A recombined collagen liquid quantitative filling device

Abstract

The application discloses a kind of recombination collagen liquid quantitative filling device, including base, perfusion pipe and first protection component;First protection component includes mounting bracket, multiple sliders and multiple elastic expansion pieces, multiple elastic expansion pieces cooperate to drive multiple sliders to be spliced to form the cylinder with both ends open, the inner wall of the top end opening of cylinder defines a tapered surface, the two end openings of cylinder are communicated by central passage, the inner wall of cylinder is provided with exhaust hole group, cylinder is discharged to perfusion pipe, bottle body and the bottle mouth of bottle body through exhaust hole group and central passage.Gas is discharged through the setting of the exhaust hole group and the central passage, which realizes the closed loop oxygen isolation of the whole process of perfusion. Through the whole process of nitrogen gas covering, such as pre-charging nitrogen before filling, continuous pressure maintaining during filling, and final gas supplementing after filling, the problem of protein oxidation inactivation is solved. Combined with the sterile air curtain at the bottle mouth, the risk of recombinant collagen contacting with air during the whole filling cycle is eliminated.

Description

Technical Field

[0001] This invention relates to the field of filling equipment technology, and in particular to a quantitative filling device for recombinant collagen liquid. Background Technology

[0002] Recombinant collagen, as a biomaterial with high bioactivity and added value, is widely used in the production of Class II and Class III sterile medical devices and cosmetic products. Because recombinant collagen needs to maintain high activity before and after use, its filling process has much higher requirements for sterility, oxidation prevention, material loss prevention, and low-shear protection than ordinary liquids. In actual production, recombinant collagen liquid is prone to oxidation and inactivation upon contact with air. Furthermore, factors such as pressure buildup and droplet splashing during the filling process can lead to residue adhesion to the tube wall, resulting in waste of high-value raw materials. Simultaneously, the contact between the filling tube opening and the outside environment can easily cause leakage, not only contaminating the production environment but also affecting the product filling accuracy and aseptic compliance. Summary of the Invention

[0003] The purpose of this invention is to provide a recombinant collagen liquid quantitative filling device that is oxygen-free throughout the process and leaves no dripping residue.

[0004] To achieve this objective, the present invention adopts the following technical solution: a recombinant collagen liquid quantitative filling device, comprising a base, a filling tube, and a first protective assembly. The base is provided with a turntable and a support, the support being located on one side of the turntable, and the support having a mounting plate that can slide vertically. The filling tube is slidably connected to the mounting plate vertically and located above the turntable, the turntable being used to transport the bottle to be filled to below the filling tube. The first protective assembly includes a mounting frame, multiple sliders, and multiple elastic telescopic components. The mounting frame is arranged around the filling tube and fixedly connected to the mounting plate, the mounting frame having multiple support plates, the support plates, and the elastic telescopic components... The shrinkable parts and the sliders are arranged in a one-to-one correspondence. The sliders are slidably connected to the mounting frame along the radial direction of the filling tube. The elastic telescopic parts are connected between the outer walls of the corresponding support plates and the corresponding sliders to drive multiple sliders to assemble into a cylinder with open ends. The inner wall of the top opening of the cylinder defines a conical surface. The conical surface abuts against the outer peripheral wall of the filling tube opening. The two openings of the cylinder are connected through a central channel. The inner wall of the cylinder is provided with an exhaust hole group. The cylinder is connected to an external nitrogen source and can exhaust gas to the filling tube, the bottle body, and the outer periphery of the bottle opening through the exhaust hole group and the central channel.

[0005] Preferably, the vent group includes at least one first vent hole opened on the inner wall of the central channel and multiple second vent holes opened on the inner wall of the bottom opening of the cylinder. The multiple second vent holes are spaced apart along the circumference of the bottle and are all inclined toward the bottle mouth of the bottle.

[0006] Preferably, the central channel includes a first section communicating with the top opening of the cylinder and a second section communicating with the bottom opening of the cylinder, wherein the inner diameter of the first section is smaller than the inner diameter of the second section, and the first vent is opened on the inner wall of the second section.

[0007] Preferably, the slider has an arc-shaped gas distribution channel inside, with both ends of the gas distribution channel penetrating the two side walls of the slider. When multiple sliders are assembled, the multiple gas distribution channels are connected end to end in sequence. The first exhaust port and the second exhaust port are connected to an external nitrogen source through the multiple gas distribution channels that are connected end to end in sequence.

[0008] Preferably, a sealing ring is provided on one side wall of the slider, the sealing ring is arranged around one end opening of the air distribution channel, and a slot is provided on the other side wall of the slider, the slot is connected to the other end opening of the air distribution channel and can engage with the sealing ring.

[0009] Preferably, the mounting bracket is provided with a plurality of guide plates corresponding one-to-one with the slider, the guide plates are provided with guide grooves, the guide grooves are provided along the radial direction of the injection tube, the outer wall of the slider is provided with a protrusion, the protrusion is connected with a screw, and the screw passes through the corresponding guide groove.

