A traditional Chinese medicine composition for treating acne with fire-evil accumulation inside and a preparation method and application thereof
By preparing exosome hydrogels formed by cross-linking traditional Chinese medicine compositions such as Viola yedoensis with PEGDA monomers, the problems of individual constitution differences and side effects of traditional Chinese medicine in treating acne caused by internal heat and dampness were solved, achieving rapid and effective treatment results.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANXI UNIV OF CHINESE MEDICINE
- Filing Date
- 2026-05-11
- Publication Date
- 2026-06-05
AI Technical Summary
Existing traditional Chinese medicines for treating acne caused by internal heat have problems such as large differences in individual constitution, insignificant effects and obvious side effects. In addition, the traditional treatment cycle is long and patients have poor compliance.
Using Viola yedoensis, Centella asiatica, Morus alba root bark, Hedyotis diffusa, Lonicera japonica, Eriobotrya japonica leaf, and Coix lacryma-jobi as the main raw materials, a traditional Chinese medicine extract was prepared through steps such as crushing, soaking, decocting, concentrating, and gradient centrifugation. The extract was then cross-linked with PEGDA monomer to form an exosome hydrogel, which was used to treat acne caused by internal heat.
This invention provides a cost-effective, low-side-effect, and highly effective traditional Chinese medicine composition that can quickly alleviate symptoms of acne caused by internal heat, shorten the treatment cycle, and reduce the burden on patients.
Abstract
Description
Technical Field
[0001] This invention relates to the field of traditional Chinese medicine composition technology, and in particular to a traditional Chinese medicine composition for treating acne caused by internal heat, its preparation method, and its application. Background Technology
[0002] Acne caused by internal heat is one of the core pathogenesis mechanisms across various types of acne. It is mainly characterized by the stagnation of internal heat that cannot be released, rising to the face and causing redness, swelling, pain, and a tendency to suppurate. This type of acne is more common in people with a constitution prone to heat, those experiencing significant emotional fluctuations, or those with irregular eating habits.
[0003] While traditional Chinese medicine (TCM) preparations are convenient, they must be used according to the patient's specific condition. For example, if someone with spleen and stomach deficiency mistakenly takes heat-clearing medications (such as Jinhua Xiaocuo Wan), it may lead to diarrhea and loss of appetite; while if someone with yin deficiency and excessive fire mistakenly uses bitter and cold purgatives, it may damage yin and exacerbate the fire. Furthermore, TCM treatment often requires 1-3 months or more to see results, and some patients discontinue treatment due to a lack of improvement in the short term. The same medication can have significantly different effects on people with different constitutions.
[0004] Therefore, providing a traditional Chinese medicine formula for treating acne caused by internal heat and dampness is of significant importance in the treatment of this type of acne. Summary of the Invention
[0005] The purpose of this invention is to provide a traditional Chinese medicine composition for treating acne caused by internal heat and its preparation method and application, thereby improving the therapeutic effect of acne caused by internal heat and its effects.
[0006] To achieve the above-mentioned objectives, the present invention provides the following technical solution: This invention provides a traditional Chinese medicine composition for treating acne caused by internal heat, the composition comprising the following raw materials in parts by weight: 18-22 parts of Viola yedoensis, 12-14 parts of Centella asiatica, 12-14 parts of Morus alba root bark, 5-7 parts of Hedyotis diffusa, 2-3 parts of Lonicera japonica, 5-7 parts of Eriobotrya japonica leaf, and 3-5 parts of Coix lacryma-jobi.
[0007] Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20 parts Viola yedoensis, 13 parts Centella asiatica, 13 parts Morus alba root bark, 6 parts Hedyotis diffusa, 2.5 parts Lonicera japonica, 6 parts Eriobotrya japonica leaf, and 4 parts Coix lacryma-jobi.
[0008] The present invention also provides a method for preparing the traditional Chinese medicine composition, comprising the following steps: (1) Weigh out Viola yedoensis, Centella asiatica, mulberry bark, Hedyotis diffusa, honeysuckle, loquat leaf and coix seed according to the proportion, and mix them to obtain the mixture; (2) The mixture is crushed to obtain crushed material; (3) Soak the crushed materials in water and then boil them. Filter the decoction to obtain the decoction. (4) Concentrate the decoction to obtain the Chinese herbal extract.
