A hair growth solution of eight-zhens ten-herb extract compound active ingredients and a preparation method thereof

Abstract

The application discloses a kind of eight treasures ten kinds of herbal extract compound active ingredient hair growth liquid and preparation method thereof, belong to the technical field of cosmetics.The hair growth liquid includes basic maintenance type, standard maintenance type, strengthening maintenance type three gradient formulations and scalp special derivative formulation, each formulation takes eight treasures ten kinds of composite herbal extract as core, is matched with active ingredient of promoting maintenance synergism.The active ingredient of promoting maintenance synergism includes bispyrimidine active substance, polypeptide component and adenosine, cooperates with eight treasures ten kinds of composite herbal extract, can realize hair follicle maintenance, hair tough and hair follicle nourishing function.Each formulation takes basic matrix, texture adjustment and soothing component, mild antiseptic system as auxiliary, product pH value is controlled at 5.0~6.5, and the sum of the weight percentage of each component is 100%;Three gradient formulations are mild and non-irritating, do not contain artificial essence, can be simultaneously applied to scalp, hairline, eyebrow and eyelash parts, and scalp special derivative formulation can selectively add mint component and azelaic acid, and is limited to scalp use only.The preparation method includes eight steps of raw material preparation, water phase preparation, oil phase mixing and emulsification, cooling feeding, pH value adjustment, auxiliary component addition, filtering defoaming and filling finished product in sequence.The hair growth liquid can be adapted to sensitive skin and various skin conditions, can nourish hair follicle, improve hair growth microenvironment, can improve hair thinning, fine and soft, easy to fall off, easy to break phenomenon, material body nature is stable, refreshing and not sticky, long-term storage stability is good, can be adapted to industrialization mass production and large-scale application and market promotion, and formulation gradient is clear, and strong expandability can meet multiple use requirements.

Description

Technical Field

[0001] This invention belongs to the field of cosmetic technology, specifically relating to a hair growth liquid composed of eight kinds of herbal extracts and active ingredients, and its preparation method. In particular, it relates to a multi-gradient hair growth liquid that can be applied to multiple areas such as the scalp, hairline, eyebrows and eyelashes, is mild and low-irritant, takes into account the stability and mass production of active ingredients, and can be used to derive a scalp-specific conditioning version, and its preparation process. Background Technology

[0002] As people's demand for hair care increases, the demand for functional hair care products targeting problems such as thinning, fineness, dryness, breakage, fragility, and easy hair loss continues to grow. In particular, hair in areas like eyebrows and eyelashes is fine and fragile, prone to thinning, sparseness, and easy loss, requiring more stringent standards for product gentleness and compatibility. For scalp care, consumers expect products to not only meet basic hair care needs but also provide additional benefits such as oil regulation, cooling and soothing effects, and relief from minor scalp discomfort. Existing products struggle to simultaneously meet the market demand for products that are suitable for multiple areas and offer synergistic effects.

[0003] Existing hair growth care products generally suffer from problems such as a single formula system, insufficient targeted nutritional supply, oily texture, and strong skin irritation. Some products, in pursuit of better results, add artificial fragrances and strong preservatives, easily causing redness and stinging in sensitive areas such as the scalp and around the eyes. Furthermore, they fail to optimize the pH environment for the active ingredients, leading to easy degradation of active substances and a decrease in actual product efficacy. Some formulas blindly increase the proportion of herbal extracts, easily resulting in problems such as turbidity, darkening of color, poor storage stability, and easy sedimentation and separation, making them unsuitable for large-scale industrial production. Other products only add trace amounts of herbal extracts conceptually, failing to deliver actual herbal care benefits and thus lacking practicality.

[0004] Meanwhile, most existing hair care products are designed only for the scalp and hair, and have not formed a highly effective compound system of herbal and active ingredients that can be applied to multiple parts such as the scalp, eyebrows, and eyelashes. Their effects on hair follicle care, hair strengthening, and improvement of dry, brittle, thin, and fine hair are limited. Moreover, most existing products are single-formula designs, lacking a tiered approach and insufficient formula compatibility. They cannot be expanded to include cooling and oil-controlling ingredients according to scalp care needs, making it difficult to meet the diverse usage needs of different cost positions, different consumer groups, and different sales channels. They also cannot balance gentleness, conditioning effect, ingredient stability, and market applicability.

[0005] A search revealed that while some existing hair growth products use a combination of herbal extracts, pyrimidine active ingredients, or polypeptide components, none have disclosed a hair growth liquid that is completely identical to the technical solution of this invention. Specifically, existing technologies do not disclose a stable system that simultaneously contains the ten specific herbal extracts described in this invention, 2,4-diaminopyrimidine-3-oxide (unodil), pyrrolidinediaminopyrimidine oxide (copilot), myristoyl pentapeptide-4, tripeptide-1 copper (copper peptide), adenosine, compound xanthan gum, allantoin, and disodium EDTA. Furthermore, it does not allow for the reasonable control of herbal additions to suit mass production, and can independently derive scalp-specific versions containing menthol components and azelaic acid. It also allows for the design of three gradient active ingredient ratios, clearly defining the technical solution suitable for use on multiple areas including the scalp, hairline, eyebrows, and eyelashes. Summary of the Invention

[0006] (1) Develop a hair growth product that is free of artificial fragrances, mild and low-irritant, and has a pH value that is compatible with the tolerance range of human skin. It can be used in sensitive areas such as around the eyes, is suitable for various skin types, reduces the risk of skin irritation, and is suitable for daily long-term use. At the same time, the general formula and the scalp-specific derivative formula are separated. The general formula is mild and non-irritating and is suitable for use on eyebrows, eyelashes and scalp in all scenarios. The scalp-specific formula can independently add menthol components and azelaic acid, and is only used on the scalp and not around the eyes, thus taking into account both safety and targeted efficacy.

