A traditional Chinese medicine composition for treating chronic tonsillitis at high altitude

Abstract

The application discloses a traditional Chinese medicine composition for treating plateau chronic tonsillitis, which is composed of the following raw materials in parts by weight: chebula 2-20 parts, emblic 2-20 parts, figwort 2-30 parts, ophiopogon 2-30 parts, saffron 1-10 parts, burdock fruit 2-20 parts, platycodon 2-20 parts and raw licorice 1-20 parts. The application is targeted at the pathogenesis of 'deficiency in origin and excess in superficiality' of plateau chronic tonsillitis, is in line with the characteristics of plateau environment, treats the root and the branch at the same time, and compared with common traditional Chinese medicine prescriptions, can accurately relieve throat discomfort, reduce the recurrence rate, has stronger treatment pertinence and more accurate curative effect. The synergistic effect of the raw materials can not only supplement lung, spleen and kidney qi and yin, and enhance the body immunity, but also clear and eliminate evil toxin in the throat, accurately solve the core of the onset of plateau chronic tonsillitis, and has remarkable curative effect.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, and specifically relates to a traditional Chinese medicine composition for treating chronic tonsillitis in high-altitude areas. Background Technology

[0002] Chronic tonsillitis is a common otolaryngological disease characterized by symptoms such as red and swollen tonsils, yellowish-white purulent spots, dry throat, itchy throat, sore throat, or a foreign body sensation in the throat. It is more common in children and young adults. This disease is mostly caused by viral or bacterial infection or allergic reaction in the tonsillar crypts. In severe cases, it can induce complications such as acute nephritis, rheumatic heart disease, rheumatoid arthritis, and prolonged low-grade fever.

[0003] The harsh environment of high-altitude areas presents challenges to the body, such as large temperature differences between day and night, strong ultraviolet radiation, dryness, low oxygen, low pressure, and strong winds and sandstorms, making people more susceptible to chronic tonsillitis.

[0004] Chronic tonsillitis at high altitudes falls under the categories of "rough tonsillitis" and "chronic throat inflammation" in Traditional Chinese Medicine. The high-altitude environment easily leads to the invasion of external pathogens and depletion of vital energy, resulting in a condition of deficiency in the root and excess in the branch, with "deficiency of both Qi and Yin in the lungs, spleen, and kidneys" as the root cause and "wind, dryness, toxins, phlegm, and blood stasis" interacting in the throat as the branch cause. "Strong wind and sand" represent wind pathogens; "dryness" represents dryness pathogens; "large temperature differences between day and night" easily attract cold pathogens or cause imbalances in cold and heat; "strong ultraviolet radiation" represents "fire heat" or "toxic heat" pathogens. Wind is the leader of all diseases; combined with dryness, cold, and heat pathogens, it easily attacks the lung's defensive gates (throat and tonsils), leading to stagnation of Qi and blood, resulting in tonsillitis. The special climate of "low oxygen and low pressure" at high altitudes represents regionally specific turbid and toxic pathogens, which, combined with dryness, easily transform into "dryness toxins," directly invading the throat, causing malnourishment and recurrent swelling and pain. Furthermore, low oxygen and low pressure directly affect the lungs' function of governing qi and respiration, leading to lung qi deficiency and weakened defensive qi. Therefore, pathogenic factors are easily invaded and linger in the throat, resulting in chronic and persistent conditions. Prolonged dryness and low oxygen first deplete lung yin, subsequently affecting kidney yin. Insufficient lung and kidney yin fluids deprive the throat of nourishment, leading to upward flaring of deficient fire, scorching the throat, causing chronic redness and swelling of the tonsils, mild pain but dryness, a noticeable foreign body sensation, and recurrent attacks. In high-altitude environments, the spleen and stomach's digestive function declines, easily leading to spleen deficiency and dampness, which accumulates into phlegm. This phlegm combines with external dryness or internal deficient fire, congealing in the throat, causing tonsil swelling, sticky phlegm that is difficult to expectorate, and a lingering condition.

