A repair composition and a method of making the same

Abstract

The application relates to the technical field of skin care raw materials, and particularly discloses a repairing composition and a preparation method thereof. The repairing composition comprises the following components in mass fractions: ceramide NP 3.5-4.5 parts; mother bacteria / rice fermentation product filtrate 3-4 parts; composite extract 6.5-10 parts; preservative 0.5-1.5 parts; auxiliary agent 4-6 parts; solvent 38-48.5 parts; and the composite extract is a compound of mussel extract, sea fennel extract, plantain leaf Eragrostis pilosa seed oil and red ganoderma extract. The application has the advantages of high efficiency soothing, anti-inflammation, repairing of skin barrier, and good oil control effect, so that the repairing effect on oily skin is improved.

Description

Technical Field

[0001] This invention relates to the field of skin care product raw materials, and in particular to a repair composition and its preparation method. Background Technology

[0002] In modern life, skin faces various challenges, such as environmental pollution, ultraviolet radiation, improper skincare, and life stress. These factors can all lead to skin damage, impaired barrier function, inflammation, and other problems. Therefore, the demand for skin repair products is increasing daily.

[0003] Skin repair primarily alleviates discomfort through soothing and anti-inflammatory effects, while also promoting skin barrier repair to restore skin health and reduce the recurrence of allergic reactions. While existing repair products offer some soothing and skin barrier repair benefits, their oil-control effects are relatively limited. For oily skin, excessive sebum secretion can lead to recurring inflammation. Simply soothing and suppressing inflammation is insufficient for rapid skin repair and fails to meet consumer needs, thus leaving room for improvement. Summary of the Invention

[0004] In order to provide a repair composition and its preparation method that are highly effective in soothing, anti-inflammatory, and repairing the skin barrier while also having good oil-controlling effects to improve the repair effect on oily skin, this application provides a repair composition and its preparation method.

[0005] In a first aspect, this application provides a repair composition, which adopts the following technical solution: A repair composition comprising the following components in parts by weight: Ceramide NP 3.5-4.5 parts; 3-4 portions of yeast / rice fermentation product filtrate; 6.5-10 parts of compound extract; Preservative: 0.5-1.5 parts; 4-6 parts of auxiliary agent; Solvent: 38-48.5 parts; The compound extract is a combination of mussel extract, sea fennel extract, plantain leaf and blue thistle seed oil, and Ganoderma lucidum extract.

[0006] By employing the above-mentioned technical solution, and combining mussel extract, sea fennel extract, plantain leaf and artichoke seed oil, Ganoderma lucidum extract with ceramide NP and yeast / rice fermentation product filtrate, significant soothing and skin cell growth-promoting effects can be achieved, thereby promoting skin barrier repair. Simultaneously, the combination of mussel extract, sea fennel extract, plantain leaf and artichoke seed oil, and Ganoderma lucidum extract exhibits a very significant oil-controlling effect, effectively and persistently inhibiting sebum secretion, thus reducing inflammation and accelerating skin barrier repair, resulting in more significant skin repair effects, especially for oily skin, where it has excellent repair efficacy.

[0007] Preferably, the mass ratio of mussel extract, sea fennel extract, plantain leaf and blue thistle seed oil, and red ganoderma extract in the compound extract is 2.5-3.5:1.5-2:1-2:1.5-2.5.

[0008] By adopting the above technical solution and specifically selecting the mass ratio of mussel extract, sea fennel extract, plantain leaf and blue thistle seed oil, and red ganoderma extract, the oil-controlling effect is more significant, and the skin repair effect is further improved.

[0009] Preferably, the mussel extract, sea fennel extract, and Ganoderma lucidum extract are all water-soluble extracts.

[0010] By adopting the above technical solution, and by specifically selecting mussel extract, sea fennel extract, and Ganoderma lucidum extract, all of which are water-soluble extracts, the compound extract can better exert synergistic effects, have better oil control effects, and further improve the soothing effect, making the skin repair effect faster.

[0011] Preferably, the solvent is a mixture of butanediol and water.

[0012] By adopting the above technical solution and specifically selecting a combination of butylene glycol and water as solvents, the solubility of each component in the solvent is increased, allowing for better synergistic effects and improved skin repair.

[0013] Preferably, the mass ratio of butanediol to water in the solvent is 38-42:38-48.5.

