Bacteriostatic and moisturizing type soap extract hand sanitizer and preparation process thereof

Abstract

The application discloses a bacteriostatic and moisturizing soap extract hand sanitizer and a preparation method thereof. The hand sanitizer takes a soap extract as a basic raw material, cooperatively modifies the soap extract through citric acid and quaternary ammonium chitosan, obtains modified soap extract with significantly improved stability and mildness, and introduces an organic small molecule myopeptide which is not applied in the field of hand sanitizer into the modified soap extract on the basis, and is prepared in combination with an amino acid type surfactant, a non-ionic surfactant, a moisturizing agent, a thickening agent and a bacteriostatic auxiliary agent and the like. The hand sanitizer has good bacteriostatic effect in the cleaning process, can form a stable moisturizing environment on the skin surface after washing, has the synergistic enhancement effect of bacteriostatic performance and moisturizing performance, and reduces the irritation to the skin. The preparation method is simple in process and mild in condition, the obtained hand sanitizer is suitable for high-frequency hand washing scenes, and has a good application prospect.

Description

Technical Field

[0001] This invention relates to the field of daily chemical products technology, specifically to an antibacterial and moisturizing soapberry extract hand sanitizer and its preparation method. Background Technology

[0002] Hand sanitizer, as a frequently used daily cleaning product, not only removes dirt and microorganisms from the skin's surface but also needs to protect the skin barrier. Current hand sanitizer products mostly use anionic or nonionic surfactants as the main cleaning ingredient, supplemented with synthetic antibacterial agents to achieve an antibacterial effect. However, with prolonged or frequent use, these products can easily damage the natural lipid structure in the skin's stratum corneum, leading to dryness, tightness, and even irritation, making them unsuitable for sensitive individuals and frequent handwashing scenarios.

[0003] As consumers increasingly demand natural, safe, and gentle daily chemical products, plant-derived functional ingredients are gradually being introduced into the hand sanitizer industry. Soapberry extract, rich in saponins, possesses natural foaming, cleaning, and antibacterial properties, and is considered a promising plant-based cleaning ingredient. However, in existing technologies, the direct application of soapberry extract to hand sanitizer systems generally suffers from insufficient aqueous phase stability, high irritation, and short effective duration, making it difficult to simultaneously guarantee antibacterial performance and good moisturizing effects.

[0004] To improve the application performance of soapberry extract, existing technologies have attempted simple physical modification by introducing solubilizers or polymeric stabilizers. However, these methods have limited ability to regulate the structure of the soapberry extract itself, and its antibacterial and moisturizing functions remain mutually restrictive, making it difficult to achieve synergistic enhancement. Meanwhile, the moisturizing ingredients commonly used in existing hand sanitizer formulations are mostly polyols, which are easily washed away during rinsing, making it difficult to form a stable moisturizing environment on the skin surface, resulting in insufficient long-lasting moisturization after washing.

[0005] Low-molecular-weight organic compounds are typically used only as auxiliary regulating or stabilizing ingredients in hand sanitizers. Their potential in antibacterial or moisturizing functions has not been fully explored. In particular, there is no technology that can synergistically apply specific functional small organic molecules with plant extracts to hand sanitizer systems to simultaneously improve antibacterial effects and skin moisturizing properties.

[0006] Therefore, there is an urgent need to provide a new technical solution that effectively modifies soap extract and introduces new functional organic small molecules, so that hand sanitizer can significantly improve the skin's moisturizing effect and comfort after washing while ensuring cleaning and antibacterial effects, thereby overcoming the above-mentioned shortcomings of existing technologies. Summary of the Invention

[0007] To overcome the problems of insufficient stability and high irritation of soapberry extract in hand sanitizer systems, as well as the difficulty in simultaneously achieving antibacterial and moisturizing properties, as described in the background art, the present invention aims to provide an antibacterial and moisturizing soapberry extract hand sanitizer and its preparation method. This invention achieves a synergistic improvement in the antibacterial and moisturizing properties of the hand sanitizer by synergistic modification of the soapberry extract and the introduction of new functional components. The modified soapberry extract obtained by synergistic modification with citric acid and quaternized chitosan is used as the main cleaning and antibacterial ingredient. Organic small molecule carnosine, which is not currently used in hand sanitizers, is introduced into the hand sanitizer system, combined with amino acid-based surfactants, nonionic surfactants, and various functional additives, to prepare the antibacterial and moisturizing soapberry extract hand sanitizer. The hand sanitizer of the present invention significantly improves the moisturizing effect and user comfort of the skin after washing while ensuring good cleaning and antibacterial performance.

