Shampoo having anti-itching effect containing greenish-olive yeast and method for preparing the same

Abstract

The present application relates to the technical field of daily chemicals, and particularly discloses a shampoo with anti-itching effect containing green phenol and a preparation method thereof. The shampoo comprises the following components in parts by weight: water 50-80 parts, surfactant 15-20 parts, thickening agent 1-6 parts, preservative 0.1-1 part, pH regulator 0.1-0.4 part and green phenol 0.01-1 part. The shampoo is prepared by a temperature control method in stages, wherein water, surfactant and thickening agent are mixed at 75-80 DEG C, the temperature is lowered to 40-45 DEG C, then the preservative, pH regulator and green phenol are added, and the mixture is stirred uniformly and then cooled to discharge. The green phenol is added to the shampoo system, so that it can fully contact with the scalp during shampooing, thereby reducing the inflammatory reaction of the scalp and relieving the symptoms of redness and itching. The patch test and human efficacy test results show that the product has good skin compatibility and significant soothing and anti-itching effect, and has good formula stability, and is suitable for the field of scalp care.

Description

Technical Field

[0001] This invention relates to the field of daily chemical products technology, specifically to a shampoo containing chlorophenol koji with antipruritic effects and its preparation method. Background Technology

[0002] The scalp is an important part of human skin, containing numerous hair follicles, sweat glands, and sebaceous glands. It secretes sebum and sweat to moisturize the hair and form a natural protective film. The scalp has a rich blood supply and a dense network of nerve endings, providing nutritional support to the hair follicles while also being sensitive to external stimuli. When exposed to chemicals, temperature changes, or physical friction, it is prone to causing discomfort such as redness, swelling, and itching.

[0003] With improved living standards and increased awareness of personal hygiene, people are washing their hair more frequently, with some even washing it daily. Shampoo, as the primary hair and scalp care product, comes into direct contact with the scalp with each use. While frequent washing can remove dirt and excess oil, it can also increase the contact between surfactants and other ingredients and the scalp, potentially irritating it, triggering the secretion of inflammatory factors, damaging the scalp barrier function, and causing itching or discomfort.

[0004] In current technology, the research and development of shampoo products mainly focuses on cleansing ability, conditioning effect, and fragrance experience, with relatively little attention paid to scalp soothing and anti-itch functions. Although some products have attempted to add soothing ingredients, a stable and reasonable formula system has not been formed, or the amount added is insufficient, making it difficult to effectively reduce irritation while ensuring cleansing effect.

[0005] Therefore, it is of practical significance to provide a shampoo product that can effectively reduce scalp irritation and relieve itching and discomfort while maintaining the basic cleaning performance of shampoo. Summary of the Invention

[0006] To overcome the problems of insufficient scalp soothing in existing shampoos and their tendency to cause redness and itching due to external stimuli, the present invention aims to provide a shampoo containing chlorophenol koji with anti-itch properties and its preparation method. The present invention adds a specific amount of chlorophenol koji to a conventional shampoo base system and rationally combines it with water, surfactants, thickeners, preservatives, and pH adjusters. A two-stage temperature-controlled process is used to prepare the shampoo, ensuring that the chlorophenol koji is added and evenly dispersed in the system under suitable temperature conditions, thus allowing for full contact with the scalp during shampooing. By adding chlorophenol koji to the shampoo system, the present invention effectively reduces scalp irritation and provides a good soothing and anti-itch effect.

[0007] The objective of this invention can be achieved through the following technical solutions: A shampoo containing chlorophenol koji with antipruritic effects, the shampoo comprising the following components in parts by weight: 50-80 parts water; 15-20 parts surfactant; 1-6 parts thickener; 0.1-1 part preservative; 0.1-0.4 parts pH adjuster; and 0.01-1 part chlorophenol koji.

[0008] Optionally, the amount of chlorophenol koji used is 0.1 to 1 part.

