An intimate care oil capsule based on oil-soluble chimeric collagen and a method of making the same

Abstract

This invention discloses a feminine care oil capsule based on oil-soluble chimeric collagen and its preparation method, relating to the field of cosmetic technology. The oil phase contents include: 0.5–2.0 wt% oil-soluble chimeric collagen, 95–98 wt% plant oil-based carrier, 0.3–3.0 wt% biomimetic sebum membrane lipid composition, and 0.1–0.5 wt% antioxidant; wherein the biomimetic sebum membrane lipid composition is composed of ceramide, cholesterol, and free fatty acids in a molar ratio of (0.8–1.2):(0.8–1.2):(0.8–1.2). By constructing oil-soluble chimeric collagen molecules, which are stably dispersed in the plant oil-based carrier and self-assembled into nanomicelles, the technical problem that traditional water-soluble collagen cannot be applied to anhydrous oil phase systems is solved. Combined with the scientific formulation of the biomimetic sebum membrane lipid composition, it effectively enhances the vulvar skin barrier repair ability and moisturizing durability. With the specific preparation process and soft capsule dosage form, it achieves high stability of active ingredients, precise dosage, and no preservatives added.

Description

Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to a feminine care oil capsule based on oil-soluble chimeric collagen and its preparation method. Background Technology

[0002] Cosmetic technology refers to the multidisciplinary and interdisciplinary technological system involved in the research, development, production, and application of cosmetics. It encompasses fields such as raw material chemistry, colloid and interface science, skin biology, formulation engineering, stability evaluation, and safety assessment. The aim is to use scientific formulation and advanced processes to create safe, effective, stable, and user-friendly topical products from active or inactive ingredients that have the functions of cleansing, protecting, beautifying, modifying, or improving the skin, hair, and mucous membranes. This technology not only focuses on the sensory experience and efficacy claims of the product but also emphasizes respect for and compatibility with the skin barrier structure and microecology, especially in the care of special areas (such as the eye area and intimate areas), where gentleness, physiological compatibility, and functionality must be considered.

[0003] Traditional collagen is a hydrophilic macromolecule that is insoluble, easily aggregates, and rapidly deactivated in nonpolar carriers such as plant oils. This prevents its bioactivity from being effectively utilized in oil-based intimate care products. In addition, active ingredients such as collagen and unsaturated lipids are easily degraded by light, heat, and oxygen when stored in the oil phase for a long time. Furthermore, the addition of preservatives or emulsifiers may irritate sensitive intimate areas. Summary of the Invention

[0004] In view of the aforementioned existing problems, the present invention is proposed.

[0005] Therefore, this invention provides a feminine care oil capsule based on oil-soluble chimeric collagen to solve the problems of traditional collagen being a hydrophilic macromolecule that is insoluble, easily aggregates, and rapidly inactivated in non-polar carriers such as plant oils, resulting in its inability to effectively exert its biological activity in oil-based feminine care products. At the same time, active substances such as collagen and unsaturated lipids are easily degraded by light, heat, and oxygen during long-term storage in the oil phase, and the conventional addition of preservatives or emulsifiers may irritate sensitive intimate areas.

[0006] To solve the above-mentioned technical problems, the present invention provides the following technical solution: In a first aspect, the present invention provides a feminine care oil capsule based on oil-soluble chimeric collagen, wherein the oil phase contents include: 0.5–2.0 wt% oil-soluble chimeric collagen, 95–98 wt% plant oil-based carrier, 0.3–3.0 wt% biomimetic sebum membrane lipid composition, and 0.1–0.5 wt% antioxidant; The biomimetic sebaceous membrane lipid composition therein consists of ceramides, cholesterol, and free fatty acids in a molar ratio of (0.8–1.2):(0.8–1.2):(0.8–1.2).