[0007] (2) Construct an efficacy-type compound system of eight treasures and ten flavors herbal extracts, abandon the concept of adding trace amounts, and use sufficient herbal ingredients to combine dipyrimidine active ingredients, polypeptide combinations, adenosine and copper peptide active components to provide comprehensive nutritional support for scalp hair, eyebrows, eyelashes and other parts of the body, nourish hair follicles, improve the microenvironment of hair growth, and improve problems such as sparse hair, shortage and slow growth.

[0008] (3) Enhance the strength of hair cuticle and hair shaft structure, improve the problem of easy breakage, fragility and easy fall of eyebrows, eyelashes and hair, improve the firmness and thickness of hair, make hair denser, stronger, black and shiny, and optimize the appearance of sparse and soft hair.

[0009] (4) Design three gradient formulas with different active ingredient addition ratios. All three formulas contain complete eight-treasure ten-flavor herbal components, xanthan gum and allantoin as basic stabilizing components and core active ingredients. The only difference is the amount of active ingredients added, so as to adapt to the usage needs of different cost positions, different consumer groups and different sales channels, and form a standardized product line.

[0010] (5) Optimize the product preparation process and formula system, accurately control the product pH value to 5.0-6.5 to ensure the stability of active ingredients, add xanthan gum to adjust the texture of the material, so that the material is clear, stable, refreshing and non-sticky, and does not easily clog hair follicles; reasonably control the amount of herbal extract added, while ensuring the efficacy of herbal extracts, improve the stability of mass production and storage, the production process complies with the cosmetic industrial production standards, is easy to operate, and facilitates subsequent industrial production, filing and promotion and patent protection.

[0011] This invention provides three hair growth serums with different proportions of active ingredients. All components are listed by weight percentage, and the sum of the weight percentages of all components is 100%. The pH value of the finished product is controlled between 5.0 and 6.5. All three formulas are free of menthol and azelaic acid, making them gentle and safe for simultaneous use on the scalp, hairline, eyebrows, and eyelashes. The proportions of ten herbal extracts are carefully controlled to balance conditioning effects and production stability. Furthermore, based on these three formulas, a scalp-specific formula can be independently derived, adding menthol cooling components and azelaic acid conditioning components as needed. This derived formula is for scalp use only and not for eyebrows, eyelashes, or the mucous membrane area around the eyes.

[0012] This product is composed of a base matrix, a complex of eight precious herbs and ten flavors, active ingredients that promote nourishment and enhance efficacy, texture-regulating and soothing ingredients, a gentle preservative system, pH adjusters, and natural fragrance components.

[0013] The base matrix includes deionized water, butylene glycol, panthenol, sodium hyaluronate, beta-glucan, squalane, tocopheryl acetate, PEG-40 hydrogenated castor oil, hydrogenated lecithin, and disodium EDTA. Hydrogenated lecithin is only added to the standard and intensive care formulas; it is not added to the basic care formula. Beta-glucan is only added to the standard, intensive care, and scalp-specific derivative formulas; it is not added to the basic care formula.

[0014] Texture-regulating and soothing ingredients include xanthan gum and allantoin; xanthan gum is used to regulate the rheological properties and texture of the system, improve the uniformity and stability of the formula, and reduce the risk of separation and water separation; allantoin can soothe the skin, repair the skin barrier around the hair follicles, reduce the potential irritation of active ingredients, improve the gentleness of the product, and make the formula safe for use in sensitive areas such as the eye area.

[0015] The Eight Treasures and Ten Flavors Compound Herbal Extract consists of ginseng root extract, black mulberry fruit extract, ganoderma extract, privet fruit extract, arborvitae leaf extract, licorice extract, eclipta extract, centella asiatica extract, coleus forsythia extract, and eusmarinus extract. All herbal ingredients are functional additives, and the amount added is reasonably controlled to fully exert the synergistic nourishing effects of the herbs. At the same time, it is suitable for industrial mass production and is not prone to problems such as turbidity, precipitation, and discoloration.

[0016] The active ingredients that enhance hair growth and health include 2,4-diaminopyrimidine-3-oxide (Unodil), pyrrolidinediaminopyrimidine oxide (Copilot), biotin tripeptide-1, myristoyl pentapeptide-4, tripeptide-1 copper (copper peptide), and adenosine. Unodil focuses on awakening dormant hair follicles, prolonging the hair growth phase, and promoting new hair growth; Copilot focuses on regulating scalp sebum secretion, strengthening hair follicle roots, and reducing hair loss. The combination of these two ingredients works synergistically to control oil production and prevent hair loss while promoting new hair growth. It is suitable for multiple areas including the scalp, hairline, eyebrows, and eyelashes, offering gentle, stable, and significantly enhanced effects. In subsequent descriptions, Unodil, Copilot, and copper peptide will be referred to by their common names.

