A fat-reducing composition, oral preparation and use thereof

Abstract

This invention provides a weight-loss composition comprising 20-30 parts of Astragalus membranaceus water extract, 20-30 parts of Lycium barbarum water extract, 10-20 parts of Ginseng water extract, 10-20 parts of Hawthorn water extract, 10-20 parts of Mulberry leaf water extract, 10-20 parts of Lotus leaf water extract, 10-20 parts of Pu-erh tea water extract, 10-20 parts of Green tea water extract, 8-15 parts of Pomegranate water extract, 8-15 parts of Broccoli water extract, 5-10 parts of Ginger water extract, and 5-10 parts of Cinnamon powder. This invention further provides an oral food preparation containing this composition, as well as a food product. This invention further protects the use of the composition or preparation in the preparation of health foods or medicines that control body fat or help maintain healthy blood lipid levels. The composition provided by this invention can effectively reduce weight, lower blood lipids, and lower body fat, has high safety, few toxic side effects, and uses widely available raw materials, possessing significant market value and development prospects.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine and food technology, specifically relating to a weight-loss composition and oral preparation, and also to the application of the composition and oral preparation in the preparation of food, health food and medicine. Technical Background Obesity has become a global public health crisis. According to the World Health Organization, the number of obese people worldwide is doubling every five years, currently reaching at least 500 million. Therefore, developing safe and effective weight-loss products has significant clinical and social value. However, existing weight-loss products suffer from serious safety defects or technological deficiencies. Chemical weight-loss drugs have significant side effects. While GLP-1 receptor agonists such as semaglutide, which have been marketed in recent years, have shown good weight-loss effects, they pose serious safety risks such as thyroid tumors, pancreatitis, and gallbladder disease, and require long-term injections, with significant weight rebound after discontinuation.

[0002] Given the unavoidable safety drawbacks of chemical weight-loss drugs, the management and treatment of obesity are gradually shifting towards traditional Chinese medicine and natural products. Traditional Chinese medicine for weight loss is characterized by multi-target, multi-pathway, and holistic regulation, conforming to the safe weight-loss principle of "no anorexia, no diarrhea, and no damage to physical strength." However, existing traditional Chinese medicine weight-loss compositions generally suffer from technical problems such as insufficient compatibility. Some formulas simply pile up medicinal materials, lacking the guidance of the principles of monarch, minister, assistant, and guide in traditional Chinese medicine, resulting in unstable efficacy. Most products remain at the level of empirical medication, lacking in-depth research on the mechanisms of weight loss through modern pharmacology.

[0003] In conclusion, existing weight loss products either have serious safety defects or need improvement in terms of technology. There is an urgent need to develop a weight loss Chinese medicine product based on the holistic concept of traditional Chinese medicine, with scientific and reasonable formulation, high safety and definite efficacy, to meet the urgent needs of obese people for safe weight loss products. Summary of the Invention

[0004] To overcome the shortcomings of the prior art, the present invention provides a weight loss composition, formulation, and its application in related products with multi-pathway synergy.

[0005] In a first aspect, the composition provided by the present invention comprises the following components in parts by weight: 20-30 parts of Astragalus membranaceus water extract, 20-30 parts of Lycium barbarum water extract, 10-20 parts of Ginseng water extract, 10-20 parts of Hawthorn water extract, 10-20 parts of Mulberry leaf water extract, 10-20 parts of Lotus leaf water extract, 10-20 parts of Pu-erh tea water extract, 10-20 parts of Green tea water extract, 8-15 parts of Pomegranate water extract, 8-15 parts of Broccoli water extract, 5-10 parts of Ginger water extract, and 5-10 parts of Cinnamon powder. The composition is formed by directly mixing the above components.

[0006] The aqueous extracts used in this invention are obtained by extraction with water as the solvent. Specifically, each extract is obtained by extraction with water as the solvent at a mass ratio of 1:20 for the raw material and the solvent. The extraction can be performed using conventional Chinese medicine extraction methods in the art, such as heating extraction, ultrasonic extraction, reflux extraction, or a combination of the above methods. As a specific embodiment of this invention, the aqueous extracts are obtained by taking the corresponding Chinese herbal raw materials, adding water equivalent to 20 times their mass, and extracting by decoction. The resulting extract is then concentrated and dried to obtain the extract.