[0009] Alternatively, the surfactant may include sodium lauryl ether sulfate, cocamidopropyl betaine, and sodium lauroamphoacetate.

[0010] Alternatively, thickeners may include PEG-150 distearate and cocamide MEA.

[0011] Optionally, preservatives include 1,2-hexanediol and p-hydroxyacetophenone.

[0012] Optionally, pH adjusters include citric acid and sodium citrate.

[0013] Optionally, the shampoo is a viscous liquid formulation.

[0014] Optionally, a method for preparing a shampoo containing chlorophyll kojic acid with antipruritic effects, the method comprising the following steps: S1. Add water, surfactant and thickener to the emulsification pot in proportion, heat to 75-80℃, and stir evenly. S2, cool to 40-45℃, add preservative, pH adjuster and chlorophenol koji, stir evenly, continue to cool to room temperature, and discharge.

[0015] The beneficial effects of this invention are: This invention introduces chlorophenol koji into the shampoo formulation system, allowing it to directly contact the scalp during shampooing. This effectively regulates scalp irritation while maintaining the original cleansing properties. Chlorophyll koji can reduce the secretion of inflammatory factors caused by external stimuli, significantly alleviating discomfort symptoms such as scalp redness and itching, and improving the product's soothing properties and safety. Patch testing verified that no adverse skin reactions were observed at different observation time points in the embodiments of this invention, while the control group (without chlorophenol koji or with excessively low amounts) showed some degree of irritation, indicating that the product of this invention has excellent skin tolerance and low irritation. Furthermore, this invention employs a staged temperature-controlled addition process, adding chlorophenol koji at an appropriate temperature to ensure its stability and uniform dispersion in the system. This results in a stable product formulation structure, a simple process, and direct compatibility with existing shampoo production processes, demonstrating promising prospects for industrial application. Attached Figure Description

[0016] The invention will now be further described with reference to the accompanying drawings.

[0017] Figure 1 Comparison chart of test results evaluating the improvement of scalp itching after use of samples with different formulation ratios; Figure 2 A comparative chart showing the results of subjective evaluation tests on the sensory irritation of samples with different ratios. Detailed Implementation

[0018] The present invention will be further described below with reference to specific embodiments. However, the present invention is not limited to the following embodiments. Equivalent adjustments made without departing from the spirit and essence of the present invention should also be considered to fall within the protection scope of the present invention.

[0019] Example 1: The purpose of this example is to verify that, under the preferred intermediate ratio conditions, the shampoo of the present invention can significantly improve the scalp soothing and anti-itch effect while ensuring cleaning performance.

[0020] The preparation method of this embodiment includes the following steps: S1. Weigh 78.9 parts of water and add it to the emulsifying pot. Start the stirring device and control the stirring speed to 300-500 r / min. While stirring, add 18 parts of surfactant and 2 parts of thickener in sequence. The surfactant is sodium lauryl ether sulfate, cocamidopropyl betaine and sodium lauroyl amphoteric acetate. The thickener is PEG-150 distearate and cocamide MEA. Heat to 75-80℃ and keep warm for 10-20 minutes to make the system fully homogenized. S2, cool to 40-45℃, add 0.5 parts of preservative and 0.1 parts of pH adjuster, and adjust the pH to 5.5-6.5; S3, add 0.5 parts of green phenol koji, continue stirring for 10-15 minutes to disperse it evenly, and then discharge the material after cooling to room temperature.

[0021] Example 2: The purpose of this example is to verify the stability and soothing effect of the shampoo system of the present invention when each component is close to the upper limit of the claim scope.

[0022] The preparation method of this embodiment includes the following steps: S1, weigh 80 parts of water and add them to the emulsification pot. Under stirring conditions, add 20 parts of surfactant and 6 parts of thickener, heat to 75-80℃ and keep warm for 15-20 minutes. S2, after cooling to 40-45℃, add 1 part preservative and 0.4 parts pH adjuster to adjust pH to 5.5-6.5; S3, add 1 part of chlorophenol koji, stir for 15 minutes, then cool to room temperature and discharge.