[0014] By adopting the above technical solution and by specifically selecting the mass ratio of butanediol and water, the solubility of each component can be further improved, resulting in better product quality.

[0015] Preferably, the preservative is 1,2-hexanediol, and the adjuvant is PEG-40 hydrogenated castor oil.

[0016] By adopting the above technical solution and specifically selecting 1,2-hexanediol, it has good antibacterial and preservative effects, while having low irritation and higher product safety.

[0017] Preferably, the additive is PEG-40 hydrogenated castor oil.

[0018] By adopting the above technical solution and specifically selecting PEG-40 hydrogenated castor oil, the oil-soluble components can be better and more evenly dispersed in the system.

[0019] Secondly, this application provides a method for preparing a repair composition, employing the following technical solution: A method for preparing the above-mentioned repair composition includes the following steps: Step 1), mix ceramide NP and plantago seed oil, heat to 80-85℃, then add the adjuvant and mix evenly to obtain premix A; Step 2), mix the solvent, compound extract, yeast / rice fermentation product filtrate, and preservative to obtain premix B; Step 3), add premix A to premix B and mix well to obtain the repair composition.

[0020] By adopting the above technical solution, the resulting repair composition has excellent soothing, anti-inflammatory, skin barrier repair, and oil control effects. Through the combination of multiple effects, it has a very significant repair effect on oily skin, and the repair effect is fast, which well meets the needs of consumers.

[0021] In summary, this application has the following beneficial effects: 1. This application utilizes mussel extract, sea fennel extract, plantain leaf and artichoke seed oil, Ganoderma lucidum extract, ceramide NP, and yeast / rice ferment filtrate to achieve significant soothing and skin cell growth-promoting effects, thereby promoting skin barrier repair. Furthermore, the combination of mussel extract, sea fennel extract, plantain leaf and artichoke seed oil, and Ganoderma lucidum extract provides significant oil control, effectively and persistently inhibiting sebum secretion, thus reducing inflammation and accelerating skin barrier repair. This results in a more significant skin repair effect, especially for oily skin, where it exhibits excellent repair efficacy.

[0022] 2. In this application, by specifically selecting the mass ratio of mussel extract, sea fennel extract, plantain leaf and blue thistle seed oil, and red ganoderma extract, the oil-controlling effect is more significant, and the skin repair effect is further improved.

[0023] 3. In this application, the mussel extract, sea fennel extract, and Ganoderma lucidum extract are preferably selected as water-soluble extracts. The compound extract can better exert synergistic effects, have better oil control effects, and further improve the soothing effect, so that the skin repair effect can be seen faster. Detailed Implementation

[0024] The present application will be further described in detail below with reference to the embodiments. Example 1

[0025] A repair composition, prepared by means of the following steps: Step 1): Add 3.5 kg of ceramide NP and 1 kg of plantago seed oil to a mixing tank, heat to 80°C, stir at 120 r / min for 3 min, then add 4 kg of PEG-40 hydrogenated castor oil, stir at 120 r / min for 3 min to obtain premix A.

[0026] Step 2): Add 38 kg of butylene glycol, 48.5 kg of deionized water, 2.5 kg of mussel extract, 1.5-2 kg of sea fennel extract, 1.5 kg of Ganoderma lucidum extract, 3 kg of yeast / rice fermentation product filtrate, and 0.5 kg of 1,2-hexanediol into a mixing tank and stir at 120 r / min for 5 min to obtain premix B.

[0027] Step 3): Add premix A to premix B, stir at 120 r / min for 10 min to obtain the repair composition.

[0028] Ceramide NP was purchased from Guangzhou Kexin Biotechnology Co., Ltd., and is oil-soluble.

[0029] Butylene glycol was purchased from Cosfa International Trading (Guangzhou) Co., Ltd.

[0030] The mussel extract was purchased from Guangzhou Jingyue New Materials Co., Ltd., and is water-soluble.

[0031] Sea fennel extract was purchased from Guangzhou Dilai Biotechnology Co., Ltd., and is water-soluble.

[0032] The plantain leaf and blue thistle seed oil was purchased from Guangzhou Mingli Biotechnology Co., Ltd., and is oil-soluble.

[0033] The Ganoderma lucidum extract was purchased from Guangzhou Hongzhong Biotechnology Co., Ltd., and is water-soluble.

[0034] The yeast / rice fermentation product filtrate was purchased from Guangzhou Dawson Chemical Technology Co., Ltd., and is water-soluble.

