for 2 hours, and coarsely filter. Add purified water to the residue again at a material-to-liquid ratio of 1:8, boil at 85℃ for 2 hours, and coarsely filter. Concentrate the alcohol coarse filtrate and combine it with the two purified water coarse filtrates to obtain the jujube seed extract. Using a combination of alcohol reflux extraction and water extraction can fully extract the sedative active ingredients such as saponins and flavonoids from jujube seeds, avoiding the loss of active ingredients caused by a single extraction method.

[0010] ② Gastrodia elata extraction: Gastrodia elata is pulverized and passed through a 10-mesh sieve. 75% edible alcohol is added at a material-to-liquid ratio of 1:15, and the mixture is refluxed at 85℃ for 2 hours, followed by coarse filtration. The residue is then added to purified water at a material-to-liquid ratio of 1:10, and boiled at 85℃ for 2 hours, followed by coarse filtration. The residue is then added to purified water again at a material-to-liquid ratio of 1:8, and boiled at 85℃ for 2 hours, followed by coarse filtration. The alcohol-based coarse filtrate is concentrated and combined with the two purified water coarse filtrates to obtain the Gastrodia elata extract. Similarly, segmented extraction can fully release the effective components such as gastrodin in Gastrodia elata, exerting its effects of calming the liver and kidneys, and sedating the nerves.

[0011] ③ Extraction of Mixed Raw Materials: Poria cocos, lily bulb, longan, wolfberry, eucommia leaf, red date, and millet were pulverized and passed through a 10-mesh sieve. Pure water was added at a material-to-liquid ratio of 1:10, and the mixture was boiled at 85℃ for 2 hours, followed by coarse filtration. The residue was then added to pure water at a material-to-liquid ratio of 1:8, and boiled at 85℃ for 2 hours, followed by coarse filtration. The residue was then added to pure water again at a material-to-liquid ratio of 1:8, and boiled at 85℃ for 2 hours, followed by coarse filtration. The three coarse filtrates were combined to obtain the mixed raw material extract. All raw materials in this group are food and medicinal ingredients. The multiple water extraction process can fully extract the polysaccharides, amino acids, vitamins, and other nutrients, while avoiding the destruction of some heat-sensitive nutrients by alcohol.

[0012] (2) Combining and concentrating: Combine the jujube seed extract, gastrodia extract and mixed raw material extract obtained in step (1), and concentrate under reduced pressure to a material-to-liquid ratio of 1:10 to reduce the volume of material and liquid, increase the concentration of effective ingredients, and reduce the energy consumption of subsequent processes.

[0013] (3) Enzymatic hydrolysis: Adjust the pH of the concentrated solution to 6.5, add 3‰ (v / v) α-amylase, and hydrolyze at 90℃ for 2 hours to remove starch from the solution. Since millet and other grains in the raw materials contain a certain amount of starch, excessive starch will seriously affect the solubility of the product. Hydrolysis with α-amylase can effectively remove starch and improve the product's reconstitution performance. Subsequently, adjust the pH of the solution to 7.5, add 3‰ (v / v) neutral protease, and stir at 40℃ for 3 hours to convert proteins in the solution that only have basic nutritional functions and are prone to forming unstable structures into active protein peptides. This not only improves the absorption and utilization rate of nutrients but also eliminates the instability caused by proteins and extends the product's shelf life.

[0014] (4) Clarification and filtration: Add 3% (by volume) of 1% chitosan clarifying agent to the enzymatically hydrolyzed liquid and clarify for 60-120 min, preferably 90 min. Chitosan clarifying agent can effectively remove impurities, colloidal substances and some pigments from the liquid, achieving deastringency and decolorization, and improving the taste and appearance of the product; then perform plate and frame filtration to further remove insoluble impurities, obtain a clear and transparent filtrate, and then concentrate the filtrate to further increase the concentration of effective ingredients.

