Fermented traditional chinese medicine powder for women and preparation method thereof

Abstract

This invention provides a fermented traditional Chinese medicine powder for women, which is related to the field of pharmaceutical technology. Based on dry weight, it is composed of the following raw materials: Astragalus membranaceus 15 parts, Citrus aurantium 9 parts, Polygonatum odoratum 9 parts, Angelica dahurica 6 parts, Longan aril 12 parts, Lilium brownii 6 parts, Lycium barbarum 12 parts, Poria cocos 9 parts, Nelumbo nucifera 9 parts, Lophatherum gracile 6 parts, Polygonatum sibiricum 15 parts, Morus alba 15 parts, Pueraria lobata 9 parts, Ziziphus jujuba var. spinosa 6 parts, Angelica sinensis 9 parts, Ganoderma lucidum 15 parts, and Ziziphus jujuba 9 parts. The powder is produced through solid-state fermentation with compound probiotics, low-temperature drying, ultra-fine pulverization, and irradiation sterilization. The fermented Chinese herbal powder for women, which is a formula for replenishing qi and blood, provided by this invention, solves the problems of poor targeting and insufficient precision in conditioning of existing tonifying medicines for women's physiological characteristics. It can effectively improve the sub-health state of women caused by insufficient qi and blood, deficiency of yin fluids, and restlessness, such as insomnia, dreaminess, sallow complexion, dull skin, fatigue, dizziness, and palpitations.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical technology, and in particular to a fermented traditional Chinese medicine powder for women that invigorates qi and nourishes blood, and its preparation method. Background Technology

[0002] With the fast pace of modern life, increased work pressure, and irregular eating habits such as staying up late, women experience more frequent depletion of Qi and blood due to their special physiological cycles such as menstruation, pregnancy, childbirth, and lactation. This makes them prone to sub-health conditions such as insufficient Qi and blood, deficiency of Yin fluids, and restlessness. Clinical manifestations include a sallow or pale complexion, fatigue, dizziness, palpitations, insomnia, dull skin, and irregular menstruation. Long-term effects can impact endocrine status and quality of life. Therefore, replenishing Qi and blood, nourishing Yin and calming the mind, and beautifying the complexion and soothing the heart have become core needs for daily health maintenance for modern women.

[0003] Traditional Chinese medicine (TCM) compositions that are both food and medicine are widely used in the fields of regulating qi and blood and enhancing immunity due to their high safety and suitability for long-term use. Existing technologies include publicly available TCM compound formulas for enhancing immunity and replenishing qi and blood. For example, CN118557676B discloses a TCM composition with immune-enhancing effects and its preparation method. This composition is composed of multiple medicinal materials such as Astragalus membranaceus, ginseng, Codonopsis pilosula, Angelica sinensis, longan pulp, Cistanche deserticola, Eucommia ulmoides leaf, Polygonatum sibiricum, Lycium barbarum, mulberry, Poria cocos, and Dioscorea opposita, and is prepared through water extraction, concentration, and drying. It can be used to strengthen the body's resistance, replenish qi and blood, and enhance immunity.

[0004] However, this composition is a general immune-enhancing formula. Although it can achieve the effects of replenishing qi and blood and strengthening the body to a certain extent, it is not designed to take into account the special physiological characteristics of women during menstruation, pregnancy, childbirth and lactation. Therefore, it lacks precision in regulating typical problems such as qi and blood deficiency, insomnia and dreaminess, sallow complexion and dull skin in women, and is not very targeted. Summary of the Invention

[0005] To address the aforementioned problems, this invention provides a fermented traditional Chinese medicine powder for women to replenish qi and blood, and its preparation method, which can improve women's qi and blood deficiency, insomnia, excessive dreaming, sallow complexion, and dull skin.

[0006] To achieve the above objectives, the technical solution adopted by the present invention is as follows: This invention provides a fermented traditional Chinese medicine powder for women, containing qi and blood to invigorate and nourish the body. Based on dry weight, it comprises the following raw materials: Astragalus membranaceus 15 parts, Citrus aurantium 9 parts, Polygonatum odoratum 9 parts, Angelica dahurica 6 parts, Longan aril 12 parts, Lilium brownii 6 parts, Lycium barbarum 12 parts, Poria cocos 9 parts, Nelumbo nucifera 9 parts, Lophatherum gracile 6 parts, Polygonatum sibiricum 15 parts, Morus alba 15 parts, Pueraria lobata 9 parts, Ziziphus jujuba var. spinosa 6 parts, Angelica sinensis 9 parts, Ganoderma lucidum 15 parts, and Ziziphus jujuba 9 parts. The powder is prepared through solid-state fermentation with compound probiotics, low-temperature drying, ultra-fine pulverization, and irradiation sterilization.