[0007] The raw material used in this invention is Astragalus membranaceus, a legume. Astragalus membranaceus (Fisch.) Bge. var. mongholicus (Bge.) Hsiao or Astragalus membranaceus Astragalus membranaceus The dried root of Astragalus membranaceus (Fisch.) Bge. is a substance that is traditionally used as both food and Chinese medicine. According to the pharmacopoeia, Astragalus membranaceus is sweet and slightly warm in nature; it enters the lung and spleen meridians; and has the effects of tonifying qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, generating fluids and nourishing blood, promoting circulation and relieving pain, promoting pus drainage and detoxification, and promoting wound healing and tissue regeneration.

[0008] The raw material used in this invention is Lycium barbarum, a plant belonging to the Solanaceae family. Lyciumm barbarum The dried, ripe fruit of *L.* is a substance that is traditionally used as both food and a Chinese medicinal herb. According to the pharmacopoeia, wolfberry is sweet and neutral in nature; it enters the liver and kidney meridians; and it has the effects of nourishing the liver and kidneys, benefiting essence and improving eyesight.

[0009] The ginseng used in this invention is ginseng, a plant belonging to the Araliaceae family. Panax ginseng The dried roots and rhizomes of CA Mey., and artificially cultivated ginseng, are considered new resource foods (new food raw materials). According to the pharmacopoeia, ginseng is sweet and slightly bitter in taste, and slightly warm in nature; it enters the spleen, lung, heart, and kidney meridians; it has the effects of greatly replenishing vital energy, restoring pulse and consolidating the body, tonifying the spleen and benefiting the lungs, promoting body fluid and nourishing blood, and calming the mind and improving intelligence.

[0010] The raw material used in this invention is hawthorn, a plant of the Rosaceae family. Crataegus pinnatifida Bge.var. major NE Br. or hawthorn Crataegus pinnatifida The dried, ripe fruit of *Begonia* is traditionally considered both a food and a medicinal herb. According to the pharmacopoeia, hawthorn is sour and sweet in taste, and slightly warm in nature; it enters the spleen, stomach, and liver meridians; and has the effects of promoting digestion, strengthening the stomach, regulating qi and dispersing blood stasis, and reducing turbidity and lipids.

[0011] The raw material used in this invention is mulberry leaves, which are from the mulberry plant (Morus alba). Morus alba The dried leaves of L. are traditionally used as both food and medicinal material. According to the pharmacopoeia, mulberry leaves are sweet, bitter, and cold in nature; they enter the lung and liver meridians; and have the effects of dispersing wind-heat, clearing the lungs and moistening dryness, and clearing the liver and improving eyesight.

[0012] The raw material used in this invention is lotus leaf, a plant of the Nymphaeaceae family. Nelumbo nucifera The dried leaves of *Garertn.* are traditionally used as both food and medicinal material. According to the pharmacopoeia, lotus leaves are bitter and neutral in nature; they enter the liver, spleen, and stomach meridians; and have the effects of clearing heat and dampness, promoting the upward movement of clear yang, cooling blood, and stopping bleeding.

[0013] The raw material used in this invention, Pu'er tea, belongs to fermented tea. It refers to tea made from Yunnan large-leaf sun-dried green tea within the geographical indication protection area, using specific processing techniques within the geographical indication protection area, and possessing unique quality characteristics.

[0014] The green tea used in this invention is a non-fermented tea, typically made from fresh leaves through processes such as fixation, rolling, and drying. The green tea used in this invention is preferably a renowned and high-quality green tea produced in East my country, such as Longjing, Biluochun, Huangshan Maofeng, Taiping Houkui, Liuan Guapian, Enshi Yulu, and Xinyang Maojian.

[0015] The raw material used in this invention is pomegranate, a common fruit. Specifically, it uses the seeds enclosed in the pulp of the pomegranate fruit (Punica granatum L.), a plant belonging to the Lythraceae family and the Punica genus. Pomegranates are rich in vitamin C, potassium, dietary fiber, and polyphenolic antioxidants, and have antioxidant, cardiovascular protective, and digestive-improving effects.

[0016] The broccoli used in this invention is a common vegetable, specifically the tender stems with flower buds from *Brassica oleracea* L. var. *italic Planch.*, a plant belonging to the Brassicaceae family. Broccoli is rich in a wide range of nutrients, including a complete range of vitamins, especially folic acid.

[0017] The raw material used in this invention is ginger, a plant of the ginger family. Zingiber officinale The fresh rhizome of Rosc. is a substance traditionally used as both food and medicinal material. Ginger is pungent and slightly warm in nature. It enters the lung, spleen, and stomach meridians; it has the effects of relieving exterior syndromes and dispelling cold, warming the middle jiao and stopping vomiting, resolving phlegm and relieving cough, and detoxifying fish and crab poisoning.

