A biobased material-containing cleaning composition selectively deposits an active

Abstract

The present application relates to the technical field of daily chemicals, and discloses a bio-based material-containing cleaning composition capable of selectively depositing effective substances, which comprises, by total weight, a sophorolipid compound, a rhamnolipid, a tridecyl alcohol polyether-2 carboxylic acid amide MEA, a tridecyl alcohol fatty acid ester, an amphoteric surfactant, a water-insoluble and surfactant-soluble scalp care agent, an anionic surfactant and pure water in a specific ratio. Through the synergistic effect of the above components, a functional micelle system capable of quickly dissociating when diluted with water during use is constructed. The quick dissociation of the system promotes the release of the wrapped scalp care agent and efficient deposition on the scalp. Meanwhile, the system mainly based on bio-based surfactants is easy to rinse, reducing the residue of the surfactants. The present application maintains the ideal viscosity and mildness of the product while achieving efficient deposition of the effective substances and low residue of the system.

Description

Technical Field

[0001] This invention relates to the field of daily chemical products technology, specifically to a bio-based cleaning composition containing selectively deposited active ingredients. Background Technology

[0002] Currently, consumers' focus on personal care has expanded from basic cleansing to scalp health management. Demands for scalp care, such as oil control, dandruff removal, itching relief, and irritation reduction, are becoming increasingly prominent. This market demand has driven the functionalization of shampoos and conditioners, with the addition of various effective scalp care ingredients to formulas becoming a common technological approach.

[0003] To address the aforementioned scalp care needs, the industry has developed various technologies aimed at improving the deposition efficiency of active ingredients on the scalp. The mainstream approach involves incorporating specific surfactant systems into shampoo-free products. These systems, by adjusting the types and ratios of surfactants, form micellar structures capable of encapsulating water-insoluble active ingredients. These structures remain stable during product storage, but upon application and dilution with water, their structure is disrupted, releasing the encapsulated active ingredients onto the scalp surface.

[0004] Current technologies still have limitations in achieving efficient deposition of active ingredients, and their improvement in deposition efficiency is limited. Many micellar systems designed to promote deposition do not disintegrate sufficiently or rapidly during dilution. This results in most of the active ingredients remaining trapped within the micelles and being lost during rinsing, failing to reach the scalp and thus wasting the beneficial components.

[0005] Existing technologies often lead to new technical contradictions. Some technologies using specific polyether sulfate surfactants, while improving deposition rates to some extent, also leave residues on the skin. Surfactant residue is a potential factor contributing to skin barrier damage and irritation. This creates a technical dilemma: methods used to improve active ingredient deposition may inadvertently exacerbate the residue of undesirable substances.

[0006] Furthermore, attempts to achieve both mildness and product stability also face challenges. Some polyether-free sulfate systems used to reduce irritation do not achieve the desired level of mildness in actual use. Introducing partially bio-based surfactants often leads to decreased product viscosity, preventing the formation of marketable product forms and limiting their commercial application. Therefore, developing a technical solution that synergistically achieves efficient deposition of active ingredients, low system residue, stable formulation properties, and a mild skin feel is a key technical challenge to be solved in this field.

[0007] Therefore, the present invention provides a bio-based cleaning composition for selectively depositing active ingredients to address the shortcomings of the prior art. Summary of the Invention

[0008] To address the shortcomings of existing technologies, this invention provides a bio-based cleaning composition that selectively deposits active ingredients, solving the problems of low active ingredient deposition efficiency and high surfactant residue in existing wash-off products.

[0009] To achieve the above objectives, the present invention provides a bio-based cleaning composition for selectively depositing effective substances, comprising the following components by weight percentage: 1-10% sophorolipids; 1-5% rhamnolipid; 0.3-1% of tridecyl alcohol polyether-2-carboxyamide MEA; 0.5-10% tridecyl alcohol fatty acid esters; 0.5-10% amphoteric surfactants; 0.1-1% water-insoluble, surfactant-soluble scalp care products; 5-30% anionic surfactants; The remainder is pure water.

[0010] By employing the above technical solution, this invention constructs a micelle system that is stable in the product storage state but can trigger rapid release of the active ingredient upon dilution. Its mechanism of action lies in the fact that surfactants in conventional wash-off products typically form tight and stable micelle structures, firmly encapsulating water-insoluble active ingredients within the core. This causes the active ingredients to be carried away by the water flow along with the micelles during rinsing, preventing effective deposition on the target surface. The technical solution of this invention fundamentally alters this micelle behavior pattern through the synergistic effect of specific components.

