Kidney-tonifying and blood-activating traditional chinese medicine composition and its application in improving visual function after operation

Abstract

This invention discloses a kidney-tonifying and blood-activating traditional Chinese medicine composition and its application in improving postoperative visual function, belonging to the field of pharmaceutical technology. The kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention is made from 10 parts of Cuscuta chinensis, 15 parts of Broussonetia papyrifera fruit, 18 parts of Lycium barbarum, 15 parts of Leonurus japonicus, 20 parts of Leonurus japonicus, 10 parts of Ligusticum chuanxiong, 9 parts of Prunus persica kernel, 6 parts of Carthamus tinctorius, 15 parts of Poria cocos, 18 parts of Albizia julibrissin bark, 12 parts of Astragalus membranaceus, and 12 parts of Pueraria lobata root. It can be standardized and adjusted according to clinical complications. This invention focuses on the critical point of "kidney deficiency and blood stasis" one month after posterior scleral reinforcement surgery, using the principles of tonifying the liver and kidneys and activating blood circulation to improve ocular microcirculation, enhance and stabilize vision, thereby protecting visual function, and conforming to the treatment principle of "treating the root cause when the condition is mild."

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical technology, specifically to the application of a kidney-tonifying and blood-activating traditional Chinese medicine composition in improving visual function after posterior scleral reinforcement surgery for high myopia macular degeneration. Background Technology

[0002] The abnormal mechanical traction caused by excessive elongation of the axial length in high myopia can lead to macular schisis, macular holes, and even retinal detachment, posing a serious threat to the patient's visual function. Posterior scleral reinforcement (PSR) is currently one of the key surgical methods for relieving mechanical traction in high myopia-related macular degeneration (tractional macular disease, MTM) and stabilizing the ocular structure. This surgery effectively and moderately shortens the axial length, reduces the schisis cavity, promotes the closure of the macular hole, and facilitates retinal repositioning; it avoids the damage to intraocular tissues caused by pars plana vitrectomy and has no special requirements for postoperative positioning, making it a safe and effective method for treating MTM. It is important to clarify that the main function of posterior scleral reinforcement is to slow the progression of myopia and prevent further development of fundus lesions, rather than directly treating myopia or restoring lost vision. While PSR (Peripheral Retina Surgery) has achieved definite anatomical efficacy in controlling axial elongation and stabilizing vision, it also carries significant risks of complications, such as early postoperative inflammation, persistent retinal effusion, and microcirculatory disturbances (e.g., hemorrhage or ischemia), which seriously affect the final visual function prognosis of patients. These complications may be related to various factors, including intraoperative injury, biocompatibility issues with the reinforcement material, local immune reactions, axial shortening, morphological changes from posterior staphyloma, and relative displacement of the retina. Western medicine typically administers corticosteroids after posterior scleral reinforcement surgery to reduce early inflammation and alleviate symptoms such as conjunctival congestion, edema, and pain. The recovery and improvement of visual function usually takes 3 months to 6 months, or even more than a year. This process involves complex mechanisms such as posterior pole scleral remodeling, gradual retinal repositioning, and gradual improvement or disappearance of visual distortion. It is evident that conventional Western medicine postoperative care mainly targets early inflammation, but lacks targeted drug treatment strategies for promoting and protecting visual function in the mid-to-long term and reducing long-term complications. This provides potential space and application value for the synergistic intervention of traditional Chinese medicine after PSR.

[0003] Traditional Chinese medicine (TCM) has shown significant effects in reducing local inflammation, promoting exudate absorption, improving local microcirculation, shortening recovery time, thus improving vision and protecting visual function. TCM believes that the fundamental pathogenesis of high myopia lies in liver and kidney deficiency, resulting in insufficient nourishment of the eyes by essence and blood, and stagnation of the meridians. Based on this, Researcher Lu Xuejing, an academic successor of the renowned TCM master Liao Pinzheng, believes that the pathological evolution of high myopia presents a typical dual damage characteristic of "structure and function." From the perspective of modern ophthalmic pathology, progressive elongation of the axial length leads to the formation of posterior staphyloma, followed by vitreous liquefaction and posterior vitreous detachment. This mechanical traction can induce serious complications such as macular schisis, macular hole, and even retinal detachment. Researcher Lu Xuejing analyzes this from the perspective of TCM pathogenesis, further focusing on and deepening the pathogenesis of high myopia based on liver and kidney deficiency and stagnation of the meridians. On the one hand, long-term depletion of essence and blood, coupled with continuous vitreous traction and local ischemia and hypoxia, makes the "deficiency" of the pathogenesis profound, reaching the point of kidney essence depletion. Kidney essence deficiency is the root cause of the disease. The *Ling Shu* (Spiritual Pivot) states, "The essence of the five viscera and six bowels all ascends to the eyes." Kidney essence deficiency can directly lead to malnourishment of the sclera and weakening of its structure, which is the fundamental basis for the deepening of the pathogenesis. On the other hand, mechanical stress causes tissue damage and circulatory disorders, consistent with the pathogenesis of blood stasis obstructing the collaterals in traditional Chinese medicine. The accompanying pathological products such as scleral liquefaction and tissue edema belong to the microscopic category of phlegm and dampness. Deficiency and stasis are intertwined; myopic tractional macular degeneration is a case of deficiency in the root and excess in the branch, with its core pathogenesis being kidney deficiency and blood stasis. It is worth noting that although posterior scleral reinforcement surgery can effectively delay axial elongation and reduce the traction of the vitreous body and posterior staphyloma on the retina, thereby alleviating the condition, the local inflammatory reaction and scar formation caused by surgical trauma may create a new pathological microenvironment. The pathological changes in the macular area after surgery, such as edema, hemorrhage, and subretinal fluid, are typical manifestations of "blood outside the channels." This leads to a more complex pathological pattern in the postoperative stage of PSR, where, in addition to the existing kidney deficiency and blood stasis, there is an accumulation of pathological products such as "blood stasis" and "phlegm-dampness" caused by injury to the collaterals. The kidneys store essence, which generates marrow, which connects to the brain, which is the sea of ​​marrow, and the eyes are related to the brain. Kidney deficiency and blood stasis prevent essence and blood from nourishing the eyes, resulting in malnourishment of the eye collaterals, hence blurred vision is the main symptom; insufficient kidney essence leads to an empty sea of ​​marrow, resulting in malnourishment of the sensory orifices, hence dizziness, tinnitus, and weakness in the lower back and knees; deficiency of essence and blood prevents body fluids from ascending, resulting in dry mouth and constipation; blood stasis and phlegm-dampness disturb the mind, causing insomnia, dreaminess, and anxiety; prolonged illness with mixed deficiency and excess, stagnation transforming into heat, results in red eyes and a thick, greasy yellow-white tongue coating; a pale or dark red tongue with ecchymosis and a thready, hesitant pulse are all signs of kidney deficiency and blood stasis.

