Hormone face and dermatitis repair essence and application thereof

Abstract

This invention discloses an essence for repairing hormone-induced facial dermatitis and its application, belonging to the field of cosmetics and skin repair technology. The essence uses deionized water as the main solvent, with butylene glycol and glycerin as the core moisturizing base. It is compounded with five major active ingredients: niacinamide, Bacillus ferment precipitate, mussel extract, sodium hyaluronate, and allantoin, supplemented with auxiliary components such as 1,3-propylene glycol, capryloyl hydroxamic acid, 1,2-hexanediol, ethylhexylglycerin, disodium EDTA, and ethanol. Through scientific compounding, a synergistic repair system is formed, achieving integrated effects of skin barrier repair, anti-inflammatory soothing, microecological balance regulation, deep moisturizing and water locking, and redness reduction and stabilization. The formula of this invention is gentle and non-irritating, free of hormones, fragrances, pigments, and strong allergens, suitable for use on hormone-induced facial dermatitis, dermatitis-prone skin, and severely sensitive skin. The product has good stability, high safety, and is suitable for industrial production, possessing significant skin repair value and promising market application prospects.

Description

Technical Field

[0001] This invention belongs to the field of cosmetics and skin repair technology, specifically relating to an essence for repairing hormone-induced facial dermatitis and its application. Background Technology

[0002] Steroid-induced rosacea, also known as hormone-dependent dermatitis, is a stubborn skin problem caused by the long-term improper use of ointments, cosmetics, and skincare products containing corticosteroids. This leads to severe damage to the skin barrier, abnormal dilation of capillaries, imbalance of the skin's microecology, and the continuous release of inflammatory factors. Clinical manifestations include recurring redness, burning and stinging, dryness and peeling, itching and tightness, sensitivity and fragility, and extremely low tolerance. Regular moisturizing skincare products are ineffective in providing relief, and the condition is easily aggravated by external stimuli. With the rapid expansion of the skincare market in recent years, a large number of substandard products have entered the market, leading to a year-on-year increase in the incidence of steroid-induced rosacea, which has become a common skin problem troubling many consumers.

[0003] Allergic dermatitis is an inflammatory skin reaction triggered by external allergens. It is also accompanied by barrier damage, inflammation, dryness, and sensitivity, sharing a high degree of consistency with steroid-induced dermatitis in terms of repair. Whether it's steroid-dependent dermatitis or allergic dermatitis, their core pathological characteristics are incomplete skin barrier structure, decreased stratum corneum moisture content, increased transepidermal water loss, disordered skin microbiome, and persistent expression of inflammatory factors. Therefore, repair requires a multi-pronged approach, encompassing barrier reconstruction, anti-inflammatory soothing, microecological regulation, and moisturizing and water-locking.

[0004] Currently, products on the market targeting hormone-induced facial dermatitis and dermatitis have many shortcomings: First, their formulas are highly irritating, with some products containing alcohol, fragrances, pigments, and strong preservatives, further damaging the skin barrier and exacerbating redness and stinging; Second, their effects are singular, focusing only on basic moisturizing and lacking a multi-target synergistic repair mechanism targeting the skin barrier, microecology, and inflammatory response; Third, their ingredient combinations are unreasonable, failing to form a scientific synergistic effect, resulting in limited effectiveness in barrier reconstruction, redness reduction and soothing, and microecological regulation; Fourth, the safety of some products is questionable, containing unknown additives, making them unsuitable for long-term use on severely sensitive skin and dermatitis; Fifth, the formulas and manufacturing processes are poorly compatible, leading to insufficient product stability and problems such as layering, discoloration, and inactivation.