[0015] (5) Formulation: Corn oligopeptides, inulin, maltodextrin, stevia, and sodium citrate are added to the concentrated filtrate. After thorough dissolution, the filtrate is processed into fine particles using conventional food-grade spray drying technology, which is the nutritional powder; or it can be directly packaged into an oral liquid according to the conventional oral liquid formulation requirements. Among them, maltodextrin can improve the product's formability and solubility, inulin can regulate the balance of intestinal flora, stevia can improve the product's taste, and sodium citrate can regulate the product's pH value and stabilize product performance. The synergistic effect of the various excipients enhances the overall quality of the product.

[0016] Beneficial effects Compared with the prior art, the present invention has the following significant advantages: 1. Scientific formulation, addressing both symptoms and root cause: This invention follows the holistic view of traditional Chinese medicine, using jujube seed, poria cocos, and lily bulb to build a foundation for calming the mind; longan, goji berries, and red dates to nourish qi and blood; millet as a nutrient carrier; gastrodia elata and eucommia ulmoides leaves to soothe the liver and benefit the kidneys; and corn oligopeptides to supplement modern active nutrition. This achieves the coordinated regulation of the heart, liver, spleen, and kidneys, not only quickly relieving symptoms such as insomnia and excessive dreaming, but also regulating the function of the internal organs from the root, improving physical constitution, and avoiding the limitations of single calming products, thus addressing both symptoms and root cause.

[0017] 2. Nourishing without stagnation, clearing within nourishment: While using a large amount of nourishing ingredients such as jujube seed, longan, and wolfberry, this invention combines poria and millet to strengthen the spleen and promote diuresis, avoiding discomfort such as bloating and stomach upset caused by excessive nourishment; and with lily to clear the heart and relieve irritability, and gastrodia to calm the liver and subdue yang, the whole formula is nourishing without clogging, with mild medicinal properties, and is suitable for long-term conditioning.

[0018] 3. Safe and reliable, with a wide range of users: The raw materials of this invention are all food and medicine homologous ingredients, without any toxic or harmful components. The medicinal properties are mild and the safety is high. It is suitable for long-term use by various groups of people with sleep disorders, excessive mental exertion, insufficient qi and blood, menopausal irritability and insomnia, and those who need to combat fatigue due to excessive stress. It has a wide user base.

[0019] 4. Advanced technology and high utilization rate of active ingredients: This invention adopts a segmented extraction process, combining the advantages of alcohol reflux extraction and water extraction to fully extract the active ingredients from each raw material and avoid loss of active ingredients; at the same time, enzymatic hydrolysis technology is introduced to remove starch impurities and convert proteins into easily absorbed active peptides, significantly improving the bioavailability of nutrients and enhancing the health benefits of the product; the application of modern processes such as chitosan clarification and spray drying further improves the solubility, taste and appearance of the product.

[0020] 5. Flexible dosage form and convenient use: This invention can be made into two dosage forms, granules or oral liquid. Granules are easy to prepare and drink, while oral liquid is easy to carry and take, which can meet the needs of different people and different scenarios, and is highly practical. Detailed Implementation

[0021] The technical solutions in the embodiments of this application will be clearly and completely described below. Obviously, the described embodiments are only some, not all, of the embodiments of this invention. All other embodiments obtained by those skilled in the art based on the embodiments of this invention without creative effort are within the scope of protection of this invention.

[0022] It should be noted that the raw materials used in the following examples are all food-grade or food-medicine homologous raw materials, which can be purchased through conventional commercial channels; the equipment used are all conventional equipment in the food processing field, and the process parameters can be appropriately adjusted according to the actual production situation.

[0023] Example 1 An oligopeptide nutritional powder for improving intelligence and aiding sleep, the raw material formula is as follows: 40kg of jujube seed, 30kg of poria cocos, 30kg of lily bulb, 15kg of longan, 15kg of wolfberry, 15kg of eucommia leaf, 10kg of gastrodia elata, 15kg of red dates, 15kg of millet, 3kg of corn oligopeptide, 1.75kg of inulin, 1.5kg of maltodextrin, 55g of stevia, and 120g of sodium citrate.