[0010] Preferably, the elastic telescopic member includes a first connecting rod, a second connecting rod, and a sleeve. The first connecting rod is connected to the slider, and the second connecting rod is connected to the support plate. The first connecting rod and the second connecting rod are slidably connected to both ends of the sleeve, and a spring is provided inside the sleeve. The two ends of the spring abut against the first connecting rod and the second connecting rod, respectively.

[0011] Preferably, the base is also equipped with a second protective component, which includes a positioning ring and a positioning plate. The positioning ring is fixed above the turntable, and the positioning plate is located below the mounting plate and is slidably connected to the base along the radial direction of the turntable. The positioning ring has a first connecting portion, the inner wall of which defines a first arc-shaped groove. The positioning plate has a second connecting portion, the inner wall of which defines a second arc-shaped groove. The first connecting portion and the second connecting portion are detachably connected so that the first arc-shaped groove and the second arc-shaped groove are combined to form a positioning groove that matches the shape of the bottle.

[0012] Preferably, the first connecting part is provided with an arc-shaped first outlet and a first gas guiding channel communicating with the first outlet. The first outlet is coaxially disposed above the first arc-shaped groove. The two ends of the first gas guiding channel form openings on both sides of the first arc-shaped groove. The second connecting part is provided with an arc-shaped second outlet and a second gas guiding channel communicating with the second outlet. The second outlet is coaxially disposed above the second arc-shaped groove. The second gas guiding channel is communicated with an external nitrogen source. The two ends of the second gas guiding channel form openings on both sides of the second arc-shaped groove. When the first connecting part and the second connecting part are connected, the two ends of the first gas guiding channel and the two ends of the second gas guiding channel are correspondingly connected so that the first outlet and the second outlet emit gas around the bottle body.

[0013] Preferably, the second air guide channel is provided with plugs at both ends, the plugs protruding toward the positioning ring and being able to be inserted and engaged with the openings at both ends of the first air guide channel.

[0014] The beneficial effects of this invention are as follows: When the filling device is working, the turntable first transports the bottle to be filled to the area below the filling tube. The mounting plate moves downward, causing the filling tube and the cylinder to move synchronously until the cylinder contacts the bottle. Before filling, the venting port group can fill the bottle opening with nitrogen to form a turbulent flow around the bottle opening, keeping the area around the bottle opening sterile. At the same time, nitrogen can be pre-filled into the filling tube and the bottle through the central channel to quickly replace the air inside the bottle and limit dripping at the opening of the filling tube, reducing the possibility of residual contaminants inside the bottle and preventing contamination of the raw materials inside the filling tube. Afterward, the filling tube moves downward relative to the mounting plate. The filling tube pushes the conical surface to separate multiple sliders, connecting the filling tube to the bottle. The filling tube then begins injecting recombinant collagen solution into the bottle. During filling, the venting system continuously injects nitrogen gas at a low flow rate into the filling tube and bottle opening, ensuring the air inside the bottle remains sterile throughout the filling process and preventing high-speed airflow from damaging the protein structure. After filling, the filling tube moves relative to the mounting plate, and the elastic telescopic component drives the sliders to reset and reassemble into a cylinder. The venting system then releases gas again, ensuring a protective gas layer remains in the upper part of the bottle after filling. The turntable rotates and repeats the above steps for new filling. By setting up the venting system and central channel, a closed-loop oxygen-free process is achieved throughout the filling process. Pre-filling with nitrogen before filling, continuous pressure maintenance during filling, and post-filling nitrogen coverage solve the problem of protein oxidation and inactivation. Combined with a sterile air curtain at the bottle opening, the risk of recombinant collagen contacting air throughout the entire filling cycle is eliminated. Furthermore, the venting port group provides different venting flow rates to the filling tube and bottle at different stages of filling, enabling low-shear and low-disturbance filling. Through phased adaptive flow control, it fully protects the collagen molecular structure, avoiding the problem of high-speed airflow impacting the liquid surface and generating bubbles, which can damage the three-dimensional structure of the protein. At the same time, it can continuously discharge gas from the bottle, preventing liquid back splashing caused by pressure buildup inside the bottle. While ensuring sterile and oxygen-barrier effects, it achieves low-damage protection for recombinant collagen molecules. By incorporating a slider and an elastic telescopic component, the slider automatically opens through the engagement of its conical surface with the filling tube and automatically closes through the elastic force of the telescopic component. This process separates or connects the filling tube and the bottle without any electrical drive or valve opening / closing, effectively simplifying the structure of the first protection component and reducing layout and maintenance costs. Furthermore, the cylinder and central channel work together to seal the bottom opening of the filling tube before filling, preventing leakage. During the upward movement of the filling tube, the conical surface can adhere to the outer wall of the filling tube and move downwards relative to it, thereby scraping all residual liquid from the tube wall into the bottle, achieving residual liquid recovery, reducing raw material loss, and preventing environmental pollution. Attached Figure Description

[0015] Figure 1 This is a schematic diagram of the recombinant collagen liquid quantitative filling device according to an embodiment of this application; Figure 2 This is a schematic diagram of the installation of the first protection component according to an embodiment of this application; Figure 3 yes Figure 2 Enlarged view of point A in the middle; Figure 4 This is a schematic diagram of the structure of the first protection component according to an embodiment of this application; Figure 5 This is a schematic diagram of the slider structure according to an embodiment of this application; Figure 6 This is a partial schematic diagram of the positioning ring according to an embodiment of this application; Figure 7 This is a schematic diagram of the positioning plate in an embodiment of this application.