[0005] In existing technologies, some repair products only use basic moisturizing ingredients such as sodium hyaluronate and glycerin, which cannot achieve barrier repair and anti-inflammatory soothing; some products add plant extracts, but the ingredients are complex and can easily cause allergies; and some products rely on a single active ingredient, which cannot form a synergistic effect. Therefore, developing a gentle and safe serum that can target multiple points, is precisely adapted to the repair of hormone-induced facial dermatitis and dermatitis, has a stable formula, and can be industrially produced has become an urgent technical problem to be solved in the field of skin repair. Summary of the Invention

[0006] This invention provides an essence for repairing hormone-induced facial dermatitis and its application, overcoming the shortcomings of existing repair products such as strong irritation, single efficacy, and poor repair effect. It constructs a multi-target synergistic repair formula system with barrier repair, anti-inflammatory soothing, microecological regulation, and deep moisturizing as its core. It provides an essence that is hormone-free, fragrance-free, pigment-free, gentle, and hypoallergenic, suitable for damaged skin such as hormone-dependent dermatitis and allergic dermatitis. The formula composition and preparation process are optimized to improve product stability and safety. The production process is simple and gentle, allowing for large-scale industrial production. Simultaneously, the product's texture is improved, making it easy to absorb, non-sticky, and non-comedogenic, meeting the needs of daily long-term use.

[0007] This invention's essence uses deionized water as the main solvent, with butylene glycol and glycerin as the core moisturizing base, and is compounded with five core active ingredients: niacinamide, Bacillus ferment precipitate, mussel extract, sodium hyaluronate, and allantoin. Sodium hyaluronate is classified as a moisturizer, while the others are skin conditioning agents, supplemented with 1,3... Propylene glycol, octanoyl hydroxamic acid, 1,2 Hexanediol, ethylhexylglycerin, disodium EDTA, ethanol, and other auxiliary components are scientifically formulated to form a synergistic repair system, achieving integrated effects of skin barrier repair, anti-inflammatory soothing, microecological balance regulation, deep moisturizing and water locking, and redness reduction and stabilization. This invention's formula is gentle and hypoallergenic, free of hormones, fragrances, pigments, and strong sensitizing ingredients, making it suitable for use on hormone-induced facial dermatitis, dermatitis-prone skin, and severely sensitive skin. The product exhibits good stability, high safety, and suitability for industrial production, demonstrating significant skin repair value and promising market application prospects.

[0008] To achieve the above objectives, the present invention adopts the following technical solution:

[0009] A serum for repairing hormone-induced facial dermatitis and dermatitis comprises a solvent, a moisturizer, a skin conditioning agent, a chelating agent, and a mild preservative and solubilizing component; the skin conditioning agent includes niacinamide, Bacillus ferment filtrate, mussel extract, and allantoin; the moisturizer includes butylene glycol, glycerin, and sodium hyaluronate; the chelating agent is disodium EDTA; and the mild preservative and solubilizing component includes capryloyl hydroxamic acid, 1,3-dimethylaminopropionic acid, and 1,3-dimethylaminopropionic acid. Propylene glycol, 1,2 Hexanediol and ethylhexylglycerin are introduced by the skin-nourishing enzyme composition, which synergistically act as preservatives; the essence can achieve skin barrier repair, anti-inflammatory and soothing, microecological regulation and deep moisturizing synergistic effects, and is suitable for skin repair of hormone-dependent dermatitis and allergic dermatitis.

[0010] Preferably, it contains 55.0% deionized water by weight. 65.0%, Butylene glycol 25.0% 35.0%, Glycerin 1.0% 3.0%, nicotinamide 1.0% 3.0%, mussel extract 0.05% 0.20%, allantoin 0.05% 0.20%, Sodium Hyaluronate 0.05% 0.15%, Disodium EDTA 0.02% 0.05%, the total weight percentage of all components is 100%.

[0011] Preferably, the Bacillus fermentation product is added in the form of a skin-rejuvenating enzyme composition, which further comprises protease, water, 1,2 Hexanediol and ethylhexylglycerin are added at a rate of 1.5% to the skin-rejuvenating enzyme composition. 3.0%.

[0012] Preferably, it also contains ethanol, which is food-grade ethanol with a purity of 96.00% and a content of 0.5%–2.5% by weight. The addition of low concentration of food-grade ethanol as a cosolvent and penetration enhancer results in a gentle dosage that does not irritate damaged skin.

[0013] Preferably, it also contains 1,3 Propylene glycol, the 1,3 Propylene glycol is used in combination with capryloyl hydroxamic acid, with the weight percentage of capryloyl hydroxamic acid being 0.05%. 0.10%.

[0014] Preferably, the sodium hyaluronate is a macromolecular sodium hyaluronate, which can form a hydration protective film on the skin surface to reduce moisture loss, fill the gaps in the stratum corneum, and improve barrier integrity.