[0007] As a preferred embodiment of the intimate care oil capsule based on oil-soluble chimeric collagen described in this invention, the oil-soluble chimeric collagen is an amphiphilic molecule formed by grafting collagen peptides with a molecular weight of 500–2000 Da with C8–C18 fatty acids or phospholipids via covalent bonds. It is used to form a transparent and homogeneous solution in the plant oil-based carrier and self-assembles into nanomicelles with a particle size of 20–100 nm.

[0008] As a preferred embodiment of the intimate care oil capsule based on oil-soluble chimeric collagen described in this invention, the collagen peptides are derived from type I or type III collagen, the grafting site is the ε-amino group of lysine residues, and each collagen peptide molecule is connected to 1–3 hydrophobic chains.

[0009] Secondly, the present invention provides a method for preparing a feminine care oil capsule based on oil-soluble chimeric collagen, comprising: Step 1: Dissolve collagen peptides with a molecular weight of 500 to 2000 Daltons in a buffer solution with a pH of 7.0 to 8.0, add C8 to C18 fatty acids or phospholipids activated by N-hydroxysuccinimide, and react at 25 to 35 degrees Celsius for 4 to 8 hours to generate crude oil-soluble chimeric collagen. Step 2: Dialyze the crude oil-soluble chimeric collagen obtained in Step 1, and then freeze-dry it to obtain oil-soluble chimeric collagen solid. Step 3: Add the oil-soluble chimeric collagen solid obtained in Step 2 to a plant oil-based carrier, stir at 40 to 50 degrees Celsius until a transparent and homogeneous solution is formed, and cool to room temperature to form a nano micelle dispersion by self-assembly. Step 4: Add a biomimetic sebum membrane lipid composition premixed with ceramide, cholesterol and free fatty acids in a molar ratio of 0.8 to 1.2: 0.8 to 1.2: 0.8 to 1.2 to the nanomicelle dispersion obtained in Step 3, then add an antioxidant, and stir at 30 to 40 degrees Celsius for 30 to 60 minutes under an inert gas atmosphere to obtain a homogeneous oil phase contents; Step 5: Fill the homogeneous oil phase contents obtained in Step 4 into the soft capsule shell, and after shaping, drying and sterilization, produce a private care oil capsule based on oil-soluble chimeric collagen.

[0010] As a preferred embodiment of the preparation method of the intimate care oil capsule based on oil-soluble chimeric collagen according to the present invention, wherein: in step one, the collagen peptides are derived from type I or type III collagen, the buffer solution is phosphate buffer, and the C8 to C18 fatty acids or phospholipids activated by N-hydroxysuccinimide are prepared by activating the corresponding fatty acids or phospholipids with N-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide in anhydrous dichloromethane at 0 to 5 degrees Celsius for 2 hours.

[0011] As a preferred embodiment of the preparation method of the intimate care oil capsule based on oil-soluble chimeric collagen according to the present invention, in step two, the dialysis treatment uses a dialysis bag with a molecular weight cutoff of 1000 Daltons, and dialyzes in deionized water for 48 hours, changing the deionized water every 6 hours. After dialysis, the sample is pre-frozen at -80 degrees Celsius for 4 hours, and then freeze-dried at a vacuum degree ≤10 Pa and a cold trap temperature of -50 degrees Celsius for 24 hours to obtain a white, loose oil-soluble chimeric collagen solid.

[0012] As a preferred embodiment of the preparation method of the intimate care oil capsule based on oil-soluble chimeric collagen according to the present invention, in step three, the plant oil-based carrier is at least one of jojoba oil, squalane or sweet almond oil, the stirring speed is 300 to 500 rpm, the stirring time is 30 to 60 minutes, the cooling process is carried out in a light-proof environment to naturally drop to 25 degrees Celsius, and after standing for 1 hour, a nano-micelle dispersion with a particle size of 20 to 100 nanometers is formed.