[0004] Based on this, Researcher Lu Xuejing proposed the principle of "staged treatment" in Traditional Chinese Medicine (TCM) for scleral reinforcement surgery after macular degeneration in high myopia, reflecting the core concept of TCM syndrome differentiation and treatment. This principle, grounded in the evolution of the pathogenesis, adopts corresponding treatment strategies targeting the pathological characteristics of different postoperative stages, possessing clear scientific validity and clinical guiding significance. From the perspective of pathogenesis, the early postoperative stage is characterized by wind-heat in the liver meridian and obstruction of blood stasis, a finding consistent with modern medicine's understanding of the pathophysiological process of postoperative inflammatory response. Researcher Lu Xuejing emphasizes prioritizing the elimination of pathogenic factors at this stage, using tonifying drugs cautiously, which aligns with the principle of "treating the symptoms in acute cases" while avoiding the adverse effects of tonifying drugs exacerbating the inflammatory response. Research evidence shows that combining TCM treatment to clear wind-heat in the liver meridian, promote diuresis, invigorate blood circulation, and reduce swelling during the perioperative period of posterior scleral reinforcement surgery can effectively reduce postoperative complications. The reduction in complications not only helps alleviate postoperative discomfort but also creates favorable conditions for the recovery of postoperative visual function. In light of this, our team routinely administered oral, non-decoction-based traditional Chinese medicine (TCM) to patients diagnosed with high myopia macular degeneration (traction) undergoing posterior scleral reinforcement surgery during the perioperative period. The medicine aimed to clear heat and dampness in the liver meridian, promote diuresis, invigorate blood circulation, and reduce swelling. Subsequent clinical observation and case follow-up showed that most patients' inflammatory symptoms such as redness, swelling, and pain had largely disappeared one month after PSR surgery. At this stage, the pathogenesis returned to its root cause, still primarily characterized by a complex pattern of "kidney deficiency and blood stasis." This discovery not only provided a clear basis for postoperative staged treatment but also laid the foundation for the timing of subsequent intervention with kidney-tonifying and blood-activating therapies. Modern TCM research has also confirmed that kidney-tonifying and blood-activating therapies can significantly treat high myopia and its macular complications through multiple mechanisms, including improving local microcirculation in the retina and choroid, inhibiting cell apoptosis, and protecting retinal mitochondrial function. Therefore, adopting a treatment approach that tonifies the liver and kidneys and invigorates blood circulation at this time aligns with the principle of "treating the root cause in a gradual manner" and is consistent with the modern medical goals of improving microcirculation and protecting visual function.

[0005] Based on the above theoretical understanding and clinical practice, this invention provides a traditional Chinese medicine composition targeting the pathogenesis of kidney deficiency and blood stasis one month after PSR surgery, in order to provide an effective intervention to promote the recovery of postoperative visual function. Summary of the Invention

[0006] This invention proposes a kidney-tonifying and blood-activating traditional Chinese medicine composition and its application in improving postoperative visual function. This composition focuses on the key point of the pathogenesis shifting to "kidney deficiency and blood stasis" one month after posterior scleral reinforcement surgery, and improves postoperative visual function by tonifying the liver and kidneys and activating blood circulation.

[0007] To achieve the above objectives, the present invention is implemented through the following technical solution: A kidney-tonifying and blood-activating traditional Chinese medicine composition is made from the following raw materials in parts by weight: 10 parts of Cuscuta chinensis, 15 parts of Broussonetia papyrifera, 18 parts of Lycium barbarum, 15 parts of Leonurus japonicus, 20 parts of Leonurus japonicus, 10 parts of Ligusticum chuanxiong, 9 parts of Prunus persica, 6 parts of Carthamus tinctorius, 15 parts of Poria cocos, 18 parts of Albizia julibrissin bark, 12 parts of Astragalus membranaceus, and 12 parts of Pueraria lobata.

[0008] Based on this, standardized additions and subtractions can be made according to clinical complications: for insomnia, add 30 parts of Polygonum multiflorum vine; for excessive dreaming, add 25 parts of oyster shell; for dry mouth, add 20 parts of Dendrobium nobile; for constipation, add 15 parts of Cassia tora seed; for anxiety, add 10 parts of Bupleurum chinense and / or 10 parts of Curcuma longa; for red eyes, add at least one of the following: 15 parts of Morus alba root bark, 15 parts of Scutellaria baicalensis root, and 15 parts of Paeonia suffruticosa root bark; for a thick, greasy, yellow-white tongue coating, add 12 parts of Phellodendron chinense bark and / or 15 parts of Eupatorium fortunei.

[0009] Specifically, in the first scheme, when insomnia symptoms appear one month after posterior scleral reinforcement surgery, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of the present invention is adjusted, and the weight parts are as follows: Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, Polygonum multiflorum vine 30 parts.

[0010] In the second option, when symptoms of excessive dreaming appear one month after posterior scleral reinforcement surgery, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of the present invention is adjusted, and the weight parts are as follows: Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, and Ostrea gigas 25 parts.

[0011] In the third option, when insomnia and excessive dreaming symptoms appear one month after posterior scleral reinforcement surgery, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of the present invention is adjusted, and the weight parts are as follows: Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, Polygonum multiflorum vine 30 parts, and Ostrea gigas 25 parts.

[0012] In the fourth option, when dry mouth symptoms appear one month after posterior scleral reinforcement surgery, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of the present invention is adjusted, and the weight parts are as follows: Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, Dendrobium nobile 20 parts.

[0013] In the fifth option, when constipation occurs one month after posterior scleral reinforcement surgery, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of the present invention is adjusted as follows by weight: Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, and Cassia tora 15 parts.

[0014] In the sixth option, when anxiety symptoms appear one month after posterior scleral reinforcement surgery, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention is adjusted as follows (by weight): Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, and Bupleurum chinense 10 parts. In the sixth option, Bupleurum chinense can be replaced with Curcuma longa, or it can be added to the sixth option simultaneously with Curcuma longa.

[0015] In the seventh option, when conjunctival consolidation surgery is performed one month later and conjunctival congestion occurs, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention is adjusted as follows (by weight): Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, and Morus alba root bark 15 parts. In the seventh option, Morus alba root bark can be replaced with Scutellaria baicalensis or Paeonia suffruticosa root bark. Morus alba root bark, Scutellaria baicalensis, and Paeonia suffruticosa root bark can be added individually to the seventh option, or they can be added in pairs or all three at the same time.