[0016] In the diagram: 1. Base; 11. Turntable; 12. Bracket; 121. Mounting plate; 2. Filling pipe; 3. First protective assembly; 31. Mounting bracket; 311. Support plate; 312. Guide plate; 3121. Guide groove; 313. Connecting rod; 32. Slider; 321. Gas distribution channel; 322. Air inlet pipe; 323. Sealing ring; 324. Slot; 33. Elastic telescopic component; 331. First connecting rod; 332. Second connecting rod; 333. Sleeve; 34. Cylinder; 341. Conical surface; 342. 3421, First hole section; 3422, Second hole section; 343, First exhaust port; 344, Second exhaust port; 4, Second protective component; 41, Positioning ring; 411, First connecting part; 412, First air guide ring; 4121, First outlet; 4122, First air guide channel; 42, Positioning plate; 421, Second connecting part; 422, Second air guide ring; 4221, Second outlet; 4222, Second air guide channel; 4223, Plug; 43, Rodless cylinder; 5, Bottle body. Specific Implementation The present invention will now be described in further detail with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and not intended to limit it. Furthermore, it should be noted that, for ease of description, the accompanying drawings show only the parts relevant to the present invention, and not all of the structures.

[0018] In the description of this invention, unless otherwise explicitly specified and limited, the terms "connected," "linked," and "fixed" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral part; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; they can refer to the internal communication of two components or the interaction between two components. Those skilled in the art can understand the specific meaning of the above terms in this invention based on the specific circumstances.

[0019] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on top" of the second feature includes the first feature directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature includes the first feature directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0020] In the description of this embodiment, the terms "upper," "lower," "right," etc., refer to the orientation or positional relationship shown in the accompanying drawings. They are used only for ease of description and simplification of operation, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on the present invention. In addition, the terms "first" and "second" are used only for distinction in description and have no special meaning.

[0021] Reference Figures 1 to 7 As shown, a recombinant collagen liquid quantitative filling device according to an embodiment of this application includes a base 1, a filling tube 2, and a first protective component 3. The base 1 is provided with a rotatable turntable 11 and a support 12. The turntable 11 has multiple holes for placing bottles 5 to be filled. The outer circumference of the turntable 11 is provided with bottle feeding and bottle dispensing devices. The support 12 is located on one side of the turntable 11 and is provided with a mounting plate 121 that can slide vertically. The filling tube 2 is slidably connected to the mounting plate 121 in the vertical direction and is located above the turntable 11. The support 12 and the filling tube 2 are respectively connected to vertical driving components. The turntable 11 is used to transport the bottles 5 to be filled to the area below the filling tube 2. Specifically, the filling pipe 2 is located above the turntable 11 and corresponds to the axis of the bottle 5 in the hole. When the turntable 11 rotates, it can rotate and transfer the unfilled bottle 5 upstream to the bottom of the filling pipe 2, and rotate and transfer the filled bottle 5 downstream.

[0022] The first protective component 3 includes a mounting frame 31, multiple sliders 32, and multiple elastic telescopic members 33. The mounting frame 31 is circular and surrounds and hugs the outer wall of the filling tube 2. The mounting frame 31 is fixed to the mounting plate 121 through multiple circumferentially arranged connecting rods 313. The mounting frame 31 is provided with multiple support plates 311 arranged at intervals along the circumference of the filling tube 2. The support plates 311 are vertically oriented downwards. The support plates 311, elastic telescopic members 33, and sliders 32 are arranged in a one-to-one correspondence. The sliders 32 are slidably connected to the mounting frame 31 along the radial direction of the filling tube 2. The elastic telescopic members 33 are connected between the outer walls of the corresponding support plates 311 and the corresponding sliders 32. The multiple elastic telescopic members 33 cooperate to drive the multiple sliders 32 to assemble into a cylinder 34 with open ends. The bottom opening of the filling tube 2 is located in the top opening of the cylinder 34, and the top opening of the bottle 5 is located in the bottom opening of the cylinder 34. The inner wall of the top opening of the cylinder 34 defines a tapered surface 341 that is wider at the top and narrower at the bottom. The tapered surface 341 abuts against the outer peripheral wall of the inlet of the filling tube 2. The two ends of the cylinder 34 are connected through a central channel 342 inside the cylinder 34. The central channel 342, the filling tube 2, and the bottle 5 are coaxial. The inner wall of the cylinder 34 is provided with an exhaust port group. The cylinder 34 is connected to an external nitrogen source through an air inlet pipe 322, which is located on the outer wall of one of the sliders 32. The cylinder 34 can exhaust gas into the filling tube 2, the bottle 5, and the outer periphery of the bottle opening through the exhaust port group and the central channel 342. In this embodiment, the exhaust port group includes at least one vent structure opened on the inner wall of the cylinder 34 that can fill nitrogen (continuously introduce nitrogen) into the two ends through the central channel 342, and a vent structure surrounding the bottle opening to fill nitrogen into the bottle opening.

