A bacteriostatic, antipruritic and antioxidant traditional Chinese medicine composition taking extract of radix polygoni multiflori as main active ingredient and its preparation method and application

Abstract

The application discloses a bacteriostatic, itching-relieving and antioxidant traditional Chinese medicine composition taking a prepared radix polygoni multiflori extract as a main active ingredient, which is composed of the following ingredients in parts by weight: the prepared radix polygoni multiflori extract 15-35 parts, the cypress leaf extract 5-20 parts, the black sesame seed extract 3-12 parts and the ligustrum lucidum fruit extract 3-12 parts. The ultrasonic-assisted cellulase extraction is adopted to greatly improve the dissolution rate of stilbene glucoside in the prepared radix polygoni multiflori and the active ingredient content of the extract is high; the multi-flavor traditional Chinese medicine is compounded to realize the bacteriostasis (staphylococcus aureus and malassezia), itching relief and antioxidant effects in a synergistic manner, the bacteriostasis circle diameter is greater than or equal to 15 mm, and the DPPH free radical scavenging rate is greater than or equal to 75%; the natural traditional Chinese medicine ingredient is mild and non-irritating, is suitable for a scalp care scene, and can be widely used in hair washing and hair care daily chemical products.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine composition technology, specifically to a traditional Chinese medicine composition with processed Polygonum multiflorum extract as the main active ingredient, which is antibacterial, antipruritic, and antioxidant, as well as its preparation method and application. Background Technology

[0002] Scalp itching, bacterial imbalance, and oxidative damage are common scalp problems, often caused by the proliferation of microorganisms such as Malassezia and Staphylococcus aureus, as well as the accumulation of free radicals. These issues can easily lead to dandruff, scalp sensitivity, and dry hair. Current scalp care products mostly rely on chemical antibacterial agents, which can disrupt the scalp's microecology with long-term use, and have drawbacks such as high irritation and limited efficacy.

[0003] Processed Polygonum multiflorum is a traditional Chinese medicine for hair care, containing active ingredients such as stilbene glycosides, which have antioxidant and scalp-nourishing effects. Arborvitae leaf, black sesame, and Ligustrum lucidum are also classic hair-care herbs, possessing antibacterial, antipruritic, and hair-darkening properties. However, traditional Chinese medicine extraction methods suffer from low dissolution rates of active ingredients and significant loss of activity, making it difficult to fully realize the combined effects of these herbs.

[0004] Based on this, we developed a traditional Chinese medicine composition that is highly efficient in extraction, stable in composition, and has antibacterial, antipruritic, and antioxidant effects, which is suitable for the needs of scalp care products and has important application value. Summary of the Invention

[0005] To address the shortcomings of existing technologies, this invention provides a traditional Chinese medicine composition with processed Polygonum multiflorum extract as the main active ingredient, which is antibacterial, antipruritic, and antioxidant. This composition solves the problems of low extraction efficiency, single efficacy, and poor scalp applicability of traditional extraction methods. The invention also provides a preparation method and daily chemical applications for this composition.

[0006] To address the aforementioned technical problems, according to one aspect of the present invention, the present invention provides the following technical solution: A traditional Chinese medicine composition with processed Polygonum multiflorum extract as the main active ingredient, comprising the following components by weight: 15-35 parts processed Polygonum multiflorum extract, 5-20 parts Platycladus orientalis leaf extract, 3-12 parts black sesame extract, and 3-12 parts Ligustrum lucidum extract.

[0007] As a preferred embodiment of the antibacterial, antipruritic, and antioxidant traditional Chinese medicine composition with processed Polygonum multiflorum extract as the main active ingredient, the processed Polygonum multiflorum extract is prepared by ultrasound-assisted cellulase extraction. The extraction conditions are: material-liquid ratio 1:8-1:15, cellulase dosage 0.3-2.0%, ultrasound power 150-450W, enzymatic hydrolysis temperature 40-60℃, enzymatic hydrolysis time 1-4 hours, and the stilbene glycoside content in the extract is ≥2.0%.