[0008] The objective of this invention can be achieved through the following technical solutions: A hand sanitizer containing antibacterial and moisturizing soapberry extract, comprising the following raw materials in parts by weight: 2-8 parts modified soapberry extract; 0.1-2.0 parts organic small molecule functional agent; 5-15 parts amino acid surfactant; 2-8 parts nonionic surfactant; 3-10 parts moisturizer; 0.2-1.5 parts thickener; 0.05-0.5 parts antibacterial adjuvant; 0.05-0.3 parts chelating agent; 0.05-0.5 parts pH adjuster; and 60-85 parts deionized water. The modified soapberry extract is a modified product obtained by the synergistic modification of soapberry extract with citric acid and quaternized chitosan. The organic small molecule functional agent is carnosine, which is not currently used in hand sanitizers and can synergistically work with the modified soapberry extract to give the hand sanitizer a synergistic enhancement effect of both antibacterial and moisturizing properties.

[0009] Optionally, the modified soapberry extract comprises the following raw materials in parts by weight: 70-90 parts soapberry extract; 1-6 parts citric acid; 3-15 parts quaternized chitosan; and 20-60 parts deionized water.

[0010] Optionally, the preparation method of the modified soapberry extract includes the following steps: (1) Add soapberry extract to deionized water and disperse under stirring to obtain soapberry extract dispersion system; (2) Citric acid and quaternized chitosan were added to the soapberry extract dispersion system and synergistically modified under stirring conditions to obtain the modified system; (3) Stabilize the modified system to obtain the modified soap extract.

[0011] Optionally, the reaction conditions in step (1) are: stirring for 10 to 40 minutes at 25 to 50°C to fully disperse the soap extract.

[0012] Optionally, the reaction conditions in step (2) are as follows: at 40-70°C, the pH of the system is controlled at 4.0-6.5, and the mixture is stirred for 30-120 min to carry out synergistic modification treatment.

[0013] Optionally, the reaction conditions in step (3) are homogenization or filtration at 20–40°C, followed by drying at 40–60°C to obtain the modified soap extract.

[0014] Optionally, the amino acid-type surfactant is a mixture of sodium cocoyl glycinate and sodium lauroyl sarcosinate in a mass ratio of (1-3):(3-1); the nonionic surfactant is a mixture of decyl glucoside and dodecyl glucoside in a mass ratio of (1-4):(4-1); the humectant is a mixture of glycerin and 1,3-propanediol in a mass ratio of (2-8):(8-2); the thickener is a mixture of hydroxyethyl cellulose and xanthan gum in a mass ratio of (3-9):(1-7); the antibacterial adjuvant is a mixture of phenoxyethanol and ethylhexylglycerin in a mass ratio of (5-20):(1-5); the chelating agent is a mixture of disodium ethylenediaminetetraacetate and sodium phytate in a mass ratio of (1-10):(10-1); and the pH adjuster is a mixture of citric acid and sodium citrate in a mass ratio of (1-8):(8-1).

[0015] Optionally, a method for preparing an antibacterial and moisturizing soapberry extract hand sanitizer includes the following steps: S1, add deionized water into the reaction vessel, and under heating and stirring conditions, add modified soap extract and organic small molecule functional agent in sequence to fully disperse them and obtain a homogeneous basic system; S2, add amino acid surfactant, nonionic surfactant, humectant, antibacterial agent and chelating agent to a homogeneous basic system in sequence, mix evenly under stirring conditions to obtain a functional composite system; S3. Thickener is added to the functional composite system to adjust the viscosity of the system, and pH adjuster is added to adjust the pH of the system. After cooling to room temperature, defoaming is performed to obtain antibacterial and moisturizing soapberry extract hand sanitizer.

[0016] Optionally, the reaction conditions for step S1 are: stirring for 10 to 30 minutes at 30 to 60°C to fully disperse the modified soap extract and the organic small molecule functional agent to obtain a homogeneous basic system; the reaction conditions for step S2 are: stirring for 20 to 60 minutes at 30 to 55°C to fully mix the various surfactants, humectants, antibacterial auxiliaries and chelating agents.