[0023] It should be noted that, in this embodiment, the drive device of the turntable 11, the drive device of the mounting plate 121, the drive device of the infusion tube 2, and the recombinant collagen liquid infusion device (a plunger metering pump in this embodiment) connected to the infusion tube 2 are all controlled by the same control system, thereby ensuring that each component operates in sequence. The control system can be a centralized or distributed controller. For example, the controller can be a single microcontroller or a combination of multiple distributed microcontrollers. The microcontroller can run a control program to control each component to achieve its function.

[0024] Understandably, when the filling device is working, the turntable 11 first transfers the bottle 5 to be filled to the area below the filling tube 2. The mounting plate 121 moves down, causing the filling tube 2 and the cylinder 34 to move synchronously until the cylinder 34 contacts the bottle 5. Before filling, the venting port group can fill the bottle mouth with nitrogen to form turbulence around the bottle mouth, keeping the area around the bottle mouth sterile. At the same time, nitrogen can be pre-filled into the filling tube 2 and the bottle 5 through the central channel 342 to quickly replace the air inside the bottle 5 and limit dripping at the opening of the filling tube 2, reducing the possibility of residual contaminants inside the bottle and preventing contamination of the raw materials inside the filling tube 2. After the air inside the bottle 5 is replaced, the filling tube 2 moves down relative to the mounting plate 121, and the filling tube 2 pushes the conical surface 341 to drive multiple The slider 32 separates, allowing the filling tube 2 to connect with the bottle body 5. The filling tube 2 begins to inject recombinant collagen liquid into the bottle body 5. During the filling process, the slider 32, connected to the air inlet tube 322, can continuously inject nitrogen gas into the filling tube 2 and the bottle mouth at a small flow rate through its first exhaust port 343 and second exhaust port 344. This ensures that the air inside the bottle remains sterile throughout the filling process and prevents liquid back splashing caused by pressure buildup inside the bottle, while also preventing high-speed airflow from impacting the liquid surface and damaging the protein structure. After the filling tube 2 has finished injecting the liquid, the filling tube 2 moves upward relative to the mounting plate 121. The elastic telescopic component 33 drives the slider 32 to reset and reassemble to form a cylinder 34. The exhaust port group releases gas again, ensuring that protective gas remains in the upper layer of the bottle after filling. The turntable 11 rotates and repeats the above steps for a new filling.

[0025] By setting up an exhaust port group and a central channel 342, a closed-loop oxygen-free system is achieved throughout the filling process. Nitrogen coverage throughout the entire process—pre-filling with nitrogen before filling, maintaining pressure during filling, and replenishing gas at the end—solves the problem of protein oxidation and inactivation. Combined with a sterile air curtain at the bottle opening, this eliminates the risk of recombinant collagen coming into contact with air throughout the filling cycle. Furthermore, the exhaust port group adjusts the vent flow rate to the filling tube 2 and bottle 5 at different stages of filling, enabling low-shear, low-disturbance filling. This staged adaptive flow control fully protects the collagen molecular structure, avoiding the problem of high-speed airflow impacting the liquid surface and generating bubbles that damage the three-dimensional structure of the protein. Simultaneously, it continuously vents gas from the bottle, preventing liquid backflow caused by pressure buildup. This ensures sterile oxygen-free conditions while minimizing damage to the recombinant collagen molecules. By setting up slider 32 and elastic telescopic component 33, on the one hand, slider 32 automatically opens through the cooperation of conical surface 341 with filling tube 2, and automatically closes through the elastic force of elastic telescopic component 33. The filling tube 2 and bottle body 5 can be separated or connected without electrical structure drive or valve opening and closing throughout the process, which effectively simplifies the structure of the first protection component 3 and reduces the layout and maintenance costs. On the other hand, cylinder 34 and central channel 342 cooperate to seal the bottom opening of filling tube 2 before filling to prevent leakage. During the upward movement of filling tube 2, conical surface 341 can fit against the outer wall of filling tube 2 and move downward relative to filling tube 2, thereby scraping all the liquid remaining on the tube wall into the bottle body 5, realizing residual liquid recovery. Combined with the anti-drip effect of central channel 342, it solves the two major sources of loss: tube opening leakage and tube wall adhesion residue, reduces the filling loss of high-value recombinant collagen raw materials, and eliminates the risk of microbial contamination from residual liquid, which fully meets the aseptic production requirements of GMP (Good Manufacturing Practice for Pharmaceuticals).