[0008] As a preferred embodiment of the antibacterial, antipruritic, and antioxidant traditional Chinese medicine composition with processed Polygonum multiflorum extract as the main active ingredient, as described in this invention, it further includes 2-8 parts of licorice extract.

[0009] As a preferred embodiment of the antibacterial, antipruritic, and antioxidant traditional Chinese medicine composition with processed Polygonum multiflorum extract as the main active ingredient, the composition has an inhibition zone diameter of ≥15mm against Staphylococcus aureus and Malassezia, and a DPPH free radical scavenging rate of ≥75%.

[0010] As a preferred embodiment of the antibacterial, antipruritic, and antioxidant traditional Chinese medicine composition with processed Polygonum multiflorum extract as the main active ingredient, the composition is a traditional Chinese medicine composition for cosmetic use.

[0011] A method for preparing a traditional Chinese medicine composition with processed Polygonum multiflorum extract as the main active ingredient, comprising the following steps: S1: After pulverizing the processed Polygonum multiflorum, add water and control the material-to-liquid ratio to 1:8-1:15. Add 0.3-2.0% (w / w) of cellulase and perform ultrasonic-assisted enzymatic hydrolysis. S2: Filter the enzymatic hydrolysate and concentrate it to a relative density of 1.10-1.30 to obtain processed Polygonum multiflorum extract; S3: Mix the processed Polygonum multiflorum extract with Platycladus orientalis leaf extract, black sesame extract, and Ligustrum lucidum extract in a certain proportion until homogeneous.

[0012] Compared with the prior art, the beneficial effects of this invention are: the use of ultrasound-assisted cellulase extraction significantly improves the dissolution rate of stilbene glycosides in processed Polygonum multiflorum, and the content of active ingredients in the extract is high; This product is formulated with a blend of multiple traditional Chinese medicines, which work synergistically to achieve antibacterial (Staphylococcus aureus, Malassezia), antipruritic, and antioxidant effects. The antibacterial zone diameter is ≥15mm, and the DPPH free radical scavenging rate is ≥75%. The natural Chinese medicine ingredients are gentle and non-irritating, suitable for scalp care scenarios, and can be widely used in shampoos and conditioners. Detailed Implementation

[0013] To make the objectives, technical solutions, and advantages of the present invention clearer, the embodiments of the present invention will be described in further detail below.

[0014] Example 1

[0015] Traditional Chinese medicine composition formula (parts by weight): 25 parts of processed Polygonum multiflorum extract, 12 parts of Platycladus orientalis leaf extract, 7 parts of black sesame extract, 7 parts of Ligustrum lucidum extract, and 5 parts of licorice extract.

[0016] Preparation of Polygonum multiflorum extract: Polygonum multiflorum was pulverized, the material-to-liquid ratio was 1:10, 1.0% cellulase was added, the ultrasonic power was 300W, enzymatic hydrolysis was carried out at 50℃ for 2 hours, followed by ultrasonication for 60 minutes; the enzyme was inactivated at 85℃ for 15 minutes, and the mixture was filtered and concentrated to a relative density of 1.20 and a stilbene glycoside content of 2.5%.

[0017] Product preparation: Mix the extracts evenly to obtain a traditional Chinese medicine composition, add 3% by weight to the shampoo soap base to make shampoo soap.

[0018] Example 2

[0019] Traditional Chinese medicine composition formula (parts by weight): 15 parts of processed Polygonum multiflorum extract, 20 parts of Platycladus orientalis leaf extract, 3 parts of black sesame extract, and 12 parts of Ligustrum lucidum extract.

[0020] Extraction and preparation: material-liquid ratio 1:8, cellulase dosage 0.3%, ultrasonic power 150W, enzymatic hydrolysis at 40℃ for 4 hours, ultrasonication for 30 minutes; concentrated to a relative density of 1.10, stilbene glycoside content 2.1%.