[0005] Currently, Western medicine commonly uses antibiotics such as amoxicillin-clavulanate potassium and pidotimod to treat chronic tonsillitis. However, long-term use of antibiotics easily leads to drug resistance and cannot fundamentally improve the depletion of the body's vital energy caused by the high-altitude environment. For those with recurrent attacks or respiratory problems, surgical removal of the tonsils is often performed, which is highly invasive and may affect the body's immune function, thus having certain limitations. Traditional Chinese medicine formulas are mostly designed for common chronic tonsillitis, without fully considering the effects of the special environment of low oxygen, dryness, and strong ultraviolet radiation at high altitudes on the body, nor are they specifically formulated to address the core pathogenesis of chronic tonsillitis at high altitudes, which is characterized by "deficiency of the root and excess of the branch," thus failing to meet the treatment needs of people in high-altitude areas. Therefore, this invention combines the pathogenesis of chronic tonsillitis at high altitudes with the principles of TCM syndrome differentiation and treatment to develop a highly targeted and effective TCM composition, filling a gap in existing technology.

[0006] The information disclosed in this background section is intended only to enhance the understanding of the overall background of the invention and should not be construed as an admission or in any way implying that the information constitutes prior art known to those skilled in the art. Summary of the Invention

[0007] The purpose of this invention is to provide a traditional Chinese medicine composition for treating chronic tonsillitis in high-altitude areas, thereby overcoming the defects in the prior art.

[0008] To achieve the above objectives, the present invention provides a traditional Chinese medicine composition for treating chronic tonsillitis in high-altitude areas, comprising the following raw materials in parts by weight: 2-20 parts of Terminalia chebula, 2-20 parts of Phyllanthus emblica, 2-30 parts of Scrophularia ningpoensis, 2-30 parts of Ophiopogon japonicus, 1-10 parts of Saffron, 2-20 parts of Arctium lappa, 2-20 parts of Platycodon grandiflorus, and 1-20 parts of Glycyrrhiza uralensis.

[0009] Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 5-18 parts of Terminalia chebula, 5-18 parts of Phyllanthus emblica, 5-25 parts of Scrophularia ningpoensis, 5-25 parts of Ophiopogon japonicus, 1.5-8 parts of Saffron, 5-18 parts of Arctium lappa, 5-18 parts of Platycodon grandiflorus, and 5-15 parts of Glycyrrhiza uralensis.

[0010] Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 8-15 parts of Terminalia chebula, 8-15 parts of Phyllanthus emblica, 7-20 parts of Scrophularia ningpoensis, 7-20 parts of Ophiopogon japonicus, 3-6 parts of Saffron, 8-15 parts of Arctium lappa, 8-15 parts of Platycodon grandiflorus, and 6-12 parts of Glycyrrhiza uralensis.

[0011] Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 9-14 parts of Terminalia chebula, 9-14 parts of Phyllanthus emblica, 10-18 parts of Scrophularia ningpoensis, 10-18 parts of Ophiopogon japonicus, 3.5-5 parts of Saffron, 9-14 parts of Arctium lappa, 9-14 parts of Platycodon grandiflorus, and 7-10 parts of Glycyrrhiza uralensis.

[0012] Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 9 parts Terminalia chebula, 9 parts Phyllanthus emblica, 12 parts Scrophularia ningpoensis, 12 parts Ophiopogon japonicus, 1.5 parts Saffron, 9 parts Arctium lappa, 9 parts Platycodon grandiflorus, and 6 parts Glycyrrhiza uralensis.

[0013] Preferably, the traditional Chinese medicine composition is prepared by the following method: Mix all ingredients evenly according to the specified ratio, add boiling water and steep for 10-120 minutes to obtain the drinking preparation.

[0014] Alternatively, mix all the ingredients evenly according to the ratio, soak in cold water for 20-40 minutes, bring to a boil over high heat, and then simmer over low heat for 20-30 minutes to obtain the decoction preparation.

[0015] Preferably, the traditional Chinese medicine composition is used to treat chronic tonsillitis at high altitudes.