[0017] Optionally, the reaction conditions in step S3 are as follows: add thickener at 20-40°C and stir for 10-30 minutes, then adjust the pH of the system to 5.5-6.5, and obtain the finished hand sanitizer after defoaming treatment.

[0018] The beneficial effects of this invention are: This invention utilizes citric acid and quaternized chitosan to synergistically modify saponin extract, constructing a stable hydrophilic modified structure on the surface of saponin molecules. This significantly improves the dispersion stability of saponin extract in aqueous hand sanitizer systems and effectively reduces skin irritation. Simultaneously, it introduces organic small-molecule carnosine into the hand sanitizer system for the first time, enabling it to synergistically interact with the modified saponin extract during the cleaning process. This inhibits common bacteria while creating a moisturizing environment with slow-release properties on the skin surface, thus maintaining skin moisture content and a soft touch even under high-frequency washing conditions. This achieves simultaneous enhancement of antibacterial and moisturizing properties, demonstrating significant inventiveness and practical value. Attached Figure Description

[0019] The invention will now be further described with reference to the accompanying drawings.

[0020] Figure 1 A comparison of the infrared spectra of soapberry extract and modified soapberry extract; Figure 2 This is a comparison chart of the antibacterial rate results for samples with different ratios. Detailed Implementation

[0021] The present invention will be further described below with reference to specific embodiments. However, the present invention is not limited to the following embodiments. Equivalent adjustments made without departing from the spirit and essence of the present invention should also be considered to fall within the protection scope of the present invention.

[0022] Example 1: Under the condition that the dosage of each raw material and the reaction conditions are taken at the lower limit allowed by the claims, it is verified that the hand sanitizer of the present invention still has good antibacterial and moisturizing properties even at low dosage, and the feasibility of the technical solution is demonstrated.

[0023] S1, Preparation of modified soapberry extract Weigh out 70 parts of soapberry extract, 1 part of citric acid, 3 parts of quaternized chitosan, and 20 parts of deionized water. Add the soapberry extract to the deionized water and stir at 25°C for 10 minutes to fully disperse it, thus obtaining a soapberry extract dispersion system. Add citric acid and quaternized chitosan to the dispersion system, adjust the pH of the system to 4.0 at 40°C, and stir for 30 minutes for synergistic modification treatment. Then filter at 20°C and dry at 40°C to obtain the modified soapberry extract.

[0024] S2, Preparation of the basic hand sanitizer system Add 60 parts of deionized water to a reaction vessel and stir at 30°C. Then add 2 parts of modified soapberry extract and 0.1 parts of carnosine to disperse them fully and obtain a homogeneous basic system. Subsequently, add 5 parts of amino acid surfactant, 2 parts of nonionic surfactant, 3 parts of humectant, 0.05 parts of antibacterial agent and 0.05 parts of chelating agent to the reaction vessel and stir at 30°C for 20 minutes to obtain a functional composite system. S3, Preparation of finished hand sanitizer Add 0.2 parts of thickener to the functional composite system, stir for 10 minutes at 20°C to adjust the viscosity of the system, then add 0.05 parts of pH adjuster to adjust the pH of the system to 5.5. After defoaming treatment, antibacterial and moisturizing soapberry extract hand sanitizer is obtained.

[0025] Example 2: Under the condition of taking the median value of the amount of each raw material and the reaction conditions, the optimal balance effect of the hand sanitizer of the present invention in terms of comprehensive performance was verified, which reflects the synergistic enhancement of antibacterial and moisturizing properties.