[0013] As a preferred embodiment of the preparation method of the intimate care oil capsule based on oil-soluble chimeric collagen according to the present invention, in step four, the ceramide is ceramide NP, the free fatty acid is oleic acid or linoleic acid, the biomimetic sebum membrane lipid composition is pre-melted and mixed at 40 degrees Celsius for 10 minutes to form a homogeneous lipid phase, the antioxidant is d-α-tocopherol, the amount added is 0.1% to 0.5% of the total mass of the oil phase, the inert gas is nitrogen or argon, and the oxygen content of the system is maintained below 50 ppm during stirring.

[0014] As a preferred embodiment of the preparation method of the intimate care oil capsule based on oil-soluble chimeric collagen according to the present invention, in step five, the soft capsule shell is prepared by hydroxypropyl methylcellulose, glycerin and sorbitol in a mass ratio of 10:3:2. The filling is carried out by a rotary molding soft capsule machine with a filling amount of 0.5 to 1.0 ml per capsule. The shaping is carried out for 2 hours under the conditions of relative humidity of 30% to 40% and temperature of 20 to 25 degrees Celsius. The drying is carried out by a gradient temperature increase method, drying at 30 degrees Celsius for 4 hours and drying at 35 degrees Celsius for 6 hours in sequence, and the final moisture content is controlled below 5%.

[0015] As a preferred embodiment of the preparation method of the intimate care oil capsule based on oil-soluble chimeric collagen according to the present invention, the sterilization process is carried out by ethylene oxide gas sterilization, and the sterilization conditions are ethylene oxide concentration of 600 mg / L, temperature of 37 degrees Celsius, relative humidity of 60%, and action time of 6 hours. After sterilization, the residual amount of ethylene oxide is reduced to less than 10 micrograms per gram after 72 hours of analysis, so as to obtain the finished intimate care oil capsule that meets the cosmetic safety technical specifications.

[0016] The beneficial effects of this invention are as follows: By constructing oil-soluble chimeric collagen molecules, which are stably dispersed in a plant oil-based carrier and self-assembled into nanomicelles, the technical problem that traditional water-soluble collagen cannot be applied to anhydrous oil-phase systems is solved. Combined with the scientific formulation of biomimetic sebum membrane lipid composition, it effectively enhances the vulvar skin barrier repair ability and moisturizing durability. With the specific preparation process and soft capsule dosage form, it achieves high stability of active ingredients, precise dosage and no preservatives added, taking into account the physiological characteristics of intimate areas and the safety of use. Attached Figure Description

[0017] To more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings used in the following description of the embodiments will be briefly introduced. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0018] Figure 1 This is a flowchart of the intimate care oil capsule based on oil-soluble chimeric collagen in Example 1. Detailed Implementation

[0019] To make the above-mentioned objects, features and advantages of the present invention more apparent and understandable, the specific embodiments of the present invention will be described in detail below with reference to the accompanying drawings.

[0020] Many specific details are set forth in the following description in order to provide a full understanding of the invention. However, the invention may also be practiced in other ways different from those described herein, and those skilled in the art can make similar extensions without departing from the spirit of the invention. Therefore, the invention is not limited to the specific embodiments disclosed below.

[0021] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in different places in this specification does not necessarily refer to the same embodiment, nor is it a single or selective embodiment that is mutually exclusive with other embodiments.

[0022] Example 1, referring to Figure 1 This embodiment provides a feminine care oil capsule based on oil-soluble chimeric collagen. Its oil phase contents consist of the following components by weight percentage: 1.2 wt% oil-soluble chimeric collagen, 96.0 wt% jojoba oil, 2.3 wt% biomimetic sebum membrane lipid composition, and 0.5 wt% d-α-tocopherol. The biomimetic sebum membrane lipid composition is a mixture of ceramide NP, cholesterol, and oleic acid in a molar ratio of 1.0:1.0:1.0.