[0016] In the eighth option, when symptoms of a thick, greasy, yellow-white tongue coating appear one month after posterior scleral reinforcement surgery, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention is adjusted as follows (by weight): Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, and Eupatorium fortunei 15 parts. In the eighth option, Eupatorium fortunei can be replaced with Phellodendron chinense; simultaneously, both Eupatorium fortunei and Phellodendron chinense can be added to the eighth option.

[0017] The present invention also claims protection for the use of the aforementioned kidney-tonifying and blood-activating traditional Chinese medicine composition in the preparation of a medicament for improving visual function after scleral reinforcement surgery for high myopia macular degeneration.

[0018] Furthermore, the medication is administered at least one month after posterior scleral reinforcement surgery.

[0019] The present invention relates to a kidney-tonifying and blood-activating traditional Chinese medicine composition and its application in improving visual function after surgery. Its beneficial effects are as follows: The traditional Chinese medicine of the present invention is used at the critical point of "kidney deficiency and blood stasis" one month after posterior scleral reinforcement surgery. It tonifies the liver and kidneys, activates blood circulation and unblocks collaterals. It can not only improve the microcirculation of the eye and improve and stabilize visual function, thereby achieving the purpose of protecting visual function, but also conforms to the treatment principle of "treating the root cause when the condition is slow". Attached Figure Description

[0020] To more clearly illustrate the technical solutions in the embodiments of the present invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0021] Figure 1 These are OCTA images from Case 1 in Example 21, where A is an image of fundus blood flow in the macula within a 6x6mm area via OCTA before treatment with the composition of the present invention (1 month post-treatment); B is an image of fundus blood flow in the macula within a 6x6mm area via OCTA after treatment with the composition of the present invention (2 months post-treatment); C is an image of fundus blood flow in the macula within a 6x6mm area via OCTA 1 month post-treatment (3 months post-treatment); and D is an image of fundus blood flow in the macula within a 6x6mm area via OCTA 4 months post-treatment (6 months post-treatment). Figure 2 These are OCTA images from Example 21, Case 2, where: A is an image of fundus blood flow in the macular region within a 6x6mm area via OCTA before treatment with the composition of the present invention (1 month post-treatment); B is an image of fundus blood flow in the macular region within a 6x6mm area via OCTA after treatment with the composition of the present invention (2 months post-treatment); C is an image of fundus blood flow in the macular region within a 6x6mm area via OCTA 1 month post-treatment (3 months post-treatment); and D is an image of fundus blood flow in the macular region within a 6x6mm area via OCTA 4 months post-treatment (6 months post-treatment). Figure 3 These are OCTA images from Example 21, Case 3; where A is an image of fundus blood flow in the macular region within a 6x6mm area via OCTA before treatment with the composition of the present invention (1 month post-treatment); B is an image of fundus blood flow in the macular region within a 6x6mm area via OCTA after treatment with the composition of the present invention (2 months post-treatment); C is an image of fundus blood flow in the macular region within a 6x6mm area via OCTA 1 month post-treatment (3 months post-treatment); and D is an image of fundus blood flow in the macular region within a 6x6mm area via OCTA 4 months post-treatment (6 months post-treatment). Figure 4These are OCTA images from Example 21, Case 4; where A is an image of fundus blood flow in the macula within a 6x6mm area via OCTA before treatment with the composition of the present invention (1 month post-treatment); B is an image of fundus blood flow in the macula within a 6x6mm area via OCTA after treatment with the composition of the present invention (2 months post-treatment); C is an image of fundus blood flow in the macula within a 6x6mm area via OCTA 1 month post-treatment (3 months post-treatment); and D is an image of fundus blood flow in the macula within a 6x6mm area via OCTA 4 months post-treatment (6 months post-treatment). Figure 5 These are OCTA images from Example 21, Case 5; where A is an image of fundus blood flow in the macular region within a 6x6mm area via OCTA before treatment with the composition of the present invention (1 month post-treatment); B is an image of fundus blood flow in the macular region within a 6x6mm area via OCTA after treatment with the composition of the present invention (2 months post-treatment); C is an image of fundus blood flow in the macular region within a 6x6mm area via OCTA 1 month post-treatment (3 months post-treatment); and D is an image of fundus blood flow in the macular region within a 6x6mm area via OCTA 4 months post-treatment (6 months post-treatment). Detailed Implementation

[0022] This invention's kidney-tonifying and blood-activating traditional Chinese medicine composition inherits the core framework of the modified Zhujing Pill formula (Cuscuta chinensis, Broussonetia papyrifera, Lycium barbarum, and Leonurus japonicus), and has undergone targeted modifications aimed at enhancing blood activation and meridian unblocking. In this formula, Cuscuta chinensis, Broussonetia papyrifera, and Lycium barbarum are the principal herbs for tonifying the kidney and replenishing essence: Cuscuta chinensis is sweet and warm, entering the kidney; the *Compendium of Materia Medica* states that it "tonifies the kidney and nourishes the liver, warms the spleen and assists the stomach," replenishing both congenital kidney essence and acquired spleen and stomach, aligning with the principle of "essence and blood sharing the same origin"; Broussonetia papyrifera is sweet and cold, specifically entering the liver and kidney; the *Treatise on the Nature of Medicinal Herbs* records that it "benefits qi, nourishes the skin, and brightens the eyes," effectively tonifying the yin of the liver and kidneys to brighten the eyes; Lycium barbarum is sweet, neutral, and moistening; the *Compendium of Materia Medica* states that it "nourishes the kidney and moistens the lungs, brightens the eyes." The three herbs work together to replenish the essence and blood of the liver and kidneys to strengthen their foundation. Leonurus japonicus, Leonurus japonicus, Carthamus tinctorius, Ligusticum chuanxiong, and Prunus persica are used as assistant herbs, working together to invigorate blood circulation, promote diuresis, and remove blood stasis. Leonurus japonicus is pungent, sweet, and slightly warm; the *Shennong Bencao Jing* states that it "brightens the eyes and benefits essence," invigorating blood circulation and assisting the principal herbs in tonifying the body. Leonurus japonicus is bitter, pungent, and slightly cold, specifically entering the blood; the *Ben Cao Qiu Zhen* states that it "eliminates water retention, promotes blood circulation, removes blood stasis, and generates new blood," improving retinal circulation by eliminating dampness and removing blood stasis. Carthamus tinctorius, Prunus persica, and Ligusticum chuanxiong work synergistically to further enhance the blood-activating, blood-stasis-removing, and meridian-clearing effects, aiming to strengthen the improvement of retinal microcirculation. Patients with this condition are more prone to excessive worry about their condition after surgery; therefore, Poria cocos is added to calm the mind and soothe the nerves, and Albizia julibrissin bark is added to relieve depression and calm the nerves, aiming to guide the medicine to the heart and liver, embodying the principle of "heart and kidney interaction." Astragalus membranaceus and Pueraria lobata are further added to infuse the entire formula with power. Astragalus is sweet and warm, greatly tonifying the Qi of the spleen and stomach. Sufficient Qi leads to vigorous blood circulation and also aids in the distribution of body fluids. Kudzu root is light and ascending, effectively guiding the clear Yang and medicinal power upwards to the head and eyes. The combination of these two herbs not only assists in the dispersing of blood-activating herbs but also facilitates the transformation and transportation of diuretics, ultimately dispersing water retention and eliminating stagnation, allowing kidney essence to ascend and nourishing the eyes. The entire formula tonifies the kidneys without causing stagnation, activates blood without harming the body's vital energy, and integrates tonifying the liver and kidneys to replenish essence and blood, activating blood circulation to reduce swelling, and nourishing blood to remove blood stasis and unblock the meridians, subtly aligning with the principle that "when essence is abundant, blood is active; when blood flows smoothly, essence is distributed." The combined effects of these herbs tonify kidney essence to nourish the eyes and activate blood vessels to enhance mental clarity.