[0017] The mild preservative system is composed of p-hydroxyacetophenone and ethylhexylglycerin, which is gentle and non-irritating, suitable for use in sensitive areas; the pH adjuster uses a citric acid / sodium citrate buffer system to adjust the pH of the system to 5.0-6.5, ensuring the stability of the system and the active ingredients; orange blossom essential oil is a natural fragrance component that replaces artificial fragrances, enhancing the sensory experience of the product, and its addition amount meets the relevant cosmetic standards.

[0018] The scalp-specific derivative formula may selectively include one or more of the following components: peppermint extract, peppermint leaf extract, and menthol, at an addition amount of 0.01–0.4% (by weight); and azelaic acid at an addition amount of 0.3–2.5% (by weight). This type of derivative formula is for scalp use only and should not be used on eyebrows, eyelashes, or the mucous membranes around the eyes. Furthermore, the scalp-specific derivative formula can be slightly adjusted based on the standard conditioning formula, with each component of the Eight Treasures and Ten Flavors compound herbal extract remaining within the weight percentage range of the corresponding components in the standard conditioning formula, without affecting the system stability or product efficacy.

[0019] ① Basic maintenance type (all components are weight percentages) Deionized water balance Butanediol 2.0–5.0% Xanthan gum 0.02–0.06% Panthenol 0.05–0.30% Sodium hyaluronate 0.01–0.10% Allantoin 0.05–0.25% Squalane 0.1–0.6% Tocopheryl acetate 0.05–0.20% PEG-40 hydrogenated castor oil 0.8–1.6% Disodium EDTA 0.02-0.05% Ginseng root extract 0.03–0.20% Black mulberry fruit extract 0.03–0.20% Ganoderma lucidum extract 0.03-0.15% Privet fruit extract 0.03–0.20% Platycladus orientalis leaf extract 0.03–0.20% Licorice extract 0.03–0.20% Usma grass extract 0.03–0.20% Centella asiatica extract 0.03–0.15% Extract of Coleus forsythia suspensa: 0.03–0.15% Eclipta prostrata extract 0.03–0.15% Unodil 0.1%–0.8% Biotin tripeptide-1 0.05–0.25% Myristoyl pentapeptide-4 0.001–0.005% Orange blossom essential oil 0.002-0.03% p-Hydroxyacetophenone 0.30–0.55% Ethylhexylglycerin 0.15–0.35% Citric acid / sodium citrate buffer system (appropriate amount) pH 5.0–6.5 ② Standard maintenance type (all components are weight percentages) Deionized water balance Butanediol 2.5–6.0% Xanthan gum 0.03–0.08% Panthenol 0.05–0.40% Sodium hyaluronate 0.01–0.12% β-glucan 0.05–0.35% Allantoin 0.10–0.30% Squalane 0.2–0.8% Tocopheryl acetate 0.05–0.25% Hydrogenated lecithin 0.15–0.40% PEG-40 hydrogenated castor oil 0.7-1.8% Disodium EDTA 0.02-0.05% Ginseng root extract 0.05–0.30% Black mulberry fruit extract 0.05–0.30% Ganoderma lucidum extract 0.05-0.25% Privet fruit extract 0.05–0.30% Platycladus orientalis leaf extract 0.05–0.30% Licorice extract 0.05–0.30% Usma grass extract 0.10–0.35% Centella asiatica extract 0.05–0.25% Extract of Coleus forsythia suspensa: 0.08–0.25% Eclipta prostrata extract 0.05–0.25% Unodil 0.2%–1.2% Comparable volume: 0.2%–1.5% Biotin tripeptide-1 0.05–0.30% Myristoyl pentapeptide-4 0.002–0.007% Copper peptide 0.01–0.08% Adenosine 0.08–0.25% Orange blossom essential oil 0.003-0.05% p-Hydroxyacetophenone 0.30–0.55% Ethylhexylglycerin 0.15–0.40% Citric acid / sodium citrate buffer system (appropriate amount) pH 5.0–6.5 ③ Enhanced Maintenance Type (all components are weight percentages) Deionized water balance Butanediol 3.0–7.0% Xanthan gum 0.04–0.10% Panthenol 0.15–0.50% Sodium hyaluronate 0.03–0.18% β-glucan 0.15–0.45% Allantoin 0.15–0.35% Squalane 0.4–1.0% Tocopheryl acetate 0.15–0.35% Hydrogenated lecithin 0.25–0.70% PEG-40 hydrogenated castor oil 0.4–1.2% Disodium EDTA 0.02-0.05% Ginseng root extract 0.08–0.35% Black mulberry fruit extract 0.08–0.35% Ganoderma lucidum extract 0.08-0.30% Privet fruit extract 0.08–0.35% Platycladus orientalis leaf extract 0.08–0.35% Licorice extract 0.08–0.35% Usma grass extract 0.18–0.40% Centella asiatica extract 0.08–0.30% Extract of Coleus forsythia