[0026] S1, Preparation of modified soapberry extract Weigh out 80 parts of soapberry extract, 3.5 parts of citric acid, 9 parts of quaternized chitosan, and 40 parts of deionized water. Add the soapberry extract to the deionized water and stir at 37℃ for 25 min to ensure thorough dispersion. Add citric acid and quaternized chitosan to the dispersion system, adjust the pH to 5.2 at 55℃, and stir for 75 min for synergistic modification. Then homogenize at 30℃ and dry at 50℃ to obtain the modified soapberry extract. Figure 1 A comparison of the infrared spectra before and after modification shows that the unmodified soapberry extract exhibits a clear and broad –OH stretching vibration absorption peak in the 3600–3200 cm⁻¹ region, indicating that its molecule is rich in polyhydroxy structures. A strong absorption peak appears in the 1100–1000 cm⁻¹ region, corresponding to the C–O–C and C–O stretching vibration characteristics in the saponin and polysaccharide structures. After synergistic modification with citric acid and quaternized chitosan, a new C=O stretching vibration absorption peak appears in the infrared spectrum at approximately 1730 cm⁻¹, while the –COO- related absorption peak is significantly enhanced in the 1600–1400 cm⁻¹ region, indicating that the carboxyl group of citric acid has been successfully introduced and participates in the modification. The enhanced absorption peak near 1450 cm⁻¹ indicates that the ammonium salt structure in the quaternized chitosan participates in the formation of a stable composite system. In summary, the clear changes in the infrared spectrum demonstrate that citric acid and quaternized chitosan have successfully synergistically modified the soapberry extract, verifying the formation of the modified structure. S2, Preparation of the basic hand sanitizer system 72 parts of deionized water were added to a reaction vessel and stirred at 45°C. Then, 5 parts of modified soapberry extract and 1.0 part of carnosine were added sequentially to disperse them fully. Next, 10 parts of amino acid surfactant, 5 parts of nonionic surfactant, 6 parts of humectant, 0.25 parts of antibacterial agent and 0.18 parts of chelating agent were added sequentially and stirred at 45°C for 40 minutes to obtain a functional composite system. S3, Preparation of finished hand sanitizer Add 0.8 parts of thickener to the functional composite system, stir for 20 minutes at 30°C, then add 0.25 parts of pH adjuster to adjust the pH of the system to 6.0. After defoaming treatment, antibacterial and moisturizing soapberry extract hand sanitizer is obtained.

[0027] Example 3: Under the condition that the dosage of each raw material and the reaction conditions are taken at the upper limit allowed by the claims, the antibacterial and moisturizing effects of the hand sanitizer of the present invention are verified under the condition of high functional component addition, and the technical solution has good adaptability.

[0028] S1, Preparation of modified soapberry extract Weigh out 90 parts of soapberry extract, 6 parts of citric acid, 15 parts of quaternized chitosan, and 60 parts of deionized water. Add the soapberry extract to the deionized water and stir at 50°C for 40 min to ensure thorough dispersion. Add citric acid and quaternized chitosan to the dispersion system, adjust the pH of the system to 6.5 at 70°C, and stir for 120 min for synergistic modification. Then, homogenize at 40°C and dry at 60°C to obtain the modified soapberry extract. S2, Preparation of the basic hand sanitizer system Add 85 parts of deionized water to a reaction vessel and stir at 60°C. Then add 8 parts of modified soapberry extract and 2.0 parts of carnosine to disperse them fully. Next, add 15 parts of amino acid surfactant, 8 parts of nonionic surfactant, 10 parts of humectant, 0.5 parts of antibacterial agent and 0.3 parts of chelating agent to the reaction vessel and stir at 55°C for 60 minutes to obtain a functional composite system. S3, Preparation of finished hand sanitizer Add 1.5 parts of thickener to the functional composite system and stir for 30 minutes at 40°C. Then add 0.5 parts of pH adjuster to adjust the pH of the system to 6.5. After defoaming treatment, antibacterial and moisturizing soapberry extract hand sanitizer is obtained.

[0029] Comparative Example 1: Under the conditions of single modification of soapberry extract with citric acid and synergistic modification by removing quaternized chitosan, the stabilization effect of the modified soapberry extract and its influence on the antibacterial and moisturizing synergistic effect of hand sanitizer were compared.

[0030] S1, Preparation of modified soapberry extract Weigh out 80 parts of soapberry extract, 3.5 parts of citric acid, and 49 parts of deionized water. Add the soapberry extract to the deionized water and stir at 37°C for 25 minutes to ensure complete dispersion. Add citric acid to the dispersion system, adjust the pH of the system to 5.2 at 55°C, and stir for 75 minutes for modification. Then homogenize at 30°C and dry at 50°C to obtain the modified soapberry extract. S2, Preparation of the basic hand sanitizer system 72 parts of deionized water were added to a reaction vessel and stirred at 45°C. Then, 5 parts of modified soapberry extract and 1.0 part of carnosine were added sequentially to disperse them fully. Next, 10 parts of amino acid surfactant, 5 parts of nonionic surfactant, 6 parts of humectant, 0.25 parts of antibacterial agent and 0.18 parts of chelating agent were added sequentially and stirred at 45°C for 40 minutes to obtain a functional composite system. S3, Preparation of finished hand sanitizer Add 0.8 parts of thickener to the functional composite system, stir at 30℃ for 20 min, then add 0.25 parts of pH adjuster to adjust the pH of the system to 6.0. After defoaming treatment, the hand sanitizer product is obtained.