[0009] Preferably, the particle size of the crushed material in step (2) is ≤0.6cm.
[0010] Preferably, the mass ratio of the crushed material to water in step (3) is 1:8~12, the number of times of decocting is 2~3, and the time for each decocting is 20~30min.
[0011] Preferably, the mass of the concentrated Chinese herbal extract obtained in step (4) is 1.5 to 2.5 times the mass of the mixture in step (1).
[0012] The present invention also provides the application of the aforementioned traditional Chinese medicine composition in the preparation of products for treating acne caused by internal heat.
[0013] The present invention also provides a product for preparing acne for treating acne caused by internal heat, the product comprising the aforementioned traditional Chinese medicine composition.
[0014] The present invention also provides a method for preparing the product, comprising the following steps: A. Take the traditional Chinese medicine liquid prepared from the traditional Chinese medicine composition and perform gradient centrifugation to separate the traditional Chinese medicine exosomes; B. Resuspend the exosomes of traditional Chinese medicine in water to obtain an aqueous solution of exosomes of traditional Chinese medicine; C. Mix the aqueous solution of Chinese herbal exosomes with PEGDA monomer to obtain a mixture, add a photoinitiator to the mixture, and then perform photocrosslinking treatment to obtain exosome hydrogel; D. Soak the exosome hydrogel in deionized water to obtain the finished product.
[0015] Preferably, the gradient centrifugation method in step A is as follows: centrifuge the herbal liquid at 280~290×g for 8~10 min to obtain supernatant 1; centrifuge supernatant 1 at 3200~3400×g for 14~16 min to obtain supernatant 2; centrifuge supernatant 2 at 11000~12000×g for 20~25 min to obtain supernatant 3; centrifuge supernatant 3 at 105000~115000×g for 80~100 min, and the precipitate is the herbal exosome; The mass ratio of the herbal exosomes to water in step B is 1:60~80; In step C, the mass ratio of the herbal exosomes to the PEGDA monomer is 70-90:10-30; the photoinitiator is Irgacure 2959, and the final concentration of the photoinitiator in the mixture is 0.08-0.12%; the photocrosslinking treatment method is irradiation under ultraviolet light for 2-3 minutes. The soaking time in step D is 20-24 hours, and the water is changed every 4-6 hours during the process.
[0016] This invention provides a traditional Chinese medicine composition for treating acne caused by internal heat, its preparation method, and its application. The composition comprises the following raw materials in parts by weight: 18-22 parts of Viola yedoensis, 12-14 parts of Centella asiatica, 12-14 parts of Morus alba root bark, 5-7 parts of Hedyotis diffusa, 2-3 parts of Lonicera japonica, 5-7 parts of Eriobotrya japonica leaf, and 3-5 parts of Coix lacryma-jobi. The composition uses pure natural medicinal materials, making it cost-effective, easy to promote, and without significant side effects. It can effectively reduce the burden and pain on patients, minimize its impact on people's physical and mental health, and has broad application prospects. Detailed Implementation
[0017] This invention provides a traditional Chinese medicine composition for treating acne caused by internal heat, the composition comprising the following raw materials in parts by weight: 18-22 parts of Viola yedoensis, 12-14 parts of Centella asiatica, 12-14 parts of Morus alba root bark, 5-7 parts of Hedyotis diffusa, 2-3 parts of Lonicera japonica, 5-7 parts of Eriobotrya japonica leaf, and 3-5 parts of Coix lacryma-jobi.
[0018] Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20 parts Viola yedoensis, 13 parts Centella asiatica, 13 parts Morus alba root bark, 6 parts Hedyotis diffusa, 2.5 parts Lonicera japonica, 6 parts Eriobotrya japonica leaf, and 4 parts Coix lacryma-jobi.
[0019] The present invention also provides a method for preparing the traditional Chinese medicine composition, comprising the following steps: (1) Weigh out Viola yedoensis, Centella asiatica, mulberry bark, Hedyotis diffusa, honeysuckle, loquat leaf and coix seed according to the proportion, and mix them to obtain the mixture; (2) The mixture is crushed to obtain crushed material; (3) Soak the crushed materials in water and then boil them. Filter the decoction to obtain the decoction. (4) Concentrate the decoction to obtain the Chinese herbal extract.