[0011] The innovative mechanism of this technical solution can be explained as follows: Construction of Functional Micelles: The sophorolipid complex (first and second sophorolipids) in this invention, together with rhamnolipids, constitutes the basic framework of the bio-based surfactant. Unlike conventional thickeners that form denser micelle structures, the specific combination of tridecyl alcohol polyether-2-carboxyamide MEA and tridecyl alcohol fatty acid esters, while providing a suitable viscosity for the system, can synergistically form a relatively loosely structured micelle with low association energy in conjunction with the aforementioned bio-based surfactant. These micelles are sufficiently stable to encapsulate scalp care agents at high concentrations, but their structural stability rapidly decreases upon dilution with water.

[0012] Dilution-triggered active ingredient release: During product use, when a large amount of water is introduced, the total surfactant concentration in the system decreases, disrupting the structural equilibrium of the aforementioned functional micelles and causing rapid dissociation. This process allows the water-insoluble scalp care agent, previously encapsulated within the micelle core, to be released and exist as an independent, free entity in the aqueous system.

[0013] Selective deposition of active ingredients: Because the released scalp care agent is water-insoluble, it exhibits a high affinity for hydrophobic surfaces in aqueous environments. Therefore, it can preferentially deposit and adhere to the scalp surface independently of the surfactant rinsing process, thus achieving high deposition efficiency.

[0014] Low residue characteristics of the system: The bio-based surfactants such as sophorolipids and rhamnolipids used in this invention have weak interactions with skin keratin proteins and are more easily rinsed away by water. Therefore, while achieving efficient deposition of active ingredients, the entire surfactant system leaves a low residue on the skin. This reduces the tightness of the skin after cleansing and the potential risk of irritation, thus improving the overall gentleness of the product.

[0015] In summary, this invention, through the precise formulation of the above components, successfully achieves the technical effect of selective deposition: that is, it promotes the efficient deposition of the desired effective substances, while reducing the residue of undesirable substances (surfactants) and maintaining the excellent application performance of the product.

[0016] Preferably, in the sophorolipid, the weight ratio of the second sophorolipid (HLB value 11-15) to the first sophorolipid (HLB value 3-5) is (3:7) to (7:3).

[0017] By adopting the above technical solution, the combination of two sophorolipids with different HLB values ​​can precisely control the hydrophilic and lipophilic balance of micelles, which is crucial for constructing micelle structures that are easy to dissociate upon dilution.

[0018] Preferably, the critical micelle concentration (CMC) of the rhamnolipid is 50-120 mg / L.

[0019] By adopting the above technical solution, using rhamnolipids with low CMC values ​​helps to form micelles at lower concentrations, thereby improving the overall efficiency and stability of the system.

[0020] Preferably, the tridecyl alcohol fatty acid ester is selected from one or more of tridecyl alcohol stearate, tridecyl alcohol trimellitate, tridecyl alcohol behenate, tridecyl alcohol neopentanoate, and tridecyl alcohol isononanoate.

[0021] By adopting the above technical solutions, especially when using tridecanoic acid isononanoate, not only can functional micelles be synergistically constructed, but the product can also be provided with excellent spreadability and skin feel.

[0022] Preferably, the amphoteric surfactant is selected from one or two of lauramidopropyl betaine, cocamidopropyl betaine, lauramidohydroxysulfonate, cocoyl hydroxysulfonate, sodium lauroyl amphoteric acetate, and sodium cocoyl amphoteric acetate.

[0023] By adopting the above technical solutions, these amphoteric surfactants provide auxiliary cleaning and foaming capabilities while being mild in nature, which helps to reduce the irritation of the entire system.

[0024] Preferably, the scalp care agent is selected from one or more of piroctone ethanolamine salt, salicylic acid, capryloyl glycine, bisabolol, and clomibazole.

[0025] By adopting the above technical solution, these water-insoluble and surfactant-soluble active ingredients can be stably loaded into the cleaning composition of the present invention and efficiently deposited on the scalp during use.

[0026] Preferably, the anionic surfactant is one or a combination of two of sodium lauryl ether sulfate, ammonium dodecyl sulfate, sodium α-olefin sulfonate, and sodium methyl fatty taurate.

[0027] By adopting the above technical solution, one or a combination of two of sodium lauryl ether sulfate, ammonium dodecyl sulfate, sodium α-olefin sulfonate, and sodium methyl fatty taurate are used as the main surfactant, providing basic cleaning power and foaming properties. The technical solution of the present invention can significantly reduce the amount of such surfactants remaining on the skin.

[0028] Preferably, the composition further comprises one or more essential stabilizing components selected from cationic polymers, chelating agents, and pH adjusters.

[0029] By adopting the above technical solutions, these components ensure the physicochemical stability and safety of the product during its shelf life.