suspensa: 0.12–0.30% Eclipta prostrata extract 0.08–0.30% Unodil 0.4–1.5% Comparable volume: 0.4%–1.8% Biotin tripeptide-1 0.15–0.40% Myristoyl pentapeptide-4 0.004~0.010% Copper peptide 0.04–0.12% Adenosine 0.12–0.35% Orange blossom essential oil 0.01-0.06% p-Hydroxyacetophenone 0.40–0.70% Ethylhexylglycerin 0.25–0.50% Citric acid / sodium citrate buffer system (appropriate amount) pH 5.0–6.5 3. Specific embodiments (all components below are weight percentages) Example 1: Basic Maintenance Type Deionized water balance Butylene glycol 3.5% Xanthan gum 0.05% Panthenol 0.15% Sodium hyaluronate 0.03% Allantoin 0.15% Squalane 0.3% Tocopheryl acetate 0.1% PEG-40 hydrogenated castor oil 1.5% Disodium EDTA 0.03% Ginseng root extract 0.06% Black mulberry fruit extract 0.06% Ganoderma lucidum extract 0.05% Privet fruit extract 0.06% 0.06% of Platycladus orientalis leaf extract Licorice extract 0.06% Usma grass extract 0.06% Centella asiatica extract 0.05% 0.05% extract of Coleus forsythiae Eclipta prostrata extract 0.05% Unodil 0.3% Biotin tripeptide-1 0.1% Myristoyl pentapeptide-4 0.0015% Orange blossom essential oil 0.01% p-Hydroxyacetophenone 0.45% Ethylhexylglycerin 0.25% Add an appropriate amount of citric acid / sodium citrate buffer system and adjust the pH to 5.8. Example 2 Standard Maintenance Type Deionized water balance Butylene glycol 4.0% Xanthan gum 0.06% Panthenol 0.2% Sodium hyaluronate 0.05% β-glucan 0.2% Allantoin 0.2% Squalane 0.4% Tocopheryl acetate 0.15% Hydrogenated lecithin 0.25% PEG-40 hydrogenated castor oil 1.5% Disodium EDTA 0.03% Ginseng root extract 0.12% Black mulberry fruit extract 0.12% Ganoderma lucidum extract 0.10% Privet extract 0.12% 0.12% of Platycladus orientalis leaf extract Licorice extract 0.12% Usma grass extract 0.20% Centella asiatica extract 0.10% 0.12% extract of Coleus forsythiae Eclipta prostrata extract 0.10% Unodil 0.5% Comparable to 0.6% Biotin tripeptide-1 0.15% Myristoyl pentapeptide-4 0.003% Copper peptide 0.03% Adenosine 0.14% Orange blossom essential oil 0.02% p-Hydroxyacetophenone 0.4% Ethylhexylglycerin 0.3% Add an appropriate amount of citric acid / sodium citrate buffer system and adjust the pH to 5.8. Example 3: Enhanced Maintenance Type Deionized water balance Butanediol 5.0% Xanthan gum 0.08% Panthenol 0.3% Sodium hyaluronate 0.08% β-glucan 0.3% Allantoin 0.25% Squalane 0.6% Tocopheryl acetate 0.25% Hydrogenated lecithin 0.4% PEG-40 hydrogenated castor oil 0.8% Disodium EDTA 0.03% Ginseng root extract 0.30% Black mulberry fruit extract 0.30% Ganoderma lucidum extract 0.25% Privet fruit extract 0.30% 0.30% of Platycladus orientalis leaf extract Licorice extract 0.30% Usma grass extract 0.35% Centella asiatica extract 0.25% 0.25% extract of Coleus forsythiae Eclipta prostrata extract 0.25% Unodil 0.8% Comparable to 1.0% Biotin tripeptide-1 0.25% Myristoyl pentapeptide-4 0.005% Copper peptide 0.06% Adenosine 0.20% Orange blossom essential oil 0.03% p-Hydroxyacetophenone 0.6% Ethylhexylglycerin 0.4% Add an appropriate amount of citric acid / sodium citrate buffer system and adjust the pH to 5.8. Example 4: Cooling and oil-controlling scalp formula (derived formula) Deionized water balance Butylene glycol 4.0% Xanthan gum 0.06% Panthenol 0.2% Sodium hyaluronate 0.05% β-glucan 0.2% Allantoin 0.2% Squalane 0.4% Tocopheryl acetate 0.15% Hydrogenated lecithin 0.25% PEG-40 hydrogenated castor oil 1.5% Disodium EDTA 0.03% Ginseng root extract 0.12% Black mulberry fruit extract 0.12% Ganoderma lucidum extract 0.12% Privet extract 0.12% 0.12% of Platycladus orientalis leaf extract Licorice extract 0.12% Usma grass extract 0.20% Centella asiatica extract 0.12% 0.15% extract of Coleus forsythiae Eclipta prostrata extract 0.12% Unodil 0.5% Comparable to 0.6% Biotin tripeptide-1 0.15% Myristoyl pentapeptide-4 0.003% Copper peptide 0.03% Adenosine 0.14% Menthol 0.15% Azelaic acid 1.0% Orange blossom essential oil 0.02% p-Hydroxyacetophenone 0.4% Ethylhexylglycerin 0.3% Add an appropriate amount of citric acid / sodium citrate buffer system and adjust the pH to 5.8.