[0020] In this invention, the particle size of the crushed material in step (2) is ≤0.6cm.
[0021] In this invention, the mass ratio of the crushed material to water in step (3) is 1:8~12, the number of times of decocting is 2~3, and the time for each decocting is 20~30min.
[0022] In this invention, the mass of the concentrated Chinese herbal extract obtained in step (4) is 1.5 to 2.5 times the mass of the mixture in step (1).
[0023] The present invention also provides the application of the aforementioned traditional Chinese medicine composition in the preparation of products for treating acne caused by internal heat.
[0024] The present invention also provides a product for preparing acne for treating acne caused by internal heat, the product comprising the aforementioned traditional Chinese medicine composition.
[0025] The present invention also provides a method for preparing the product, comprising the following steps: A. Take the traditional Chinese medicine liquid prepared from the traditional Chinese medicine composition and perform gradient centrifugation to separate the traditional Chinese medicine exosomes; B. Resuspend the exosomes of traditional Chinese medicine in water to obtain an aqueous solution of exosomes of traditional Chinese medicine; C. Mix the aqueous solution of Chinese herbal exosomes with PEGDA monomer to obtain a mixture, add a photoinitiator to the mixture, and then perform photocrosslinking treatment to obtain exosome hydrogel; D. Soak the exosome hydrogel in deionized water to obtain the finished product.
[0026] In this invention, the gradient centrifugation method described in step A is as follows: the herbal liquid is centrifuged at 280~290×g for 8~10 min to obtain supernatant 1; supernatant 1 is centrifuged at 3200~3400×g for 14~16 min to obtain supernatant 2; supernatant 2 is centrifuged at 11000~12000×g for 20~25 min to obtain supernatant 3; supernatant 3 is centrifuged at 10500~11500×g for 80~100 min, and the precipitate is the herbal exosome; A further preferred method is as follows: centrifuge the herbal liquid at 285×g for 9 min to obtain supernatant 1; centrifuge supernatant 1 at 3300×g for 15 min to obtain supernatant 2; centrifuge supernatant 2 at 11500×g for 23 min to obtain supernatant 3; centrifuge supernatant 3 at 110000×g for 90 min, and the precipitate is the herbal exosome. The mass ratio of the herbal exosomes to water in step B is 1:60~80, more preferably 1:70; In step C, the preferred mass ratio of the herbal exosomes to the PEGDA monomer is 70-90:10-30, more preferably 80:20; the preferred photoinitiator is Irgacure 2959, and the final concentration of the photoinitiator in the mixture is preferably 0.08-0.12%, more preferably 0.1%; the preferred method for photocrosslinking treatment is irradiation under ultraviolet light for 2-3 minutes, more preferably 3 minutes. The soaking time in step D is preferably 20-24 hours, more preferably 22 hours, and the water is preferably changed every 4-6 hours during the treatment, more preferably every 5 hours.
[0027] The technical solutions provided by the present invention will be described in detail below with reference to the embodiments, but they should not be construed as limiting the scope of protection of the present invention.
[0028] Example 1
[0029] 1. A method for preparing a traditional Chinese medicine composition for treating acne caused by internal heat, comprising the following steps: (1) Weigh the raw materials according to the mass ratio of 18 parts of Viola yedoensis, 12 parts of Centella asiatica, 14 parts of mulberry bark, 7 parts of Hedyotis diffusa, 3 parts of honeysuckle, 5 parts of loquat leaf, and 3 parts of coix seed, and mix them to obtain a mixture. (2) Crush the mixture to a particle size ≤ 0.6 cm to obtain crushed material; (3) Soak the crushed material in 8 times its weight of water and then boil for 30 minutes. Boil twice in a row and filter to obtain the decoction. (4) Concentrate the decoction to obtain a traditional Chinese medicine extract. Note: The mass of the concentrated Chinese herbal extract obtained in step (4) is 2.5 times the mass of the mixture in step (1).