[0023] This invention's kidney-tonifying and blood-activating traditional Chinese medicine composition is designed to address the core pathogenesis of "kidney deficiency and blood stasis" one month after posterior scleral reinforcement surgery. Kidney deficiency and blood stasis prevent essence and blood from nourishing the eyes, leading to malnourishment of the eye's collaterals, hence blurred vision as the primary symptom; insufficient kidney essence leads to emptiness of the marrow sea, resulting in malnourishment of the sensory orifices, causing dizziness, tinnitus, and weakness in the lower back and knees; deficiency of essence and blood prevents body fluids from ascending, resulting in dry mouth and constipation; blood stasis and phlegm-dampness disturb the mind, causing insomnia, excessive dreaming, and anxiety; prolonged illness with mixed deficiency and excess, leading to stagnation and heat, results in red eyes and a thick, greasy yellow-white tongue coating. Based on this understanding of the pathogenesis, this invention standardizes and modifies the basic formula to address different concurrent symptoms, enhancing the targeted nature of the treatment: for insomnia, add 30g of Polygonum multiflorum vine for its calming and soothing effects, so that a calm mind leads to clear vision; For those with excessive dreaming, add 25g of oyster shell for its calming and soothing effects; for those with dry mouth, add 20g of dendrobium to nourish yin, generate fluids, and moisten the upper body; for those with constipation, add 15g of cassia seed to moisten the intestines, promote bowel movements, and facilitate the smooth flow of qi; for those with anxiety, add 10g of bupleurum and / or 10g of turmeric to soothe the liver, relieve depression, and regulate qi; for those with red eyes, add at least one of 15g each of mulberry bark, scutellaria, and peony bark to clear heat, cool the blood, and directly dispel stagnant heat; for those with a thick, greasy, yellow-white tongue coating, add 12g of phellodendron bark and / or 15g of agastache to clear heat, dry dampness, and resolve turbidity. The symptoms of dry mouth, insomnia, constipation, anxiety, and red eyes mentioned above are actually specific manifestations of the core pathogenesis of "kidney deficiency and blood stasis" at different organs and levels. The treatment of these postoperative symptoms by adjusting the prescription based on syndrome differentiation is essentially a deeper treatment of the core pathogenesis (kidney deficiency and blood stasis). This is achieved through the synergistic effect of these modified medications and the basic prescription, thereby regulating the whole body and improving the systemic symptoms caused by the pathogenesis, creating a good internal environment for the circulation of qi and blood in the eyes, and promoting the recovery of visual function.

[0024] The present invention will be further described in detail below with reference to specific embodiments and accompanying drawings.

[0025] In clinical application, the composition of this invention can be standardized and modified based on the patient's specific concurrent symptoms to form a more targeted treatment plan. Specifically: In the first scheme, when insomnia symptoms appear one month after posterior scleral reinforcement surgery, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention is adjusted, and the ingredients are as follows by weight: Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, and Polygonum multiflorum vine 30 parts. In the first scheme, Polygonum multiflorum vine is mainly added to synergistically work with the other components, achieving the purpose of treating and consolidating vision after posterior scleral reinforcement surgery, while also improving insomnia symptoms.

[0026] In the second approach, when symptoms of excessive dreaming appear one month after posterior scleral reinforcement surgery, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention is adjusted as follows (by weight): Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, and Ostrea gigas 25 parts. In this second approach, Ostrea gigas is primarily added to synergize with the other components, achieving the goal of visual recovery and preventative consolidation after posterior scleral reinforcement surgery while also improving symptoms of excessive dreaming.

[0027] In the third option, when insomnia and excessive dreaming symptoms appear one month after posterior scleral reinforcement surgery, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention is adjusted, and the ingredients are as follows by weight: Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, Polygonum multiflorum vine 30 parts, and Ostrea gigas 25 parts. In this third option, Polygonum multiflorum vine and Ostrea gigas are mainly added simultaneously to work synergistically with the other components, achieving the goal of visual recovery and prevention and consolidation after posterior scleral reinforcement surgery, while also improving insomnia and excessive dreaming symptoms.

[0028] In the fourth option, when dry mouth symptoms appear one month after posterior scleral reinforcement surgery, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention is adjusted, and the ingredients are as follows by weight: Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, and Dendrobium nobile 20 parts. In the fourth option, Dendrobium nobile is mainly added to synergize with the other components, achieving the goal of visual recovery and prevention and consolidation after posterior scleral reinforcement surgery, while also improving dry mouth symptoms.

[0029] In the fifth option, when constipation occurs one month after posterior scleral reinforcement surgery, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention is adjusted, and the ingredients are as follows by weight: Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, and Cassia tora 15 parts. In this fifth option, Cassia tora is mainly added to synergize with the other components, achieving the goal of visual recovery and prevention and consolidation after posterior scleral reinforcement surgery, while also improving constipation symptoms.

[0030] In the sixth option, when anxiety symptoms appear one month after posterior scleral reinforcement surgery, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention is adjusted by weight as follows: Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, and Bupleurum chinense 10 parts. In the sixth option, Bupleurum chinense can be replaced with Curcuma longa, or it can be added to the sixth option simultaneously with Curcuma longa. In the sixth option, Bupleurum chinense and / or Curcuma longa are mainly added to work synergistically with the other components to achieve the purpose of visual recovery and prevention and consolidation after posterior scleral reinforcement surgery, while also improving anxiety symptoms.