[0031] Comparative Example 2: Under the conditions of single modification of soapberry extract using only quaternized chitosan and synergistic modification by removing citric acid, the stabilization effect of the modified soapberry extract and its influence on the antibacterial and moisturizing synergistic effect of hand sanitizer were compared.

[0032] S1, Preparation of modified soapberry extract Weigh out 80 parts of soapberry extract, 9 parts of quaternized chitosan, and 43.5 parts of deionized water. Add the soapberry extract to the deionized water and stir at 37°C for 25 min to ensure complete dispersion. Add the quaternized chitosan to the dispersion system, adjust the pH of the system to 5.2 at 55°C, and stir for 75 min for modification. Then, homogenize the mixture at 30°C and dry it at 50°C to obtain the modified soapberry extract. S2, Preparation of the basic hand sanitizer system 72 parts of deionized water were added to a reaction vessel and stirred at 45°C. Then, 5 parts of modified soapberry extract and 1.0 part of carnosine were added sequentially to disperse them fully. Next, 10 parts of amino acid surfactant, 5 parts of nonionic surfactant, 6 parts of humectant, 0.25 parts of antibacterial agent and 0.18 parts of chelating agent were added sequentially and stirred at 45°C for 40 minutes to obtain a functional composite system. S3, Preparation of finished hand sanitizer Add 0.8 parts of thickener to the functional composite system, stir at 30℃ for 20 min, then add 0.25 parts of pH adjuster to adjust the pH of the system to 6.0. After defoaming treatment, the hand sanitizer product is obtained.

[0033] Comparative Example 3: Without adding organic small molecule carnosine, the contribution of carnosine to the synergistic enhancement of the antibacterial and moisturizing properties of hand sanitizer was compared, verifying its unexpected role in the system of this invention.

[0034] S1, Preparation of modified soapberry extract Weigh out 80 parts of soapberry extract, 3.5 parts of citric acid, 9 parts of quaternized chitosan, and 40 parts of deionized water. Add the soapberry extract to the deionized water and stir at 37°C for 25 minutes to ensure complete dispersion. Add citric acid and quaternized chitosan to the dispersion system, adjust the pH of the system to 5.2 at 55°C, and stir for 75 minutes for synergistic modification. Then, homogenize at 30°C and dry at 50°C to obtain the modified soapberry extract. S2, Preparation of the basic hand sanitizer system Add 73 parts of deionized water to a reaction vessel and stir at 45°C. Then add 5 parts of modified soapberry extract to disperse it fully. Next, add 10 parts of amino acid surfactant, 5 parts of nonionic surfactant, 6 parts of humectant, 0.25 parts of antibacterial agent and 0.18 parts of chelating agent to the reaction vessel and stir at 45°C for 40 minutes to obtain a functional composite system. S3, Preparation of finished hand sanitizer Add 0.8 parts of thickener to the functional composite system, stir at 30℃ for 20 min, then add 0.25 parts of pH adjuster to adjust the pH of the system to 6.0. After defoaming treatment, the hand sanitizer product is obtained.

[0035] Performance testing: 1. Antibacterial performance test method Hand sanitizer samples prepared in Examples 1, 2, and 3, as well as Comparative Examples 1 to 3, were used to prepare test solutions at the same concentration. *Escherichia coli* and *Staphylococcus aureus* were used as representative test bacteria. Under aseptic conditions, the test solutions were thoroughly contacted with the bacterial suspensions and treated under the same temperature and incubation conditions. After incubation, the antibacterial performance of each hand sanitizer sample was evaluated by comparing the colony growth after treatment, thereby comparing the differences in antibacterial effects among different formulation systems.

[0036] 2. Method for testing the skin's moisturizing properties after washing Healthy volunteers were selected and their hands were cleansed using the hand sanitizers from Examples 1, 2, and 3, and Comparative Examples 1 to 3, respectively, with consistent washing time, dosage, and rinsing conditions. After washing and air drying, the skin surface moisture content was measured at specified time points, and changes in skin moisture immediately after washing and after a certain period were recorded. The moisturizing performance of each hand sanitizer sample was evaluated by comparing the differences in skin moisture retention capacity between the different examples and comparative examples.