[0016] The traditional Chinese medicine composition of this invention is based on the principle of "combining syndrome differentiation with disease differentiation" in traditional Chinese medicine. It combines the core pathogenesis of chronic tonsillitis in high-altitude areas, which is "deficiency of both lung, spleen and kidney qi and yin as the root cause, and wind, dryness, toxin, phlegm and blood stasis as the symptoms," and makes targeted combinations. The ingredients work synergistically to take into account both strengthening the body's resistance and eliminating pathogens, so as to achieve the same treatment for both the root cause and the symptoms.

[0017] The properties, flavors, meridian tropisms, and effects of each ingredient are as follows (all are officially named using traditional Chinese medicine names to ensure that those skilled in the art can clearly identify each ingredient): Terminalia chebula: It tastes bitter, sour, astringent, and neutral, and enters the lung and large intestine meridians.

[0018] Phyllanthus emblica: It has a sweet and astringent taste and enters the lung meridian.

[0019] Scrophularia: It tastes bitter, sweet, and salty, and is cold in nature. It enters the lung, stomach, and kidney meridians.

[0020] Ophiopogon japonicus: sweet, slightly bitter, cold and neutral in nature, enters the heart, lung and stomach meridians.

[0021] Saffron: It has a sweet taste and is slightly cold in nature. It enters the heart and liver meridians.

[0022] Burdock seed: pungent and bitter in taste, slightly cold in nature. It enters the lung and stomach meridians.

[0023] Platycodon grandiflorus: It has a pungent and bitter taste, is neutral in nature, and enters the lung meridian.

[0024] Raw licorice root: sweet in taste, neutral in nature, and enters the heart, lung, spleen, and stomach meridians.

[0025] The formula contains Terminalia chebula, which astringes and reduces heat, promotes saliva production, and soothes the throat, making it a key herb for treating chronic pharyngitis. Phyllanthus emblica clears heat, cools the blood, nourishes yin, promotes saliva production, and moistens the throat to stop coughing. Together, they form the principal herbs, one astringing and the other moistening, addressing both the root cause and the symptoms, specifically treating throat discomfort caused by yin deficiency and dryness at high altitudes. Scrophularia ningpoensis nourishes yin, reduces heat, detoxifies, and disperses nodules. It not only nourishes kidney yin and clears deficiency heat, but also softens and disperses nodules in the tonsils, directly treating chronically enlarged tonsils. Ophiopogon japonicus nourishes yin, moistens the lungs, benefits the stomach, promotes saliva production, clears the heart, and relieves irritability, directly alleviating dry throat and tongue. These two herbs assist the principal herbs in strengthening their yin-nourishing, dryness-moistening, and deficiency-heat-clearing effects, providing crucial support for the formula's "root-cause treatment." Saffron invigorates blood, removes blood stasis, cools the blood, detoxifies, and disperses stagnation and nodules. Chronic inflammation often involves local blood and qi stagnation. Saffron can improve local microcirculation in the throat, helping to dissipate tonsil swelling. Its cooling and detoxifying properties can also clear away latent heat, and its mild effects are unlikely to harm the body's vital energy. Burdock seed disperses wind-heat, promotes lung function and rash eruption, and detoxifies and soothes the throat. These two herbs serve as adjuvants, addressing the issues of "uncleared toxins" and "blood and qi stagnation." Platycodon grandiflorus promotes lung function and soothes the throat, eliminates phlegm and drains pus, and carries the medicine upwards. Licorice clears heat and detoxifies, eliminates phlegm and stops cough, relieves spasms and pain, and harmonizes the other herbs, serving as the guiding herb. This formula uses Tibetan herbs "Terminalia chebula and Phyllanthus emblica" combined with Chinese herbs "Scrophularia ningpoensis and Ophiopogon japonicus" to nourish the yin of the lungs and kidneys and astringe deficient fire to treat the root cause; "saffron and burdock seed" to invigorate blood, disperse stagnation, and clear away latent toxins to treat the symptoms; and "Platycodon grandiflorus and licorice" to soothe the throat, relieve pain, and carry the medicine upwards as guiding herbs. The formula is nourishing without being greasy, clearing without being cold, and dispersing nodules without harming the body's vital energy. It is an excellent formulation approach for the Yin deficiency and fire excess syndrome of chronic tonsillitis in high-altitude areas.