[0035] 1,2-Hexanediol was purchased from Guangzhou Aoxue Chemical Co., Ltd. Example 2

[0036] A repair composition, prepared by means of the following steps: Step 1): Add 4 kg of ceramide NP and 1.5 kg of plantago asiatica seed oil to a mixing tank, heat to 82°C, stir at 130 r / min for 4 min, then add 5 kg of PEG-40 hydrogenated castor oil, stir at 130 r / min for 4 min to obtain premix A.

[0037] Step 2): Add 40 kg of butylene glycol, 43 kg of deionized water, 3 kg of mussel extract, 1.8 kg of sea fennel extract, 2 kg of Ganoderma lucidum extract, 3.5 kg of yeast / rice fermentation product filtrate, and 1 kg of 1,2-hexanediol into a mixing tank and stir at 130 r / min for 6 min to obtain premix B.

[0038] Step 3): Add premix A to premix B, stir at 130 r / min for 12 min to obtain the repair composition.

[0039] Ceramide NP was purchased from Guangzhou Kexin Biotechnology Co., Ltd., and is oil-soluble.

[0040] Butylene glycol was purchased from Cosfa International Trading (Guangzhou) Co., Ltd.

[0041] The mussel extract was purchased from Guangzhou Jingyue New Materials Co., Ltd., and is water-soluble.

[0042] Sea fennel extract was purchased from Guangzhou Dilai Biotechnology Co., Ltd., and is water-soluble.

[0043] The plantain leaf and blue thistle seed oil was purchased from Guangzhou Mingli Biotechnology Co., Ltd., and is oil-soluble.

[0044] The Ganoderma lucidum extract was purchased from Guangzhou Hongzhong Biotechnology Co., Ltd., and is water-soluble.

[0045] The yeast / rice fermentation product filtrate was purchased from Guangzhou Dawson Chemical Technology Co., Ltd., and is water-soluble.

[0046] 1,2-Hexanediol was purchased from Guangzhou Aoxue Chemical Co., Ltd. Example 3

[0047] A repair composition, prepared by means of the following steps: Step 1): Add 4.5 kg of ceramide NP and 2 kg of plantago seed oil to a mixing tank, heat to 85°C, stir at 150 r / min for 5 min, then add 6 kg of PEG-40 hydrogenated castor oil, stir at 150 r / min for 5 min to obtain premix A.

[0048] Step 2): Add 42 kg of butylene glycol, 38 kg of deionized water, 3.5 kg of mussel extract, 2 kg of sea fennel extract, 2.5 kg of Ganoderma lucidum extract, 4 kg of yeast / rice fermentation product filtrate, and 1.5 kg of 1,2-hexanediol into a mixing tank and stir at 150 r / min for 8 min to obtain premix B.

[0049] Step 3), add premix A to premix B, stir at 150 r / min for 15 min to obtain the repair composition.

[0050] Ceramide NP was purchased from Guangzhou Kexin Biotechnology Co., Ltd., and is oil-soluble.

[0051] Butylene glycol was purchased from Cosfa International Trading (Guangzhou) Co., Ltd.

[0052] The mussel extract was purchased from Guangzhou Jingyue New Materials Co., Ltd., and is water-soluble.

[0053] Sea fennel extract was purchased from Guangzhou Dilai Biotechnology Co., Ltd., and is water-soluble.

[0054] The plantain leaf and blue thistle seed oil was purchased from Guangzhou Mingli Biotechnology Co., Ltd., and is oil-soluble.

[0055] The Ganoderma lucidum extract was purchased from Guangzhou Hongzhong Biotechnology Co., Ltd., and is water-soluble.

[0056] The yeast / rice fermentation product filtrate was purchased from Guangzhou Dawson Chemical Technology Co., Ltd., and is water-soluble.

[0057] 1,2-Hexanediol was purchased from Guangzhou Aoxue Chemical Co., Ltd.

[0058] Comparative Example 1 A repair composition, differing from Example 2 only in that: The mussel extract was replaced with an equal amount of witch hazel extract.

[0059] The witch hazel extract was purchased from Shandong Guante Biotechnology Co., Ltd., and is water-soluble.

[0060] Comparative Example 2 A repair composition, differing from Example 2 only in that: The sea fennel extract was replaced with an equal amount of licorice extract.