[0021] Application: The composition is added to a shampoo base to prepare an antibacterial and antipruritic shampoo.

[0022] Example 3

[0023] Traditional Chinese medicine composition formula (parts by weight): 35 parts of processed Polygonum multiflorum extract, 5 parts of Platycladus orientalis leaf extract, 12 parts of black sesame extract, 3 parts of Ligustrum lucidum extract, and 8 parts of licorice extract.

[0024] Extraction and preparation: material-liquid ratio 1:15, cellulase dosage 2.0%, ultrasonic power 450W, enzymatic hydrolysis at 60℃ for 1 hour, ultrasonication for 90 min; concentrated to a relative density of 1.30, stilbene glycoside content 2.8%.

[0025] Effect detection The performance of the compositions of Examples 1-3 was tested, and the results are as follows: sheet

[0026] Test results show that the composition of the present invention has excellent antibacterial and antioxidant properties, meeting the efficacy requirements of scalp care products.

[0027] Although the present invention has been described above with reference to embodiments, various modifications can be made thereto without departing from the scope of the invention. In particular, the exhaustive description of these combinations is not provided in this specification merely for the sake of brevity and resource conservation. Therefore, the present invention is not limited to the specific embodiments disclosed herein, but includes all technical solutions falling within the scope of the claims.

Claims

1. A traditional Chinese medicine composition with processed Polygonum multiflorum extract as the main active ingredient, characterized in that, By weight, it includes the following ingredients: 15-35 parts of processed Polygonum multiflorum extract, 5-20 parts of Platycladus orientalis leaf extract, 3-12 parts of black sesame extract, and 3-12 parts of Ligustrum lucidum extract.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, The prepared Polygonum multiflorum extract was prepared by ultrasound-assisted cellulase extraction. The extraction conditions were: material-liquid ratio 1:8-1:15, cellulase dosage 0.3-2.0%, ultrasound power 150-450W, enzymatic hydrolysis temperature 40-60℃, and enzymatic hydrolysis time 1-4 hours. The stilbene glycoside content in the extract was ≥2.0%.

3. The traditional Chinese medicine composition according to claim 1 or 2, characterized in that, It also includes 2-8 parts of licorice extract.

4. The traditional Chinese medicine composition according to any one of claims 1-3, characterized in that, The composition exhibits inhibition zones ≥15 mm in diameter against Staphylococcus aureus and Malassezia, and a DPPH free radical scavenging rate ≥75%.

5. The traditional Chinese medicine composition according to any one of claims 1-4, characterized in that, The composition is a traditional Chinese medicine composition for cosmetic use.

6. A method for preparing a traditional Chinese medicine composition according to any one of claims 1-5, characterized in that, Includes the following steps: S1: After pulverizing the processed Polygonum multiflorum, add water and control the material-to-liquid ratio to 1:8-1:

15. Add 0.3-2.0% (w / w) of cellulase and perform ultrasonic-assisted enzymatic hydrolysis. S2: Filter the enzymatic hydrolysate and concentrate it to a relative density of 1.10-1.30 to obtain processed Polygonum multiflorum extract; S3: Mix the processed Polygonum multiflorum extract with Platycladus orientalis leaf extract, black sesame extract, and Ligustrum lucidum extract in a certain proportion until homogeneous.

7. The preparation method according to claim 6, characterized in that, In step (1), the sonication time is 30-90 min, and after the enzymatic hydrolysis is completed, the enzyme is inactivated by heating at 85℃ for 15 min.

8. The use of a traditional Chinese medicine composition as described in any one of claims 1-5 in the preparation of shampoo soap, shampoo or scalp care products.

9. The application according to claim 8, characterized in that, The amount of the traditional Chinese medicine composition added to the shampoo bar is 1-5% by weight.

10. The use of a traditional Chinese medicine composition as described in any one of claims 1-5 in the preparation of a scalp care product with antibacterial, antipruritic, and antioxidant effects.

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