Method for producing berberine by using recycled formic acid

By preparing a dehydrating agent by loading POCl3 onto activated and modified diatomaceous earth, the problems of high energy consumption, high impurities, and low yield in the formic acid recovery process were solved, achieving high-purity and high-yield production of berberine, reducing production costs and improving safety.

CN122145455AActive Publication Date: 2026-06-05WEIFANG HAIXIN PHARM CO LTD
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Patent Information

Application Number
CN202610629465.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-09
Publication Date
2026-06-05
Estimated Expiration
2046-05-09

AI Technical Summary

Technical Problem

The existing formic acid recovery process is energy-intensive, dangerous, has high impurities, and low yield, resulting in high production costs and substandard purity of berberine.

Method used

Activated modified diatomaceous earth was used as a dehydrating agent. Phosphorus oxychloride (POCl3) was loaded through chemical bonding and treated with aluminum chloride and 8-hydroxyquinoline to prepare a dehydrating agent for the purification and recovery of formic acid. Subsequently, berberine was prepared by cyclization reaction under conditions without high temperature and high pressure.

Benefits of technology

It achieves high purity (99.843%~99.876%) and high yield (92.6%~93.2%) of berberine, reduces solvent consumption, avoids high temperature and high pressure equipment, and improves production safety.

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Abstract

The invention discloses a method for producing berberine by using recycled formic acid, and belongs to the technical field of preparation of pharmaceutical and chemical bulk drugs. The method comprises the following steps: 1, adding diatomite powder into a diluted hydrochloric acid solution to remove impurities, carrying out acid pickling and roasting, and dropwise adding phosphorus oxychloride to prepare a water removal agent; 2, adding anhydrous sodium sulfate into the crude formic acid for pre-dehydration, filtering out precipitates, and then adding a dewatering agent for dewatering to obtain refined and recycled formic acid; 3, adding copper chloride, refined and recycled formic acid and N-2, 3-dimethoxy benzyl homopiperony lamine hydrochloride into a reactor, dropwise adding 40% glyoxal, and carrying out cyclization reaction for 3-4 hours; and 4, carrying out suction filtration to remove cyclization mother liquor, retaining solids, adjusting alkali and heating, filtering precipitates to retain filtrate, adjusting acid, cooling and crystallizing, filtering to retain solids, rinsing and drying to obtain berberine. The berberine is prepared from the recycled formic acid, the production process is safe, the product purity is high, and the yield is high.
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