[0018] The cinnamon used in this invention is cinnamon, a plant belonging to the Lauraceae family. Cinnamomum cassia Presl's dried bark is a substance that is traditionally used as both food and Chinese medicine. Cinnamon is pungent, sweet, and very hot in nature; it enters the kidney, spleen, heart, and liver meridians; it has the effects of tonifying fire and assisting yang, guiding fire back to its source, dispelling cold and relieving pain, and warming and unblocking the meridians.

[0019] The composition provided by this invention combines the properties and meridian tropism of traditional Chinese medicine with the findings of Western pharmacology. Specifically, based on traditional Chinese medicine theory, the composition of this invention uses Astragalus membranaceus, Lycium barbarum, and Ginseng as the principal ingredients to replenish qi and blood, and nourish the liver and kidneys; Hawthorn, Mulberry leaf, Lotus leaf, and Pu-erh tea as the assistant ingredients to invigorate qi and strengthen the spleen, and promote the upward movement of clear qi and downward movement of turbid qi; Green tea, Pomegranate, and Broccoli as the adjuvant ingredients for their antioxidant properties; and Ginger and Cinnamon as the guiding ingredients for their warming and dispersing properties. Furthermore, based on the findings of Western pharmacology, components such as Hawthorn, Lotus leaf, Pu-erh tea, Green tea, Broccoli, Pomegranate, Ginger, and Cinnamon all possess certain effects in inhibiting lipase activity, inhibiting fat synthesis, and promoting fat decomposition. The various components provided by this invention work together to achieve synergistic effects and a balanced regulatory effect.

[0020] This invention optimizes the dosage of each component in the composition, enabling the components to work synergistically and achieve the best overall fat reduction effect.

[0021] As a preferred embodiment of the present invention, the composition comprises the following components in parts by weight: 26-28 parts of Astragalus membranaceus water extract, 26-28 parts of Lycium barbarum water extract, 15-17 parts of Ginseng water extract, 13-15 parts of Hawthorn water extract, 13-15 parts of Mulberry leaf water extract, 13-15 parts of Lotus leaf water extract, 16-18 parts of Pu-erh tea water extract, 11-13 parts of green tea water extract, 12-14 parts of Pomegranate water extract, 8-10 parts of Broccoli water extract, 6-8 parts of Ginger water extract, and 6-8 parts of Cinnamon powder. The composition composed of the above specific proportions can achieve the best fat-reducing effect.

[0022] As a preferred embodiment of the present invention, the composition may further comprise red yeast rice, preferably 5-10 parts. Red yeast rice, as a traditional fermented food ingredient, is produced by the fungus *Monascus purpureus* of the Aspergillus family. Monascus purpureus Red yeast rice is made by parasitizing japonica rice with the mycelium of Went. Red yeast rice is sweet in taste and slightly warm in nature, and it enters the spleen, large intestine, and liver meridians. It has the effects of strengthening the spleen and promoting digestion, as well as invigorating blood circulation and removing blood stasis. Adding it to the composition can further enhance the overall fat-reducing effect of the composition.

[0023] As a preferred embodiment of the present invention, the composition may further include 20-30 parts of an appetite-regulating component. In addition to its fat-reducing effect, the addition of the appetite-regulating component enhances satiety, further achieving the effects of fat reduction and weight loss. Specifically, the appetite-regulating component preferably includes one or more of apple water extract, konjac powder, and inulin, more preferably composed of apple water extract, konjac powder, and inulin in a mass ratio of (2-3):(2-3):1. Experimental studies have shown that selecting these three specific ingredients, especially adding them to the composition according to the above-mentioned proportions, can maximize the overall fat-reducing effect of the composition.

[0024] The raw material used in this invention, konjac powder, also known as konjac glucomannan, is a natural polysaccharide extracted from the flat, round tubers of plants of the genus Amorphophallus. Its main component is glucomannan, which is a white or creamy to light brownish-yellow powder that is odorless and tasteless.

[0025] The raw material used in this invention, inulin, is a naturally occurring reserve polysaccharide found in various plants. It belongs to the fructan family and is also a natural water-soluble dietary fiber. It is mainly composed of linearly polymerized D-fructose residues linked by β-(1→2) glycosidic bonds, and typically ends with a glucose residue. Inulin is widely distributed in nature, especially abundant in the tubers or roots of plants in the Asteraceae and Campanulaceae families. Chicory and Jerusalem artichoke are the two main raw materials for commercial inulin production.