[0020] Raw material preparation: Accurately weigh all aqueous raw materials such as deionized water and butylene glycol, all oil-phase raw materials such as squalane, as well as all raw materials such as the Eight Treasures and Ten Flavors Compound Herbal Extract, nourishing and enhancing active ingredients, and auxiliary components according to the corresponding formula; clean and disinfect the production equipment in advance to ensure that the cleanliness of the production environment and equipment meets the "Cosmetic Safety Technical Specifications" (2015 Edition) and relevant industry standards to avoid contamination of raw materials.

[0021] Aqueous phase preparation: Add the aqueous phase raw materials from the base matrix (deionized water, butylene glycol, panthenol, sodium hyaluronate, β-glucan), texture-modifying and soothing ingredients (xanthan gum, allantoin), and disodium EDTA to an emulsifying pot. Start uniform stirring at 300–500 rpm, heat to 75–85°C, and maintain this temperature while stirring for 15–20 minutes until all components are completely dissolved, forming a homogeneous and transparent aqueous phase system. Note that the basic conditioning formula does not require the addition of β-glucan; only the standard conditioning, enhanced conditioning, and scalp-specific derivative formulas contain β-glucan.

[0022] Oil phase mixing and emulsification: Mix the oil phase components, such as squalane, tocopheryl acetate, and PEG-40 hydrogenated castor oil, thoroughly. For standard, enhanced, and scalp-specific formulas, hydrogenated lecithin needs to be added and thoroughly mixed. Basic formulas do not require the addition of hydrogenated lecithin. Slowly add the mixed oil phase to the aqueous system, start homogenization and emulsification for 5–10 minutes at a speed of 2000–3000 rpm, and continue stirring for 20–30 minutes until the oils are completely solubilized and the system is homogeneous, stable, and free of particles.

[0023] Cooling and Adding: Activate the cooling system to lower the temperature of the mixture to 38-45℃. Add the Eight Treasures and Ten Flavors compound herbal extract and various nourishing and enhancing active ingredients sequentially. If it is a scalp-specific derivative formula, add azelaic acid simultaneously at this step. Stir continuously for 10-15 minutes at a speed of 200-300 rpm until all ingredients are completely dissolved and the system is free of stratification and lumps. The basic nourishing formula only contains unopidil, biotin tripeptide-1, and myristoyl pentapeptide-4, excluding copidotramine, copper peptides, and adenosine. The standard, enhanced, and scalp-specific derivative formulas all contain all nourishing and enhancing active ingredients.

[0024] pH adjustment: Add an appropriate amount of citric acid / sodium citrate buffer system to adjust the pH of the system to 5.0-6.5, and stir continuously for 5-10 minutes to ensure that the pH of the system is uniform and stable and consistent with the pH requirements of the finished product.

[0025] Addition of auxiliary components: If it is a scalp-specific derivative formula, add peppermint components at this step; then add orange blossom essential oil, p-hydroxyacetophenone, and ethylhexylglycerin in sequence. Among them, p-hydroxyacetophenone and ethylhexylglycerin are mild preservatives. Adding them later can avoid the high temperature from destroying their preservative activity. Continue stirring for 15 to 30 minutes, and control the stirring speed at 200 to 300 r / min to ensure that all components are mixed evenly, without local aggregation or precipitation.

[0026] Filtration and defoaming: After stirring, filter the material through a 200-400 mesh filter cloth to remove impurities and particles. Collect the liquid and let it stand for 2-4 hours to defoam, thoroughly removing air bubbles and ensuring that the material is clear, transparent, and free of impurities, meeting the product appearance requirements.

[0027] Finished product filling: The liquid material undergoes full testing for appearance, pH value, physicochemical indicators and microbiological indicators. After passing the tests (complying with the "Cosmetic Safety Technical Specifications" (2015 edition) and relevant industry standards), it is filled, sealed, inspected by light, and packaged to obtain the finished product.

[0028] High-temperature test: Three basic formulas (basic care, standard care, and enhanced care) and a scalp-specific derivative formula were taken, with three parallel samples for each formula. These samples were placed in a constant temperature environment of 45℃ for 30 days, and the condition of the samples was observed and recorded daily. After the test, all samples remained clear and transparent, without layering, sedimentation, obvious discoloration, or odor. The pH value remained stable within the range of 5.0–6.5, and the overall system was stable without any abnormal phenomena.

[0029] Low-temperature test: Take parallel samples from each group and place them in an environment of -5 to 0℃ for 24 hours. After removal, allow them to naturally return to room temperature (25±2℃) and observe the sample state. All samples showed no turbidity, crystallization, or stratification, and their state was not significantly different from that before the test, indicating good system stability.

[0030] Room temperature sample retention test: Take parallel samples from each group above and place them at room temperature of 25±2℃ for 6 months. The appearance, odor, pH value and content of core active ingredients (unopidil, copidrox, and Bazhen Shiwei compound herbal extract) of the samples are tested monthly. After the test, there are no significant changes in the appearance, odor and pH value of the samples, the retention rate of core active ingredients is ≥90%, there are no problems of layering, deterioration or excessive microorganisms, and the products meet the storage requirements.