[0023] Oil-soluble chimeric collagen was prepared as follows: Type III collagen peptides with a molecular weight of 1500 Daltons were dissolved in phosphate buffer at pH 7.4, and lauric acid activated with N-hydroxysuccinimide was added. The mixture was reacted at 30°C for 6 hours. The reaction solution was dialyzed through a dialysis bag with a molecular weight cutoff of 1000 Daltons for 48 hours and then freeze-dried to obtain a white, loose solid. This solid was stirred in jojoba oil at 45°C for 40 minutes to form a transparent, homogeneous solution. After cooling to 25°C, the solution self-assembled into a nanomicelle dispersion with an average particle size of 63 nm. Subsequently, a pre-molten biomimetic sebum membrane lipid composition and d-α-tocopherol were added to the above dispersion, and the mixture was stirred at 35°C for 45 minutes under a nitrogen atmosphere to obtain a homogeneous oil phase.

[0024] The oil phase contents were filled into gelatin-glycerol soft capsule shells at a dosage of 0.7 mL / capsule. The capsules were then set at 25°C and 35% relative humidity for 2 hours, followed by drying at 30°C for 4 hours and 35°C for 6 hours. Finally, the capsules were sterilized with ethylene oxide (600 mg / L, 37°C, 6 hours) and eluented for 72 hours to obtain the final product. After accelerated storage at 40°C and 75% relative humidity for 6 months, no turbidity, stratification, or precipitation was observed.

[0025] Example 2 provides a feminine care oil capsule based on oil-soluble chimeric collagen. Its oil phase contents consist of the following components by weight percentage: 0.8 wt% oil-soluble chimeric collagen, 97.5 wt% squalane, 1.5 wt% biomimetic sebum membrane lipid composition, and 0.2 wt% rosemary extract.

[0026] The biomimetic sebum membrane lipid composition is composed of ceramide NP, cholesterol and linoleic acid mixed in a molar ratio of 0.9:1.1:1.0; the rosemary extract contains no less than 5% carrageenan.

[0027] Oil-soluble chimeric collagen was prepared by EDC / NHS coupling of type I collagen peptides with a molecular weight of 1800 Daltons and phosphatidylcholine. The grafting site was the ε-amino group of lysine residues, and each collagen peptide molecule was linked to 1 to 2 phospholipid chains. In preparation, the obtained chimeric collagen solid was added to squalane and stirred at 50°C and 400 rpm for 50 minutes to form a transparent solution. After cooling, it formed nanomicelles with a particle size of 89 nm.

[0028] The subsequent mixing, filling and drying processes are the same as in Example 1. The soft capsule shell uses a hydroxypropyl methylcellulose-glycerol-sorbitol system (mass ratio 10:3:2) and a filling amount of 1.0 ml / capsule.

[0029] After 14 days of accelerated oxidation testing at 60℃, the product had a peroxide value of 4.2 milliequivalents / kg, indicating that the antioxidant system effectively inhibited the deterioration of oils.

[0030] Example 3 provides a feminine care oil capsule based on oil-soluble chimeric collagen. Its oil phase contents consist of the following components by weight percentage: 1.8 wt% oil-soluble chimeric collagen, 95.2 wt% sweet almond oil, 2.8 wt% biomimetic sebum membrane lipid composition, and 0.2 wt% ethyl ferulic acid.

[0031] The biomimetic sebum membrane lipid composition is composed of ceramide NP, cholesterol, and oleic acid mixed in a molar ratio of 1.2:0.8:1.1. The oil-soluble chimeric collagen is prepared by grafting low molecular weight type III collagen peptides with a molecular weight of 600 Daltons with palmitic acid (C16), with a grafting degree of 2.5 hydrophobic chains per molecule.

[0032] Due to its short peptide segments and long hydrophobic chains, it self-assembles in sweet almond oil to form dense nanomicelles with an average particle size of 32 nanometers. In vitro Franz diffusion cell experiments showed that the cumulative penetration of this collagen in an artificial vaginal mucosa model reached 18.7 micrograms per square centimeter within 8 hours, a 70% increase compared to Example 1. The soft capsules contain 0.5 ml per capsule, suitable for precise local care after surgery or during sensitive periods.