[0030] 2. A method for preparing a gel for treating acne caused by internal heat, comprising the following steps: A. Take the herbal liquid prepared in step 1 above, centrifuge it at 280×g for 10 min to obtain supernatant 1; centrifuge supernatant 1 at 3200×g for 16 min to obtain supernatant 2; centrifuge supernatant 2 at 11000×g for 25 min to obtain supernatant 3; centrifuge supernatant 3 at 115000×g for 80 min to separate the precipitate and obtain herbal exosomes; B. Resuspend the exosomes of traditional Chinese medicine in 60 times their weight of water to obtain an aqueous solution of exosomes of traditional Chinese medicine; C. Mix the aqueous solution of Chinese herbal exosomes with PEGDA monomer at a mass ratio of 90:10 to obtain a mixture. Add the photoinitiator Irgacure 2959 to the mixture to a final concentration of 0.08%. Then irradiate under ultraviolet light for 3 minutes to obtain exosome hydrogel. D. Soak the exosome hydrogel in deionized water for 24 hours, changing the water every 6 hours during the soaking period to obtain the finished product.
[0031] Example 2
[0032] 1. A method for preparing a traditional Chinese medicine composition for treating acne caused by internal heat, comprising the following steps: (1) Weigh the raw materials according to the mass ratio of 22 parts of Viola yedoensis, 14 parts of Centella asiatica, 12 parts of mulberry bark, 5 parts of Hedyotis diffusa, 2 parts of honeysuckle, 7 parts of loquat leaf, and 5 parts of coix seed, and mix them to obtain a mixture. (2) Crush the mixture to a particle size ≤ 0.6 cm to obtain crushed material; (3) Soak the crushed material in 12 times its weight of water and then boil for 20 minutes. Boil three times in a row and filter to obtain the decoction. (4) Concentrate the decoction to obtain a traditional Chinese medicine extract. Note: The mass of the concentrated Chinese herbal extract obtained in step (4) is 1.5 times the mass of the mixture in step (1).
[0033] 2. A method for preparing a gel for treating acne caused by internal heat, comprising the following steps: A. Take the herbal liquid prepared in step 1 above, centrifuge it at 290×g for 8 min to obtain supernatant 1; centrifuge supernatant 1 at 3400×g for 14 min to obtain supernatant 2; centrifuge supernatant 2 at 12000×g for 20 min to obtain supernatant 3; centrifuge supernatant 3 at 105000×g for 100 min to separate the precipitate and obtain herbal exosomes; B. Resuspend the exosomes of traditional Chinese medicine in 80 times their weight of water to obtain an aqueous solution of exosomes of traditional Chinese medicine; C. Mix the aqueous solution of Chinese herbal exosomes with PEGDA monomer at a mass ratio of 70:30 to obtain a mixture. Add the photoinitiator Irgacure 2959 to the mixture to a final concentration of 0.12%. Then irradiate under ultraviolet light for 2 minutes to obtain exosome hydrogel. D. Soak the exosome hydrogel in deionized water for 204 hours, changing the water every 4 hours during the soaking period to obtain the finished product.
[0034] Example 3
[0035] 1. A method for preparing a traditional Chinese medicine composition for treating acne caused by internal heat, comprising the following steps: (1) Weigh the raw materials according to the following mass ratio: 20 parts of Viola yedoensis, 13 parts of Centella asiatica, 13 parts of Morus alba root bark, 6 parts of Hedyotis diffusa, 2.5 parts of Lonicera japonica, 6 parts of Eriobotrya japonica leaf, and 4 parts of Coix lacryma-jobi. Mix them together to obtain the mixture. (2) Crush the mixture to a particle size ≤ 0.6 cm to obtain crushed material; (3) Soak the crushed material in 10 times its weight of water and then boil for 25 minutes. Boil twice in a row and filter to obtain the decoction. (4) Concentrate the decoction to obtain a traditional Chinese medicine extract. Note: The mass of the concentrated Chinese herbal extract obtained in step (4) is twice the mass of the mixture in step (1).
[0036] 2. A method for preparing a gel for treating acne caused by internal heat, comprising the following steps: A. Take the Chinese herbal liquid prepared in step 1 above, centrifuge it at 285×g for 9 min to obtain supernatant 1; centrifuge supernatant 1 at 3300×g for 15 min to obtain supernatant 2; centrifuge supernatant 2 at 11500×g for 23 min to obtain supernatant 3; centrifuge supernatant 3 at 110000×g for 90 min to separate the precipitate and obtain Chinese herbal exosomes; B. Resuspend the exosomes of traditional Chinese medicine in 70 times their weight of water to obtain an aqueous solution of exosomes of traditional Chinese medicine; C. Mix the aqueous solution of Chinese herbal exosomes with PEGDA monomer at a mass ratio of 80:20 to obtain a mixture. Add the photoinitiator Irgacure 2959 to the mixture to a final concentration of 0.1%. Then irradiate under ultraviolet light for 2 minutes to obtain exosome hydrogel. D. Soak the exosome hydrogel in deionized water for 22 hours, changing the water every 5 hours during the soaking period, to obtain the finished product.