[0026] Reference Figure 4 (For ease of viewing, a slider 32 structure has been omitted) and Figure 5 As shown, it can be understood that the vent assembly includes at least one first vent 343 opened on the inner wall of the central channel 342 and multiple second vents 344 opened on the inner wall of the bottom opening of the cylinder 34. The multiple second vents 344 are spaced apart along the circumference of the bottle body 5 and are all inclined toward the bottle mouth of the bottle body 5. Specifically, in this embodiment, there are three sliders 32, each slider 32 has one first vent 343 and three second vents 344, that is, the cylinder 34 has a total of three first vents 343 and nine second vents 344. In other embodiments, there are four sliders 32, each slider 32 has two first vents 343 and four second vents 344, that is, the cylinder 34 has a total of eight first vents 343 and sixteen second vents 344.

[0027] After nitrogen gas is introduced into cylinder 34 through inlet pipe 322, the nitrogen gas enters the first exhaust port 343 and the second exhaust port 344 respectively. The nitrogen gas in the first exhaust port 343 flows through the central channel 342 toward the openings at the upper and lower ends of cylinder 34, thereby creating positive pressure at the opening of filling pipe 2 to prevent protein liquid from dripping and to displace the air inside bottle 5. Multiple second exhaust ports 344 simultaneously exhaust gas toward the outer periphery of the bottle opening of bottle 5, forming a nitrogen gas curtain at the bottle opening to isolate external air and prevent air from contacting the protein liquid.

[0028] By setting the first exhaust port 343 and the second exhaust port 344, the internal nitrogen filling and flow restriction function of the cylinder 34 and the external air curtain function are respectively realized, ensuring reasonable nitrogen distribution, while simplifying the structure of the exhaust port group and improving the structural rationality of the cylinder 34.

[0029] Reference Figure 4 As shown, it can be understood that the central channel 342 includes a first hole section 3421 communicating with the top opening of the cylinder 34 and a second hole section 3422 communicating with the bottom opening of the cylinder 34. The first hole section 3421 is formed by splicing together first arc grooves opened on the inner walls of the three sliders 32. The first hole section 3421 is formed by splicing together second arc grooves opened on the inner walls of the three sliders 32. The inner diameter of the first hole section 3421 is smaller than the inner diameter of the second hole section 3422. The first vent 343 is opened on the inner wall of the second hole section 3422.

[0030] By setting a first orifice 3421 with a diameter smaller than the second orifice 3422, nitrogen enters the central channel 342 through the first vent 343. The small size of the first orifice 3421 restricts the flow of nitrogen, reducing the impact force on the protein liquid at the nozzle. This ensures, from a hardware perspective, that the venting flow rate of the venting group is different at different stages of filling, further enhancing the low-damage protection effect of the cylinder 34 on the recombinant collagen molecules.

[0031] Reference Figure 5 As shown, it can be understood that the slider 32 has an arc-shaped gas distribution channel 321 inside. The two ends of the gas distribution channel 321 penetrate through the two side walls of the slider 32. When multiple sliders 32 are assembled, the multiple gas distribution channels 321 are connected end to end in sequence, thus forming a ring-shaped channel structure inside the cylinder 34. The first exhaust port 343 and the second exhaust port 344 are connected to the external nitrogen source through the multiple gas distribution channels 321 connected end to end in sequence. That is, the first exhaust port 343 and the second exhaust port 344 on each slider 32 are respectively connected to the gas distribution channel 321 on the same slider 32, and the gas distribution channel 321 on one of the sliders 32 is also connected to the external nitrogen source through the air inlet pipe 322.

[0032] By setting up the gas distribution channel 321, nitrogen gas passes through the inlet pipe 322 and enters each slider 32 through the gas distribution channel 321. Then, it is sprayed out from the three first exhaust holes 343 and the nine second exhaust holes 344 at the same time, so that the cylinder 34 can achieve uniform and stable gas output from the exhaust hole group through only one inlet pipe 322, thereby improving the working stability of the first protection component 3.

[0033] Furthermore, a sealing ring 323 is provided on one side wall of the slider 32, and the sealing ring 323 is arranged around one end opening of the air distribution channel 321. A slot 324 is provided on the other side wall of the slider 32, and the slot 324 is connected to the other end opening of the air distribution channel 321 and can engage with the sealing ring 323.

[0034] By setting the sealing ring 323 and the slot 324, when multiple sliders 32 are abutted and assembled, the corresponding gas distribution channels 321 are connected. The sealing ring 323 on the side wall of one slider 32 fits into the slot 324 of the adjacent slider 32, thereby sealing the gap between two adjacent gas distribution channels 321, preventing nitrogen leakage in the gas distribution channels 321, effectively improving the structural tightness between multiple sliders 32, and improving the sealing performance of the cylinder 34. In some other embodiments, adjacent sliders 32 can also be sealed by an elastic joint, which will not be described in detail here.