[0033] Example 4 provides a feminine care oil capsule based on oil-soluble chimeric collagen. Its oil phase contents consist of the following components by weight percentage: 1.0 wt% oil-soluble chimeric collagen, 72.6 wt% jojoba oil, 24.2 wt% squalane, 1.9 wt% biomimetic sebum membrane lipid composition, and 0.3 wt% d-α-tocopherol and coenzyme Q10 complex antioxidant (mass ratio 2:1).

[0034] The biomimetic sebum membrane lipid composition is composed of ceramide NP, cholesterol, and linoleic acid mixed in a molar ratio of 1.0:1.0:0.8. The oil-soluble chimeric collagen is prepared by grafting decanoic acid (C10) onto a mixture of type I and type III collagen peptides (mass ratio 1:1, average molecular weight 1300 Daltons).

[0035] The oil phase viscosity is 28 mPa·s (25°C), which is suitable for continuous filling in high-speed soft capsule machines.

[0036] After a 28-day human trial involving 30 subjects, no cases of erythema, itching, or irritation were observed, and the RIPT test results were negative, confirming its high safety and suitability for menopausal women's dryness care.

[0037] Example 5 provides a feminine care oil capsule based on oil-soluble chimeric collagen. Its oil phase contents consist of the following components by weight percentage: 0.6 wt% oil-soluble chimeric collagen, 98.0 wt% supercritical CO2 extracted sweet almond oil (peroxide value 0.8 mEq / kg), 0.5 wt% biomimetic sebum membrane lipid composition, and 0.9 wt% natural vitamin E complex.

[0038] The biomimetic sebum membrane lipid composition is composed of ceramide NP, cholesterol, and oleic acid mixed in a molar ratio of 0.8:0.8:0.8; the natural vitamin E complex contains α-, γ-, and δ-tocopherols, with a total tocopherol content ≥70%. The oil-soluble chimeric collagen is prepared by grafting type III collagen peptides (molecular weight 1600 Daltons) with oleic acid (C18), with a grafting degree of 1.5.

[0039] Despite its low collagen content, the product still achieved significant moisturizing effects due to its high purity and optimized lipid ratio: after 7 days of continuous use by 30 subjects, the average moisture content of the vulvar skin increased by 34%, and transepidermal water loss decreased by 26%.

[0040] In addition, 0.5 wt% lactic acid microcapsules are incorporated into the soft capsule shell. When the capsule ruptures, lactic acid is released simultaneously, adjusting the local pH to 5.0, which is beneficial for maintaining the dominant lactobacillus flora.

[0041] Comparative Example 1 attempted to prepare a control sample without chimeric modification. 1.0 wt% of unmodified water-soluble type III collagen (molecular weight 2000 Daltons) was directly added to jojoba oil. Even after high-speed shearing at 20,000 rpm for 10 minutes and ultrasonic treatment for 30 minutes, the resulting system remained milky white and turbid. After standing for 24 hours, flocculent precipitate appeared at the bottom, making it unsuitable for soft capsule filling. This result indicates that unmodified hydrophobic collagen cannot be stably dispersed in a nonpolar oil phase system.

[0042] Comparative Example 2 followed the formulation of Example 1, but replaced the 2.3 wt% biomimetic sebum membrane lipid composition with an equal amount of a single component—only 2.3 wt% ceramide NP was added, while the remaining components and processes remained unchanged. Although the resulting oil phase was clear and transparent, in the artificial skin barrier reconstruction model test, transepidermal water loss was reduced by only 9%, significantly lower than the 28% in Example 1. This result demonstrates that without the synergistic effect of cholesterol and free fatty acids, a lipid bilayer structure with complete barrier function cannot be formed.