[0015] Preferably, the mussel extract is rich in mussel adhesive protein, which can form a breathable bioprotective film on the skin surface and accelerate the healing of the skin barrier.

[0016] This invention also provides a method for preparing an essence, comprising the following steps:

[0017] (1) Mix deionized water, butanediol, glycerol, and disodium EDTA, and heat to 80°C. Stir at 85℃ until completely dissolved;

[0018] (2) Cool down to 45–50℃, then add nicotinamide, allantoin, sodium hyaluronate, mussel extract, and skin-nourishing enzyme composition containing Bacillus fermentation products in sequence, and stir well;

[0019] (3) Add 1,3 Propylene glycol compound, ethanol, continue stirring for 15 minutes. 25 min;

[0020] (4) Cool down to below 38°C, filter, let stand, and fill to obtain the finished product.

[0021] An application of the aforementioned serum in the preparation of skincare products for repairing hormone-dependent dermatitis and allergic dermatitis. The repairing effect of the serum is quantitatively evaluated using a skin repair efficacy index model, which comprehensively considers four indicators: barrier repair, microecological balance, anti-inflammatory and soothing effects, and moisturizing and water-locking.

[0022] Mechanism of action

[0023] This invention's serum achieves comprehensive repair for hormone-induced facial dermatitis and dermatitis through the synergistic effect of multiple components. Regarding barrier repair, niacinamide promotes ceramide production, filling intercellular gaps and strengthening the stratum corneum structure; mussel extract forms a breathable bioprotective film on the skin surface, reducing external irritation; sodium hyaluronate fills the stratum corneum and locks in moisture. These three components work synergistically to quickly rebuild a complete skin barrier. For anti-inflammatory and soothing effects, allantoin acts directly on inflamed areas, quickly relieving redness, stinging, burning, and other discomfort symptoms, inhibiting the release of inflammatory factors, and reducing skin sensitivity. Regarding microecological regulation, Bacillus fermentation products balance the skin's surface flora structure, inhibiting the excessive proliferation of harmful bacteria, providing a favorable environment for beneficial bacteria, and enhancing the skin's own immunity. For deep moisturizing, butylene glycol, glycerin, and sodium hyaluronate form a multi-layered moisturizing network, locking in moisture on the surface, replenishing moisture in the middle layer, and storing moisture in the deep layer, continuously improving dryness, roughness, and flaking. In terms of gentle stabilization, the entire formula is free of hormones, fragrances, pigments, and irritating preservatives, reducing the risk of allergies and making it suitable for long-term use to gradually restore the skin's healthy and stable state.

[0024] Compared with the prior art, the present invention has the following beneficial effects:

[0025] This multi-target synergistic repair formula integrates barrier repair, anti-inflammatory soothing, microecological regulation, and moisturizing, precisely targeting the core issues of hormone-induced rosacea and dermatitis, with significantly better repair effects than single-function products. It is gentle, safe, and hypoallergenic, free of hormones, fragrances, pigments, and strong preservatives, and has passed rigorous safety testing, making it suitable for severely sensitive skin, dermatitis, and hormone-induced rosacea. The repair effect is rapid and long-lasting, quickly relieving redness, stinging, dryness, and other discomforts. Long-term use can completely rebuild the skin barrier and reduce the recurrence rate. The formula is stable and reliable, scientifically proportioned, and has good compatibility. It exhibits excellent heat resistance, cold resistance, and centrifugal stability, and is not prone to separation, discoloration, or inactivation. It is suitable for industrial production, with a simple process, gentle conditions, and scalable production capabilities, possessing good market value and application prospects. It has an excellent skin feel, with a refreshing texture that is easily absorbed, non-sticky, and does not clog pores, making it suitable for daily use on all skin types. Detailed Implementation

[0026] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to specific embodiments. It should be understood that the specific embodiments described herein are merely illustrative and not intended to limit the invention.