[0035] Reference Figures 2 to 4 As shown, it can be understood that the mounting bracket 31 is provided with multiple guide plates 312 corresponding to the slider 32. The guide plates 312 extend radially along the injection pipe 2. The end of the guide plate 312 away from the injection pipe 2 is connected to the connecting rod 313. The guide plate 312 is provided with guide grooves 3121, which extend radially along the injection pipe 2. The outer wall of the slider 32 is provided with a protrusion, and the protrusion is connected with a screw. The screw passes through the corresponding guide groove 3121.

[0036] By setting guide groove 3121 and screw, when slider 32 moves, guide groove 3121 can limit slider 32 through screw, thereby guiding slider 32 to move linearly along the radial direction of injection tube 2, avoiding slider 32 from deviating or tilting, reducing the torque on elastic telescopic member 33, and effectively improving the movement stability of slider 32.

[0037] Furthermore, the elastic telescopic member 33 includes a first connecting rod 331, a second connecting rod 332, and a sleeve 333. The first connecting rod 331 is connected to the slider 32, and the second connecting rod 332 is connected to the support plate 311. The first connecting rod 331 and the second connecting rod 332 are respectively inserted into the openings at both ends of the sleeve 333 and are slidably connected to both ends of the sleeve 333. A spring is provided inside the sleeve 333, and the two ends of the spring abut against the first connecting rod 331 and the second connecting rod 332 respectively.

[0038] In the initial state, the second connecting rod 332 fixes and supports the spring, and the spring force acts on the first connecting rod 331, thereby pressing against the slider 32, causing multiple sliders 32 to abut against each other. When the inlet of the injection tube 2 moves downward, the injection tube 2 squeezes the conical surface 341, and the conical surface 341 drives the slider 32 to overcome the spring pressure and move radially toward the support plate 311 along the injection tube 2, realizing the separation of multiple sliders 32. When the injection tube 2 moves upward, the pressure on the conical surface 341 gradually decreases, and the spring pressure is greater than the horizontal component of the pressure of the injection tube 2, thereby driving the slider 32 to move radially toward the injection tube 2 until multiple sliders 32 reset and reassemble into a cylinder 34. By setting the first connecting rod 331, the second connecting rod 332, and the sleeve 333, the structure of the elastic telescopic component 33 can be simplified, making it easier to assemble and use the slider 32. In other embodiments, the elastic telescopic member 33 may also be configured as a rubber column abutting between the support plate 311 and the slider 32, and a corrugated tube sleeved on the outside of the rubber column and connected between the support plate 311 and the slider 32. The elastic telescopic member 33 may also be configured as a sleeve 333 telescopic tube structure connected between the support plate 311 and the slider 32, and a long-stroke spring sleeved on the sleeve 333 telescopic tube structure and abutting between the support plate 311 and the slider 32, which will not be described in detail here.

[0039] In addition, the first protection component 3 adopts a clamping installation design, which can complete the upgrade and transformation of existing equipment without making any drilling, welding or structural modifications to the original filling pipe 2 or the main body of the plunger-type filling machine. It can be directly adapted to the traditional plunger-type quantitative filling machine on the market, making it easy to promote on a large scale and effectively reducing upgrade costs.

[0040] Reference Figure 6 As shown, it can be understood that the base 1 is also equipped with a second protective component 4. The second protective component 4 includes a positioning ring 41 and a positioning plate 42. The positioning ring 41 is fixed above the turntable 11. The positioning plate 42 is located below the mounting plate 121 and is slidably connected to the base 1 along the radial direction of the turntable 11. The outer periphery of the positioning ring 41 is provided with a plurality of first connecting parts 411. The first connecting parts 411 and the holes on the turntable 11 are set one-to-one. The inner wall of the first connecting part 411 defines a first arc-shaped groove. The first arc-shaped groove and the corresponding hole are arranged coaxially. The positioning plate 42 is provided with a second connecting part 421. The inner wall of the second connecting part 421 defines a second arc-shaped groove. The first connecting part 411 and the second connecting part 421 are detachably connected so that the first arc-shaped groove and the second arc-shaped groove are combined to form a positioning groove that matches the shape of the bottle body 5. Optionally, the positioning plate 42 can be fixed to the machine base 1 by a rodless cylinder 43, or it can be fixed to the machine base 1 by a slide rail structure and connected to a driving component such as a cylinder or lead screw. The driving component of the positioning plate 42 is electrically connected to the control system.

[0041] When the turntable 11 transports the bottle 5 to below the filling tube 2, the first connecting part 411 on the outer side of the bottle 5 corresponds to the positioning plate 42 below the mounting plate 121. At this time, the positioning plate 42 moves towards the positioning ring 41, and the first connecting part 411 and the second connecting part 421 mate and join together. The first arc-shaped groove and the second arc-shaped groove are joined together to form a circular positioning groove that holds the bottle 5 in place. By setting the second protective component 4, the bottle 5 can be positioned before filling, the feeding deviation can be automatically corrected, the coaxiality of the bottle 5 and the filling tube 2 can be ensured, the misalignment and leakage can be avoided from the source, and the positioning accuracy and structural stability of the bottle 5 can be effectively improved.