[0024] Its preparation method includes the following steps: (1) Raw material pretreatment and extraction: ① Jujube seed extraction: Take 40kg of jujube seeds, crush them, pass them through a 10-mesh sieve, add 75% edible alcohol at a material-to-liquid ratio of 1:15, reflux at 85℃ for 2 hours, and coarsely filter; add purified water to the residue at a material-to-liquid ratio of 1:10, boil at 85℃ for 2 hours, and coarsely filter; add purified water to the residue again at a material-to-liquid ratio of 1:8, boil at 85℃ for 2 hours, and coarsely filter; concentrate the alcohol coarse filtrate and combine it with the two purified water coarse filtrates to obtain jujube seed extract.

[0025] ② Gastrodia elata extraction: Take 10 kg of Gastrodia elata, crush it, pass it through a 10-mesh sieve, add 75% edible alcohol at a material-to-liquid ratio of 1:15, reflux at 85℃ for 2 hours, and coarsely filter; add purified water to the residue at a material-to-liquid ratio of 1:10, boil at 85℃ for 2 hours, and coarsely filter; add purified water to the residue again at a material-to-liquid ratio of 1:8, boil at 85℃ for 2 hours, and coarsely filter; concentrate the alcohol coarse filtrate and combine it with the two purified water coarse filtrates to obtain Gastrodia elata extract.

[0026] ③ Extraction of mixed raw materials: Take 30kg of Poria cocos, 30kg of lily bulb, 15kg of longan, 15kg of wolfberry, 15kg of Eucommia ulmoides leaves, 15kg of red dates, and 15kg of millet, crush them, pass them through a 10-mesh sieve, add purified water at a material-to-liquid ratio of 1:10, boil and extract at 85℃ for 2 hours, and then coarsely filter; add purified water to the residue at a material-to-liquid ratio of 1:8, boil and extract at 85℃ for 2 hours, and then coarsely filter; add purified water to the residue again at a material-to-liquid ratio of 1:8, boil and extract at 85℃ for 2 hours, and then coarsely filter; combine the three coarse filtrates to obtain the mixed raw material extract.

[0027] (2) Combining and concentrating: Combine the jujube seed extract, gastrodia extract and mixed raw material extract, and concentrate under reduced pressure to a material-to-liquid ratio of 1:10.

[0028] (3) Enzymatic hydrolysis: Adjust the pH of the concentrated solution to 6.5, add 3‰ (v / v) α-amylase, and hydrolyze at 90℃ for 2h; then adjust the pH of the solution to 7.5, add 3‰ (v / v) neutral protease, and stir at 40℃ for 3h.

[0029] (4) Clarification and filtration: Add 3% of the liquid volume of 1% chitosan clarifying agent to the enzymatically hydrolyzed liquid, clarify for 60 minutes, remove astringency and decolorize, and then perform plate and frame filtration. Take the filtrate and concentrate it.

[0030] (5) Formulation: Add 3 kg of corn oligopeptide, 1.75 kg of inulin, 1.5 kg of maltodextrin, 55 g of stevia, and 120 g of sodium citrate to the concentrated filtrate. After dissolving completely, spray dry to form fine particles, which is the Eucommia ulmoides leaf, jujube seed, and Gastrodia elata oligopeptide brain-boosting and sleep-aiding nutritional powder.

[0031] Example 2 (Preferred Example) An oligopeptide nutritional powder for improving intelligence and aiding sleep, the raw material formula is as follows: 50kg of jujube seed, 40kg of poria cocos, 40kg of lily bulb, 25kg of longan, 25kg of wolfberry, 20kg of eucommia leaf, 15kg of gastrodia elata, 25kg of red dates, 25kg of millet, 5kg of corn oligopeptide, 2.25kg of inulin, 2.5kg of maltodextrin, 75g of stevia, and 150g of sodium citrate.