[0027] Example 1

[0028] Deionized water: 60.89%, Butylene glycol: 30.00%, Ethanol (96%): 2.00%, Skin-rejuvenating enzyme composition: 2.00%, Glycerin: 2.00%, Niacinamide: 2.00%, 1,3 Propylene glycol complex: 0.80%, mussel extract: 0.10%, allantoin: 0.10%, sodium hyaluronate: 0.08%, disodium EDTA: 0.03%; Total: 100.00%

[0029] Example 2

[0030] Deionized water: 60.39%, Butylene glycol: 29.50%, Ethanol: 1.50%, Skin-rejuvenating enzyme composition: 2.30%, Glycerin: 2.10%, Niacinamide: 2.10%, 1,3 Propylene glycol complex: 0.80%, mussel extract: 0.12%, allantoin: 0.12%, sodium hyaluronate: 0.10%, disodium EDTA: 0.03%; Total: 100.00%

[0031] Example 3

[0032] Deionized water: 61.49%, Butylene glycol: 28.50%, Ethanol: 1.00%, Skin-rejuvenating enzyme composition: 2.50%, Glycerin: 2.20%, Niacinamide: 1.90%, 1,3 Propylene glycol complex: 0.80%, mussel extract: 0.10%, allantoin: 0.15%, sodium hyaluronate: 0.08%, disodium EDTA: 0.03%; Total: 100.00%

[0033] Component description

[0034] The skin-rejuvenating enzyme composition contains water, Bacillus fermentation products, protease, 1,2 Hexanediol, ethylhexylglycerin; actual composition: water 1.16%, Bacillus fermentation product 0.50%, protease 0.10%, 1,2 Hexanediol 0.02%, ethylhexylglycerin trace amount.

[0035] 1,3 Propylene glycol complex contains 1,3 Propylene glycol, octanoyl hydroxamic acid; actual content of the ingredients is 1,3 Propylene glycol 0.74%, capryloyl hydroxamic acid 0.06%.

[0036] The ethanol is food-grade ethanol with a purity of 96.00%.

[0037] Sodium hyaluronate is a high-molecular-weight sodium hyaluronate.

[0038] Mussel extract is rich in mussel adhesive protein.

[0039] The formula of this invention is designed in strict accordance with cosmetic safety regulations, without adding any prohibited ingredients, and all raw materials comply with national cosmetic safety standards, ensuring safe and reliable use.

[0040] Functions of each component

[0041] solvent system

[0042] Deionized water: As the main solvent, it dissolves and disperses the components, provides a basic skin feel, and ensures that the product has a refreshing texture and is easily absorbed;

[0043] Ethanol: As a solubilizer and penetration enhancer, it improves the dispersibility of active ingredients. It is gentle to use and does not irritate damaged skin. At the same time, it enhances product penetration and makes the product feel refreshing.

[0044] Moisturizer system

[0045] Butylene glycol: a highly effective moisturizer that increases skin hydration, reduces product irritation, and also has a certain antibacterial effect, improving product stability;

[0046] Glycerin: A classic moisturizer that locks in moisture, relieves dryness and flaking, and improves skin softness and smoothness;

[0047] Sodium hyaluronate: a natural moisturizing factor that forms a hydrating film on the skin surface, reducing moisture loss, filling gaps in the stratum corneum, and enhancing barrier integrity.

[0048] Skin conditioning system

[0049] Niacinamide: Promotes ceramide synthesis, strengthens the skin barrier, regulates sebum, improves uneven skin tone, and also has anti-inflammatory effects to relieve skin inflammation.

[0050] Bacillus fermentation products: regulate skin microecology, inhibit harmful bacteria, enhance skin defense, and improve skin sensitivity and redness;

[0051] Mussel extract: forms a breathable protective film, accelerates barrier healing, repairs damaged skin, and enhances the skin's ability to resist external stimuli;

[0052] Allantoin: Soothes inflammation, relieves redness and stinging, promotes cell repair, accelerates skin self-renewal, and improves skin tolerance.

[0053] Chelating agents

[0054] Disodium EDTA: chelates metal ions, improves product stability, protects active ingredients from oxidation and decomposition, and extends product shelf life.

[0055] Mild anti-corrosion cosolvent system

[0056] 1,3 Propylene glycol: moisturizes, aids in solubilization, improves formula stability, and reduces overall irritation;

[0057] Capryloyl hydroxamic acid: synergistic effect of chelation and mild preservative to inhibit microbial growth and ensure product hygiene and safety;

[0058] 1,2 Hexanediol and ethylhexylglycerin: These are introduced by the skin-nourishing enzyme composition, which helps with preservation, is gentle and non-irritating, does not disrupt the skin's microecology, and is suitable for sensitive skin.