[0030] This invention provides a bio-based cleaning composition for selectively depositing active ingredients. It possesses the following beneficial effects: 1. This invention constructs a highly efficient and gentle bio-based surfactant cleaning system by compounding sophorolipids within a specific HLB value range with rhamnolipids within a specific CMC value range. This system not only provides excellent cleaning power and foaming experience, but also reduces the amount of the main surfactants in the formula remaining on the skin and scalp after use. This inhibition of unwanted residues directly improves the user experience, effectively reducing common post-wash skin tightness, irritation, and residue, thereby enhancing the overall gentleness of the product.

[0031] 2. This invention introduces a specific combination of tridecyl alcohol polyether-2-carboxyamide (MEA), tridecyl alcohol fatty acid ester, and amphoteric surfactants into a bio-based surfactant base. This combination synergistically works with the bio-based surfactant to construct a unique micelle structure. This micelle is characterized by a shorter relaxation time, lower stability, and a slower dissolution rate upon dilution—a key characteristic for achieving efficient deposition of the active ingredient. This specific combination also provides the product system with ideal viscosity, solving the thickening problem often encountered when constructing such unstable micelle systems, ensuring that the product possesses both functionality and excellent user experience.

[0032] 3. This invention achieves the technical effect of selective deposition through the aforementioned characteristics. On the one hand, it utilizes the properties of a bio-based surfactant system to reduce unwanted irritating surfactant molecules remaining on the scalp; on the other hand, it improves the deposition efficiency of water-insoluble scalp care agents on the scalp by constructing an unstable micelle system that easily disintegrates and releases the active ingredient during use. Therefore, this invention can directionally enhance the delivery of desired substances while minimizing the potential irritation from undesirable substances, enabling wash-off products to precisely and efficiently achieve their care function while performing a cleansing action. Detailed Implementation

[0033] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0034] Some of the raw materials used in this invention are commercially available products or prepared by conventional methods. The key sophorolipid complex is prepared using the following method.

[0035] Preparation Examples 1-3: Preparation Example 1: Preparation of Sophorolipid Complex A (High HLB Sophorolipid: Low HLB Sophorolipid = 3:7) In a clean reactor equipped with a stirrer, add 30.0 kg of sophorolipid (high HLB, 48% active ingredient content) and 70.0 kg of sophorolipid (low HLB, 48% active ingredient content). Start the stirrer and control the speed at 150-250 RPM to raise the reactor temperature to 40-50℃ and maintain this temperature. Continue stirring under these conditions for 20-40 minutes until the materials in the reactor are uniformly mixed, visually free of stratification or uneven particles, forming a homogeneous, flowing liquid. Allow to cool to room temperature for later use to obtain sophorolipid complex A.

[0036] Preparation Example 2: Preparation of Sophorolipid Complex B (High HLB Sophorolipid: Low HLB Sophorolipid = 5:5) In a clean reactor equipped with a stirrer, 50.0 kg of sophorolipid (high HLB, 48% active ingredient content) and 50.0 kg of sophorolipid (low HLB, 48% active ingredient content) were added. The mixture was prepared using the same process parameters as in Preparation Example 1 (rotation speed 150-250 RPM, temperature 40-50℃, stirring for 20-40 minutes) until the materials were completely homogeneous. After cooling to room temperature, the mixture was used to obtain sophorolipid complex B.

[0037] Preparation Example 3: Preparation of Sophorolipid Complex C (High HLB Sophorolipid: Low HLB Sophorolipid = 7:3) In a clean reactor equipped with a stirrer, 70.0 kg of sophorolipid (high HLB, 48% active ingredient content) and 30.0 kg of sophorolipid (low HLB, 48% active ingredient content) were added. The mixture was prepared using the same process parameters as in Preparation Example 1 (rotation speed 150-250 RPM, temperature 40-50℃, stirring for 20-40 minutes) until the materials were completely homogeneous. After cooling to room temperature, the mixture was used to obtain sophorolipid complex C.

[0038] General preparation process of cleaning compositions: Unless otherwise stated, in preferred embodiments of the present invention, the tridecyl alcohol fatty acid ester is selected from tridecyl alcohol isononanoate, the amphoteric surfactant is selected from cocamidopropyl betaine, the scalp care agent is selected from piroctone ketone ethanolamine salt, and the composition further comprises a stabilizing ingredient selected from limonene, cationic guar gum, sodium formate, phenoxyethanol, fragrance, and sodium chloride. The following are preferred embodiments 1-3, all prepared using the following process steps: Aqueous phase preparation: Add the prescribed amount of pure water and disodium ethylenediaminetetraacetate to the main reactor, and start stirring (50-150 RPM) until completely dissolved. Then, slowly disperse the cationic guar gum into the reactor under stirring, and continue stirring for 15-25 minutes until it is completely hydrated, uniform, and free of agglomeration.