[0032] Its preparation method includes the following steps: (1) Raw material pretreatment and extraction: ① Jujube seed extraction: Take 50kg of jujube seeds, crush them, pass them through a 10-mesh sieve, add 75% edible alcohol at a material-to-liquid ratio of 1:15, reflux at 85℃ for 2 hours, and coarsely filter; add purified water to the residue at a material-to-liquid ratio of 1:10, boil at 85℃ for 2 hours, and coarsely filter; add purified water to the residue again at a material-to-liquid ratio of 1:8, boil at 85℃ for 2 hours, and coarsely filter; concentrate the alcohol coarse filtrate and combine it with the two purified water coarse filtrates to obtain jujube seed extract.

[0033] ② Gastrodia elata extraction: Take 15kg of Gastrodia elata, crush it, pass it through a 10-mesh sieve, add 75% edible alcohol at a material-to-liquid ratio of 1:15, reflux at 85℃ for 2 hours, and coarsely filter; add purified water to the residue at a material-to-liquid ratio of 1:10, boil at 85℃ for 2 hours, and coarsely filter; add purified water to the residue again at a material-to-liquid ratio of 1:8, boil at 85℃ for 2 hours, and coarsely filter; concentrate the alcohol coarse filtrate and combine it with the two purified water coarse filtrates to obtain Gastrodia elata extract.

[0034] ③ Extraction of mixed raw materials: Take 40kg of Poria cocos, 40kg of lily bulb, 25kg of longan, 25kg of wolfberry, 20kg of Eucommia ulmoides leaves, 25kg of red dates, and 25kg of millet, crush them, pass them through a 10-mesh sieve, add purified water at a material-to-liquid ratio of 1:10, boil and extract at 85℃ for 2 hours, and then coarsely filter; add purified water to the residue at a material-to-liquid ratio of 1:8, boil and extract at 85℃ for 2 hours, and then coarsely filter; add purified water to the residue again at a material-to-liquid ratio of 1:8, boil and extract at 85℃ for 2 hours, and then coarsely filter; combine the three coarse filtrates to obtain the mixed raw material extract.

[0035] (2) Combining and concentrating: Combine the jujube seed extract, gastrodia extract and mixed raw material extract, and concentrate under reduced pressure to a material-to-liquid ratio of 1:10.

[0036] (3) Enzymatic hydrolysis: Adjust the pH of the concentrated solution to 6.5, add 3‰ (v / v) α-amylase, and hydrolyze at 90℃ for 2h; then adjust the pH of the solution to 7.5, add 3‰ (v / v) neutral protease, and stir at 40℃ for 3h.

[0037] (4) Clarification and filtration: Add 3% of the liquid volume of 1% chitosan clarifying agent to the enzymatically hydrolyzed liquid, clarify for 90 min, remove astringency and decolorize, and then perform plate and frame filtration. Take the filtrate and concentrate it.

[0038] (5) Formulation: Add 5 kg of corn oligopeptide, 2.25 kg of inulin, 2.5 kg of maltodextrin, 75 g of stevia, and 150 g of sodium citrate to the concentrated filtrate. After dissolving fully, spray dry to form fine particles, which is the Eucommia ulmoides leaf, jujube seed, and Gastrodia elata oligopeptide brain-boosting and sleep-aiding nutritional powder; or take the dissolved liquid and fill it directly into an oral liquid according to the conventional oral liquid filling process.

[0039] The nutritional powder prepared in this embodiment has uniform and fine particles, no sediment after mixing, good solubility, and a sweet taste without bitterness. After trial use, continuous use for 15-30 days significantly improved symptoms such as light sleep, frequent dreams, and easy waking, improved memory, increased energy, and no adverse reactions, demonstrating significant health benefits.

[0040] Example 3 An oligopeptide nutritional powder for improving intelligence and aiding sleep, the raw material formula is as follows: 60kg of jujube seed, 50kg of poria cocos, 50kg of lily bulb, 35kg of longan, 35kg of wolfberry, 25kg of eucommia leaf, 20kg of gastrodia elata, 35kg of red dates, 35kg of millet, 7kg of corn oligopeptide, 2.75kg of inulin, 3.5kg of maltodextrin, 95g of stevia, and 180g of sodium citrate.