[0026] As a preferred embodiment of the present invention, the composition may further include 20-30 parts of a nutritional regulating component. While achieving its fat-reducing effect, the addition of the nutritional regulating component ensures a balance of intestinal flora and the body's nutritional needs, thus achieving healthy fat reduction and weight loss. Specifically, the nutritional regulating component preferably includes one or more of whey protein powder, probiotic powder, and multivitamins, more preferably composed of whey protein powder, probiotic powder, and multivitamins in a mass ratio of (2-3):(2-3):(0.5-1). Experimental studies have shown that adding the above-mentioned nutrients to the composition of the present invention ensures that the fat-reducing effect is maximized while achieving a nutritional balance in the body.

[0027] As a preferred embodiment of the present invention, the composition may further include 10-20 parts of flavor-regulating components. Preferably, the flavor-regulating components of the present invention include one or more of tangerine peel water extract, chicory water extract, and branched-chain amino acids, more preferably composed of tangerine peel water extract, chicory water extract, and branched-chain amino acids in a mass ratio of (2-3):(1-2):(2-3).

[0028] The raw material used in this invention is dried tangerine peel, a plant of the Rutaceae family. Citrus reticulata Dried, mature peel of Blanco and its cultivated varieties. The aqueous extract of dried tangerine peel is rich in hesperidin, which provides a natural citrus aroma. Especially for the composition provided in this invention, the aqueous extract of dried tangerine peel can better neutralize the characteristic bitterness, and its effect is superior to other commonly used flavor modifiers, such as sucrose.

[0029] The raw material used in this invention is the dried aerial parts or roots of *Cichorium glandulosum* Boiss. et Huet or *Cichorium intybus* L., both belonging to the Asteraceae family. Chicory water extract is rich in chicoric acid, which can synergistically work with tangerine peel water extract to create a layer of sweet aftertaste, further enhancing the flavor profile of the composition.

[0030] The branched-chain amino acids (BCAAs) used in this invention are a collective term for leucine (Leu), isoleucine (Ile), and valine (Val). Adding a certain amount of BCAAs to the flavor-enhancing components can mask the overall fishy taste of the composition composed of plant-based ingredients and enhance the smoothness of the flavor profile.

[0031] In a second aspect, the present invention provides an oral formulation comprising the weight-reducing composition described in the first aspect, and an appropriate amount of excipients acceptable in the fields of food, health food, or pharmaceuticals.

[0032] In one specific embodiment of the present invention, the oral preparation is a tablet, preferably a regular tablet, lozenge, chewable tablet, dispersible tablet or effervescent tablet.

[0033] In one specific embodiment of the present invention, the oral preparation is a capsule, preferably a hard capsule or a soft capsule.

[0034] In one specific embodiment of the present invention, the oral preparation is a granule, preferably a soluble granule, a suspension granule, or an effervescent granule.

[0035] In one specific embodiment of the present invention, the oral preparation is a powder.

[0036] In one specific embodiment of the present invention, the oral preparation is a paste.

[0037] In one specific embodiment of the present invention, the oral preparation is a liquid preparation, preferably a syrup, oral liquid or beverage.

[0038] In one specific embodiment of the present invention, the oral preparation is a soluble granule or powdered solid beverage. To adjust the taste and facilitate consumption, the soluble granule or powdered solid beverage may contain a sweetener, preferably one or more of xylitol, erythritol, stevia extract, and monk fruit extract. The sweetener may be added in appropriate amounts according to actual needs.

[0039] Thirdly, the present invention provides a food comprising the composition described in the first aspect or the oral formulation described in the second aspect.

[0040] The composition provided by this invention uses raw materials from substances that are both food and traditional Chinese medicine as published by health administration departments, new food raw materials (new resource foods), and foods consumed in daily life (vegetables, fruits, tea, etc.). It can be used in food, has high safety, and low toxicity and side effects.

[0041] Fourthly, the present invention provides the use of the composition described in the first aspect or the oral formulation described in the second aspect in the preparation of health foods for controlling body fat, or in the preparation of health foods that help maintain healthy blood lipid levels.

[0042] Experimental studies have shown that the composition provided by this invention, while reducing weight in obese rats, effectively reduces the proportion of white adipose tissue (visceral fat) and slightly increases the proportion of brown adipose tissue, thereby achieving the effect of controlling body fat. The composition provided by this invention can also effectively reduce the levels of total cholesterol and triglycerides in the blood, while slightly increasing the level of high-density lipoprotein, thus helping to maintain healthy blood lipid levels.