[0037] 3. Antibacterial durability test method The hand sanitizers from Examples 1, 2, and 3, and Comparative Examples 1 to 3, were used for hand cleaning. After washing and rinsing, without the use of any additional skincare products, the residual microorganisms on the skin surface were sampled and tested at different time points. By comparing the colony recovery trend at different time points after washing, the duration of the antibacterial effect of each hand sanitizer sample was evaluated, thereby reflecting the differences in the post-wash antibacterial durability of different formulation systems.

[0038] 4. Mildness and Skin Comfort Testing Methods Hand sanitizer samples from Examples 1, 2, and 3, and Comparative Examples 1 to 3 were selected and subjected to continuous use tests on volunteers' hands under the same washing frequency. During the tests, volunteers' subjective feedback regarding skin tightness, dryness, and irritation after washing was recorded, and a comprehensive evaluation was conducted based on the observed skin condition after washing. By comparing the skin comfort performance of different examples and comparative examples under continuous use conditions, the skin barrier-friendly nature of each hand sanitizer sample was assessed.

[0039] Table 1 Performance Test Results

[0040] As shown in Table 1, Examples 1, 2 and 3 are significantly better than Comparative Examples 1 to 3 in terms of antibacterial performance, antibacterial durability, post-wash skin moisturizing performance and skin comfort. Furthermore, Example 2 shows the best performance in all performance indicators, demonstrating the significant comprehensive advantages of the technical solution of the present invention.

[0041] In terms of antibacterial properties, Figure 2 The antibacterial rates of Examples 1, 2, and 3 were 93.2%, 97.8%, and 95.6%, respectively, all significantly higher than the 82.4% to 88.6% of Comparative Examples 1 to 3. Among them, Example 2 had the highest antibacterial rate, indicating that under the median ratio conditions, the synergistic effect of modified saponin extract and carnosine can more fully exert the antibacterial effect; while the comparative examples, due to the use of only a single modification method or the lack of introduction of organic small molecules, had significantly limited antibacterial ability.

[0042] Regarding the antibacterial durability, the antibacterial duration of the examples after washing reached 4.5 h, 6.0 h and 5.2 h, respectively, which were significantly longer than the 2.8 to 3.2 h of the comparative examples. Among them, the antibacterial duration of Example 2 was the longest, indicating that the synergistic modification system formed a more stable antibacterial environment on the skin surface and effectively delayed the decay of the antibacterial effect.

[0043] Regarding the skin moisturizing performance after washing, the skin moisture content of Examples 1, 2 and 3 increased by 18.6%, 26.4% and 21.1% respectively, all higher than the 10.3% to 13.5% of the comparative examples. The increase in Example 2 was the largest, indicating that under the given conditions, the modified soapberry extract and carnosine formed a more effective synergistic moisturizing effect, which is beneficial for maintaining skin moisture after washing.

[0044] Regarding skin comfort, the skin irritation scores of the examples were 0.8, 0.3 and 0.6, respectively, which were lower than the 1.3 to 1.6 of the comparative examples. Among them, Example 2 had the lowest irritation score, indicating that it had the least irritation and the best skin tolerance. In contrast, the comparative examples were more likely to have an adverse effect on the skin barrier due to the lack of synergistic modification or the participation of small organic molecules.

[0045] In summary, by synergistically modifying soapberry extract with citric acid and quaternized chitosan, and introducing organic small molecule carnosine, the antibacterial rate and antibacterial durability of hand sanitizer can be significantly improved under reasonable formulation conditions. At the same time, the moisturizing effect of the skin after washing is significantly improved and the irritation is reduced. Among them, Example 2 showed the best performance in all performance indicators, which fully proves the effectiveness and inventiveness of the technical solution of the present invention.

Claims

1. A hand sanitizer containing antibacterial and moisturizing soapberry extract, characterized in that, The hand sanitizer comprises the following raw materials in parts by weight: 2-8 parts modified soapberry extract; 0.1-2.0 parts organic small molecule functional agent; 5-15 parts amino acid surfactant; 2-8 parts nonionic surfactant; 3-10 parts humectant; 0.2-1.5 parts thickener; 0.05-0.5 parts antibacterial adjuvant; 0.05-0.3 parts chelating agent; 0.05-0.5 parts pH adjuster; and 60-85 parts deionized water. The modified soapberry extract is a modified product obtained by the synergistic modification of soapberry extract with citric acid and quaternized chitosan. The organic small molecule functional agent is carnosine, which is not currently used in hand sanitizers and can synergistically work with the modified soapberry extract.