[0041] Its preparation method includes the following steps: (1) Raw material pretreatment and extraction: ① Jujube seed extraction: Take 60kg of jujube seeds, crush them, pass them through a 10-mesh sieve, add 75% edible alcohol at a material-to-liquid ratio of 1:15, reflux at 85℃ for 2 hours, and coarsely filter; add purified water to the residue at a material-to-liquid ratio of 1:10, boil at 85℃ for 2 hours, and coarsely filter; add purified water to the residue again at a material-to-liquid ratio of 1:8, boil at 85℃ for 2 hours, and coarsely filter; concentrate the alcohol coarse filtrate and combine it with the two purified water coarse filtrates to obtain jujube seed extract.

[0042] ② Gastrodia elata extraction: Take 20 kg of Gastrodia elata, crush it, pass it through a 10-mesh sieve, add 75% edible alcohol at a material-to-liquid ratio of 1:15, reflux at 85℃ for 2 hours, and coarsely filter; add purified water to the residue at a material-to-liquid ratio of 1:10, boil at 85℃ for 2 hours, and coarsely filter; add purified water to the residue again at a material-to-liquid ratio of 1:8, boil at 85℃ for 2 hours, and coarsely filter; concentrate the alcohol coarse filtrate and combine it with the two purified water coarse filtrates to obtain Gastrodia elata extract.

[0043] ③ Extraction of mixed raw materials: Take 50kg of Poria cocos, 50kg of lily bulb, 35kg of longan, 35kg of wolfberry, 25kg of Eucommia ulmoides leaves, 35kg of red dates, and 35kg of millet, crush them, pass them through a 10-mesh sieve, add purified water at a material-to-liquid ratio of 1:10, boil and extract at 85℃ for 2 hours, and then coarsely filter; add purified water to the residue at a material-to-liquid ratio of 1:8, boil and extract at 85℃ for 2 hours, and then coarsely filter; add purified water to the residue again at a material-to-liquid ratio of 1:8, boil and extract at 85℃ for 2 hours, and then coarsely filter; combine the three coarse filtrates to obtain the mixed raw material extract.

[0044] (2) Combining and concentrating: Combine the jujube seed extract, gastrodia extract and mixed raw material extract, and concentrate under reduced pressure to a material-to-liquid ratio of 1:10.

[0045] (3) Enzymatic hydrolysis: Adjust the pH of the concentrated solution to 6.5, add 3‰ (v / v) α-amylase, and hydrolyze at 90℃ for 2h; then adjust the pH of the solution to 7.5, add 3‰ (v / v) neutral protease, and stir at 40℃ for 3h.

[0046] (4) Clarification and filtration: Add 3% of the liquid volume of 1% chitosan clarifying agent to the enzymatically hydrolyzed liquid, clarify for 120 min, remove astringency and decolorize, and then perform plate and frame filtration. Take the filtrate and concentrate it.

[0047] (5) Formulation: Add 7 kg of corn oligopeptide, 2.75 kg of inulin, 3.5 kg of maltodextrin, 95 g of stevia, and 180 g of sodium citrate to the concentrated filtrate. After dissolving completely, spray dry to form fine particles, which is the Eucommia ulmoides leaf, jujube seed, and Gastrodia elata oligopeptide brain-boosting and sleep-aiding nutritional powder.

[0048] Example 4 The difference between this embodiment and Embodiment 2 is that in the formulation step, the dissolved liquid is directly filled into an oral liquid, while the rest of the raw material formulation and preparation steps are the same as in Embodiment 2.

[0049] The oral liquid prepared in this embodiment is clear and transparent in color, has a sweet taste, no sediment, and is easy to carry and take. Its health benefits are the same as those of the granular nutritional powder prepared in Example 2, and it can effectively improve sleep quality, enhance intelligence and brain function, and strengthen the spleen and kidneys.