[0026] Compared with the prior art, one aspect of the present invention has the following beneficial effects: (1) This invention targets the pathogenesis of chronic tonsillitis in high-altitude areas, which is characterized by "deficiency of the root and excess of the branch". It is tailored to the characteristics of the high-altitude environment and treats both the root and the branch. Compared with ordinary Chinese medicine prescriptions, it can accurately relieve throat discomfort, reduce the recurrence rate of the disease, and has a more targeted treatment and more definite curative effect. The synergistic effect of each ingredient can not only nourish the lung, spleen and kidney qi and yin and enhance the body's immunity, but also clear away the pathogenic toxins in the throat, accurately crack the core of the pathogenesis of chronic tonsillitis in high-altitude areas, and has a significant curative effect. (2) This invention takes into account both local treatment and overall conditioning, invigorates qi and nourishes yin, strengthens the body's resistance and consolidates the foundation, improves the body's adaptability to the plateau environment, enhances immunity, reduces the invasion of pathogenic factors from the root, and reduces the risk of complications; compared with Western medicine antibiotics, there is no risk of drug resistance; no need to surgically remove tonsils, avoids trauma and immune effects, achieves "treating the root cause of the disease", and better protects the health of people in plateau areas; (3) This invention avoids the drawbacks of antibiotic resistance and bacterial imbalance in Western medicine, as well as the problems of large surgical trauma and impact on immunity, and solves the core limitations of existing Western medicine treatment; it uses pure natural Chinese medicine, which is mild, has few side effects, no drug resistance, is suitable for long-term conditioning, and is applicable to a wide range of people, especially those in high-altitude areas. (4) This invention can be prepared by boiling water or conventional decoction, without the need for complicated equipment, and is easy to operate. It is suitable for high-altitude families, primary healthcare and field operations, and is easy to promote and use. (5) This invention fills the gap in the treatment of chronic tonsillitis in high-altitude areas with traditional Chinese medicine, and specifically solves the problem of insufficient compatibility of existing drugs, meeting the treatment needs of high-altitude populations; the raw materials are readily available and the cost is low, and it has both clinical treatment and body conditioning value, making it suitable for large-scale production and promotion, and providing safe and convenient treatment options for high-altitude populations. Attached Figure Description

[0027] Figure 1 The diagram shows the effects of the treatment group and the waiting group of the present invention. Detailed Implementation

[0028] The specific embodiments of the present invention will be described in detail below, but it should be understood that the scope of protection of the present invention is not limited to the specific embodiments.

[0029] The following provides a brief overview of one or more aspects to offer a basic understanding of them. This overview is not an exhaustive summary of all conceived aspects, nor is it intended to identify key or decisive elements of all aspects, nor to define the scope of any or all aspects. Its sole purpose is to present some concepts of one or more aspects in a simplified form to prepare for the more detailed descriptions that follow. Example 1:

[0030] Weigh out the following ingredients: 2g Terminalia chebula, 2g Phyllanthus emblica, 2g Scrophularia ningpoensis, 2g Ophiopogon japonicus, 1g Saffron, 2g Arctium lappa, 2g Platycodon grandiflorus, and 1g Glycyrrhiza uralensis. Mix them evenly and steep in boiling water for 10 minutes before drinking. Example 2

[0031] Weigh out the following ingredients: 2g Terminalia chebula, 5g Phyllanthus emblica, 2g Scrophularia ningpoensis, 5g Ophiopogon japonicus, 1.5g Saffron, 5g Arctium lappa, 6g Platycodon grandiflorus, and 5g Glycyrrhiza uralensis. Mix them evenly and steep in boiling water for 11 minutes before drinking. Example 3

[0032] Weigh out the following ingredients: 10g Terminalia chebula, 10g Phyllanthus emblica, 15g Scrophularia ningpoensis, 5g Ophiopogon japonicus, 3g Saffron, 10g Arctium lappa, 10g Platycodon grandiflorus, and 10g Glycyrrhiza uralensis. Mix them evenly and steep in boiling water for 12 minutes before drinking. Example 4