[0007] The present invention provides a method for preparing a fermented Chinese herbal powder for women to replenish qi and blood, comprising the following steps: S1: preparing and inspecting the following materials: Astragalus membranaceus, Citrus aurantium, Polygonatum odoratum, Angelica dahurica, Longan pulp, Lilium brownii, Lycium barbarum, Poria cocos, Nelumbo nucifera, Lophatherum gracile, Polygonatum sibiricum, Morus alba, Pueraria lobata, Ziziphus jujuba var. spinosa, Angelica sinensis, Ganoderma lucidum, and Jujube, and removing impurities, insect damage, mold and non-medicinal parts; S2: Astragalus membranaceus is stir-fried with 25% honey at 100-110℃ for 8-10 minutes; Angelica sinensis is stir-fried with 10% rice wine over low heat; Polygonatum sibiricum is steamed at 100℃ until thoroughly cooked, then sliced ​​and dried; Ziziphus jujuba var. spinosa is stir-fried at 100-110℃ until it puffs up and makes popping sounds; Jujubes are pitted and cut into pieces; the remaining materials are cleaned and dried; the moisture content of all materials is controlled to ≤12.0%; S3: Weigh and mix all the materials obtained in step S2 according to the proportion, coarsely grind them to 20 mesh, and ensure that the mixing uniformity RSD is ≤5%; S4: Adjust the pulverized material obtained in step S3 to achieve a moisture content of 38%~42%, and inoculate it with compound probiotics at 3% of the raw material dry basis. Ferment for 5 days at 30±2℃ and 75%±5% humidity, turning the material twice a day. The fermentation endpoint is when the mycelium is white, has a medicinal and wine aroma, pH 5.0~6.0, and no mold growth. S5: Dry the fermented material obtained in step S4 at ≤60℃ until the moisture content is ≤9.0%; S6: The material obtained in step S5 is ultra-finely pulverized to a particle size D90≤45μm,≥300 mesh; S7: The ultrafine powder is sterilized by cobalt-60 irradiation after mixing, with an irradiation dose of 10 kGy.

[0008] The above technical solution has the following advantages or beneficial effects: This invention provides a fermented traditional Chinese medicine powder for women, which is related to the field of pharmaceutical technology. Based on dry weight, it is composed of the following raw materials: Astragalus membranaceus 15 parts, Citrus aurantium 9 parts, Polygonatum odoratum 9 parts, Angelica dahurica 6 parts, Longan aril 12 parts, Lilium brownii 6 parts, Lycium barbarum 12 parts, Poria cocos 9 parts, Nelumbo nucifera 9 parts, Lophatherum gracile 6 parts, Polygonatum sibiricum 15 parts, Morus alba 15 parts, Pueraria lobata 9 parts, Ziziphus jujuba var. spinosa 6 parts, Angelica sinensis 9 parts, Ganoderma lucidum 15 parts, and Ziziphus jujuba 9 parts. The powder is produced through solid-state fermentation with compound probiotics, low-temperature drying, ultra-fine pulverization, and irradiation sterilization. The fermented Chinese herbal powder for women, which is a formula for replenishing qi and blood, provided by this invention, solves the problems of poor targeting and insufficient precision in conditioning of existing tonifying medicines for women's physiological characteristics. It can effectively improve the sub-health state of women caused by insufficient qi and blood, deficiency of yin fluids, and restlessness, such as insomnia, dreaminess, sallow complexion, dull skin, fatigue, dizziness, and palpitations. Attached Figure Description

[0009] The invention, its features, shape, and advantages will become more apparent from the following detailed description of non-limiting embodiments with reference to the accompanying drawings. Like reference numerals denote like parts throughout the drawings. The drawings are not intentionally drawn to scale; the focus is on illustrating the spirit of the invention.