[0059] Mechanism of action

[0060] This invention's serum achieves comprehensive repair for hormone-induced facial dermatitis and dermatitis through the synergistic effect of multiple components.

[0061] Barrier repair: Niacinamide promotes the production of ceramides, fills the intercellular spaces, and strengthens the structure of the stratum corneum; mussel extract forms a breathable biological protective film on the skin surface, reducing external irritation; sodium hyaluronate fills the stratum corneum and locks in moisture. The three work synergistically to quickly rebuild a complete skin barrier.

[0062] Anti-inflammatory and soothing: Allantoin acts directly on the inflamed area, quickly relieving discomfort symptoms such as redness, stinging, and burning, inhibiting the release of inflammatory factors, and reducing skin sensitivity.

[0063] Microecological regulation: Bacillus fermentation products balance the skin surface flora structure, inhibit the excessive reproduction of harmful bacteria, provide a good living environment for beneficial bacteria, and enhance the skin's own immunity.

[0064] Deep moisturizing: Butylene glycol, glycerin, and sodium hyaluronate form a multi-layered moisturizing network that locks in moisture on the surface, replenishes moisture in the middle layer, and stores moisture in the deep layer, continuously improving dryness, roughness, and flaking.

[0065] Gentle and stabilizing: The entire formula is free of hormones, fragrances, pigments, and irritating preservatives, reducing the risk of allergies and making it suitable for long-term use to gradually restore the skin's healthy and stable state.

[0066] Preparation method

[0067] Aqueous phase preparation: Add deionized water, butanediol, glycerol, and disodium EDTA to an emulsifying pot, turn on the stirring, heat to 80–85°C, stir until all components are completely dissolved and homogeneous, keep warm for 10 minutes to ensure the aqueous phase system is stable and free of particles.

[0068] Cooling and mixing: Turn on the cooling system to lower the system temperature to 45–50℃, then add niacinamide, allantoin, sodium hyaluronate, mussel extract, and skin-rejuvenating enzyme composition in sequence, and continue stirring until completely dissolved and evenly dispersed to avoid agglomeration or precipitation of active ingredients;

[0069] Preservative and solubilizing agent addition: Maintain temperature 45–50℃, add 1,3 Add propylene glycol compound and ethanol, and continue stirring for 15–20 minutes to ensure the system is uniform and stable and the preservative components are fully dispersed.

[0070] Cooling and discharging: Continue cooling to below 38℃, stop heating, stir for 5 minutes, filter through a 100-mesh filter to remove impurities and insoluble matter, let stand for inspection and then fill, package and store.

[0071] The entire preparation process is completed in a clean environment, with strict control over microbial indicators to ensure that the product meets cosmetic hygiene standards.

[0072] Skin repair efficacy evaluation algorithm

[0073] This invention uses the Skin Repair Efficacy Index (SRI) to quantitatively evaluate the repair effect of serums, as shown in the following formula:

[0074]

[0075] The meanings of each letter are revealed.

[0076] SRI: Skin Repair Efficacy Index, score range 0 100, the higher the score, the better the repair effect;

[0077] α: Barrier repair weighting coefficient, with a value of 0.30;

[0078] β: Microecological balance weighting coefficient, with a value of 0.25;

[0079] γ: Anti-inflammatory and soothing weighting coefficient, with a value of 0.30;

[0080] δ: Moisturizing and water-locking weighting coefficient, with a value of 0.15;

[0081] B: Barrier repair score, 0–25 points, evaluated based on TEWL (transepidermal water loss value) and stratum corneum moisture content;

[0082] M: Microecological balance score, 0–25 points, evaluated based on the ratio of beneficial bacteria to harmful bacteria on the skin and the diversity of the microbial community;

[0083] I: Anti-inflammatory and soothing score, 0–25 points, evaluated based on the rate of reduction in redness area and VAS stinging score;

[0084] H: Moisturizing and water-locking score, 0–25 points, evaluated based on skin moisture content improvement rate and water-locking rate;

[0085] TEWL: Transepidermal water loss value, unit The lower the value, the more intact the skin barrier;

[0086] VAS: Visual Analog Scale, 0–10 points, with lower scores indicating milder stinging sensations.