[0042] Reference Figure 6 and Figure 7 As shown, it can be understood that the top of the first connecting part 411 is provided with a first air guide ring 412, the inner wall of the first air guide ring 412 is provided with an arc-shaped first outlet 4121, the inside of the first connecting part 411 is provided with a first air guide channel 4122 communicating with the first outlet 4121, the first outlet 4121 is coaxially arranged above the first arc-shaped groove, and the two ends of the first air guide channel 4122 form openings on both sides of the first arc-shaped groove. The top of the second connecting part 421 is provided with a second air guide ring 422, the inner wall of the second air guide ring 422 is provided with an arc-shaped second outlet 4221, and the inside of the second connecting part 421 is provided with an opening communicating with the second outlet 4221. The second gas channel 4222 and the second outlet 4221 are coaxially arranged above the second arc-shaped groove. The second gas channel 4222 is connected to the external nitrogen source through the gas passage structure inside the positioning plate 42. The two ends of the second gas channel 4222 form openings on both sides of the second arc-shaped groove. When the first connecting part 411 and the second connecting part 421 are connected, the first gas guide ring 412 and the second gas guide ring 422 are spliced ​​synchronously to form a ring structure around the bottle body 5. The two ends of the first gas channel 4122 and the two ends of the second gas channel 4222 are connected to each other so that the first outlet 4121 and the second outlet 4221 emit gas around the bottle body 5.

[0043] By setting the first outlet 4121 and the second outlet 4221, the second protective component 4 can release air to the outer periphery of the bottle body 5 before and after filling, thereby forming an air-isolated annular air curtain outside the bottle body 5. The first protective component 3 and the second protective component 4 work together to generate a double sterile air curtain at the bottle mouth and the bottle body 5, eliminating the risk of recombinant collagen coming into contact with air throughout the filling cycle, and further enhancing the sterile protection effect of the filling device.

[0044] Furthermore, the second air guide channel 4222 is provided with plugs 4223 at both ends. The plugs 4223 protrude toward the positioning ring 41 and can be inserted and engaged with the openings at both ends of the first air guide channel 4122.

[0045] By setting the plug 4223, the first air guide channel 4122 and the second air guide channel 4222 can be quickly connected, improving the stability of the positioning groove structure. At the same time, the outer peripheral wall of the plug 4223 abuts against the inner peripheral wall of the first air guide channel 4122, which can effectively improve the sealing between the first connecting part 411 and the second connecting part 421, prevent nitrogen from leaking out of the first connecting part 411 and the second connecting part 421, save nitrogen resources, and reduce the cost of use.

[0046] Preferably, multiple second connecting portions 421 are provided, and the multiple second connecting portions 421 are arranged at intervals along the circumference of the positioning ring 41. The infusion tube 2 and the first protective component 3 are arranged in a one-to-one correspondence with the second connecting portions 421. In this application, two of each of the second connecting portions 421, infusion tube 2, first protective component 3 and second protective component 4 are provided. In other embodiments, the structures such as the second connecting portions 421 can also be three, five, etc., which will not be described in detail here.

[0047] By setting up multiple second connecting parts 421, filling pipes 2, first protective components 3 and second protective components 4, the filling device can aseptically fill multiple bottles 5 at the same time, thus multiplying the working efficiency of the filling device.

[0048] Obviously, the above embodiments of the present invention are merely examples for clearly illustrating the present invention, and are not intended to limit the implementation of the present invention. Those skilled in the art will be able to make various obvious changes, readjustments, and substitutions without departing from the scope of protection of the present invention. It is neither necessary nor possible to exhaustively describe all embodiments here. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the present invention should be included within the scope of protection of the claims of the present invention.

Claims

1. A recombinant collagen liquid quantitative filling device, characterized in that, include: The base (1) is provided with a turntable (11) and a bracket (12). The bracket (12) is located on one side of the turntable (11). The bracket (12) is provided with a mounting plate (121) that can slide in the vertical direction. The filling tube (2) is slidably connected to the mounting plate (121) in the vertical direction and located above the turntable (11). The turntable (11) is used to transfer the bottle (5) to be filled to the bottom of the filling tube (2). The first protective component (3) includes a mounting bracket (31), multiple sliders (32), and multiple elastic telescopic members (33). The mounting bracket (31) is arranged around the injection tube (2) and fixedly connected to the mounting plate (121). The mounting bracket (31) is provided with multiple support plates (311). The support plates (311), the elastic telescopic members (33), and the sliders (32) are arranged in a one-to-one correspondence. The sliders (32) are slidably connected to the mounting bracket (31) along the radial direction of the injection tube (2). The elastic telescopic members (33) are connected to the corresponding support plates (311) and the corresponding sliders (32). The outer walls are joined together by driving multiple sliders (32) to form a cylinder (34) with open ends. The inner wall of the top opening of the cylinder (34) defines a conical surface (341). The conical surface (341) abuts against the outer peripheral wall of the inlet of the filling tube (2). The two openings of the cylinder (34) are connected through a central channel (342). The inner wall of the cylinder (34) is provided with an exhaust hole group. The cylinder (34) is connected to an external nitrogen source and can exhaust gas to the filling tube (2), the bottle (5) and the outer periphery of the bottle opening of the bottle (5) through the exhaust hole group and the central channel (342).