[0010] Figure 1 This is a wireframe flowchart of the preparation method of fermented traditional Chinese medicine powder for women's qi-tonifying and blood-nourishing formula provided in Embodiment 2 of the present invention. Detailed Implementation

[0011] The present invention will be further described below with reference to the accompanying drawings and specific embodiments, but these are not intended to limit the scope of the invention. Example 1:

[0012] The fermented traditional Chinese medicine powder for women, provided in Example 1 of this invention, is composed of the following raw materials on a dry basis: 15 parts Astragalus membranaceus, 9 parts Citrus aurantium, 9 parts Polygonatum odoratum, 6 parts Angelica dahurica, 12 parts Longan aril, 6 parts Lilium brownii, 12 parts Lycium barbarum, 9 parts Poria cocos, 9 parts Nelumbo nucifera, 6 parts Lophatherum gracile, 15 parts Polygonatum sibiricum, 15 parts Morus alba, 9 parts Pueraria lobata, 6 parts Ziziphus jujuba var. spinosa, 9 parts Angelica sinensis, 15 parts Ganoderma lucidum, and 9 parts Ziziphus jujuba. The traditional Chinese medicine powder is prepared by solid-state fermentation with compound probiotics, low-temperature drying, ultra-fine pulverization, and irradiation sterilization.

[0013] The fermented traditional Chinese medicine powder for women, provided in Embodiment 1 of this invention, addresses the shortcomings of existing technologies (such as the traditional Chinese medicine composition and its preparation method disclosed in CN118557676B that enhances immune function) in terms of its poor targeting of women's physiological characteristics and insufficient precision in conditioning. This embodiment's formula follows the traditional Chinese medicine principles of invigorating qi and blood, nourishing yin and calming the mind, and promoting beauty and health. Based on the core combination of Astragalus membranaceus and Angelica sinensis for dual qi and blood tonification, it is supplemented with Polygonatum sibiricum, Polygonatum odoratum, mulberry, and wolfberry to nourish yin and blood, as well as to nourish the liver and kidneys. Simultaneously, it incorporates longan pulp, Ganoderma lucidum, and jujube seed to nourish the heart and calm the mind, improving sleep, thus forming a precise conditioning formula specifically designed for women's menstrual, pregnancy, childbirth, and lactation physiological characteristics. Astragalus and Angelica sinensis are the principal herbs. Astragalus greatly replenishes vital energy and strengthens the body's defenses, while Angelica sinensis nourishes and invigorates blood, regulates menstruation, and nourishes the body. Together, they achieve the goal of qi generating blood and blood carrying qi, fundamentally improving women's qi and blood deficiency. Polygonatum, Polygonatum odoratum, mulberry, wolfberry, longan pulp, and Ganoderma lucidum are the assistant herbs. Polygonatum odoratum replenishes qi and nourishes yin, strengthens the spleen and kidneys; Polygonatum odoratum nourishes yin and moistens dryness without being greasy; mulberry and wolfberry nourish the liver and kidneys, nourish blood and improve eyesight; longan pulp nourishes the heart and spleen, nourishes blood and calms the mind; and Ganoderma lucidum invigorates qi, calms the mind, and strengthens the body's foundation. Together, they enhance the effects of replenishing blood, nourishing yin, and calming the mind. The formula is composed of the following ingredients: Poria cocos and lotus seed strengthen the spleen and replenish qi, promoting the production of qi and blood, ensuring that the tonification is not stagnant; lily bulb and jujube seed nourish yin and clear heat, calm the mind and soothe the nerves, improving insomnia, excessive dreaming, and restlessness; bitter orange flower regulates qi and soothes the stomach, nourishes and moisturizes the skin; angelica dahurica dispels wind and moisturizes the skin, clearing away impurities; kudzu root clears heat and nourishes the skin, relieving discomfort; and light bamboo leaf clears the mind and relieves irritability, preventing excessive heat from tonification. The entire formula balances qi regulation, skin nourishment, and gentleness without causing dryness; jujube serves as the guiding ingredient, tonifying the middle jiao and replenishing qi, nourishing blood and calming the mind, harmonizing the other ingredients, ensuring that the entire formula is mild, gentle, and does not harm yin, and does not cause stagnation. For women with constitutions prone to qi and blood deficiency, yin deficiency, and mental disturbance, this formula is gentle and non-heating, suitable for modern women experiencing sub-health conditions such as sallow complexion, fatigue, dizziness, palpitations, insomnia, excessive dreaming, and dull skin due to late nights, high stress, and frequent qi and blood depletion. It can be used safely and long-term for conditioning. Example 2:

[0014] like Figure 1 As shown, a method for preparing a fermented traditional Chinese medicine powder for women, characterized by comprising the following steps: S1: Prepare 1500g of Astragalus membranaceus, 900g of Citrus aurantium, 900g of Polygonatum odoratum, 600g of Angelica dahurica, 1200g of longan pulp, 600g of lily bulb, 1200g of wolfberry, 900g of Poria cocos, 900g of lotus seed, 600g of Lophatherum gracile, 1500g of Polygonatum sibiricum, 1500g of mulberry, 900g of kudzu root, 600g of Ziziphus jujuba seed, 900g of Angelica sinensis, 1500g of Ganoderma lucidum, and 900g of jujube; and conduct inspection, removing impurities, insect-infested, moldy, and non-medicinal parts during inspection; S2: Add 25% by weight of refined honey to Astragalus membranaceus and stir-fry at 105℃ for 9 minutes; Add 10% Shaoxing wine to Angelica sinensis and stir-fry over low heat; After being steamed thoroughly at 100℃, Polygonatum sibiricum is sliced ​​and dried. Stir-fry the jujube seeds at 105℃ until they puff up and make popping sounds; remove the pits from the jujubes and cut them into pieces; All other materials are cleaned and dried; the moisture content of all materials is controlled to be ≤12.0%. S3: Weigh and mix all the materials obtained in step S2 according to the prescription amount, coarsely grind to 20 mesh, and ensure that the mixing uniformity RSD ≤ 5%; S4: Adjust the pulverized material obtained in step S3 to a moisture content of 40%, inoculate with compound probiotics at 3% dry basis of raw materials, and ferment for 5 days at 30℃ and 75% humidity, turning the material twice a day; the fermentation endpoint is when the mycelium is white, has a medicinal and wine aroma, pH 5.5, and no mold. S5: Dry the fermented material obtained in step S4 at 55°C until the moisture content is ≤9.0%; S6: Ultrafinely pulverize the material obtained in step S5 to a particle size D90≤45μm,≥300 mesh; S7: Mix the materials after ultra-fine pulverization in step S6, and sterilize them by cobalt-60 irradiation at a dose of 10 kGy to obtain fermented Chinese medicine powder for women's qi-tonifying and blood-nourishing formula.

[0015] After actual production is completed, the sterilized ultrafine powder of S7 needs to be transferred to a Class D clean area for repackaging into 5g / bag finished powder. The repackaging weight difference should be controlled within ±3%, and the heat sealing temperature should be controlled at 160~180℃. Inner and outer packaging are then performed to obtain the final product. The above preparation process requires process validation, cleaning validation, equipment validation, and environmental validation. Material balance must be tested for each batch of materials. When the material balance deviation is ≥5%, a comprehensive investigation and handling of the preparation process is required.

[0016] This embodiment optimizes the exclusive targeted formulation, scientifically combining ingredients based on the physical characteristics of women who are prone to qi and blood deficiency, yin deficiency, and mental disturbance. It eliminates unnecessary excipients and off-flavor herbs, ensuring precise formulation and specific effects. Simultaneously, it employs a proprietary Chinese medicine processing technique combined with a compound probiotic solid-state fermentation synergistic technology. All materials are uniformly cleaned, standardized, precisely mixed, and coarsely pulverized. Fermentation moisture content, temperature, humidity, and time are strictly controlled. Through probiotic metabolism, the coarse fiber and macromolecular components of the herbs are decomposed, transforming poorly absorbed components into easily absorbed small-molecule active substances, significantly improving the dissolution rate of effective ingredients and human bioavailability, resulting in a more prominent conditioning effect. The fermentation process simultaneously degrades the bitterness and off-flavor of the raw materials, eliminating the need for sweeteners and flavoring agents, thus improving palatability. The final refining process, including low-temperature drying, ultra-fine pulverization, and cobalt-60 irradiation sterilization, produces a fine powder with good solubility, high uniformity, strong stability, and resistance to moisture absorption and deterioration. This approach balances scientific formulation, high absorption efficiency, convenient administration, and long-term safety. Compared with traditional Chinese medicine powders, ordinary tonic pastes, and herbal teas, this product has a faster onset of action, a gentler and longer-lasting effect, and a more targeted approach. It is especially suitable for modern women to use for long-term conditioning to address sub-health conditions such as fatigue, dizziness, palpitations, insomnia, sallow complexion, and dull skin caused by insufficient Qi and blood, Yin deficiency, and restlessness due to factors such as staying up late, high stress, and menstrual cycles.