[0087] This model can comprehensively, objectively, and scientifically evaluate the repair effects of serums on hormone-induced facial dermatitis and dermatitis skin, providing reliable data support for formula optimization and efficacy verification.

[0088] Formula Intelligent Optimization Algorithm (FIOA)

[0089] To determine the optimal ratio of core active ingredients, this invention employs the FIOA (Formula Intelligent Optimization Algorithm):

[0090]

[0091] The meanings of each letter are revealed.

[0092] F: Overall efficacy value of the formula;

[0093] Nicotinamide content;

[0094] Content of Bacillus fermentation products;

[0095] Mussel extract content;

[0096] Sodium hyaluronate content;

[0097] Allantoin content;

[0098] Niacinamide efficacy weighting, 0.28;

[0099] The efficacy weight of Bacillus fermentation products was 0.22.

[0100] Mussel extract efficacy weighting, 0.25;

[0101] The efficacy weight of sodium hyaluronate is 0.15.

[0102] Allantoin efficacy weight, 0.10.

[0103] This algorithm can quickly calculate the overall performance value under different ratios, determine the optimal formula ratio, and maximize the synergistic effect of each component.

[0104] Quality Control Algorithm (QCA)

[0105] Q = λ × P + μ × S + ν × T

[0106] The meanings of each letter are revealed.

[0107] Q: Overall product quality score;

[0108] P: Physicochemical index score, including pH, viscosity, and content uniformity;

[0109] S: Safety index score, including irritation and sensitization;

[0110] T: Stability index score, including heat resistance, cold resistance, and centrifugal stability;

[0111] λ: Weight of physicochemical indicators, 0.40;

[0112] μ: Security weight, 0.35;

[0113] ν: Stability weight, 0.25;

[0114] Judgment criteria: Q≥90 is considered a qualified product.

[0115] This algorithm enables comprehensive monitoring of product quality, ensuring that each batch of products meets the requirements of safety, stability, and efficiency.

[0116] Efficacy verification results

[0117] Thirty subjects with hormone-dependent dermatitis were selected and used the essence from Example 1 for 28 consecutive days. The test results are as follows:

[0118] Day 7: Redness reduced by 41.5%, stinging VAS score decreased by 52%, TEWL value decreased by 35%, and burning sensation on the skin was significantly relieved;

[0119] Day 14: Dryness and flaking are significantly improved, skin moisture content increases by 48%, microecological imbalance is improved, and skin stability is significantly enhanced;

[0120] Day 28: The skin barrier has basically recovered, the SRI score has reached 82.6, the skin condition is stable, and the sensitivity symptoms have been greatly reduced.

[0121] Example 2 has an SRI score of 87.2, suitable for repairing severe steroid-induced rosacea; Example 3 has an SRI score of 84.0, exhibiting the best gentleness, suitable for extremely sensitive dermatitis skin. Overall verification results indicate that the serum of this invention has a significant repairing effect on steroid-induced rosacea and dermatitis skin.

[0122] Stability test

[0123] Heat resistance test: After being placed at 45℃ for 30 days, there was no delamination, no discoloration, no odor, and the retention rate of active ingredients was ≥95%.

[0124] Cold resistance test: After being placed at 15℃ for 24 hours and then returning to room temperature, no stratification or sedimentation was observed.

[0125] Centrifugation test: Centrifuge at 3000 r / min for 30 min, no stratification or precipitation;

[0126] Stability at room temperature: After being placed at room temperature for 6 months, there were no significant changes in appearance, odor, or efficacy.

[0127] The test results show that the essence of this invention has excellent stability and is suitable for long-term storage and use.

[0128] Security test

[0129] A patch test was conducted on 30 subjects with sensitive skin, who were observed continuously for 48 hours. No allergic reactions such as erythema, edema, or itching occurred in any of the subjects. The product is non-irritating, meets cosmetic safety standards, and is suitable for use on steroid-induced rosacea and dermatitis-prone skin. Simultaneously, eye irritation and cumulative skin irritation tests were performed, with no irritation or sensitization results, further demonstrating the product's safety and reliability.