[0037] Test case
[0038] 1. Rat experiment
[0039] Fifty male SD rats weighing 200±10g were selected and injected with Propionibacterium acnes after one week of acclimatization.
[0040] Before injection, the activated Propionibacterium acnes (P. acnes) was resuspended in physiological saline and the concentration was adjusted to 7 × 10⁻⁶. 7 Rats were injected with a concentration of cfu / mL of Propionibacterium acnes (P. acnes) suspension via the back of their rats at a rate of 30 μL / rat / day for 7 consecutive days. Three hours after the injection, oleic acid was applied to the back of the rats to promote follicular blockage and the formation of chronic inflammation.
[0041] During the injection period and for 7 days after the injection, rats were subjected to high temperature and high humidity treatment for 6 hours daily to induce acne with internal heat and dampness, which is different from ordinary acne. The temperature was controlled at 33±1℃ and the humidity at 65±2%.
[0042] After the high temperature and high humidity treatment, the acne model was observed, and 40 rats with similar living conditions and obvious acne were selected.
[0043] The selected rats were divided into four groups, numbered as experimental groups 1-3 and control group.
[0044] The gel prepared in Example 1 was applied to rats in experimental group 1, the gel prepared in Example 2 was applied to rats in experimental group 2, and the gel prepared in Example 3 was applied to rats in experimental group 3. The control group rats received no treatment. The gel was applied once daily for 10 minutes each time, for 15 consecutive days. Changes in acne in each group were observed.
[0045] The results showed that the acne in rats in experimental group 1 began to improve on the 3rd day of the application test, most of the acne improved on the 7th day, and the acne basically disappeared by the 12th day.
[0046] In group 2, the acne of rats began to improve on the 4th day of the application test, most of the acne improved on the 7th day, and by the 14th day, the acne of the remaining rats had basically disappeared except for one rat.
[0047] In group 3, the rats' acne began to improve on the 3rd day of the application test, most of the acne improved on the 6th day, and by the 14th day, the acne of all rats had basically disappeared.
[0048] After 15 days of feeding, the control group of rats showed no significant changes except for two rats whose acne symptoms decreased.
[0049] 2. Case
[0050] Case 1: Li The patient, a 21-year-old female student at Shanxi University of Traditional Chinese Medicine, had suffered from acne for three years, during which time she had used tretinoin cream and isotretinoin with unsatisfactory results. She was diagnosed with internal heat accumulation. She was advised to try applying the gel prepared in Example 1 once daily, leaving it on for 10 minutes each time. After one week of use, she returned for a follow-up visit; her acne symptoms had lessened, and itching and pain had decreased. She recovered completely after 27 days of continuous use. A follow-up visit six months later showed no recurrence.
[0051] Case 2: Ma The patient, a 22-year-old male student at Shanxi University of Traditional Chinese Medicine, had suffered from acne for 5 years. He had tried various medications, including salicylic acid, isotretinoin, and doxycycline, with unsatisfactory results. His tongue coating was yellow and dry, and combined with other symptoms, the condition was diagnosed as being caused by internal heat. He was prescribed the gel prepared in Example 3, applied twice daily, morning and evening, leaving it on for 10 minutes each time. After one week of use, he returned for a follow-up visit, and his acne symptoms had lessened. After 30 days of continuous use, he was essentially cured and continued use for another 10 days to consolidate the effect. A follow-up visit 6 months later showed no recurrence.