[0031] In the seventh option, when conjunctivitis occurs one month after posterior scleral reinforcement surgery, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention is adjusted by weight as follows: Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, and Morus alba root bark 15 parts. In the seventh option, Morus alba root bark can be replaced with Scutellaria baicalensis or Paeonia suffruticosa root bark. Morus alba root bark, Scutellaria baicalensis, and Paeonia suffruticosa root bark can be added individually, in pairs, or all three simultaneously. In the seventh option, Morus alba root bark and / or Scutellaria baicalensis and / or Paeonia suffruticosa root bark are mainly added to synergistically with the other components, achieving the goal of visual recovery and prevention and consolidation after posterior scleral reinforcement surgery, while also improving conjunctivitis symptoms.

[0032] In the eighth option, when a thick, greasy yellow-white tongue coating appears one month after posterior scleral reinforcement surgery, the formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention is adjusted by weight as follows: Cuscuta chinensis 10 parts, Broussonetia papyrifera 15 parts, Lycium barbarum 18 parts, Leonurus japonicus 15 parts, Leonurus japonicus 20 parts, Ligusticum chuanxiong 10 parts, Prunus persica 9 parts, Carthamus tinctorius 6 parts, Poria cocos 15 parts, Albizia julibrissin bark 18 parts, Astragalus membranaceus 12 parts, Pueraria lobata 12 parts, and Eupatorium fortunei 15 parts. In the eighth option, Eupatorium fortunei can be replaced with Phellodendron chinense; simultaneously, both Eupatorium fortunei and Phellodendron chinense can be added to the eighth option. In the eighth option, the main addition of Eupatorium fortunei and / or Phellodendron chinense, working synergistically with the other components, achieves the purpose of visual recovery and prevention and consolidation after posterior scleral reinforcement surgery, while also improving the symptoms of a thick, greasy yellow-white tongue coating.

[0033] The first through eighth schemes listed above only illustrate the additions and subtractions needed for a single symptom. In practice, if multiple symptoms occur simultaneously, adjustments can be made accordingly. However, in principle, no more than two medications should be added at a time to address concurrent symptoms, and all additions and subtractions must be recorded in detail.

[0034] Example 1 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera fruit, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica kernel, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, 12g of Pueraria lobata root, and 30g of Polygonum multiflorum vine.

[0035] Example 2 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, 12g of Pueraria lobata, and 25g of Ostrea gigas.

[0036] Example 3 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera fruit, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica kernel, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, 12g of Pueraria lobata root, 30g of Polygonum multiflorum vine, and 25g of Ostrea gigas.

[0037] Example 4 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, 12g of Pueraria lobata, and 20g of Dendrobium nobile.

[0038] Example 5 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, 12g of Pueraria lobata, and 15g of Cassia tora.

[0039] Example 6 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera fruit, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica kernel, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, 12g of Pueraria lobata root, and 10g of Bupleurum chinense.

[0040] Example 7 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera fruit, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica kernel, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, 12g of Pueraria lobata root, and 10g of Curcuma longa.

[0041] Example 8 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: Cuscuta chinensis 10g, Broussonetia papyrifera 15g, Lycium barbarum 18g, Leonurus japonicus 15g, Leonurus japonicus 20g, Ligusticum chuanxiong 10g, Prunus persica 9g, Carthamus tinctorius 6g, Poria cocos 15g, Albizia julibrissin bark 18g, Astragalus membranaceus 12g, Pueraria lobata 12g, Bupleurum chinense 10g, and Curcuma longa 10g.

[0042] Example 9 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera fruit, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica kernel, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, 12g of Pueraria lobata root, and 15g of Morus alba root bark.

[0043] Example 10 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera fruit, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica kernel, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, 12g of Pueraria lobata root, and 15g of Scutellaria baicalensis.

[0044] Example 11 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera fruit, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica kernel, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, 12g of Pueraria lobata root, and 15g of Paeonia suffruticosa bark.

[0045] Example 12 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera fruit, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica kernel, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, 12g of Pueraria lobata root, 15g of Morus alba root bark, and 15g of Paeonia suffruticosa root bark.

[0046] Example 13 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera fruit, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica kernel, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, 12g of Pueraria lobata root, 15g of Morus alba root bark, and 15g of Scutellaria baicalensis.

[0047] Example 14 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: Cuscuta chinensis 10g, Broussonetia papyrifera 15g, Lycium barbarum 18g, Leonurus japonicus 15g, Leonurus japonicus 20g, Ligusticum chuanxiong 10g, Prunus persica 9g, Carthamus tinctorius 6g, Poria cocos 15g, Albizia julibrissin bark 18g, Astragalus membranaceus 12g, Pueraria lobata 12g, Scutellaria baicalensis 15g, and Paeonia suffruticosa 15g.

[0048] Example 15 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: Cuscuta chinensis 10g, Broussonetia papyrifera 15g, Lycium barbarum 18g, Leonurus japonicus 15g, Leonurus japonicus 20g, Ligusticum chuanxiong 10g, Prunus persica 9g, Carthamus tinctorius 6g, Poria cocos 15g, Albizia julibrissin bark 18g, Astragalus membranaceus 12g, Pueraria lobata 12g, Morus alba root bark 15g, Scutellaria baicalensis 15g, and Paeonia suffruticosa root bark 15g.

[0049] Example 16 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, 12g of Pueraria lobata, and 15g of Eupatorium fortunei.

[0050] Example 17 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera fruit, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica kernel, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, 12g of Pueraria lobata root, and 15g of Phellodendron chinense bark.

[0051] Example 18 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera fruit, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica kernel, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, 12g of Pueraria lobata, 15g of Eupatorium fortunei, and 15g of Phellodendron chinense.

[0052] Example 19 A traditional Chinese medicine composition for improving visual function after posterior scleral reinforcement surgery, comprising: 10g of Cuscuta chinensis, 15g of Broussonetia papyrifera fruit, 18g of Lycium barbarum, 15g of Leonurus japonicus, 20g of Leonurus japonicus, 10g of Ligusticum chuanxiong, 9g of Prunus persica kernel, 6g of Carthamus tinctorius, 15g of Poria cocos, 18g of Albizia julibrissin bark, 12g of Astragalus membranaceus, and 12g of Pueraria lobata root.

[0053] Example 20 A randomized, controlled, double-blind clinical trial was conducted to collect 100 patients who underwent posterior scleral reinforcement surgery for macular degeneration with high myopia at Chengdu University of Traditional Chinese Medicine Yinhai Eye Hospital between August 2024 and October 2025. The inclusion criteria were: (1) meeting the diagnostic criteria for macular degeneration with high myopia; (2) having undergone posterior scleral reinforcement surgery more than one month prior; (3) being between 18 and 75 years old; and (4) having signed an informed consent form. Patients were randomly divided into an experimental group and a control group of 50 patients each, in a 1:1 ratio. The experimental group and the control group were further subdivided into dry mouth group, insomnia and anxiety group, thick and greasy yellow-white tongue coating group, constipation group, and red eyes group based on symptoms and TCM diagnosis, with 10 patients in each group. The oral medications for the experimental group are shown in Table 1, while the control group did not take any medication. The daily routines of both groups were the same.