[0050] Experimental verification One hundred volunteers with symptoms of light sleep, frequent dreams, and easy awakening were randomly divided into 5 groups of 20 each. Each group took the product prepared according to Examples 1-4 of this invention and a commercially available brain-boosting and sleep-aiding nutritional powder for 30 consecutive days. The improvement in sleep and the volunteers' physical responses were observed and recorded. The results are shown in the table below:

[0051] The above experimental results show that the Eucommia ulmoides leaf, Ziziphus jujuba seed, and Gastrodia elata oligopeptide nutritional powder and oral liquid prepared by this invention have a sleep improvement efficacy rate of over 90%, with the efficacy rates of preferred embodiments 2 and 4 reaching over 95%, significantly higher than similar products on the market. Furthermore, none of the volunteers who took the products of this invention experienced any adverse reactions, indicating high safety. In contrast, three volunteers with commercially available products experienced mild abdominal bloating and discomfort, demonstrating that the products of this invention have a scientific formulation, mild medicinal properties, and significant advantages.

[0052] I. Pharmacological efficacy test of the sleep-aiding nutritional supplement of the present invention: Sixty healthy male NIH mice, weighing 16-21g, were randomly divided into six groups: a blank control group, the product of Example 1, the product of Example 2, the product of Example 3, the product of Example 4, and a commercially available nutritional powder, with 10 mice in each group. The dosage of the nutritional product was 450mg / kg. The nutritional products prepared in each example were resuspended in distilled water, and each group was administered the product by gavage at a dose of 0.5mL / 10g per body weight for 20 consecutive days, once daily. The blank control group was administered an equal volume of distilled water by gavage. The results are shown in Table 1.

[0053] Table 1: Effects on sleep response in mice (±s, n=10)

[0054] Note: Different lowercase letters in the same column indicate significant differences (Duncan's new multiple range method, P < 0.05), and different uppercase letters in the same column indicate extremely significant differences (Duncan's new multiple range method, P < 0.01). As shown in Table 1, the nutritional product of the present invention can significantly increase the sleep duration of mice.

[0055] The above embodiments are only used to illustrate the technical solutions of this application, and are not intended to limit this application. Although this application has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some or all of the technical features therein. Such modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the scope of the technical solutions of this application.

Claims

1. An oligopeptide nutritional powder for improving intelligence and aiding sleep, characterized in that, By weight, its raw material composition includes: 40.0-60.0 kg of jujube seed, 30.0-50.0 kg of poria cocos, 30.0-50.0 kg of lily bulb, 15.0-35.0 kg of longan, 15.0-35.0 kg of wolfberry, 15.0-25.0 kg of eucommia leaf, 10.0-20.0 kg of gastrodia elata, 15.0-35.0 kg of red dates, 15.0-35.0 kg of millet, 3.0-7.0 kg of corn oligopeptide, 1.75-2.75 kg of inulin, 1.5-3.5 kg of maltodextrin, 55-95 g of stevia, and 120-180 g of sodium citrate.

2. The oligopeptide brain-boosting and sleep-aiding nutritional powder according to claim 1, characterized in that, The preferred proportions of the raw material formula are as follows: 50 kg of jujube seed, 40 kg of poria cocos, 40 kg of lily bulb, 25 kg of longan, 25 kg of wolfberry, 20 kg of eucommia leaf, 15 kg of gastrodia elata, 25 kg of red dates, 25 kg of millet, 5 kg of corn oligopeptide, 2.25 kg of inulin, 2.5 kg of maltodextrin, 75 g of stevia, and 150 g of sodium citrate.

3. The oligopeptide brain-boosting and sleep-aiding nutritional powder according to claim 1 or 2, characterized in that, The nutritional powder can be made into fine granules or directly packaged as an oral liquid.