[0031] The test results show that the formulation system of the present invention has good stability and can meet the requirements of industrial production, transportation and long-term storage. The derived formulation has the same stability as the basic formulation and has high feasibility for mass production, which can ensure the stability of the efficacy and quality of the product during the shelf life. Beneficial effects

[0032] Synergistic effect of multiple components, applicable to a wide range of scenarios: With the core nourishing ingredients of eight precious herbs and ten flavors, combined with unopidil and copidoside active ingredients, peptide combination, copper peptide and adenosine, and compounded with allantoin, xanthan gum and disodium EDTA to build a stable and gentle system, free of artificial fragrance, gentle and low irritation, it can be safely applied to multiple areas such as scalp, hairline, eyebrows, eyelashes, etc., and is suitable for use on sensitive skin, solving the technical problems of poor compatibility and strong irritation of existing products.

[0033] The formula has a clear gradient and is suitable for diverse needs: It is designed with three gradient formulas: basic, standard and enhanced. The amount of active ingredients and herbal additives is reasonably set according to the gradient and increases step by step. The efficacy is gradually improved and can meet the usage needs of different consumer groups, different cost positions and different sales channels. The product line layout is standardized and rationalized, which solves the shortcomings of existing products with single formulas and inability to meet diverse needs.

[0034] Excellent mass production and storage stability: By rationally controlling the proportion of herbal extracts, combined with precise pH control and a stable system formula, problems such as turbidity, sedimentation, and discoloration of the material are effectively avoided. The material is refreshing and non-sticky, and does not easily clog hair follicles. It is suitable for industrial mass production and has good long-term storage stability, solving the technical problems of difficult mass production and poor storage stability of existing products.

[0035] The active ingredients are scientifically formulated and have strong synergistic effects: Unopilol and Copidol are combined to achieve a synergistic effect of promoting hair regrowth and controlling oil and preventing hair loss. Combined with nutrients such as peptides and copper peptides, it nourishes hair follicles and strengthens hair in all aspects, improving the problems of dry, thin, and easy-to-fall-off hair. The conditioning effect is significant, solving the defects of existing products with limited conditioning effects and unreasonable compounding.

[0036] Highly versatile formula: Based on the three formulas, scalp-specific formulas can be flexibly derived, and cooling and oil-controlling components can be added as needed. The usage scenarios are clearly differentiated, and safety and efficacy are both taken into account, which can cover more niche care needs and enhance the product's market competitiveness.

[0037] The preparation process is suitable for industrial mass production: The preparation process of this invention is simple and controllable, and the key parameters (temperature, rotation speed, time) are clear and controllable. Production can be completed using general equipment in the cosmetics industry without the need for customized special equipment. The process has good stability, high product qualification rate, complies with cosmetic production standards, facilitates large-scale production, registration and promotion and market transformation, and reduces industrial production costs.

Claims

1. A hair growth liquid containing a compound of eight-treasure and ten-flavor herbal extracts and active ingredients, characterized in that, It includes three gradient formulas and a scalp-specific derivative formula. The components of each formula are expressed as a weight percentage, and the sum of the weight percentages of all components is 100%. The pH value of the finished product is controlled between 5.0 and 6.

5. The three gradient formulas do not contain menthol or azelaic acid and can be used on the scalp, hairline, eyebrows, and eyelashes. The scalp-specific derivative formula may selectively contain menthol and / or azelaic acid and is used only on the scalp, not on eyebrows, eyelashes, or the mucous membrane area around the eyes.

2. The hair growth liquid according to claim 1, characterized in that, Each formula of the hair growth serum consists of a base matrix, a complex of eight precious herbs and ten flavors, active ingredients that promote nourishment and enhance efficacy, texture-regulating and soothing ingredients, a gentle preservative system, a pH adjuster, and natural fragrance components. The specific components are as follows: The base matrix mainly includes deionized water, butylene glycol, panthenol, sodium hyaluronate, β-glucan, squalane, tocopheryl acetate, PEG-40 hydrogenated castor oil, hydrogenated lecithin, and disodium EDTA. Hydrogenated lecithin is added only to the standard and enhanced care formulas, and not to the basic care formula. β-glucan is added only to the standard, enhanced care, and scalp-specific derivative formulas, and not to the basic care formula. The texture-regulating and soothing ingredients include xanthan gum and allantoin; The Eight Treasures and Ten Flavors Compound Herbal Extract consists of ginseng root extract, black mulberry fruit extract, Ganoderma lucidum extract, privet fruit extract, arborvitae leaf extract, licorice extract, Eclipta prostrata extract, Centella asiatica extract, Coleus forsythia extract, and Usma extract. The active ingredients that promote enhanced health and efficacy include 2,4-diaminopyrimidine-3-oxide (unodil), pyrrolidinediaminopyrimidine oxide (copilot), biotin tripeptide-1, myristoyl pentapeptide-4, tripeptide-1 copper (copper peptide), and adenosine. The basic health formula contains only unodil, biotin tripeptide-1, and myristoyl pentapeptide-4, excluding copilot, copper peptide, and adenosine. The standard, enhanced, and scalp-specific formulas all contain all of the aforementioned active ingredients that promote enhanced health and efficacy. The mild anti-corrosion system is composed of p-hydroxyacetophenone and ethylhexylglycerin; The pH adjuster uses a citric acid / sodium citrate buffer system; The natural fragrance component is orange blossom essential oil.