[0033] Weigh out the following ingredients: 17g Terminalia chebula, 17g Phyllanthus emblica, 15g Scrophularia ningpoensis, 15g Ophiopogon japonicus, 1.6g Saffron, 18g Arctium lappa, 15g Platycodon grandiflorus, and 8g Glycyrrhiza uralensis. Mix them evenly and steep in boiling water for 16 minutes before drinking. Example 5

[0034] Weigh out the following ingredients: 8g Terminalia chebula, 8g Phyllanthus emblica, 7g Scrophularia ningpoensis, 7g Ophiopogon japonicus, 3g Saffron, 8g Arctium lappa, 8g Platycodon grandiflorus, and 6g Glycyrrhiza uralensis. Mix them evenly and steep in boiling water for 18 minutes before drinking. Example 6

[0035] Weigh out the following ingredients: 15g Terminalia chebula, 15g Phyllanthus emblica, 20g Scrophularia ningpoensis, 20g Ophiopogon japonicus, 6g Saffron, 15g Arctium lappa, 15g Platycodon grandiflorus, and 12g Glycyrrhiza uralensis. Mix them evenly and steep in boiling water for 20 minutes before drinking. Example 7

[0036] Weigh out the following ingredients: 18g Terminalia chebula, 18g Phyllanthus emblica, 25g Scrophularia ningpoensis, 25g Ophiopogon japonicus, 8g Saffron, 18g Arctium lappa, 18g Platycodon grandiflorus, and 15g Glycyrrhiza uralensis. Mix them evenly and steep in boiling water for 20 minutes before drinking. Example 8

[0037] Weigh out the following ingredients: 9g of Terminalia chebula, 9g of Phyllanthus emblica, 10g of Scrophularia ningpoensis, 10g of Ophiopogon japonicus, 3.5g of Saffron, 9g of Arctium lappa, 9g of Platycodon grandiflorus, and 7g of Glycyrrhiza uralensis. Mix them evenly and steep in boiling water for 20 minutes before drinking. Example 9

[0038] Weigh out the following ingredients: 14g Terminalia chebula, 14g Phyllanthus emblica, 18g Scrophularia ningpoensis, 18g Ophiopogon japonicus, 5g Saffron, 14g Arctium lappa, 14g Platycodon grandiflorus, and 10g Glycyrrhiza uralensis. Mix them evenly and steep in boiling water for 19 minutes before drinking. Example 10

[0039] Weigh out the following ingredients: 13g Terminalia chebula, 13g Phyllanthus emblica, 18g Scrophularia ningpoensis, 18g Ophiopogon japonicus, 1.5g Saffron, 13g Arctium lappa, 13g Platycodon grandiflorus, and 10g Glycyrrhiza uralensis. Mix them evenly and steep in boiling water for 18 minutes before drinking. Example 11

[0040] Weigh out the following ingredients: 13g Terminalia chebula, 13g Phyllanthus emblica, 18g Scrophularia ningpoensis, 18g Ophiopogon japonicus, 1.5g Saffron, 13g Arctium lappa, 13g Platycodon grandiflorus, and 10g Glycyrrhiza uralensis. Mix them evenly and steep in boiling water for 18 minutes before drinking. Example 12

[0041] Weigh out the following ingredients: 16g Terminalia chebula, 16g Phyllanthus emblica, 20g Scrophularia ningpoensis, 20g Ophiopogon japonicus, 3.5g Saffron, 15g Arctium lappa, 15g Platycodon grandiflorus, and 10g Glycyrrhiza uralensis. Mix them evenly and steep in boiling water for 120 minutes before drinking. Example 13

[0042] Weigh out the following ingredients: 8g Terminalia chebula, 10g Phyllanthus emblica, 20g Scrophularia ningpoensis, 15g Ophiopogon japonicus, 3.5g Saffron, 12g Arctium lappa, 12g Platycodon grandiflorus, and 9g Glycyrrhiza uralensis. Mix them evenly and steep in boiling water for 17 minutes before drinking. Example 14