4. A method for preparing an oligopeptide brain-boosting and sleep-aiding nutritional powder as described in any one of claims 1-3, characterized in that, Includes the following steps: (1) Raw material pretreatment and extraction: After pulverizing and sieving the jujube seed, gastrodia elata and other mixed raw materials, the extract was obtained by a segmented extraction process, specifically as follows: ① Jujube seed extraction: Crush jujube seeds, pass through a 10-mesh sieve, add 75% edible alcohol at a material-to-liquid ratio of 1:15, reflux at 85℃ for 2 hours, and coarsely filter; add purified water to the residue at a material-to-liquid ratio of 1:10, boil at 85℃ for 2 hours, and coarsely filter; add purified water to the residue again at a material-to-liquid ratio of 1:8, boil at 85℃ for 2 hours, and coarsely filter; concentrate the alcohol coarse filtrate and combine it with the two purified water coarse filtrates to obtain jujube seed extract; ② Gastrodia elata extraction: Gastrodia elata is pulverized and passed through a 10-mesh sieve. 75% edible alcohol is added at a material-to-liquid ratio of 1:15, and the mixture is refluxed at 85°C for 2 hours and coarsely filtered. The residue is added to purified water at a material-to-liquid ratio of 1:10 and boiled at 85°C for 2 hours and coarsely filtered. The residue is then added to purified water at a material-to-liquid ratio of 1:8 and boiled at 85°C for 2 hours and coarsely filtered. The alcohol coarse filtrate is concentrated and combined with the two purified water coarse filtrates to obtain the Gastrodia elata extract. ③ Extraction of mixed raw materials: Take Poria cocos, lily bulb, longan, wolfberry, Eucommia ulmoides leaf, red date, and millet, grind them into powder, pass them through a 10-mesh sieve, add purified water at a material-to-liquid ratio of 1:10, boil and extract at 85℃ for 2 hours, and then coarsely filter; add purified water to the residue at a material-to-liquid ratio of 1:8, boil and extract at 85℃ for 2 hours, and then coarsely filter; add purified water to the residue again at a material-to-liquid ratio of 1:8, boil and extract at 85℃ for 2 hours, and then coarsely filter; combine the three coarse filtrates to obtain the mixed raw material extract; (2) Combining and concentrating: Combine the jujube seed extract, gastrodia extract and mixed raw material extract obtained in step (1) and concentrate under reduced pressure to a material-to-liquid ratio of 1:10; (3) Enzymatic hydrolysis: Adjust the pH of the concentrated solution to 6.5, add 3‰ (v / v) α-amylase, and hydrolyze at 90℃ for 2h to remove starch from the solution; then adjust the pH of the solution to 7.5, add 3‰ (v / v) neutral protease, and stir at 40℃ for 3h to hydrolyze the protein in the solution into protein peptides. (4) Clarification and filtration: Add 3% of the liquid volume of 1% chitosan clarifying agent to the enzymatically hydrolyzed liquid, clarify for 60-120 minutes to achieve deastringency and decolorization, and then perform plate and frame filtration and concentrate the filtrate. (5) Formulation: Add corn oligopeptide, inulin, maltodextrin, stevia and sodium citrate to the concentrated filtrate. After dissolving fully, spray dry to form fine particles, which are the nutritional powder; or directly fill into oral liquid according to the conventional oral liquid formulation requirements.

5. The method for preparing an oligopeptide brain-boosting and sleep-aiding nutritional powder according to claim 4, characterized in that, In step (4), the preferred clarification time for the chitosan clarifying agent is 90 min.

6. The method for preparing an oligopeptide brain-boosting and sleep-aiding nutritional powder according to claim 4, characterized in that, The spray drying process parameters in step (5) are the conventional food-grade spray drying parameters to ensure that the resulting particles are uniform, fine, and have good solubility.

7. The oligopeptide brain-boosting and sleep-aiding nutritional powder according to any one of claims 1-3, characterized in that, The nutritional powder has health benefits such as nourishing the heart and calming the mind, improving intelligence and brain function, and strengthening the spleen and kidneys. It is suitable for people with sleep disorders, excessive mental exertion, insufficient qi and blood, menopausal irritability and insomnia, and those who need to combat fatigue due to excessive stress.

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