[0023] Example 3: The purpose of this example is to verify that when each component is close to the lower limit of the claim, the shampoo of the present invention can still form a stable system and maintain the antipruritic effect.

[0024] The preparation method of this embodiment includes the following steps: S1, weigh 50 parts of water and add them to the emulsification pot. Under stirring conditions, add 15 parts of surfactant and 1 part of thickener, heat to 75-80℃ and keep warm for 10 minutes. S2, after cooling to 40-45℃, add 0.1 parts of preservative and 0.1 parts of pH adjuster to adjust pH to 5.5-6.5; S3, add 0.01 parts of chlorophenol koji, stir for 10 minutes, cool to room temperature and then discharge.

[0025] Comparative Example 1: The purpose of this comparative example is to verify the changes in scalp irritation caused by shampoo without the addition of chlorophyll koji.

[0026] The preparation method of this comparative example includes the following steps: S1, weigh 79.4 parts of water and add it to the emulsification pot, add 18 parts of surfactant and 2 parts of thickener, heat to 75-80℃ and stir evenly; S2, after cooling to 40-45℃, add 0.5 parts of preservative and 0.1 parts of pH adjuster to adjust pH to 5.5-6.5; S3, cool to room temperature, then discharge.

[0027] Comparative Example 2: The purpose of this comparative example is to verify the changes in its soothing and antipruritic effects when the amount of chlorophyll koji added is too low.

[0028] The preparation method of this comparative example includes the following steps: S1, weigh 79.3 parts of water and add it to the emulsification pot, add 18 parts of surfactant and 2 parts of thickener, heat to 75-80℃ and stir evenly; S2, after cooling to 40-45℃, add 0.5 parts of preservative and 0.1 parts of pH adjuster; S3, add 0.1 parts of green phenol koji, stir evenly, adjust the pH to 5.5-6.5, cool to room temperature and discharge.

[0029] Performance testing: 1. Patch test The skin irritation of the product was evaluated using a closed patch test. Thirty eligible subjects were recruited, selected as healthy volunteers without skin diseases or a history of allergies. Approximately 0.020 g to 0.025 g of the test sample was placed in a patch tester and applied to the flexor surface of the subject's forearm using hypoallergenic adhesive tape for 24 hours. After 24 hours, the test sample was removed, and skin reactions were observed at 0.5 hours, 24 hours, and 48 hours after removal. The number of subjects with grade 0, 1, 2, and 3 reactions was recorded according to current skin reaction grading standards to evaluate the product's skin irritation and soothing effect.

[0030] 2. Evaluation test on improvement of scalp itching after use The antipruritic effect of the product was tested using human efficacy evaluation methods. Thirty subjects who reported mild or intermittent scalp itching were recruited. They used the test sample shampoo for 7 consecutive days, once daily, with consistent shampooing method, rinsing time, and dosage. Before use, the severity of scalp itching was recorded using a visual analog scale (0-10), where 0 indicated no itching and 10 indicated severe itching. After 7 days of continuous use, the scores were recorded again, and the itching improvement rate was calculated to evaluate the product's antipruritic effect.

[0031] 3. pH value and stability test Physicochemical stability tests were conducted on the products of each embodiment and comparative example. The pH value of the product at 25°C was measured using a pH meter, and each sample was measured three times and the average value was taken. Subsequently, the samples were stored in constant temperature environments of 4°C, 25°C and 45°C for 30 days, respectively. During this period, the appearance, including color, odor, layering and viscosity changes, were observed every 7 days, and the pH value changes were measured again to evaluate the storage stability of the product.

[0032] 4. Sensory stimulation subjective evaluation test A double-blind method was used to evaluate sensory irritation. Twenty participants were recruited and randomly assigned to different numbered test samples for shampooing. After shampooing, the participants were observed for discomfort such as stinging, tightness, or burning on the scalp. The evaluation criteria were divided into three levels: no irritation, mild irritation, and significant irritation. The proportion of participants experiencing each level was statistically analyzed to comprehensively evaluate the immediate irritation level during product use.