[0130] The above description is merely an embodiment of this application and is not intended to limit the scope of protection of this application. Various modifications and variations can be made to this application by those skilled in the art. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of this application should be included within the scope of protection of this application.

[0131] The above description is merely a specific embodiment of this application, but the scope of protection of this application is not limited thereto. Any variations or substitutions that can be easily conceived by those skilled in the art within the scope of the technology disclosed in this application should be included within the scope of protection of this application. Therefore, the scope of protection of this application should be determined by the scope of the claims.

Claims

1. An essence for repairing hormone-induced facial dermatitis and dermatitis, characterized in that, The product comprises a solvent, a moisturizer, a skin conditioning agent, a chelating agent, and a mild preservative-co-solvent component; the skin conditioning agent includes niacinamide, Bacillus ferment filtrate, mussel extract, and allantoin; the moisturizer includes butylene glycol, glycerin, and sodium hyaluronate; the chelating agent is disodium EDTA; and the mild preservative-co-solvent component includes capryloyl hydroxamic acid, 1,3-dimethylaminopropionic acid, and other ingredients. Propylene glycol, 1,2 Hexanediol and ethylhexylglycerin are introduced by the skin-nourishing enzyme composition, which synergistically act as preservatives; the essence can achieve skin barrier repair, anti-inflammatory and soothing, microecological regulation and deep moisturizing synergistic effects, and is suitable for skin repair of hormone-dependent dermatitis and allergic dermatitis.

2. The essence according to claim 1, characterized in that, By weight percentage, it contains 55.0%–65.0% deionized water, 25.0%–35.0% butylene glycol, and 1.0% glycerin. 3.0%, nicotinamide 1.0% 3.0%, mussel extract 0.05%–0.20%, allantoin 0.05%–0.20%, sodium hyaluronate 0.05%–0.15%, disodium EDTA 0.02%–0.05%, with the total weight percentage of all components being 100%.

3. The essence according to claim 2, characterized in that, The Bacillus fermentation product is added in the form of a skin-rejuvenating enzyme composition, which further comprises protease, water, 1,2 Hexanediol and ethylhexylglycerin are added in amounts of 1.5%–3.0% of the skin-rejuvenating enzyme composition.

4. The serum according to claim 1, characterized in that, It also contains ethanol, which is food-grade ethanol with a purity of 96.00% and a content of 0.5%–2.5% by weight. The addition of low concentration of food-grade ethanol as a cosolvent and penetration enhancer makes it gentle and non-irritating to damaged skin.

5. The essence according to claim 1, characterized in that, Also includes 1,3 Propylene glycol, the 1,3 Propylene glycol is used in combination with capryloyl hydroxamic acid, with the weight percentage of capryloyl hydroxamic acid being 0.05%–0.10%.

6. The essence according to claim 1, characterized in that, The sodium hyaluronate is a macromolecular sodium hyaluronate, which can form a hydration protective film on the skin surface to reduce moisture loss, fill the gaps in the stratum corneum, and improve the integrity of the skin barrier.

7. The serum according to claim 1, characterized in that, The mussel extract is rich in mussel adhesive protein, which can form a breathable bioprotective film on the skin surface and accelerate the healing of the skin barrier.

8. A claim 1 7. A method for preparing the serum according to any one of the claims, characterized in that it comprises the following steps: (1) Mix deionized water, butanediol, glycerol and disodium EDTA, heat to 80–85°C and stir until completely dissolved; (2) Cool down to 45–50℃, then add nicotinamide, allantoin, sodium hyaluronate, mussel extract, and skin-nourishing enzyme composition containing Bacillus fermentation products in sequence, and stir well; (3) Add 1,3 Add propylene glycol compound and ethanol, and continue stirring for 15–25 minutes. (4) Cool down to below 38°C, filter, let stand, and fill to obtain the finished product.

9. Claim 1 7. The use of any one of the serums in the preparation of skin care products for repairing hormone-dependent dermatitis and allergic dermatitis.

10. The application according to claim 9, characterized in that, The repairing effect of the serum is quantitatively evaluated using a skin repair efficacy index model, which comprehensively considers four indicators: barrier repair, microecological balance, anti-inflammatory and soothing, and moisturizing and water-locking.

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