[0043] Fifthly, the present invention provides the use of the composition described in the first aspect or the oral formulation described in the second aspect in the preparation of weight loss and / or muscle gain medicines.

[0044] Compared with existing technologies, the composition provided by this invention combines traditional Chinese medicine compatibility theory with modern pharmacological research results. It uses a variety of Chinese herbal extracts in a specific ratio, allowing the components to complement and enhance each other in their mechanism of action. This results in an overall efficacy of the composition that is far greater than the simple sum of the individual effects of the components. The raw materials selected for this invention are all nationally approved medicinal and edible substances or new food ingredients, ensuring high safety, low toxicity and side effects. Furthermore, the raw materials are widely available, possessing significant market value and development prospects. Detailed Implementation

[0045] The present invention provides the following embodiments to further illustrate various aspects of the invention. These embodiments are non-limiting and should not be construed as limiting any aspect of the invention. The scope of protection of the present invention is limited only by the claims. Various modifications and improvements can be made to various aspects of the present invention by those skilled in the art without departing from the scope of the claims, and these modifications and improvements also fall within the scope of protection of the present invention.

[0046] Additionally, it should be noted that, unless otherwise specified, all materials and reagents used in the following embodiments are commonly used in the art and can be obtained through conventional commercial means; all methods used are conventional methods known to those skilled in the art.

[0047] Example The following are ingredients used in the composition of the experimental examples: Astragalus water extract is prepared by the following method: Astragalus purchased from Tongrentang is boiled in water three times for three hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. The extract is collected, centrifuged and filtered, the filtrate is collected, and spray-dried to obtain the extract.

[0048] The water extract of wolfberry was prepared by the following method: wolfberry purchased from Tongrentang was boiled in water three times for three hours each time. The total amount of water used for extraction was equivalent to 20 times the mass of the raw material. The extract was collected, centrifuged and filtered, the filtrate was collected and spray-dried to obtain the final product.

[0049] The ginseng water extract is prepared by the following method: Take ginseng purchased from Tongrentang, add water and boil to extract 3 times, 3 hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. Collect the extract, centrifuge and filter, collect the filtrate, and spray dry to obtain the extract.

[0050] Hawthorn water extract is prepared by the following method: Hawthorn purchased from Tongrentang is boiled in water three times for three hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. The extract is collected, centrifuged and filtered, the filtrate is collected, and spray-dried to obtain the final product.

[0051] The water extract of mulberry leaves was prepared by the following method: mulberry leaves purchased from Tongrentang were boiled in water three times for three hours each time. The total amount of water used for extraction was equivalent to 20 times the mass of the raw material. The extract was collected, centrifuged and filtered, and the filtrate was collected and spray-dried to obtain the final product.

[0052] The lotus leaf water extract was prepared by the following method: lotus leaves purchased from Tongrentang were boiled in water for 3 times, each time for 3 hours. The total amount of water used for extraction was equivalent to 20 times the mass of the raw material. The extract was collected, centrifuged and filtered, the filtrate was collected, and spray-dried to obtain the final product.

[0053] Pu-erh tea water extract is prepared by the following method: Purchase Pu-erh tea, dry it, add water and boil it three times for three hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. Collect the extract, centrifuge and filter it, collect the filtrate, and spray dry it to obtain the product.

[0054] The green tea water extract is prepared by the following method: Purchase green tea "Maojian", dry it, add water and boil it three times for 3 hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. Collect the extract, centrifuge and filter it, collect the filtrate, and spray dry it to obtain the product.

[0055] The water extract of pomegranate is prepared by the following method: Purchase pomegranate fruit, take pomegranate seeds, dry them, crush them, add water and boil them three times for three hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. Collect the extract, centrifuge and filter it, collect the filtrate, and spray dry it to obtain the product.

[0056] Broccoli water extract is prepared by the following method: Purchase broccoli, take its tender stems, chop them, add water and boil to extract 3 times, 3 hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. Collect the extract, centrifuge and filter, collect the filtrate, and spray dry to obtain the product.

[0057] The ginger water extract is prepared by the following method: Purchase fresh ginger, crush it, add water and boil it three times for three hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. Collect the extract, centrifuge and filter it, collect the filtrate, and spray dry it to obtain the final product.

[0058] Cinnamon powder is prepared by the following method: take cinnamon purchased from Tongrentang, remove the bark, slice, dry, and pulverize it.

[0059] Red yeast rice, CAS: 21516-68-7, purchased from Shanghai McLean Biochemical Technology Co., Ltd.