3. The hair growth liquid according to claim 1 or 2, characterized in that, The specific components and weight percentage ranges of the three gradient formulations are as follows: ① Basic H-type cultivation: Deionized water balance, butylene glycol 2.0–5.0%, xanthan gum 0.02–0.06%, panthenol 0.05–0.30%, sodium hyaluronate 0.01–0.10%, allantoin 0.05–0.25%, squalane 0.1–0.6%, tocopheryl acetate 0.05–0.20%, PEG-40 hydrogenated castor oil 0.8–1.6%, disodium EDTA 0.02–0.05%, ginseng root extract 0.03–0.20%, black mulberry fruit extract 0%. 0.03–0.20%, Ganoderma lucidum extract 0.03–0.15%, Ligustrum lucidum extract 0.03–0.20%, Platycladus orientalis leaf extract 0.03–0.20%, Glycyrrhiza uralensis extract 0.03–0.20%, Usma scabra extract 0.03–0.20%, Centella asiatica extract 0.03–0.15%, Coleus forsythia suspensa extract 0.03–0.15%, Eclipta prostrata extract 0.03–0.15%, Unodil 0.1–0.8%, Biotin tripeptide-1 0.05–0.25%, Myristoyl pentapeptide-4 0.001–0.005%, Neroli oleracea essential oil 0.002–0.03%, p-hydroxyacetophenone 0.30–0.55%, Ethylhexylglycerin 0.15–0.35%, Citric acid / sodium citrate buffer system as needed; ② Standard maintenance type: Deionized water balance, butylene glycol 2.5–6.0%, xanthan gum 0.03–0.08%, panthenol 0.05–0.40%, sodium hyaluronate 0.01–0.12%, β-glucan 0.05–0.35%, allantoin 0.10–0.30%, squalane 0.2–0.8%, tocopheryl acetate 0.05–0.25%, hydrogenated lecithin 0.15–0.40%, PEG-40 hydrogenated castor oil 0.7–1.8%, disodium EDTA 0.02–0.05%, ginseng root extract 0.05–0.3%. 0%, Black Mulberry Fruit Extract 0.05-0.30%, Ganoderma Lucidum Extract 0.05-0.25%, Ligustrum lucidum Extract 0.05-0.30%, Platycladus orientalis Leaf Extract 0.05-0.30%, Licorice Extract 0.05-0.30%, Usma Extract 0.10-0.35%, Centella Asiatica Extract 0.05-0.25%, Coleus forsythia Extract 0.08-0.25%, Eclipta prostrata Extract 0.05-0.25%, Unopil 0.2-1.2%, Copilot 0.2-1.5%, Biotin Tripeptide-1 0.05–0.30%, myristoyl pentapeptide-4 0.002–0.007%, copper peptide 0.01–0.08%, adenosine 0.08–0.25%, neroli essential oil 0.003–0.05%, p-hydroxyacetophenone 0.30–0.55%, ethylhexylglycerin 0.15–0.40%, and an appropriate amount of citric acid / sodium citrate buffer system; ③ Enhanced maintenance type: Deionized water balance, butylene glycol 3.0–7.0%, xanthan gum 0.04–0.10%, panthenol 0.15–0.50%, sodium hyaluronate 0.03–0.18%, β-glucan 0.15–0.45%, allantoin 0.15–0.35%, squalane 0.4–1.0%, tocopheryl acetate 0.15–0.35%, hydrogenated lecithin 0.25–0.70%, PEG-40 hydrogenated castor oil 0.4–1.2%, disodium EDTA 0.02–0.05%, ginseng root extract 0.08–0.3%. 5%, Black Mulberry Fruit Extract 0.08–0.35%, Ganoderma Lucidum Extract 0.08–0.30%, Ligustrum lucidum Extract 0.08–0.35%, Platycladus orientalis Leaf Extract 0.08–0.35%, Licorice Extract 0.08–0.35%, Usma Extract 0.18–0.40%, Centella Asiatica Extract 0.08–0.30%, Coleus forsythia Extract 0.12–0.30%, Eclipta prostrata Extract 0.08–0.30%, Unopil 0.4–1.5%, Copilot 0.4–1.8%, Biotin Tripeptide-1 0.15–0.40%, myristoyl pentapeptide-4 0.004–0.010%, copper peptide 0.04–0.12%, adenosine 0.12–0.35%, neroli essential oil 0.01–0.06%, p-hydroxyacetophenone 0.40–0.70%, ethylhexylglycerin 0.25–0.50%, and an appropriate amount of citric acid / sodium citrate buffer system.

4. The hair growth liquid according to claim 1 or 2, characterized in that, The components and weight percentage range of the scalp-specific derivative formula are as follows: Based on the standard conditioning formula of claim 3, one or more of peppermint extract, peppermint leaf extract, and menthol are selectively added, with an addition amount of 0.01-0.4% (weight percentage), and azelaic acid of 0.3-2.5% (weight percentage) is added; the components of the Eight Treasures and Ten Flavors Compound Herbal Extract in the scalp-specific derivative formula can be slightly adjusted, and the addition amount of each component after the adjustment is still within the weight percentage range of the corresponding components in the standard conditioning formula of claim 3.