[0043] Weigh out the following ingredients: 13g Terminalia chebula, 15g Phyllanthus emblica, 22g Scrophularia ningpoensis, 23g Ophiopogon japonicus, 3g Saffron, 15g Arctium lappa, 15g Platycodon grandiflorus, and 12g Glycyrrhiza uralensis. Mix them evenly and steep in boiling water for 16 minutes before drinking. Example 15

[0044] Weigh out the following ingredients: 9g of Terminalia chebula, 9g of Phyllanthus emblica, 12g of Scrophularia ningpoensis, 12g of Ophiopogon japonicus, 1.5g of Saffron, 9g of Arctium lappa, 9g of Platycodon grandiflorus, and 6g of Glycyrrhiza uralensis. Mix them evenly and steep in boiling water for 10 minutes before drinking.

[0045] 1. Experimental Method: 1.1 Cases and Grouping According to relevant diagnostic, inclusion, and exclusion criteria, 60 patients diagnosed with high-altitude chronic tonsillitis between July 1, 2025 and November 20, 2025 were included. Patients were aged 18-45 years and of any gender. They were randomly divided into a treatment group (n=30) and a waiting-for-treatment group (n=30) based on their consultation time (numbered 1-60). The treatment group received the traditional Chinese medicine composition obtained in Example 15, one dose per day, soaked in cold water for 30 minutes, brought to a boil over high heat, then simmered over low heat for 20-25 minutes, yielding 300-400ml of the decoction, taken warm in three divided doses (half an hour after meals) for 14 consecutive days. The waiting-for-treatment group received the traditional Chinese medicine composition obtained in Example 15 14 days after enrollment, with the same usage.

[0046] 1.2 Diagnostic Criteria 1.2.1 Western Medicine Diagnostic Criteria Refer to the diagnostic criteria for chronic tonsillitis in "Otorhinolaryngology Head and Neck Surgery".

[0047] (1) Clinical manifestations include dryness, itching, foreign body sensation in the throat, irritating cough and other discomforts, and some patients may have sore throat. There is also a history of recurrent acute tonsillitis; (2) The tonsils and palatoglossal arch are chronically congested, and the mucosa is dark red. When the palatoglossal arch is squeezed with a tongue depressor, yellowish-white cheesy punctate material can sometimes be seen oozing from the crypt opening.

[0048] 1.2.2 Traditional Chinese Medicine Diagnostic Criteria Referring to the "Standards for Diagnosis and Efficacy of Diseases and Syndromes in Traditional Chinese Medicine" issued by the State Administration of Traditional Chinese Medicine and the "Guiding Principles for Clinical Research of New Traditional Chinese Medicines" (2002 edition) issued by the Ministry of Health of the People's Republic of China, and considering the characteristics of chronic tonsillitis in high-altitude areas, the following guidelines are proposed: (1) Main symptoms: dry throat, burning, slight pain, slight itching, dry cough with little or no phlegm and sticky phlegm, red and swollen tonsils, etc. (2) Concurrent symptoms: Patients often experience symptoms such as irritability, hot flashes, night sweats, and constipation; (3) Tongue and pulse: Red tongue, thready and rapid pulse; (4) The onset of the disease is without obvious external symptoms; A diagnosis can be established by observing at least two of the primary and secondary symptoms, along with the tongue and pulse.

[0049] 1.3 Inclusion Criteria (1) Meets the above diagnostic criteria and is able to cooperate with the research and treatment of patients; (2) Age 18-45, gender not limited; (3) The patient has not received any medications or external treatments for chronic tonsillitis in the past week; (4) The subjects voluntarily participate in the clinical trial and sign an informed consent form; (5) Residing in a high-altitude area for more than one month.