[0054] The experimental group's administration of the herbal composition: The raw materials of the herbal composition were decocted with water according to the conventional decoction ratio (generally 1:3 or 1:5). Two doses were taken every three days, twice a day, one packet (150ml) each time, taken warm half an hour after meals. A second consultation was conducted after a total of 6 doses. After the second consultation, the herbal composition was changed to the basic formula (Cuscuta chinensis 10g, Broussonetia papyrifera 15g, Lycium barbarum 18g, Leonurus japonicus 15g, Leonurus japonicus 20g, Ligusticum chuanxiong 10g, Prunus persica 9g, Carthamus tinctorius 6g, Poria cocos 15g, Albizia julibrissin bark 18g, Astragalus membranaceus 12g, Pueraria lobata 12g), two doses every three days, twice a day, one packet (150ml) each time, taken warm half an hour after meals. A total of 14 doses were administered.

[0055] Ophthalmological examinations were performed before treatment with the herbal composition of this invention, 9 days after treatment, 1 month after treatment (i.e., 2 months post-surgery), 1 month after treatment (3 months post-surgery), and 4 months after treatment (6 months post-surgery) to observe the patients' best corrected visual acuity (OD). The therapeutic effect of the formula of this invention on patients after posterior scleral reinforcement surgery is evaluated, as shown in Table 1: Table 1

[0056]

[0057] The best corrected visual acuity of patients before treatment (V1, i.e., 1 month post-surgery), after treatment (V2, i.e., 2 months post-surgery), 1 month post-surgery (V3, i.e., 3 months post-surgery), and 4 months post-surgery (V4, i.e., 6 months post-surgery) was compared, and the statistical results are shown in Table 2. Table 2 Best corrected visual acuity (X±S, logMAR) for the two groups

[0058]

[0059] Note: The comparisons between groups at each time point in Table 2 were performed using independent samples t-tests, and the t-values ​​and p-values ​​are reported; the comparisons within groups were performed using repeated measures ANOVA, and the F-values ​​and p-values ​​are reported.

[0060] Table 2 shows that, firstly, in the inter-group comparison, the BCVA of the traditional Chinese medicine group was significantly better than that of the control group at time point V4 (P = 0.047); secondly, repeated measures ANOVA showed that the BCVA of both groups changed significantly over time during the observation period from V1 to V4 (P < 0.05). This indicates that the visual acuity of both groups improved overall over time (due to structural stability after posterior scleral reinforcement surgery), but the traditional Chinese medicine group was significantly better than the control group 4 months after treatment, demonstrating the additional therapeutic effect of traditional Chinese medicine. Combining traditional Chinese medicine treatment with posterior scleral reinforcement surgery has a long-term advantage in improving BCVA, superior to surgical treatment alone.

[0061] Example 21 Case 1 (Dry mouth): Ms. Liu, female, 49 years old. Chief complaint: Blurred vision one month after posterior scleral reinforcement surgery on the right eye. The patient underwent posterior scleral reinforcement surgery one month ago and is now seeking traditional Chinese medicine rehabilitation treatment to improve her vision. Current symptoms: blurred vision, dry mouth, dizziness, tinnitus, insomnia with excessive dreaming, soreness and weakness in the lower back and knees, dark red tongue with ecchymosis, thin coating, and thready and hesitant pulse. The diagnosis is liver and kidney deficiency with blood stasis in the eye meridians. The patient is treated with the basic formula of the kidney-tonifying and blood-activating Chinese herbal composition of this invention, with the addition of 20g of Dendrobium. Specialist examination: no conjunctival congestion in the right eye, clear cornea, cloudy lens, and fundus examination showing high myopia changes. Visual acuity in the right eye is 0.1; visual acuity in the left eye is 0.7.

[0062] The prescription is as follows: Cuscuta chinensis 10g, Broussonetia papyrifera 15g, Lycium barbarum 18g, Leonurus japonicus 15g, Leonurus japonicus 20g, Ligusticum chuanxiong 10g, Prunus persica 9g, Carthamus tinctorius 6g, Poria cocos 15g, Albizia julibrissin bark 18g, Astragalus membranaceus 12g, Pueraria lobata 12g, Dendrobium nobile 20g.

[0063] The raw materials of the Chinese herbal medicine composition are decocted with water according to the conventional decoction ratio (usually 1:3 or 1:5). Two doses are taken every three days, twice a day, one packet (specification: 150ml) each time, taken warm half an hour after meals. A second consultation is required after a total of 6 doses.

[0064] Second visit: The patient reported clearer vision and no longer experienced dry mouth, but occasionally felt dizzy and had tinnitus, insomnia with vivid dreams, and weakness in the lower back and knees. The tongue was slightly dark with little coating, and the pulse was thready and hesitant. The diagnosis remained unchanged. Since the dry mouth had improved, the basic prescription was continued: Cuscuta chinensis 10g, Broussonetia papyrifera 15g, Lycium barbarum 18g, Leonurus japonicus 15g, Leonurus japonicus 20g, Ligusticum chuanxiong 10g, Prunus persica 9g, Carthamus tinctorius 6g, Poria cocos 15g, Albizia julibrissin bark 18g, Astragalus membranaceus 12g, and Pueraria lobata 12g. Prepare 14 doses according to this prescription, decoct as needed, take two doses every three days, twice a day, one packet (150ml) each time, taken warm half an hour after meals.

[0065] The patient took traditional Chinese medicine orally for one month (two months post-surgery). Post-treatment and follow-up visual acuity are shown in Table 3. Simultaneously, OCTA optical coherence tomography (OCTA) was performed to obtain OCTA blood flow data. Figure 1As shown.

[0066] Case 2 (Insomnia, vivid dreams, and anxiety) Ms. Zhang, female, 60 years old. Chief complaint: Blurred vision one month after posterior scleral reinforcement surgery on the right eye. The patient underwent posterior scleral reinforcement surgery at our hospital one month ago. She is currently experiencing blurred vision in her right eye and is seeking traditional Chinese medicine rehabilitation treatment to improve this condition. Current symptoms include: blurred vision, difficulty falling asleep (half a tablet of estazolam / night), shallow sleep with frequent dreams, irritability, anxiety about blindness, dark red tongue with ecchymosis, thin coating, and a wiry, thready pulse. The diagnosis is liver and kidney deficiency with blood stasis in the eye meridians. The patient is prescribed the basic formula of this invention's kidney-tonifying and blood-activating traditional Chinese medicine composition, with the addition of 30g of Polygonum multiflorum vine, 25g of oyster shell, 10g of Bupleurum chinense, and 10g of Curcuma longa. Specialist examination: No conjunctival congestion in the right eye, transparent cornea, cloudy lens, and fundus examination showing high myopia changes. Visual acuity: Right eye 0.15; Left eye 0.6.