[0017] In summary, the fermented traditional Chinese medicine powder for women, which is a formula for invigorating qi and nourishing blood, provided by this invention relates to the field of pharmaceutical technology. Based on dry weight, it is composed of the following raw materials: Astragalus membranaceus 15 parts, Citrus aurantium 9 parts, Polygonatum odoratum 9 parts, Angelica dahurica 6 parts, Longan aril 12 parts, Lilium brownii 6 parts, Lycium barbarum 12 parts, Poria cocos 9 parts, Nelumbo nucifera 9 parts, Lophatherum gracile 6 parts, Polygonatum sibiricum 15 parts, Morus alba 15 parts, Pueraria lobata 9 parts, Ziziphus jujuba var. spinosa 6 parts, Angelica sinensis 9 parts, Ganoderma lucidum 15 parts, and Ziziphus jujuba 9 parts. The powder is produced through solid-state fermentation with compound probiotics, low-temperature drying, ultra-fine pulverization, and irradiation sterilization. The fermented Chinese herbal powder for women, which is a formula for replenishing qi and blood, provided by this invention, solves the problems of poor targeting and insufficient precision in conditioning of existing tonifying medicines for women's physiological characteristics. It can effectively improve the sub-health state of women caused by insufficient qi and blood, deficiency of yin fluids, and restlessness, such as insomnia, dreaminess, sallow complexion, dull skin, fatigue, dizziness, and palpitations.

[0018] The preferred embodiments of the present invention have been described above. It should be understood that the present invention is not limited to the specific embodiments described above, and the devices and structures not described in detail should be understood as being implemented in a manner common to the art; any possible variations and modifications made by those skilled in the art without departing from the technical solution of the present invention, or equivalent embodiments with equivalent changes, do not affect the essential content of the present invention. Therefore, any simple modifications, equivalent changes, and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still fall within the protection scope of the technical solution of the present invention.

Claims

1. A female qi and blood tonifying prescription fermented traditional Chinese medicine powder, characterized in that, By mass parts of dry basis, it is composed of the following raw medicinal materials: 15 parts of Huangqi, 9 parts of Daidehua, 9 parts of Yuzhu, 6 parts of Baizhi, 12 parts of Longyemr, 6 parts of Baihe, 12 parts of Gouqi, 9 parts of Fuling, 9 parts of Lianrou, 6 parts of DanzhuYe, 15 parts of Huangjing, 15 parts of Sangshen, 9 parts of Gegen, 6 parts of Suanzaoren, 9 parts of Dangui, 15 parts of Lingzhi and 9 parts of Dazao; the traditional Chinese medicine powder is prepared through solid state fermentation of compound probiotics, low temperature drying, ultrafine grinding and irradiation sterilization.

2. The method for preparing the female Yiqi Buxie Decoction fermented traditional Chinese medicine powder of claim 1, characterized in that, It comprises the following steps: S1: preparing and inspecting Huangqi, Daidehua, Yuzhu, Baizhi, Longyemr, Baihe, Gouqi, Fuling, Lianrou, DanzhuYe, Huangjing, Sangshen, Gegen, Suanzaoren, Dangui, Lingzhi and Dazao materials, removing impurities, insect damage, mold and non-medicinal parts; S2: Huangqi is added with 25% by mass of refined honey and is fried at 100-110℃ for 8-10 minutes; Dangui is added with 10% by mass of yellow rice wine and is slightly fried on a small fire; Huangjing is steamed at 100℃ until the core is transparent, then it is sliced and dried; Suanzaoren is fried at 100-110℃ until it is puffed and has a popping sound; Dazao is cored and cut into pieces; the remaining materials are dried; the moisture content of all the materials is controlled to be less than or equal to 12.0%; S3: all the materials obtained in step S2 are weighed and mixed according to the proportion, coarsely ground to 20 mesh, and the uniformity RSD is less than or equal to 5%; S4: the ground material obtained in step S3 is adjusted so that the moisture content is 38%-42%, 3% of the raw material dry basis is added with compound probiotics, and the fermentation is carried out at 30±2℃ and humidity 75%±5% for 5 days, with daily turning 2 times; the end point of fermentation is white mycelium, medicinal and wine aroma, pH 5.0-6.0, and no mold; S5: the fermented material obtained in step S4 is dried at ≤60℃ until the moisture content is less than or equal to 9.0%; S6: the material obtained in step S5 is ultrafine ground to a particle size D90≤45μm, ≥300 mesh; S7: the ultrafine powder is sterilized by cobalt-60 irradiation, and the irradiation dose is 10kGy.

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