[0050] 1.4 Exclusion Criteria (1) Those who do not meet the diagnostic criteria of Western medicine and the diagnostic criteria of traditional Chinese medicine syndromes; (2) Medication for treating chronic tonsillitis has been used within the past week; (3) Pregnant or lactating women; (4) Individuals allergic to this drug; (5) Patients with concurrent respiratory diseases such as bronchitis, pneumonia, severe laryngitis, or other primary diseases; 1.5. Shedding Criteria (1) Severe adverse reactions, allergies, etc. occur; (2) Those who fail to take medication as prescribed; (3) Cases that withdrew from the experiment before the course of treatment was completed or lost to follow-up for various other reasons; (4) Patients whose condition deteriorates rapidly and who urgently need to receive other treatments.

[0051] The reasons for the dropout of cases are not included in the statistical data.

[0052] 1.6 Observation Indicators 1.6.1 Safety Indicators If any adverse events occur during the experiment, record in detail the time of occurrence, clinical symptoms and signs, duration, severity, effective measures taken and outcome, as well as the liver and kidney function of the two groups of patients.

[0053] Table 1: Safety Evaluation Standards 1.6.2. Therapeutic Indicators (1) TCM Symptom and Sign Scoring: The symptoms and signs were scored according to the TCM Otorhinolaryngology textbook. Symptoms included dry throat and sore throat, cough and phlegm, foreign body sensation in the throat, and snoring during sleep. Signs included tonsil size and tonsil secretion. The scores were 0, 2, 4, and 6 points respectively based on the severity.

[0054] (2) Laboratory indicators: Fasting venous blood was drawn before and after treatment to detect the levels of serum inflammatory factors TNF-α, IFN-γ and IL-4 protein.

[0055] (3) Efficacy criteria: Refer to the relevant criteria in the "Standards for Diagnosis and Efficacy of Diseases and Syndromes in Traditional Chinese Medicine"; record the symptom and sign scores before and after treatment, and calculate the total effective rate of each group; Significant effect: Most tonsil symptoms, size, and secretions are relieved, and the score reduction rate is ≥67%; Effective: Tonsil symptoms, size, and secretions are partially relieved, and the score reduction rate is ≥33% and <67%; Ineffective: Tonsil symptoms, size, and secretions are not significantly relieved, and the score reduction rate is ≤33%.

[0056] 1.7 Statistical Analysis After the experiment, data were entered, a database was constructed, and statistical analysis was performed using SPSS 26.0. Independent samples t-test was used between groups, and paired samples t-test was used within groups. Chip 2 test was used for count data. P < 0.05 was used to indicate that the difference between the two groups was statistically significant.

[0057] 2. Research Results 2.1 Safety Evaluation As shown in Table 2, no adverse reactions occurred in either group during this experiment, and no abnormalities were observed in liver and kidney function.

[0058] Table 2: Safety Evaluation of the Two Groups 2.2 Evaluation of therapeutic effect Before enrollment, there were no significant differences between the treatment group and the waiting-for-treatment group in symptoms and signs such as dry throat, sore throat, foreign body sensation in the throat, cough and sputum, snoring during sleep, tonsil size, and tonsil secretions, as well as in the expression levels of serum inflammatory factors TNF-α, IFN-γ, and IL-4 proteins (p>0.05). After 14 days of enrollment, patients in the treatment group showed significant improvement in symptoms and signs such as dry throat, sore throat, foreign body sensation in the throat, cough and sputum, tonsil size, and tonsil secretions compared to the waiting-for-treatment group (p<0.05), as shown in Table 3. Figure 1As shown in Table 4, the levels of TNF-α and IL-4 proteins were significantly decreased, while the level of IFN-γ protein was significantly increased (p < 0.05); the clinical efficacy is shown in Table 5.

[0059] Table 3 Comparison of symptom and sign scores between the two groups ( ) Note: **** P < 0.0001, ** P < 0.01, * P < 0.05, compared with pre-admission values ​​in this group; #### P < 0.0001, ### P < 0.001, ## P < 0.01, # P < 0.05, compared with the waiting-for-treatment group at the same time point. Table 4 Comparison of TNF-α, IFN-γ, and IL-4 protein levels between the two groups Note: **** P < 0.0001, ** P < 0.01, compared with pre-admission values ​​in this group; #### P < 0.0001, compared with the waiting-for-treatment group at the same time point. Table 5. Comparison of clinical efficacy between the two groups 14 days after enrollment (cases) Note: * P < 0.05, compared with the waiting treatment group The foregoing description of specific exemplary embodiments of the invention is for illustrative and explanatory purposes. These descriptions are not intended to limit the invention to the precise forms disclosed, and it will be apparent that many changes and variations can be made in accordance with the foregoing teachings. The exemplary embodiments were chosen and described in order to explain the specific principles of the invention and its practical application, thereby enabling those skilled in the art to implement and utilize various different exemplary embodiments of the invention, as well as various different choices and variations. The scope of the invention is intended to be defined by the claims and their equivalents.