[0043] Comparative Example 3 omitted the oil-soluble chimeric collagen. The oil phase consisted of 97.2 wt% jojoba oil, 2.3 wt% biomimetic sebum membrane lipid composition (molar ratio 1.0:1.0:1.0), and 0.5 wt% d-α-tocopherol. The remaining preparation process was the same as in Example 1. After 7 days of continuous use in 30 subjects, the subjective improvement rate of vulvar dryness symptoms was 41%, compared to 79% in Example 1. Histopathological staining showed no significant change in epidermal collagen fiber density in the comparative example group, while collagen deposition significantly increased in the Example 1 group. These results confirm that oil-soluble chimeric collagen has an irreplaceable functional contribution to promoting local tissue repair and regeneration. In summary, this invention solves the technical problem that traditional water-soluble collagen cannot be applied to anhydrous oil-phase systems by constructing oil-soluble chimeric collagen molecules, which are stably dispersed in a plant oil-based carrier and self-assembled into nanomicelles. Combined with the scientific formulation of a biomimetic sebum membrane lipid composition, it effectively enhances the vulvar skin barrier repair ability and moisturizing durability. With the specific preparation process and soft capsule dosage form, it achieves high stability of active ingredients, precise dosage and no preservatives added, taking into account the physiological characteristics of intimate areas and the safety of use.

[0044] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit it. Although the present invention has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications or equivalent substitutions can be made to the technical solutions of the present invention without departing from the spirit and scope of the technical solutions of the present invention, and all such modifications or substitutions should be covered within the scope of the claims of the present invention.

Claims

1. A feminine hygiene oil capsule based on oil-soluble chimeric collagen, characterized in that: The oil phase contents include: 0.5–2.0 wt% oil-soluble chimeric collagen, 95–98 wt% plant oil-based carrier, 0.3–3.0 wt% biomimetic sebum membrane lipid composition, and 0.1–0.5 wt% antioxidant; The biomimetic sebaceous membrane lipid composition therein consists of ceramides, cholesterol, and free fatty acids in a molar ratio of (0.8–1.2):(0.8–1.2):(0.8–1.2).

2. The intimate care oil capsule based on oil-soluble chimeric collagen as described in claim 1, characterized in that: The oil-soluble chimeric collagen is an amphiphilic molecule formed by grafting collagen peptides with a molecular weight of 500–2000 Da with C8–C18 fatty acids or phospholipids via covalent bonds. It is used to form a transparent and homogeneous solution in the plant oil-based carrier and self-assembles into nanomicelles with a particle size of 20–100 nm.

3. The intimate care oil capsule based on oil-soluble chimeric collagen as described in claim 2, characterized in that: The collagen peptides are derived from type I or type III collagen, with the grafting site being the ε-amino group of lysine residues, and each collagen peptide molecule is linked to 1–3 hydrophobic chains.

4. A method for preparing a feminine hygiene oil capsule based on oil-soluble chimeric collagen, as described in any one of claims 1-3, characterized in that: include: Step 1: Dissolve collagen peptides with a molecular weight of 500 to 2000 Daltons in a buffer solution with a pH of 7.0 to 8.0, add C8 to C18 fatty acids or phospholipids activated by N-hydroxysuccinimide, and react at 25 to 35 degrees Celsius for 4 to 8 hours to generate crude oil-soluble chimeric collagen. Step 2: Dialyze the crude oil-soluble chimeric collagen obtained in Step 1, and then freeze-dry it to obtain oil-soluble chimeric collagen solid. Step 3: Add the oil-soluble chimeric collagen solid obtained in Step 2 to a plant oil-based carrier, stir at 40 to 50 degrees Celsius until a transparent and homogeneous solution is formed, and cool to room temperature to form a nano micelle dispersion by self-assembly. Step 4: Add a biomimetic sebum membrane lipid composition premixed with ceramide, cholesterol and free fatty acids in a molar ratio of 0.8 to 1.2: 0.8 to 1.2: 0.8 to 1.2 to the nanomicelle dispersion obtained in Step 3, then add an antioxidant, and stir at 30 to 40 degrees Celsius for 30 to 60 minutes under an inert gas atmosphere to obtain a homogeneous oil phase contents; Step 5: Fill the homogeneous oil phase contents obtained in Step 4 into the soft capsule shell, and after shaping, drying and sterilization, produce a private care oil capsule based on oil-soluble chimeric collagen.