[0039] Oil / suractive phase pre-dissolution: In a pre-dissolution vessel, sodium lauryl ether sulfate, ammonium dodecyl sulfate, the sophorolipid complex from the preparation example, rhamnolipid, tridecyl alcohol polyether-2-carboxylamide MEA, tridecyl isonononate, cocamidopropyl betaine, and pyrrolidone ethanolamine salt are added sequentially. Stirring is started (100-200 RPM) and heating is applied to raise the temperature inside the vessel to 55-65°C. This temperature is maintained and stirred for 20-40 minutes until all components (especially pyrrolidone ethanolamine salt) are completely dissolved, forming a clear, homogeneous oil / suractive phase.

[0040] Mixing and homogenization: The oil / suractive phase prepared in step 2 is slowly added to the aqueous phase prepared in step 1 by pumping or pouring while stirring. After the addition is complete, the system temperature is maintained at 45-55℃, and stirring is continued for 20-30 minutes to ensure that the two phases are completely and uniformly mixed.

[0041] Cooling and subsequent addition: Turn off the heating and open the cooling jacket to reduce the temperature of the material inside the vessel to below 40°C. While stirring, add sodium benzoate, phenoxyethanol, and flavoring in sequence.

[0042] Final adjustment: Adjust the pH of the system to the range of 5.5-6.0 using citric acid. Finally, add sodium chloride and stir until completely dissolved to adjust the system viscosity. After passing inspection, stop stirring, allow to stand to defoam, and then discharge the material.

[0043] Examples 1-3 Table 1 below provides specific formulations for three preferred embodiments of the present invention, with each component used in weight percentage (wt%). These three embodiments demonstrate implementation within the preferred ratio range of the sophorolipid complex (high HLB: low HLB ratio of 3:7 to 7:3).

[0044] Table 1: Formulation composition of Examples 1-3 raw material Example 1 Example 2 Example 3 Sodium lauryl ether sulfate (70%) 20.00 5.00 30.00 Ammonium dodecyl sulfate (70%) 6.00 6.00 6.00 Cationic guar gum 0.25 0.25 0.25 Sodium benzoate 0.30 0.30 0.30 Phenoxyethanol 0.60 0.60 0.60 essence 1.00 1.00 1.00 Disodium ethylenediaminetetraacetate 0.12 0.12 0.12 Sodium chloride 0.50 0.50 0.50 Citric acid Appropriate amount Appropriate amount Appropriate amount Sophorolipids (high HLB) (48%) 5.00 7.00 3.00 Sophorolipids (low HLB) (48%) 5.00 3.00 7.00 Rhamnose glycolipids (50%) 2.50 1.00 5.00 Tridecyl alcohol polyether-2-carboxyamide MEA 0.50 0.30 1.00 Tridecanoic acid isononate 0.80 0.80 0.80 Cocamidopropyl betaine (30%) 3.33 0.50 10.00 Piroctone ethanolamine salt 0.50 0.10 1.00 pure water Supplement to 100 Supplement to 100 Supplement to 100 Comparative Examples 1-9: Comparative Example 1: Compared with Example 1, this comparative example is a conventional sulfate cleaning composition that does not contain the core technical solution of the present invention. The difference is that: sophorolipid (high HLB), sophorolipid (low HLB), rhamnolipid, tridecyl alcohol polyether-2-carboxyamide MEA and tridecyl alcohol isononanoate are not added; in order to maintain the basic viscosity of the system, the amount of sodium chloride is adjusted to 1.2%.

[0045] Comparative Example 2: Compared with Example 1, this comparative example aims to investigate the effect of the absence of sophorolipid complex (component A), the difference being that sophorolipid (high HLB) and sophorolipid (low HLB) were not added.

[0046] Comparative Example 3: Compared with Example 1, this comparative example aims to examine the effect of the absence of rhamnolipin (component B), the difference being that rhamnolipin was not added.

[0047] Comparative Example 4: Compared with Example 1, this comparative example aims to examine the effect of the absence of tridecyl alcohol polyether-2-carboxyamide MEA (component C), the difference being that tridecyl alcohol polyether-2-carboxyamide MEA was not added.

[0048] Comparative Example 5: Compared with Example 1, this comparative example aims to examine the effect of the absence of tridecanoyl isononanoate (component D), the difference being that tridecanoyl isononanoate was not added.

[0049] Comparative Example 6: Compared with Example 1, this comparative example aims to examine the effect of the absence of an amphoteric surfactant (component E), the difference being that cocamidopropyl betaine was not added.

[0050] Comparative Example 7: Compared with Example 1, this comparative example aims to demonstrate the uniqueness of the tridecyl alcohol polyether-2-carboxyamide MEA used in this invention, the difference being that an equal amount of the conventional thickener cocoyl monoethanolamide (CMEA) is used instead of tridecyl alcohol polyether-2-carboxyamide MEA.