[0060] Apple water extract is prepared by the following method: Purchase Guoguang apples, take the pulp, crush it, add water and boil to extract 3 times, 3 hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. Collect the extract, centrifuge and filter, collect the filtrate, and spray dry to obtain the product.

[0061] Konjac powder, CAS: 37220-17-0, purchased from Nanjing Songguan Biotechnology Co., Ltd.

[0062] Inulin, CAS: 9005-80-5, purchased from Guangdong Mingtong Biotechnology Co., Ltd.

[0063] Whey protein powder, CAS: 68458-87-7, purchased from Shandong Pingju Biotechnology Co., Ltd.

[0064] The compound probiotic powder was purchased from Jiangsu Caiwei Biotechnology Co., Ltd.

[0065] The multivitamins were purchased from Jiangsu Caiwei Biotechnology Co., Ltd.

[0066] The water extract of dried tangerine peel is prepared by the following method: Take dried tangerine peel purchased from Tongrentang, add water and boil to extract 3 times, 3 hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. Collect the extract, centrifuge and filter, collect the filtrate, and spray dry to obtain the product.

[0067] Chicory water extract is prepared by the following method: take Chinese herbal chicory purchased from Tongrentang, add water and boil to extract 3 times, 3 hours each time. The total amount of water used for extraction is equivalent to 20 times the mass of the raw material. Collect the extract, centrifuge and filter, collect the filtrate, and spray dry to obtain the product.

[0068] Branched-chain amino acids, CAS: 69430-36-0, purchased from Shandong Pingju Biotechnology Co., Ltd.

[0069] Example 1 This embodiment provides a weight-loss composition, which is composed of the following components: 27 g of Astragalus membranaceus water extract, 27 g of Lycium barbarum water extract, 16 g of Ginseng water extract, 14 g of Hawthorn water extract, 14 g of Mulberry leaf water extract, 14 g of Lotus leaf water extract, 17 g of Pu-erh tea water extract, 12 g of Green tea water extract, 13 g of Pomegranate water extract, 9 g of Broccoli water extract, 7 g of Ginger water extract, and 7 g of Cinnamon powder.

[0070] Example 2 This embodiment provides a weight-loss composition, which is composed of the following components: 20 g of Astragalus membranaceus water extract, 20 g of Lycium barbarum water extract, 10 g of Ginseng water extract, 10 g of Hawthorn water extract, 10 g of Mulberry leaf water extract, 10 g of Lotus leaf water extract, 10 g of Pu-erh tea water extract, 20 g of Green tea water extract, 15 g of Pomegranate water extract, 15 g of Broccoli water extract, 10 g of Ginger water extract, and 10 g of Cinnamon powder.

[0071] Example 3 This embodiment provides a weight-loss composition, which is composed of the following components: 30 g of Astragalus membranaceus water extract, 30 g of Lycium barbarum water extract, 20 g of Ginseng water extract, 20 g of Hawthorn water extract, 20 g of Mulberry leaf water extract, 20 g of Lotus leaf water extract, 20 g of Pu-erh tea water extract, 10 g of Green tea water extract, 8 g of Pomegranate water extract, 8 g of Broccoli water extract, 5 g of Ginger water extract, and 5 g of Cinnamon powder.

[0072] Example 4 This embodiment provides a weight-loss composition, which differs from Example 1 only in that 8g of red yeast rice is added.

[0073] Example 5 This embodiment provides a fat-reducing composition, which differs from Example 1 only in that it also contains 28 g of an appetite-regulating component; the appetite-regulating component is composed of apple water extract, konjac powder, and inulin in a mass ratio of 3:2:1.

[0074] Example 6 This embodiment provides a weight loss composition, which differs from Example 1 only in that it also includes 25 g of a nutritional regulating component; the nutritional regulating component is composed of whey protein powder, probiotic powder, and compound vitamins in a mass ratio of 3:3:1.

[0075] Example 7 This embodiment provides a weight loss composition, which differs from Example 5 only in that it also includes 28 g of a nutritional regulating component; the nutritional regulating component is composed of whey protein powder, probiotic powder, and compound vitamins in a mass ratio of 3:3:1.

[0076] Example 8 This embodiment provides a fat-reducing composition, which differs from Example 1 only in that it also contains 25 g of flavor-regulating components; the flavor-regulating components are composed of tangerine peel water extract, chicory water extract, and branched-chain amino acids in a mass ratio of 3:2:3.