2. The recombinant collagen liquid quantitative filling device according to claim 1, characterized in that, The vent assembly includes at least one first vent (343) opened on the inner wall of the central channel (342) and a plurality of second vents (344) opened on the inner wall of the bottom opening of the cylinder (34). The plurality of second vents (344) are arranged at intervals along the circumference of the bottle body (5) and are all inclined toward the bottle mouth of the bottle body (5).

3. The recombinant collagen liquid quantitative filling device according to claim 2, characterized in that, The central channel (342) includes a first hole section (3421) communicating with the top opening of the cylinder (34) and a second hole section (3422) communicating with the bottom opening of the cylinder (34). The inner diameter of the first hole section (3421) is smaller than the inner diameter of the second hole section (3422). The first exhaust hole (343) is opened on the inner wall of the second hole section (3422).

4. The recombinant collagen liquid quantitative filling device according to claim 2 or 3, characterized in that, The slider (32) is provided with an arc-shaped gas distribution channel (321). The two ends of the gas distribution channel (321) penetrate the two side walls of the slider (32). When multiple sliders (32) are assembled, the multiple gas distribution channels (321) are connected end to end in sequence. The first exhaust port (343) and the second exhaust port (344) are connected to an external nitrogen source through the multiple gas distribution channels (321) that are connected end to end in sequence.

5. The recombinant collagen liquid quantitative filling device according to claim 4, characterized in that, A sealing ring (323) is provided on one side wall of the slider (32), and the sealing ring (323) is arranged around one end opening of the gas distribution channel (321). A slot (324) is provided on the other side wall of the slider (32), and the slot (324) is connected to the other end opening of the gas distribution channel (321) and can engage with the sealing ring (323).

6. The recombinant collagen liquid quantitative filling device according to claim 1, characterized in that, The mounting bracket (31) is provided with a plurality of guide plates (312) corresponding one-to-one with the slider (32). The guide plate (312) is provided with a guide groove (3121), which extends radially along the injection tube (2). The outer wall of the slider (32) is provided with a protrusion, and the protrusion is connected with a screw, which passes through the corresponding guide groove (3121).

7. The recombinant collagen liquid quantitative filling device according to claim 1 or 6, characterized in that, The elastic telescopic member (33) includes a first connecting rod (331), a second connecting rod (332), and a sleeve (333). The first connecting rod (331) is connected to the slider (32), and the second connecting rod (332) is connected to the support plate (311). The first connecting rod (331) and the second connecting rod (332) are slidably connected to both ends of the sleeve (333). A spring is provided inside the sleeve (333), and both ends of the spring abut against the first connecting rod (331) and the second connecting rod (332) respectively.

8. The recombinant collagen liquid quantitative filling device according to claim 1, characterized in that, The base (1) is also equipped with a second protective component (4), which includes a positioning ring (41) and a positioning plate (42). The positioning ring (41) is fixed above the turntable (11), and the positioning plate (42) is located below the mounting plate (121) and is slidably connected to the base (1) along the radial direction of the turntable (11). The positioning ring (41) is provided with a first connecting part (411), and the inner wall of the first connecting part (411) defines a first arc-shaped groove. The positioning plate (42) is provided with a second connecting part (421), and the inner wall of the second connecting part (421) defines a second arc-shaped groove. The first connecting part (411) and the second connecting part (421) are detachably connected so that the first arc-shaped groove and the second arc-shaped groove are combined to form a positioning groove that matches the shape of the bottle (5).

9. The recombinant collagen liquid quantitative filling device according to claim 8, characterized in that, The first connecting part (411) is provided with an arc-shaped first outlet (4121) and a first air guide channel (4122) communicating with the first outlet (4121). The first outlet (4121) is coaxially disposed above the first arc-shaped groove. The two ends of the first air guide channel (4122) form openings on both sides of the first arc-shaped groove. The second connecting part (421) is provided with an arc-shaped second outlet (4221) and a second air guide channel (4222) communicating with the second outlet (4221). 221) Coaxially disposed above the second arc-shaped groove, the second gas guide channel (4222) is connected to an external nitrogen source, and the two ends of the second gas guide channel (4222) form openings on both sides of the second arc-shaped groove respectively. When the first connecting part (411) and the second connecting part (421) are connected, the two ends of the first gas guide channel (4122) and the two ends of the second gas guide channel (4222) are connected to each other so that the first outlet (4121) and the second outlet (4221) emit gas around the bottle body (5).

10. The recombinant collagen liquid quantitative filling device according to claim 9, characterized in that, The second air guide channel (4222) is provided with plugs (4223) at both ends. The plugs (4223) protrude toward the positioning ring (41) and can be inserted into the openings at both ends of the first air guide channel (4122).

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