[0067] The prescription is as follows: Cuscuta chinensis 10g, Broussonetia papyrifera 15g, Lycium barbarum 18g, Leonurus japonicus 15g, Leonurus japonicus 20g, Ligusticum chuanxiong 10g, Prunus persica 9g, Carthamus tinctorius 6g, Poria cocos 15g, Albizia julibrissin bark 18g, Astragalus membranaceus 12g, Pueraria lobata 12g, Polygonum multiflorum vine 30g, Ostrea gigas 25g (decocted first), Bupleurum chinense 10g, Curcuma longa 10g.

[0068] Take 10 doses of Chinese medicine, decocted by the decocting agent. Take two doses every three days, twice a day, one packet (150ml) each time, half an hour after meals.

[0069] Second visit: After taking the previous medication, the patient felt that their vision was clearer than before. Symptoms such as difficulty falling asleep due to fear of blindness (1 / 4 tablet of estazolam / night) and shallow sleep with frequent dreams had improved significantly. However, they were still irritable when faced with stressful situations. Their tongue was slightly dark with little coating, and their pulse was thready and hesitant. The diagnosis remained unchanged, and the basic formula was continued with the addition of Polygonum multiflorum vine, oyster shell, Bupleurum chinense, and Curcuma longa: Cuscuta chinensis 10g, Broussonetia papyrifera fruit 15g, Lycium barbarum fruit 18g, Leonurus japonicus fruit 15g, Leonurus japonicus 20g, Ligusticum chuanxiong rhizome 10g, Prunus persica kernel 9g, Carthamus tinctorius 6g, Poria cocos 15g, Albizia julibrissin bark 18g, Astragalus membranaceus 12g, Pueraria lobata root 12g, Polygonum multiflorum vine 30g, oyster shell 25g (decocted first), Bupleurum chinense 10g, Curcuma longa 10g.

[0070] Take 10 doses of Chinese medicine, decocted by the decocting agent. Take two doses every three days, twice a day, one packet (150ml) each time, half an hour after meals.

[0071] The patient took traditional Chinese medicine orally for one month. Post-treatment and follow-up visual acuity are shown in Table 3. OCTA blood flow was as follows... Figure 2 .

[0072] Case 3 (thick, greasy yellow-white tongue coating): Ms. Chen, female, 25 years old. Chief complaint: Blurred vision one month after posterior scleral reinforcement surgery on the right eye. The patient underwent posterior scleral reinforcement surgery at our hospital one month ago and is now seeking traditional Chinese medicine rehabilitation treatment to improve her vision. Current symptoms: blurred vision, poor appetite, dark red tongue with a thick, greasy yellow-white coating, and a thready, hesitant pulse. The diagnosis is liver and kidney deficiency with blood stasis in the eye meridians. The patient is prescribed the basic formula of this invention's kidney-tonifying and blood-activating traditional Chinese medicine composition, with the addition of 12g of Phellodendron bark and 15g of Eupatorium fortunei. Specialist examination: No conjunctival congestion in the right eye, clear cornea, clear lens, fundus examination showing high myopia changes. Right eye visual acuity 0.5; left eye visual acuity 0.8.

[0073] The specific prescription is as follows: Cuscuta chinensis 10g, Broussonetia papyrifera 15g, Lycium barbarum 18g, Leonurus japonicus 15g, Leonurus japonicus 20g, Ligusticum chuanxiong 10g, Prunus persica 9g, Carthamus tinctorius 6g, Poria cocos 15g, Albizia julibrissin bark 18g, Astragalus membranaceus 12g, Pueraria lobata 12g, Phellodendron chinense 12g, Eupatorium fortunei 15g.

[0074] Take 6 doses of Chinese medicine, decocted by the decocting agent, two doses every three days, twice a day, one packet each time (specification: 150ml), taken warm half an hour after meals.

[0075] Second visit: The patient reported improved vision and appetite, a pale tongue with a greasy coating in the middle and back, and a thready, hesitant pulse. The diagnosis remained unchanged, and the basic formula was modified by adding 15g of Eupatorium fortunei. The herbal formula is as follows: Cuscuta chinensis 10g, Broussonetia papyrifera 15g, Lycium barbarum 18g, Leonurus japonicus 15g, Leonurus japonicus 20g, Ligusticum chuanxiong 10g, Prunus persica 9g, Carthamus tinctorius 6g, Poria cocos 15g, Albizia julibrissin bark 18g, Astragalus membranaceus 12g, Pueraria lobata 12g, and Eupatorium fortunei 15g. Fourteen doses of the herbal medicine were prescribed, to be decocted and taken twice daily (two doses every three days), one packet (150ml) each time, warm, half an hour after meals.

[0076] The patient took traditional Chinese medicine orally for one month. Post-treatment and follow-up visual acuity are shown in Table 3. OCTA blood flow was as follows... Figure 3 As shown.

[0077] Case 4 (Constipation): Mr. Wang, male, 54 years old. Chief complaint: Blurred vision one month after posterior scleral reinforcement surgery on the right eye. The patient underwent posterior scleral reinforcement surgery at our hospital one month ago and is now seeking traditional Chinese medicine rehabilitation treatment to improve his vision. Current symptoms: blurred vision, dizziness and tinnitus, soreness and weakness in the lower back and knees, normal sleep, constipation (once every 3 days) with small amount of stool, normal urination, dark red tongue with little coating, and thready and hesitant pulse. The diagnosis is liver and kidney deficiency with blood stasis in the eye meridians. He is treated with the basic formula of the kidney-tonifying and blood-activating traditional Chinese medicine composition of this invention, with the addition of 15g of cassia seed. Specialist examination: no conjunctival congestion in the right eye, clear cornea, cloudy lens, and fundus examination showing high myopia changes. Visual acuity in the right eye is 0.2; visual acuity in the left eye is 0.5.

[0078] The specific prescription is as follows: Cuscuta chinensis 10g, Broussonetia papyrifera 15g, Lycium barbarum 18g, Leonurus japonicus 15g, Leonurus japonicus 20g, Ligusticum chuanxiong 10g, Prunus persica 9g, Carthamus tinctorius 6g, Poria cocos 15g, Albizia julibrissin bark 18g, Astragalus membranaceus 12g, Pueraria lobata 12g, and Cassia tora 15g.