[0077] Example 9 This embodiment provides a fat-reducing composition, which differs from Example 7 only in that it also includes 20 g of flavor-regulating components; the flavor-regulating components are composed of tangerine peel water extract, chicory water extract, and branched-chain amino acids in a mass ratio of 3:2:2.

[0078] Example 10 This embodiment provides a weight-loss composition comprising: 27 g of Astragalus membranaceus water extract, 27 g of Lycium barbarum water extract, 16 g of Ginseng water extract, 14 g of Hawthorn water extract, 14 g of Mulberry leaf water extract, 14 g of Lotus leaf water extract, 17 g of Pu-erh tea water extract, 12 g of green tea water extract, 13 g of Pomegranate water extract, 9 g of Broccoli water extract, 7 g of Ginger water extract, 7 g of Cinnamon powder, 8 g of Red yeast rice, 25 g of an appetite-regulating component composed of apple water extract, konjac powder, and inulin in a mass ratio of 3:2:1, 25 g of a nutritional regulating component composed of whey protein powder, probiotic powder, and multivitamins in a mass ratio of 3:3:1, and 18 g of a flavor regulating component composed of tangerine peel water extract, chicory water extract, and branched-chain amino acids in a mass ratio of 3:2:2.

[0079] Example 11 This embodiment provides a solid beverage (granules) prepared by the following method: 30 g of the composition provided in Example 1, 8 g of xylitol and 20 g of maltodextrin are mixed and granulated by dry granulation to obtain the product.

[0080] In the solid beverage provided in this embodiment, the composition provided in Example 1 is replaced with the composition provided in Examples 2 to 10, and the amount of excipients is adjusted appropriately to obtain the corresponding granules of each embodiment composition.

[0081] Comparative Example 1 This comparative example provides a composition that differs from Example 1 of the present invention only in that the principal ingredient in the composition does not contain ginseng water extract, but contains 35 g of astragalus water extract and 35 g of wolfberry water extract.

[0082] Comparative Example 2 This comparative example provides a composition that differs from Example 1 of the present invention only in that the composition does not contain mulberry leaf water extract and lotus leaf water extract, but contains 28 g of hawthorn water extract and 31 g of Pu-erh tea water extract.

[0083] Comparative Example 3 This comparative example provides a composition that differs from Example 1 of the present invention only in that the adjuvant in the composition does not contain pomegranate water extract and broccoli water extract, but contains 34 g of green tea water extract.

[0084] Comparative Example 4 This comparative example provides a composition that differs from Example 1 of the present invention only in that the composition does not contain cinnamon powder, but contains 14 g of ginger water extract.

[0085] Experimental Example Establishment of a dietary-induced obesity model in rats: Male Wistar rats, SPF grade, 3 months old, weighing (220±10) g, were used. The control group was fed a standard complete rat diet, while the others were fed a high-fat diet (60% standard complete rat diet, 12% lard, 5% sucrose, 5% milk powder, 5% peanuts, 10% eggs, 1% sesame oil, and 2% salt). After 3 months of feeding, obesity was defined as a weight exceeding the average weight of the control group (fed on a normal diet) by 20%. Eighty dietary-induced obese rats meeting the obesity standard were selected, divided into 8 groups of 10 each (model group, Example 1, Example 2, Example 3, Comparative Example 1, Comparative Example 2, Comparative Example 3, and Comparative Example 4). Each group was administered the above-mentioned composition by gavage for 30 days at a concentration of 600 mg / kg / d. The experimental groups (Examples 1-3 and Comparative Examples 1-4) were administered the same concentration of the composition by gavage, while the model group was administered an equal volume of physiological saline by gavage.

[0086] The rats were weighed before and after gavage using an electronic scale, and the weight loss was calculated. The percentage of weight loss to pre-gavage weight was used as the weight loss rate. One day before the experiment, 2 mL of blood was collected from the rat's orbital cavity and centrifuged at 4℃ and 2500 r / min for 5 min. The serum levels of total cholesterol, triglycerides, and high-density lipoprotein were measured using an automated biochemical analyzer. After the experiment, the rats were euthanized, and visceral fat (white fat) from the perirenal abdominal wall and epididymis was weighed, as was subscapular and retronasal fat (brown fat). The percentages of retronasal fat mass relative to body weight and visceral fat mass relative to body weight were calculated. The results are shown in Tables 1-3.