[0061] The licorice extract was purchased from Xi'an An'ao Biotechnology Co., Ltd., and is water-soluble.

[0062] Comparative Example 3 A repair composition, differing from Example 2 only in that: Replace the plantain and blue thistle seed oil with an equal amount of lavender essential oil.

[0063] The lavender essential oil was purchased from Yikang Natural Fragrance Oil Refinery in Jishui County and is oil-soluble.

[0064] Comparative Example 4 A repair composition, differing from Example 2 only in that: Centella asiatica extract was used to replace Ganoderma lucidum extract in an equal amount.

[0065] Centella asiatica extract was purchased from Shaanxi Junhe Biotechnology Co., Ltd., and is water-soluble.

[0066] Comparative Example 5 A repair composition, differing from Example 2 only in that: Mussel extract was replaced with an equal amount of witch hazel extract, sea fennel extract was replaced with an equal amount of licorice extract, plantain seed oil was replaced with an equal amount of lavender essential oil, and Ganoderma lucidum extract was replaced with an equal amount of centella asiatica extract.

[0067] The witch hazel extract was purchased from Shandong Guante Biotechnology Co., Ltd., and is water-soluble.

[0068] The licorice extract was purchased from Xi'an An'ao Biotechnology Co., Ltd., and is water-soluble.

[0069] The lavender essential oil was purchased from Yikang Natural Fragrance Oil Refinery in Jishui County and is oil-soluble.

[0070] Centella asiatica extract was purchased from Shaanxi Junhe Biotechnology Co., Ltd., and is water-soluble.

[0071] Experiment 1 The hyaluronidase inhibition rate (%) of the test samples prepared from the repair compositions of each embodiment and comparative example was determined according to T / JSRH 003-2023 "Test of Anti-allergic Activity of Cosmetic Raw Materials - Hyaluronidase Inhibition Method".

[0072] Test sample: 10g of repair composition and 90g of deionized water are mixed evenly to obtain the test sample.

[0073] Experiment 2 Cellular inflammatory factor inhibition experiment: Cell seeding: Dilute macrophages (mouse monocytic leukemia cell line RAW264.7, purchased from the Chinese Academy of Sciences Cell Bank, catalog number: TCM13) with cell culture medium to the seeding density (confluence reaches 45%-60% 24 h after seeding), seed into 96-well plates, with 200 μL of medium per well, and incubate in a CO2 incubator for 24 h.

[0074] Drug administration: Discard the culture medium in the 96-well plate and proceed with induction and drug administration. Add the test sample and 1 μg / mL LPS culture medium to the test sample wells at a 1:1 volume ratio. Add cell culture medium containing LPS to the negative control wells and cell culture medium to the blank control wells. Add 200 μL of cell culture medium to each well and continue culturing in a CO2 incubator for 24 h.

[0075] Cell supernatant collection: After incubation, collect 200 μL of cell culture supernatant into a 1.5 mL sterile centrifuge tube and store at -80°C.

[0076] ELISA detection: Perform the detection according to the instructions of the TNF-α ELISA detection kit.

[0077] Test sample: 10g of repair composition and 90g of deionized water are mixed evenly to obtain the test sample.

[0078] Experiment 3 We are recruiting several volunteers, in groups of 10. All volunteers have oily skin, all have allergies, and are female, aged 40-50.

[0079] Volunteers were divided into groups and used the test samples prepared from the repair compositions of each embodiment and comparative example. They used the samples once in the morning and once in the evening. Before each use, they washed their face with water and a disposable face towel. After the skin was naturally dry, they took 5 ml of the test sample and applied it evenly to their face. They continued to use the sample for 30 days.

[0080] Before the experiment, volunteers washed their faces with water and disposable face towels. After their skin dried naturally, the skin moisture content was measured and recorded as the initial skin moisture content before the experiment. After 2 hours of free movement in a constant temperature environment of 25℃, the skin moisture content was measured again and recorded as the skin moisture content 2 hours before the experiment. The skin moisture loss over time 2 hours before the experiment was calculated using the following formula: Initial skin moisture content before experiment - Skin moisture content 2 hours before experiment = Skin moisture loss over time 2 hours before experiment.