[0052] As can be seen from the above embodiments, the present invention provides a traditional Chinese medicine composition for treating acne caused by internal heat, its preparation method, and its application. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 18-22 parts of Viola yedoensis, 12-14 parts of Centella asiatica, 12-14 parts of Morus alba root bark, 5-7 parts of Hedyotis diffusa, 2-3 parts of Lonicera japonica, 5-7 parts of Eriobotrya japonica leaf, and 3-5 parts of Coix lacryma-jobi. The traditional Chinese medicine composition of the present invention uses pure natural medicinal materials as raw materials, which makes the cost controllable, easy to promote, and has no obvious side effects. It can effectively reduce the burden and pain of patients, reduce its impact on people's physical and mental health, and has broad application prospects.
[0053] The above description is only a preferred embodiment of the present invention. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of the present invention, and these improvements and modifications should also be considered within the scope of protection of the present invention.
Claims
1. A traditional Chinese medicine composition for treating acne caused by internal heat, characterized in that, The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 18-22 parts of Viola yedoensis, 12-14 parts of Centella asiatica, 12-14 parts of Morus alba root bark, 5-7 parts of Hedyotis diffusa, 2-3 parts of Lonicera japonica, 5-7 parts of Eriobotrya japonica leaf, and 3-5 parts of Coix lacryma-jobi.
2. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 20 parts Viola yedoensis, 13 parts Centella asiatica, 13 parts Morus alba root bark, 6 parts Hedyotis diffusa, 2.5 parts Lonicera japonica, 6 parts Eriobotrya japonica leaf, and 4 parts Coix lacryma-jobi.
3. The method for preparing the traditional Chinese medicine composition according to any one of claims 1 to 2, characterized in that, Includes the following steps: (1) Weigh out Viola yedoensis, Centella asiatica, mulberry bark, Hedyotis diffusa, honeysuckle, loquat leaf and coix seed according to the proportion, and mix them to obtain the mixture; (2) The mixture is crushed to obtain crushed material; (3) Soak the crushed materials in water and then boil them. Filter the decoction to obtain the decoction. (4) Concentrate the decoction to obtain the Chinese herbal extract.
4. The preparation method according to claim 3, characterized in that, The particle size of the crushed material in step (2) is ≤0.6cm.
5. The preparation method according to claim 3, characterized in that, The mass ratio of the crushed material to water in step (3) is 1:8~12, the number of times of decocting is 2~3, and the time for each decocting is 20~30 minutes.
6. The preparation method according to claim 3, characterized in that, The mass of the concentrated Chinese herbal extract obtained in step (4) is 1.5 to 2.5 times the mass of the mixture in step (1).
7. The use of the traditional Chinese medicine composition according to any one of claims 1 to 2 in the preparation of a product for treating acne caused by internal heat.
8. A product for treating acne caused by internal heat and dampness, characterized in that, The product includes the traditional Chinese medicine composition according to any one of claims 1 to 2.
9. The method for preparing the product according to claim 8, characterized in that, Includes the following steps: A. Take the traditional Chinese medicine liquid prepared by the traditional Chinese medicine composition according to any one of claims 1 to 2, perform gradient centrifugation, and separate the traditional Chinese medicine exosomes; B. Resuspend the exosomes of traditional Chinese medicine in water to obtain an aqueous solution of exosomes of traditional Chinese medicine; C. Mix the aqueous solution of Chinese herbal exosomes with PEGDA monomer to obtain a mixture, add a photoinitiator to the mixture, and then perform photocrosslinking treatment to obtain exosome hydrogel; D. Soak the exosome hydrogel in deionized water to obtain the finished product.
10. The preparation method according to claim 9, characterized in that, The gradient centrifugation method described in step A is as follows: centrifuge the Chinese medicine solution at 280~290×g for 8~10 min to separate the supernatant 1; Centrifuge supernatant 1 at 3200~3400×g for 14~16 min to separate supernatant 2; Centrifuge supernatant 2 at 11000~12000×g for 20~25min to separate supernatant 3; Centrifuge the supernatant 3 at 105000~115000×g for 80~100min, and the precipitate is the exosome of traditional Chinese medicine; The mass ratio of the herbal exosomes to water in step B is 1:60~80; In step C, the mass ratio of the herbal exosomes to the PEGDA monomer is 70-90:10-30; the photoinitiator is Irgacure 2959, and the final concentration of the photoinitiator in the mixture is 0.08-0.12%; the photocrosslinking treatment method is irradiation under ultraviolet light for 2-3 minutes. The soaking time in step D is 20-24 hours, and the water is changed every 4-6 hours during the process.