[0087] Table 1: Weight loss rate of diet-induced obese rats (n=10)

[0088] Table 2: Blood lipid levels in diet-induced obese rats (n=10)

[0089] Table 3: Body fat percentage of diet-induced obese rats (n=10)

[0090] The results above show that the composition provided by this invention can effectively reduce the body weight of obese rats; it can effectively reduce the levels of total cholesterol and triglycerides in the blood, while slightly increasing the level of high-density lipoprotein; it can also effectively reduce the proportion of white fat (visceral fat) relative to body weight, and has no effect on the proportion of brown fat (post-coital fat), and may even slightly increase it. Among these, Example 1 shows the best overall effect.

[0091] Unless otherwise stated, the technical terms used herein have the same meanings as commonly understood by one of ordinary skill in the art. This invention may also be practiced using any methods and materials similar to or equivalent to those described herein. While specific embodiments and preferred methods and materials are described herein, they do not impose any limitation on the invention.

Claims

1. A weight-loss composition, characterized in that, It contains the following ingredients in parts by weight: 20-30 parts of Astragalus membranaceus water extract, 20-30 parts of Lycium barbarum water extract, 10-20 parts of Ginseng water extract, 10-20 parts of Hawthorn water extract, 10-20 parts of Mulberry leaf water extract, 10-20 parts of Lotus leaf water extract, 10-20 parts of Pu-erh tea water extract, 10-20 parts of Green tea water extract, 8-15 parts of Pomegranate water extract, 8-15 parts of Broccoli water extract, 5-10 parts of Ginger water extract, and 5-10 parts of Cinnamon powder.

2. The composition according to claim 1, characterized in that, It contains the following ingredients in parts by weight: Astragalus membranaceus water extract 26-28 parts, Lycium barbarum water extract 26-28 parts, Ginseng water extract 15-17 parts, Hawthorn water extract 13-15 parts, Mulberry leaf water extract 13-15 parts, Lotus leaf water extract 13-15 parts, Pu-erh tea water extract 16-18 parts, Green tea water extract 11-13 parts, Pomegranate water extract 12-14 parts, Broccoli water extract 8-10 parts, Ginger water extract 6-8 parts, and Cinnamon powder 6-8 parts.

3. The composition according to claim 1 or 2, characterized in that, It also contains red yeast rice, preferably containing 5 to 10 parts of red yeast rice; And / or, wherein it further comprises 20-30 parts of an appetite-regulating component; preferably, the appetite-regulating component comprises one or more of apple water extract, konjac powder, and inulin, more preferably composed of apple water extract, konjac powder, and inulin in a mass ratio of (2-3):(2-3):

1.

4. The composition according to any one of claims 1 to 3, characterized in that, It also contains 20-30 portions of nutritional regulation components; Preferably, the nutritional regulating component comprises one or more of whey protein powder, probiotic powder, and compound vitamins, and more preferably is composed of whey protein powder, probiotic powder, and compound vitamins in a mass ratio of (2~3):(2~3):(0.5~1).

5. The composition according to any one of claims 1 to 4, characterized in that, It also contains flavor-regulating components; Preferably, the flavor-regulating component comprises one or more of tangerine peel water extract, chicory water extract, and branched-chain amino acids, and more preferably is composed of tangerine peel water extract, chicory water extract, and branched-chain amino acids in a mass ratio of (2~3):(1~2):(2~3).

6. An oral preparation, characterized in that, The composition comprises any one of claims 1 to 5, and excipients; Preferably, the oral preparation is a tablet, preferably selected from ordinary tablets, lozenges, chewable tablets, dispersible tablets, or effervescent tablets; or, The oral preparation is a capsule, preferably a hard capsule or a soft capsule; or... The oral formulation is a granule, preferably a soluble granule, suspension granule, or effervescent granule; or... The oral preparation is a powder; or, The oral preparation is a paste; or, The oral preparation is a liquid preparation, preferably a syrup, oral liquid, or beverage.

7. The oral formulation according to claim 6, characterized in that, The oral preparation is a soluble granule or a solid beverage; Preferably, the soluble granules or solid beverage contains a sweetener, preferably one or more of xylitol, erythritol, stevia extract, and monk fruit extract.

8. A food product, characterized in that, It comprises the composition according to any one of claims 1 to 5 or the oral formulation according to claim 6 or 7.

9. The use of the composition according to any one of claims 1 to 5 or the oral formulation according to claim 6 or 7 in the preparation of health foods for controlling body fat or in the preparation of health foods that help maintain healthy blood lipid levels.

10. The use of the composition containing red yeast rice according to any one of claims 1 to 5 or the formulation according to claim 6 or 7 in the preparation of a weight loss and / or muscle-building medicine.

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