[0051] Comparative Example 8: Compared with Example 1, this comparative example aims to demonstrate the necessity of the core bio-based surfactant dosage range defined by the present invention. The difference is that the dosage of sophorolipid (high HLB) was reduced to 0.25%, the dosage of sophorolipid (low HLB) was reduced to 0.25%, and the dosage of rhamnolipin was reduced to 0.1%, all of which are lower than the lower limit required by the present invention.

[0052] Comparative Example 9: Compared with Example 1, this comparative example is intended to be compared with another prior art scheme aimed at improving the deposition efficiency of active ingredient, the difference being that: sophorolipid (high HLB), sophorolipid (low HLB), rhamnolipid, tridecyl alcohol polyether-2-carboxyamide MEA and tridecyl alcohol isononanoate are not added, but instead 5.61% of the branched surfactant sodium tridecyl alcohol polyether sulfate (65% active ingredient) is added.

[0053] Test Examples 1-4: Test Example 1: Assessment of the likelihood of active ingredient release from micelles (diffusion coefficient ratio test) Test method: This test aims to quantitatively assess the extent to which a scalp care agent (pyrrolidone ethanolamine salt) dissociates from surfactant micelles under simulated dilution conditions using nuclear magnetic resonance (NMR) diffusion sequence spectroscopy.

[0054] The test samples were Examples 1-3 and Comparative Examples 1, 2, 4, 7, and 9. First, each sample was precisely diluted with deionized water to achieve a total surfactant concentration of 1.3% (by weight). This concentration was used to simulate the scalp surface concentration of the product during actual washing. An appropriate amount of the diluted sample was transferred into a 5mm NMR test tube; no further pretreatment was required.

[0055] Data acquisition was performed using a Bruker Avance 700MHz NMR spectrometer equipped with a BBOz-gradient probe under isothermal conditions of 25℃. All experiments were conducted in open-field mode. The diffusion coefficient was determined using a longitudinal eddy current delayed excitation echo sequence of bipolar gradient pulses. The experimental parameters were set as follows: the diffusion delay time was fixed at 150 ms, and the gradient pulse duration was adjusted within the range of 3000-6000 μs. The gradient field intensity was stepped 32 times in a linear sequence, ranging from 2% to 95% of the maximum gradient intensity (generated by a GREAT3 / 10 amplifier at 10 A, corresponding to 53.5 G / cm).

[0056] The acquired data was processed using the instrument's built-in TopSpin software. The average diffusion coefficient of the surfactant micelles was calculated by fitting the signal intensity decay curve as a function of gradient intensity using the Stejskal-Tanner equation. ) and the diffusion coefficient of pyrrolidone ethanolamine salt molecules ( Finally, the diffusion coefficient ratio is calculated using the following formula (). ): .

[0057] Test results: Table 2: Test results of diffusion coefficients and diffusion coefficient ratios for each embodiment and comparative example.

[0058] in conclusion: The data from this test provides direct physical evidence for the mechanism of the technical solution of this invention. The diffusion coefficient ratio R value is an indicator of the degree of association between the active ingredient molecules and the surfactant micelles.

[0059] The data in Table 2 show that the diffusion coefficient ratio R values ​​of Examples 1-3 are all significantly greater than 4.5, indicating that in the diluted state, the diffusion rate (D1) of the surfactant micelles is much higher than the apparent diffusion rate (D2) of the piroctone ethanolamine salt molecules. This significant rate difference proves that the piroctone ethanolamine salt molecules are no longer completely constrained by the large micelle structure, but rather dissociate significantly from the micelles, existing in the solution in a smaller, freer form, thus possessing the prerequisite for independent deposition on the scalp surface during rinsing.

[0060] In contrast, the R values ​​of Comparative Example 1 (conventional formulation) and Comparative Example 7 (using conventional thickener CMEA) were only 1.05 and 1.58, respectively, close to 1. This indicates that in these systems, the piroctone ethanolamine salt is tightly encapsulated within the micelles and moves as a whole with the micelles, thus being easily carried away by the water flow along with the micelles during rinsing. The data from Comparative Examples 2, 4, and 9 further demonstrate the synergistic effect of the components in the composition of this invention; the absence of any key component leads to a significant decrease in the R value, i.e., a weakening of the dissociation ability of the active ingredient.

[0061] Therefore, the test results confirm that the present invention has successfully constructed a micelle system that can effectively release active substances when used (diluted with water) by compounding specific components, which is the technical basis for achieving high deposition efficiency in the future.