2. The antibacterial and moisturizing soapberry extract hand sanitizer according to claim 1, characterized in that, The modified soapberry extract comprises the following raw materials in parts by weight: 70-90 parts soapberry extract; 1-6 parts citric acid; 3-15 parts quaternized chitosan; and 20-60 parts deionized water.

3. A hand sanitizer containing antibacterial and moisturizing soapberry extract according to claim 1 or 2, characterized in that, The preparation method of the modified soapberry extract includes the following steps: (1) Add soapberry extract to deionized water and disperse under stirring to obtain soapberry extract dispersion system; (2) Citric acid and quaternized chitosan were added to the soapberry extract dispersion system and synergistically modified under stirring conditions to obtain the modified system; (3) Stabilize the modified system to obtain the modified soap extract.

4. The antibacterial and moisturizing soapberry extract hand sanitizer according to claim 3, characterized in that, The reaction conditions for step (1) are: stirring for 10 to 40 minutes at 25 to 50°C to fully disperse the soap extract.

5. The antibacterial and moisturizing soapberry extract hand sanitizer according to claim 3, characterized in that, The reaction conditions for step (2) are as follows: at 40-70°C, the pH of the system is controlled at 4.0-6.5, and the mixture is stirred for 30-120 minutes to carry out synergistic modification treatment.

6. The antibacterial and moisturizing soapberry extract hand sanitizer according to claim 3, characterized in that, The reaction conditions for step (3) are homogenization or filtration at 20–40°C, followed by drying at 40–60°C to obtain the modified soapberry extract.

7. The antibacterial and moisturizing soapberry extract hand sanitizer according to claim 1, characterized in that, The amino acid-type surfactant is composed of sodium cocoyl glycinate and sodium lauroyl sarcosinate in a mass ratio of (1-3):(3-1); the nonionic surfactant is composed of decyl glucoside and dodecyl glucoside in a mass ratio of (1-4):(4-1); the humectant is composed of glycerin and 1,3-propanediol in a mass ratio of (2-8):(8-2); the thickener is composed of hydroxyethyl cellulose and xanthan gum in a mass ratio of (3-9):(1-7); the antibacterial adjuvant is composed of phenoxyethanol and ethylhexylglycerin in a mass ratio of (5-20):(1-5); the chelating agent is composed of disodium ethylenediaminetetraacetate and sodium phytate in a mass ratio of (1-10):(10-1); and the pH adjuster is composed of citric acid and sodium citrate in a mass ratio of (1-8):(8-1).

8. A method for preparing an antibacterial and moisturizing soapberry extract hand sanitizer, characterized in that, The preparation method Includes the following steps: S1, deionized water is added to the reaction vessel, and modified soap extract and organic small molecule functional agent are added sequentially under heating and stirring conditions to obtain a homogeneous basic system; S2, add amino acid surfactant, nonionic surfactant, humectant, antibacterial agent and chelating agent to a homogeneous basic system in sequence, mix evenly under stirring conditions to obtain a functional composite system; S3. Thickener is added to the functional composite system to adjust the viscosity of the system, and pH adjuster is added to adjust the pH of the system. After cooling to room temperature, defoaming is performed to obtain antibacterial and moisturizing soapberry extract hand sanitizer.

9. The method for preparing an antibacterial and moisturizing soapberry extract hand sanitizer according to claim 8, characterized in that, The reaction conditions for step S1 are: stirring for 10 to 30 minutes at 30 to 60°C to fully disperse the modified soapberry extract and the organic small molecule functional agent to obtain a homogeneous basic system; the reaction conditions for step S2 are: stirring for 20 to 60 minutes at 30 to 55°C.

10. The method for preparing an antibacterial and moisturizing soapberry extract hand sanitizer according to claim 8, characterized in that, The reaction conditions for step S3 are as follows: a thickener is added at 20–40°C and stirred for 10–30 minutes. The pH of the system is then adjusted to 5.5–6.5, and the hand sanitizer is obtained after defoaming treatment.

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