[0079] Take 6 doses of Chinese medicine, decocted by the decocting agent, two doses every three days, twice a day, one packet each time (specification: 150ml), taken warm half an hour after meals.

[0080] Second visit: The patient reported improved vision and bowel movements, with constipation decreasing to once every two days. Dizziness, tinnitus, and lower back and knee weakness only appeared due to poor rest. The tongue was slightly dark with little coating, and the pulse was thready and hesitant. The diagnosis remained unchanged; the basic formula was continued with the addition of 15g of cassia seed. 14 doses of Chinese medicine were prescribed, to be decocted separately, two doses every three days, twice daily, one packet (150ml) each time, taken warm half an hour after meals.

[0081] The patient took traditional Chinese medicine orally for one month. Post-treatment and follow-up visual acuity are shown in Table 3. OCTA blood flow was as follows... Figure 4 .

[0082] Case 5 (Red Eyes): Mr. Tang, male, 29 years old. Chief complaint: Blurred vision one month after posterior scleral reinforcement surgery on the right eye. The patient underwent posterior scleral reinforcement surgery at our hospital one month ago and is now seeking traditional Chinese medicine rehabilitation treatment to improve his vision. Current symptoms: Blurred vision, red eyes, occasional soreness and weakness in the lower back and knees, dark red tongue without ecchymosis, thin coating, and thready pulse. The diagnosis is liver and kidney deficiency with blood stasis in the eye meridians. He was prescribed the basic formula of the kidney-tonifying and blood-activating Chinese herbal composition of this invention, with the addition of 15g each of mulberry bark, scutellaria, and peony bark. Specialist examination: Conjunctival hyperemia in the right eye, transparent cornea, transparent lens, and fundus examination showing high myopia changes. Visual acuity: Right eye 0.6; Left eye visual acuity 0.8.

[0083] The prescription is as follows: Cuscuta chinensis 10g, Broussonetia papyrifera 15g, Lycium barbarum 18g, Leonurus japonicus 15g, Leonurus japonicus 20g, Ligusticum chuanxiong 10g, Prunus persica 9g, Carthamus tinctorius 6g, Poria cocos 15g, Albizia julibrissin bark 18g, Astragalus membranaceus 12g, Pueraria lobata 12g, Morus alba root bark 15g, Scutellaria baicalensis 15g, Paeonia suffruticosa root bark 15g.

[0084] Take 10 doses of Chinese medicine, decocted by the decocting agent. Take two doses every three days, twice a day, one packet (150ml) each time, half an hour after meals.

[0085] Second visit: The patient reported clearer vision than before, but experienced recurring red eyes after eating hot pot, occasional lower back and knee weakness, a slightly dark tongue with little coating, and a thready, hesitant pulse. The diagnosis remained unchanged, and the basic formula was continued with the addition of mulberry bark, scutellaria, and peony bark: Cuscuta seed 10g, Broussonetia fruit 15g, Lycium fruit 18g, Leonurus seed 15g, Motherwort 20g, Ligusticum chuanxiong 10g, Peach kernel 9g, Safflower 6g, Poria cocos 15g, Albizia bark 18g, Astragalus 12g, Pueraria root 12g, Mulberry bark 15g, Scutellaria baicalensis 15g, Peony bark 15g. Ten doses of the herbal medicine were prescribed, to be decocted, two doses every three days, twice a day, one packet (150ml) each time, taken warm half an hour after meals.

[0086] The patient took traditional Chinese medicine orally for one month. Post-treatment and follow-up visual acuity are shown in Table 3. OCTA blood flow was as follows... Figure 5 As shown.

[0087] Table 3 Best Corrected Visual Acuity

[0088]

[0089] Table 3 shows that with the traditional Chinese medicine treatment of this invention, postoperative corrected visual acuity was significantly improved, and at the same time... Figures 1-5 It can be seen that retinal blood flow significantly increased, and retinal microcirculation gradually improved. Furthermore, no rejection reaction caused by the surgery itself was observed during the treatment period. The overall regulatory effect of traditional Chinese medicine one month post-surgery promoted postoperative visual function recovery, increased retinal blood flow circulation, and reduced the occurrence of rejection reactions.

[0090] The technical solutions provided by the embodiments of the present invention have been described in detail above. Specific examples have been used to illustrate the principles and implementation methods of the embodiments of the present invention. The descriptions of the embodiments above are only for helping to understand the principles of the embodiments of the present invention. At the same time, for those skilled in the art, there will be changes in the specific implementation methods and application scope based on the embodiments of the present invention. Therefore, the content of this specification should not be construed as a limitation of the present invention.

Claims

1. A kidney-tonifying and blood-activating traditional Chinese medicine composition, characterized in that, It is made from the following raw materials in parts by weight: 10 parts Cuscuta chinensis, 15 parts Broussonetia papyrifera, 18 parts Lycium barbarum, 15 parts Leonurus japonicus, 20 parts Leonurus japonicus, 10 parts Ligusticum chuanxiong, 9 parts Prunus persica, 6 parts Carthamus tinctorius, 15 parts Poria cocos, 18 parts Albizia julibrissin bark, 12 parts Astragalus membranaceus, and 12 parts Pueraria lobata.

2. The kidney-tonifying and blood-activating traditional Chinese medicine composition according to claim 1, characterized in that, It also contains 30 portions of Polygonum multiflorum vine.

3. The kidney-tonifying and blood-activating traditional Chinese medicine composition according to claim 1, characterized in that, It also contains 25 servings of oysters.

4. The kidney-tonifying and blood-activating traditional Chinese medicine composition according to claim 1, characterized in that, It also contains 20 portions of Dendrobium.

5. The kidney-tonifying and blood-activating traditional Chinese medicine composition according to claim 1, characterized in that, It also contains 15 portions of cassia seeds.

6. The kidney-tonifying and blood-activating traditional Chinese medicine composition according to claim 1, characterized in that, It also contains 10 parts Bupleurum and / or 10 parts Curcuma.

7. The kidney-tonifying and blood-activating traditional Chinese medicine composition according to claim 1, characterized in that, It also contains at least one of the following: 15 parts mulberry bark, 15 parts scutellaria barbata, and 15 parts peony bark.

8. The kidney-tonifying and blood-activating traditional Chinese medicine composition according to claim 1, characterized in that, It also contains 12 parts of Phellodendron bark and / or 15 parts of Eupatorium fortunei.

9. The use of a kidney-tonifying and blood-activating traditional Chinese medicine composition according to any one of claims 1-8 in the preparation of a medicament for improving visual function after scleral reinforcement surgery for high myopia macular degeneration.

10. The application according to claim 9, characterized in that, The medication is administered at least one month after posterior scleral reinforcement surgery.

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