[0062] Test Example 2: Comparative Test of Scalp Care Product Deposition Efficiency Test method: This test used an in vitro porcine skin model to quantitatively determine the efficiency of each formulation in depositing pyroxone ethanolamine salt onto the substrate surface.

[0063] Before the experiment, fresh pig back skin was taken, subcutaneous fat and connective tissue were removed, and the skin was rinsed clean with physiological saline. The skin was then cut into 4cm × 4cm pieces. 1.0g of the sample was evenly applied to the pig skin surface, and a finger cot was used to gently rub the skin in a circular motion for 2 minutes. Subsequently, the skin was rinsed for 10 seconds under a constant temperature water flow of 37±2℃ (flow rate 2L / min). Excess moisture on the pig skin surface was then blotted dry with filter paper.

[0064] The treated pigskin was placed in a beaker containing 20 mL of methanol and sonicated for 30 minutes to extract the piroctone ethanolamine salt deposited on the pigskin. The extract was filtered through a 0.22 μm filter membrane and then injected into a high-performance liquid chromatograph (HPLC) for analysis. The chromatographic conditions were: C18 reversed-phase column (4.6 mm × 250 mm, 5 μm); mobile phase: methanol:water = 80:20 (V / V); flow rate: 1.0 mL / min; column temperature: 30℃; detection wavelength: 305 nm. The content of piroctone ethanolamine salt in the extract was calculated using an external standard curve. The deposition efficiency was calculated using the following formula: ; Test results: Table 3: Test results of piroctone ethanolamine salt deposition efficiency of each example and comparative example sample Pyrrolidone ethanolamine salt deposition efficiency (%) Example 1 11.54 Example 2 11.89 Example 3 11.65 Comparative Example 1 1.30 Comparative Example 2 6.75 Comparative Example 3 9.75 Comparative Example 4 9.15 Comparative Example 5 10.81 Comparative Example 6 10.23 Comparative Example 7 8.77 Comparative Example 8 2.07 Comparative Example 9 4.07 in conclusion: The quantitative results of this test show that the formulations in Examples 1-3 all exhibited significantly higher deposition efficiencies than all comparative examples of pyrrolidone ethanolamine salt, with deposition rates all exceeding 11.5%. This result directly verifies the functionality of the high diffusion coefficient ratio phenomenon observed in Test Example 1. The high deposition efficiency is a natural consequence of the effective dissociation of pyrrolidone ethanolamine salt from the micelles and its independent existence in the diluted system.

[0065] Comparative Example 1, as a conventional formulation without the core components of this invention, had a deposition efficiency of only 1.30%, forming the performance baseline. Comparative Examples 2 (lacking the sophorolipid complex) and 3 (lacking rhamnolipids) both showed a significant decrease in deposition efficiency, demonstrating that the synergistic effect of the two bio-based surfactants is necessary for constructing an efficient release system. Data from Comparative Examples 4, 5, and 6 showed that the absence of any one of tridecanoyl ether-2-carboxyamide MEA, tridecanoyl isononanoate, or an amphoteric surfactant led to a decrease in deposition efficiency, indicating that these components play an indispensable role in regulating micellar structure to facilitate active ingredient release and deposition.

[0066] Of particular note is that in Comparative Example 7, replacing tridecyl alcohol polyether-2-carboxyamide MEA with the conventional thickener CMEA significantly reduced the deposition efficiency. This confirms that the role of tridecyl alcohol polyether-2-carboxyamide MEA in this system goes far beyond macroscopic thickening; rather, it is a key regulator of microscopic micelle behavior. The low deposition rates of Comparative Example 8 (with insufficient core component dosage) and Comparative Example 9 (using other deposition techniques) respectively establish the effective concentration range of the present invention and its performance advantages compared to existing technologies.

[0067] In summary, the test data confirms that the present invention, through a specific combination of sophorolipid complex, rhamnolipid, tridecyl alcohol polyether-2-carboxylamide MEA, tridecyl alcohol fatty acid ester, and amphoteric surfactant, can significantly improve the deposition efficiency of water-insoluble active ingredients in wash-off products.

[0068] Test Example 3: Comparison Test of Surfactant Residue Test method: This test used a human volunteer forearm skin model and quantitatively analyzed the amount of surfactant remaining in the stratum corneum of the skin after each formulation was used by tape peeling method.

[0069] Twenty healthy volunteers were recruited. A 4cm x 4cm test area was marked on the inner forearm of each volunteer. The area was first cleaned by wiping it with a 75% ethanol cotton pad. 1.0g of the test sample was applied evenly to the area and gently massaged in a circular motion with the fingertips for 1 minute. The foam was then rinsed off with 200mL of deionized water and dried with a cool hairdryer.