[0033] Table 1 Performance Test Results

[0034] As shown in Table 1, different formulations exhibited significant differences in skin irritation, antipruritic effect, and stability. Example 2 showed no adverse reactions at the 0.5h, 24h, and 48h observation points in the patch test, and none of the 20 subjects showed irritation in the immediate irritation evaluation, indicating optimal skin compatibility. Example 1 also showed no adverse reactions, but its antipruritic improvement rate was slightly lower than that of Example 2. Example 3 showed one mild reaction at the initial 0.5h, and its improvement rate was lower than that of Examples 1 and 2, indicating that while the soothing effect was still better than the comparative example when the amount of chlorophyll kojic acid added was at the lower limit, it was somewhat weakened.

[0035] In terms of pruritus improvement rate, Example 2 achieved 82%, significantly higher than Example 1 (68%) and Example 3 (45%), and also much higher than Comparative Example 2 (28%) and Comparative Example 1 (12%), showing a clear dose-response relationship. Comparative Example 1, which did not contain chlorophenol koji, had the lowest improvement rate and the most adverse reactions in the patch test, indicating that the conventional formula has a certain degree of irritation to the scalp. Although Comparative Example 2 added a small amount of chlorophenol koji, the soothing effect was limited due to the low dosage, verifying the importance of the amount of chlorophenol koji added to the efficacy.

[0036] In terms of stability testing, none of the embodiments showed stratification, precipitation or significant pH fluctuations after being stored at 45°C for 30 days, indicating good system stability. However, the comparative sample showed slight viscosity changes, indicating that the addition of chlorophenol koji in the formulation system of this invention did not affect the product stability, but rather made the overall system more stable.

[0037] In summary, by rationally adding chlorophyll koji to the shampoo system, this invention significantly improves the scalp soothing and anti-itch effect while ensuring the stability of the formula. Among them, Example 2 shows the best overall performance, and the overall performance of each example is significantly better than that of the comparative example, which fully verifies the effectiveness and inventiveness of the technical solution of this invention.

Claims

1. A shampoo having an anti-itch effect containing greenish-olive yeast, characterized in that, The shampoo comprises the following components in parts by weight: 50-80 parts water; 15-20 parts surfactant; 1-6 parts thickener; 0.1-1 part preservative; and 0.1-0.4 parts pH adjuster. Green phenol 0.01 to 1 part.

2. A shampoo with anti-itching effect containing greenish-olive yeast according to claim 1, characterized in that, The amount of chlorophenol koji used is 0.1 to 1 part.

3. A shampoo containing chlorophyll koji with antipruritic effects according to claim 1, characterized in that, The surfactants include sodium lauryl ether sulfate, cocamidopropyl betaine, and sodium lauroyl amphoteric acid.

4. A shampoo containing chlorophyll koji with antipruritic effects according to claim 1, characterized in that, The thickeners include PEG-150 distearate and cocoamide MEA.

5. A shampoo containing chlorophyll koji with antipruritic effects according to claim 1, characterized in that, The preservatives include 1,2-hexanediol and p-hydroxyacetophenone.

6. A shampoo containing chlorophyll koji with antipruritic effects according to claim 1, characterized in that, The pH adjuster includes citric acid and sodium citrate.

7. A shampoo containing chlorophyll koji with antipruritic effects according to claim 1, characterized in that, The shampoo is a viscous liquid formulation.

8. A method for preparing a shampoo containing chlorophenol koji with antipruritic effects, characterized in that, The preparation method includes the following steps: S1. Add water, surfactant and thickener to the emulsification pot in proportion, heat to 75-80℃, and stir evenly. S2, cool to 40-45℃, add preservative, pH adjuster and chlorophenol koji, stir evenly, continue to cool to room temperature, and discharge.

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