[0081] After 30 days of continuous use of the test sample, the volunteers gathered on the 31st day for testing. Volunteers first washed their faces with water and disposable face towels, and after their skin dried naturally, the skin moisture content was measured and recorded as the initial skin moisture content after the experiment. They then engaged in free activity for 2 hours at a constant temperature of 25℃, and the skin moisture content was measured again and recorded as the skin moisture content 2 hours after the experiment. The skin moisture loss over time 2 hours after the experiment was calculated using the following formula: Initial skin moisture content after experiment - Skin moisture content 2 hours after experiment = Skin moisture loss over time 2 hours after experiment.

[0082] When testing skin moisture content, a Corneometer CM825 is used to measure facial skin moisture. The higher the measured value, the higher the skin moisture content.

[0083] Test sample: 10g of repair composition and 90g of deionized water are mixed evenly to obtain the test sample.

[0084] Experiment 4 We are recruiting several volunteers, in groups of 10. All volunteers have oily skin, all have allergies, and are female, aged 40-50.

[0085] Volunteers were divided into groups and used the repair compositions prepared in each embodiment and comparative example to prepare test samples. Before use, they washed their faces with water and disposable face towels. After the skin moisture dried naturally, the facial skin oil content was tested and recorded as the initial skin oil content. Then, 5 ml of the test sample was taken and evenly applied to the face. After 12 hours of free activity, the facial skin oil content was tested again and recorded as the 8-hour skin oil content.

[0086] The MPA580 multi-functional skin analyzer with an SM815 probe was used to test the oil content of facial skin.

[0087] The probe contains matte tape, which becomes translucent after absorbing grease. The more grease present, the greater the transparency. The amount of grease transmitted through the probe indicates the grease content, measured in μg / cm². 2 .

[0088] Test sample: 10g of repair composition and 90g of deionized water are mixed evenly to obtain the test sample.

[0089] The detailed experimental data for Experiments 1-4 are shown in Table 1.

[0090] Table 1

[0091] Based on the data comparison of the various embodiments and comparative examples in Table 1, it can be seen that all embodiments and comparative examples have good soothing, anti-inflammatory, and skin barrier repair effects. Moreover, the soothing, anti-inflammatory, and skin barrier repair effects of the embodiments are greater than those of the comparative examples. At the same time, the oil control effect of the embodiments is significantly higher than that of the comparative examples. It can be seen that the combination of mussel extract, sea fennel extract, plantain leaf and blue thistle seed oil, and red ganoderma extract in the embodiments can effectively inhibit the secretion of sebum, thereby reducing the phenomenon that oily skin is aggravated by excessive oil. Combined with better soothing, anti-inflammatory, and skin barrier repair effects, the skin repair effect can be achieved faster and better meet the needs of consumers.

[0092] This specific embodiment is merely an explanation of this application and is not intended to limit it. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they fall within the scope of the claims of this application.

Claims

1. A repair composition, characterized in that: The components include the following parts by mass: Ceramide NP 3.5-4.5 parts; 3-4 portions of yeast / rice fermentation product filtrate; 6.5-10 parts of compound extract; Preservative: 0.5-1.5 parts; 4-6 parts of auxiliary agent; Solvent: 38-48.5 parts; The compound extract is a combination of mussel extract, sea fennel extract, plantain leaf and blue thistle seed oil, and Ganoderma lucidum extract.

2. The repair composition according to claim 1, characterized in that: In the compound extract, the mass ratio of mussel extract, sea fennel extract, plantain leaf and blue thistle seed oil, and red ganoderma extract is 2.5-3.5:1.5-2:1-2:1.5-2.

5.

3. The repair composition according to claim 2, characterized in that: The mussel extract, sea fennel extract, and Ganoderma lucidum extract mentioned above are all water-soluble extracts.

4. The repair composition according to claim 1, characterized in that: The solvent is a mixture of butanediol and water.

5. The repair composition according to claim 4, characterized in that: The mass ratio of butanediol to water in the solvent is 38-42:38-48.

5.

6. The repair composition according to claim 1, characterized in that: The preservative is 1,2-hexanediol.

7. The repair composition according to claim 1, characterized in that: The additive is PEG-40 hydrogenated castor oil.

8. A method for preparing a repair composition according to any one of claims 1-7, characterized in that: Includes the following steps: Step 1), mix ceramide NP and plantago seed oil, heat to 80-85℃, then add the adjuvant and mix evenly to obtain premix A; Step 2), mix the solvent, compound extract, yeast / rice fermentation product filtrate, and preservative to obtain premix B; Step 3), add premix A to premix B and mix well to obtain the repair composition.

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