[0070] Use polypropylene sulfide (PPS) tape for peeling. Apply the tape at 65 g / cm. 2 Apply constant pressure to the skin in the test area and hold for 20 seconds before peeling off. Repeat this procedure three times at the same location, collecting three pieces of tape. Use these three tape samples for quantitative analysis of surfactants.

[0071] Surfactant quantification: The collected tape was placed in a test tube containing 5 mL of methanol and extracted by vortexing. The extract was analyzed by liquid chromatography-mass spectrometry (LC-MS) to determine the total amount of the main residual anionic surfactants (sodium lauryl ether sulfate and ammonium dodecyl sulfate).

[0072] Protein quantification: To standardize the amount of exfoliated stratum corneum, the total protein content on the tape was determined using the dicaprylic acid (BCA) method. The other half of the unextracted tape was placed in a test tube containing 0.45 mL of 0.1 mol / L NaOH and 1% SDS aqueous solution, heated in a 60°C water bath for 150 minutes, and then cooled. 200 μL of 2 mol / L hydrochloric acid solution was added for neutralization, and after stirring, a sample was taken and the total protein content was determined using a BCA protein analysis kit.

[0073] The final surfactant residue is calculated using the following formula, expressed as the mass of surfactant remaining per unit mass of protein: ; Test Results Table 4: Test results of surfactant residue in each example and comparative example sample Surfactant residue (ng / µg protein) Example 1 3.21 Example 2 2.57 Example 3 3.34 Comparative Example 1 11.94 Comparative Example 2 6.54 Comparative Example 3 7.89 Comparative Example 4 8.79 Comparative Example 5 4.21 Comparative Example 6 6.21 Comparative Example 7 3.51 Comparative Example 8 10.38 Comparative Example 9 10.78 in conclusion: Surfactant residue on the skin is one of the main causes of tightness and potential irritation after use. Quantitative results from this test showed that the surfactant residue levels in Examples 1-3 were all at extremely low levels (2.57-3.34 ng / µg protein), significantly lower than all comparative examples.

[0074] This result reveals another core advantage of the technical solution of the present invention. The bio-based surfactant system composed of specific sophorolipids and rhamnolipids provides cleaning power, but its own structure or interaction with keratinocyte proteins is relatively weak, making it easier to be rinsed away with water, thereby reducing the residue of the entire surfactant system on the skin.

[0075] The residual amount in Comparative Example 1 was as high as 11.94 ng / µg, representing the baseline level of conventional sulfate systems. Data from Comparative Examples 2 to 6 show that the absence of any one of the core components of the present invention—the bio-based surfactant combination, tridecyl alcohol polyether-2-carboxyamide MEA, tridecyl alcohol isonononate, or the amphoteric surfactant—leads to a significant increase in surfactant residuals to varying degrees, confirming the synergistic effect of these components in constructing a low-residue system.

[0076] Crucially, the data for Example 9 is particularly noteworthy. This formulation employs a conventional approach of enhancing deposition efficiency through branched surfactants. While it exhibits some deposition-promoting effect, as shown in Test Example 2, its surfactant residue is as high as 10.78 ng / µg, comparable to conventional formulations. This comparison powerfully demonstrates that the technical solution of this invention achieves high deposition efficiency of the active ingredient while simultaneously addressing the common problem of high surfactant residue in high-deposition systems.

[0077] In summary, the test data confirms that this invention, through a specific combination of components, not only constructs a micelle system that promotes the deposition of active ingredients, but also creates a gentle cleansing substrate with low skin residue, achieving the dual objectives of the selective deposition concept: increasing the deposition of desired substances and reducing the residue of undesirable substances.

[0078] Test Example 4: Product Application Performance Comparison Test Test method: This test aims to evaluate the performance of each formulation as a product in terms of macroscopic application performance, mainly including two dimensions: foam experience and system viscosity.

[0079] 1. Foam Experience Evaluation: Ten ordinary volunteers were recruited and evaluated using the half-head method. 1.0g of the sample was taken and rubbed onto a standard wig bundle to create foam for one minute. Volunteers rated the foam based on foaming speed, foam volume, foam texture (fineness and density), and the feeling after rinsing. A 5-point scale was used, with 5 being the best performance and 1 being the worst. The final result was the average of the 10 volunteers.

[0080] 2. Viscosity testing was performed using a Brookfield RVT rotational viscometer. Under constant temperature conditions of 25°C, a No. 6 rotor was selected, and the viscosity of each sample was measured at a rotation speed of 10 RPM. The values ​​were recorded after the readings stabilized, and the unit is centipoise (cps).