5. The method for preparing the intimate care oil capsule based on oil-soluble chimeric collagen as described in claim 4, characterized in that: In step one, the collagen peptides are derived from type I or type III collagen, the buffer solution is phosphate buffer, and the C8 to C18 fatty acids or phospholipids activated by N-hydroxysuccinimide are prepared by activating the corresponding fatty acids or phospholipids with N-hydroxysuccinimide and 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide in anhydrous dichloromethane at 0 to 5 degrees Celsius for 2 hours.

6. The method for preparing the intimate care oil capsule based on oil-soluble chimeric collagen as described in claim 5, characterized in that: In step two, the dialysis treatment uses a dialysis bag with a molecular weight cutoff of 1000 Daltons. Dialysis is performed in deionized water for 48 hours, with the deionized water being replaced every 6 hours. After dialysis, the sample is pre-frozen at -80 degrees Celsius for 4 hours, and then freeze-dried at a vacuum of ≤10 Pa and a cold trap temperature of -50 degrees Celsius for 24 hours to obtain a white, loose, oil-soluble chimeric collagen solid.

7. The method for preparing the intimate care oil capsule based on oil-soluble chimeric collagen as described in claim 6, characterized in that: In step three, the plant oil-based carrier is at least one of jojoba oil, squalane, or sweet almond oil. The stirring speed is 300 to 500 revolutions per minute, the stirring time is 30 to 60 minutes, the cooling process is carried out in a light-proof environment and the temperature naturally drops to 25 degrees Celsius. After standing for 1 hour, a nano-micelle dispersion with a particle size of 20 to 100 nanometers is formed.

8. The method for preparing the intimate care oil capsule based on oil-soluble chimeric collagen as described in claim 7, characterized in that: In step four, the ceramide is ceramide NP, the free fatty acid is oleic acid or linoleic acid, the biomimetic sebum membrane lipid composition is pre-melted and mixed at 40 degrees Celsius for 10 minutes to form a homogeneous lipid phase, the antioxidant is d-α-tocopherol, the amount added is 0.1% to 0.5% of the total mass of the oil phase, the inert gas is nitrogen or argon, and the oxygen content of the system is maintained below 50 ppm during stirring.

9. The method for preparing the intimate care oil capsule based on oil-soluble chimeric collagen as described in claim 8, characterized in that: In step five, the soft capsule shell is prepared from hydroxypropyl methylcellulose, glycerin and sorbitol in a mass ratio of 10:3:

2. The filling is carried out using a rotary molding soft capsule machine with a filling amount of 0.5 to 1.0 ml per capsule. The shaping is carried out for 2 hours under conditions of relative humidity of 30% to 40% and temperature of 20 to 25 degrees Celsius. The drying is carried out using a gradient temperature method, drying at 30 degrees Celsius for 4 hours and then at 35 degrees Celsius for 6 hours, with the final moisture content controlled below 5%.

10. The method for preparing the intimate care oil capsule based on oil-soluble chimeric collagen as described in claim 9, characterized in that: The sterilization process uses ethylene oxide gas sterilization. The sterilization conditions are ethylene oxide concentration of 600 mg / L, temperature of 37 degrees Celsius, relative humidity of 60%, and contact time of 6 hours. After sterilization, the residual ethylene oxide content is reduced to less than 10 micrograms per gram after 72 hours of analysis, resulting in finished feminine care oil capsules that meet the cosmetic safety technical specifications.

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