Compositions and particles for payload delivery

CN122140949APending Publication Date: 2026-06-05THORNHILL THERAPEUTICS
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THORNHILL THERAPEUTICS
Filing Date
2020-08-14
Publication Date
2026-06-05

AI Technical Summary

Technical Problem

Macromolecular and protein biopharmaceuticals are difficult to absorb by epithelial and intestinal epithelium, leading to degradation or excretion in the intestinal lumen, which affects the therapeutic effect. Furthermore, lung delivery presents challenges, limiting the clinical application and delivery efficiency of these drugs.

Method used

A composition has been developed comprising a carrier and a heterologous payload, wherein the carrier comprises a portion of a Cholix polypeptide or a Pseudomonas exotoxin A, bound to a transition metal cation or a polycation, and is capable of penetrating polarized epithelial cells to achieve efficient delivery of macromolecular and protein drugs.

Benefits of technology

It improves the absorption efficiency of macromolecular and protein drugs, reduces drug degradation and excretion in the body, achieves more efficient therapeutic effects, and simplifies the administration method.

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Abstract

Disclosed herein are compositions and particles for payload delivery. In particular, provided herein are complexes and compositions comprising particles, microparticles, or nanoparticles for delivering a payload into a cell or across a polarized epithelial cell. The compositions can include a payload for delivering the payload into or across a polarized epithelial cell in a pill or tablet.
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