Claims

1. A traditional Chinese medicine composition for treating chronic tonsillitis at high altitudes, characterized in that, It is composed of the following ingredients in parts by weight: Terminalia chebula 2-20 parts, Phyllanthus emblica 2-20 parts, Scrophularia ningpoensis 2-30 parts, Ophiopogon japonicus 2-30 parts, Saffron 1-10 parts, Arctium lappa 2-20 parts, Platycodon grandiflorus 2-20 parts, and Glycyrrhiza uralensis 1-20 parts.

2. The traditional Chinese medicine composition for treating chronic tonsillitis at high altitudes according to claim 1, characterized in that, It is composed of the following ingredients in parts by weight: Terminalia chebula 5-18 parts, Phyllanthus emblica 5-18 parts, Scrophularia ningpoensis 5-25 parts, Ophiopogon japonicus 5-25 parts, Saffron 1.5-8 parts, Arctium lappa 5-18 parts, Platycodon grandiflorus 5-18 parts, and Glycyrrhiza uralensis 5-15 parts.

3. The traditional Chinese medicine composition for treating chronic tonsillitis at high altitudes according to claim 1, characterized in that, It is composed of the following ingredients in parts by weight: 8-15 parts Terminalia chebula, 8-15 parts Phyllanthus emblica, 7-20 parts Scrophularia ningpoensis, 7-20 parts Ophiopogon japonicus, 3-6 parts Saffron, 8-15 parts Arctium lappa, 8-15 parts Platycodon grandiflorus, and 6-12 parts Glycyrrhiza uralensis.

4. The traditional Chinese medicine composition for treating chronic tonsillitis at high altitudes according to claim 1, characterized in that, It is composed of the following ingredients in parts by weight: Terminalia chebula 9-14 parts, Phyllanthus emblica 9-14 parts, Scrophularia ningpoensis 10-18 parts, Ophiopogon japonicus 10-18 parts, Saffron 3.5-5 parts, Arctium lappa 9-14 parts, Platycodon grandiflorus 9-14 parts, and Glycyrrhiza uralensis 7-10 parts.

5. The traditional Chinese medicine composition for treating chronic tonsillitis at high altitudes according to claim 1, characterized in that, It is composed of the following ingredients by weight: 9 parts Terminalia chebula, 9 parts Phyllanthus emblica, 12 parts Scrophularia ningpoensis, 12 parts Ophiopogon japonicus, 1.5 parts Saffron, 9 parts Arctium lappa, 9 parts Platycodon grandiflorus, and 6 parts Glycyrrhiza uralensis.

6. A traditional Chinese medicine composition for treating chronic tonsillitis at high altitudes according to any one of claims 1-5, characterized in that, The preparation method of the traditional Chinese medicine composition is as follows: Mix all ingredients evenly according to the specified ratio, add boiling water and steep for 10-120 minutes to obtain the drinking preparation.

7. A traditional Chinese medicine composition for treating chronic tonsillitis at high altitudes according to any one of claims 1-5, characterized in that, The preparation method of the traditional Chinese medicine composition is as follows: Mix all ingredients evenly according to the ratio, soak in cold water for 20-40 minutes, bring to a boil over high heat, then simmer over low heat for 20-30 minutes to obtain the decoction preparation.

8. A traditional Chinese medicine composition for treating chronic tonsillitis at high altitudes according to any one of claims 1-5, characterized in that, The traditional Chinese medicine composition is used to treat chronic tonsillitis in high-altitude areas.

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