5. The hair growth liquid according to claim 2, characterized in that, Unopil is used to awaken dormant hair follicles, prolong the hair growth phase, and promote new hair growth; Copidrome is used to regulate scalp sebum secretion, stabilize hair follicle roots, and reduce hair loss; the combination of unopil and Copidrome works synergistically to control oil and prevent hair loss while promoting new hair growth; xanthan gum is used to regulate the rheological properties of the system, improve the texture of the material, enhance the uniformity and stability of the formula, and reduce the risk of material separation and water separation; allantoin is used to soothe the skin, repair the skin barrier around the hair follicles, and reduce the potential irritation of active ingredients; orange blossom essential oil replaces artificial fragrances, and its addition amount meets the relevant cosmetic standards.

6. A method for preparing a hair growth liquid containing a compound of active ingredients from eight precious herbs and ten flavors as described in any one of claims 1 to 5, characterized in that, Includes the following steps: (1) Raw material preparation: According to the corresponding formula, accurately weigh all aqueous raw materials, oil raw materials, eight-treasure ten-flavor compound herbal extract, active ingredients for promoting maintenance and enhancing efficacy and auxiliary components; clean and disinfect the production equipment in advance to ensure that the cleanliness of the production environment and equipment meets the "Cosmetic Safety Technical Specifications" (2015 edition) and relevant industry standards; (2) Aqueous phase preparation: Add the aqueous phase raw materials, texture conditioning and soothing ingredients, and disodium EDTA from the basic matrix to the emulsification pot, start uniform stirring, control the stirring speed at 300-500 r / min, heat to 75-85℃, keep warm and stir for 15-20 min until all components are completely dissolved to form a uniform and transparent aqueous phase system; among them, the basic maintenance formula does not need to add β-glucan; (3) Oil phase mixing and emulsification: Squalane, tocopheryl acetate and PEG-40 hydrogenated castor oil are mixed evenly; hydrogenated lecithin is added to the standard maintenance type, the enhanced maintenance type and the scalp-specific derivative type and mixed evenly; the mixed oil phase mixture is slowly added to the aqueous phase system prepared in step (2), and the homogenization emulsification is started for 5 to 10 minutes. The homogenization speed is controlled at 2000 to 3000 r / min. The mixture is kept warm and stirred for 20 to 30 minutes until the oil is completely solubilized and the material system is uniform, stable and free of particles. (4) Cooling and adding ingredients: Turn on the cooling system to lower the temperature of the material to 38-45℃, and add the Eight Treasures and Ten Flavors Compound Herbal Extract and various active ingredients that promote nourishment and enhance efficacy in sequence; if it is a scalp-specific derivative formula, add azelaic acid at the same time, and continue stirring for 10-15 minutes, with the stirring speed controlled at 200-300r / min, until all ingredients are completely dissolved and the system is free of stratification and clumping; (5) pH adjustment: Add an appropriate amount of citric acid / sodium citrate buffer system to adjust the pH of the system to 5.0-6.5, and stir continuously for 5-10 minutes to ensure that the pH of the system is uniform and stable; (6) Addition of auxiliary components: If it is a scalp-specific derivative formula, add peppermint components; then add orange blossom essential oil, p-hydroxyacetophenone, and ethylhexylglycerin in sequence, and continue stirring for 15-30 minutes. The stirring speed is controlled at 200-300 r / min to ensure that the components are mixed evenly, without local aggregation or precipitation; among them, p-hydroxyacetophenone and ethylhexylglycerin are added later to avoid high temperature destroying their preservative activity; (7) Filtration and defoaming: Filter the material using 200-400 mesh filter cloth, collect the liquid and let it stand for 2-4 hours to defoam, and completely remove the air bubbles in the material. (8) Filling the finished product: The liquid material is tested for appearance, pH value, physicochemical indicators and microbiological indicators. After passing the test, it is filled, sealed, inspected by light and packaged to obtain the finished product.

7. The preparation method according to claim 6, characterized in that, In step (2), the aqueous phase raw materials include deionized water, butylene glycol, panthenol, and sodium hyaluronate. Other formulas besides the basic maintenance formula are additionally supplemented with β-glucan. The texture-adjusting and soothing ingredients include xanthan gum and allantoin.

8. The preparation method according to claim 6, characterized in that, In step (6), p-hydroxyacetophenone and ethylhexylglycerin need to be added later to avoid high temperature damaging their preservative activity.

9. The preparation method according to claim 6, characterized in that, In step (8), the liquid material testing must comply with the "Cosmetic Safety Technical Specifications" (2015 edition) and relevant industry standards to ensure that the finished product is free from stratification, deterioration, excessive microorganisms, and odor.

10. The hair growth liquid according to any one of claims 1 to 5, characterized in that, The hair growth serum contains no artificial fragrances, has a gentle formula that is suitable for sensitive skin, reduces the risk of irritation, and is suitable for all skin types. Its components can nourish hair follicles, improve the microenvironment for hair growth, provide favorable conditions for hair growth, enhance the strength of hair cuticles and hair shaft structure, and improve the phenomenon of sparse, fine, soft, easy-to-fall-out and easy-to-break hair. The hair growth liquid is clear, stable, refreshing and non-sticky, does not easily clog hair follicles, has good long-term storage stability, and is suitable for industrial mass production, which can meet the needs of large-scale application and market promotion.