[0081] Test results: Table 5: Application performance test results of each embodiment and comparative example sample Foam Experience (out of 5) Viscosity (cps) Example 1 5 6650 Example 2 5 7230 Example 3 5 6410 Comparative Example 1 3 8500 Comparative Example 2 4 5850 Comparative Example 3 4 4800 Comparative Example 4 4 3800 Comparative Example 5 5 2250 Comparative Example 6 3 1500 Comparative Example 7 5 5900 Comparative Example 8 4 2500 Comparative Example 9 5 8700 in conclusion: The results of this test show that the technical solution of this invention can achieve its core technical effects while also taking into account the commercial application value of the product.

[0082] Examples 1-3 all achieved the best foam experience score of 5, and their viscosity remained within the ideal range of 6000-7500 cps. This indicates that the component combination of the present invention provides excellent macroscopic usability while constructing specific micromictal structures to achieve selective deposition.

[0083] The comparative data further reveal the contribution of each component to the application performance. The foam score and viscosity of Comparative Example 6 (lacking the amphoteric surfactant) both dropped to unacceptable levels, demonstrating the necessity of the amphoteric surfactant for maintaining the foam and basic structure of the system. The viscosity of Comparative Example 4 (lacking tridecyl alcohol polyether-2-carboxylamide MEA) and Comparative Example 5 (lacking tridecyl alcohol isononanoate) both showed significant and substantial decreases, confirming that the synergistic effect of these two components is key to achieving the viscosity of the system of this invention; the absence of either one would prevent the attainment of a suitable product form.

[0084] Compared to Comparative Example 7 (using CMEA) and Comparative Example 9 (using branched surfactants), although their viscosity and foaming properties are also good, data from Test Examples 2 and 3 show that they come at the cost of sacrificing effective deposition efficiency or resulting in high surfactant residue. The technical solution of this invention solves both the deposition efficiency and residue issues without sacrificing application performance.

[0085] In summary, the data from this test confirms that the present invention, through the precise compounding of each component, successfully achieves a balance between constructing a functional micelle system and maintaining excellent product application performance, thus solving the technical bias in the prior art that often leads to excessively low product viscosity or poor foaming in pursuit of deposition efficiency.

Claims

1. A bio-based cleaning composition containing selectively deposited active ingredients, characterized in that, By weight percentage, it contains the following components: 1-10% sophorolipids; 1-5% rhamnolipid; 0.3-1% of tridecyl alcohol polyether-2-carboxyamide MEA; 0.5-10% tridecyl alcohol fatty acid esters; 0.5-10% amphoteric surfactants; 0.1-1% water-insoluble, surfactant-soluble scalp care products; 5-30% anionic surfactants; The remainder is pure water.

2. The bio-based cleaning composition for selectively depositing effective substances according to claim 1, characterized in that, The sophorolipid is a compound of a first sophorolipid and a second sophorolipid.

3. The bio-based cleaning composition for selectively depositing effective substances according to claim 2, characterized in that, The first sophorolipid has an HLB value of 3-5, and the second sophorolipid has an HLB value of 11-15.

4. The bio-based cleaning composition for selectively depositing effective substances according to claim 2, characterized in that, In the sophorolipid, the weight ratio of the second sophorolipid to the first sophorolipid is (3:7) to (7:3).

5. The bio-based cleaning composition for selectively depositing effective substances according to claim 1, characterized in that, The critical micelle concentration (CMC) of the rhamnolipid is 50-120 mg / L.

6. The bio-based cleaning composition containing selectively deposited active ingredients according to claim 1, characterized in that, The tridecyl alcohol fatty acid ester is selected from one or more of tridecyl alcohol stearate, tridecyl alcohol trimellitate, tridecyl alcohol behenate, tridecyl alcohol neopentanoate, and tridecyl alcohol isononanoate.

7. The bio-based cleaning composition for selectively depositing effective substances according to claim 1, characterized in that, The amphoteric surfactant is selected from one or two of lauramidopropyl betaine, cocamidopropyl betaine, lauramidohydroxysulfonate, cocoyl hydroxysulfonate, sodium lauroyl amphoteric acetate, and sodium cocoyl amphoteric acetate.

8. The bio-based cleaning composition containing selectively deposited active ingredients according to claim 1, characterized in that, The scalp care agent is selected from one or more of piroctone ethanolamine salt, salicylic acid, capryloyl glycine, bisabolol, and clomibazole.

9. A bio-based cleaning composition for selectively depositing active ingredients according to claim 1, characterized in that, The anionic surfactant is one or a combination of two of sodium lauryl ether sulfate, ammonium dodecyl sulfate, sodium α-olefin sulfonate, and sodium methyl fatty taurate.

10. A bio-based cleaning composition for selectively depositing active ingredients according to claim 1, characterized in that, The composition also contains 3% of one or more essential stabilizing components selected from cationic polymers, chelating agents, and pH adjusters.

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