Electromagnetic regulation and control method for improving formation of glial scar layer around implantable electrode

By applying low-frequency pulsed currents at different stages to the implanted electrode array, microglia and astrocytes were modulated, thus solving the problem of glial scar formation around the implanted electrodes and achieving long-term stability of electrode function and continuous improvement of nerve signals.

CN122163997APending Publication Date: 2026-06-09INNOVATION ACAD FOR PRECISION MEASUREMENT SCI & TECH CAS
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Patent Information

Application Number
CN202610596131.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-30
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

Existing technologies cannot simultaneously provide a controllable, non-pharmacological, and long-term safe method to improve the formation of glial scars around implanted electrodes, leading to electrode function decline and signal quality degradation.

Method used

By selecting electrode channels on an implantable brain-computer interface electrode array and applying low-frequency pulsed stimulation currents at different stages, including early, mid, and late low-frequency pulsed stimulation currents, the activity of microglia and astrocytes can be modulated to control the formation and stability of glial scar layers.

Benefits of technology

It achieves controllable, non-pharmacological, and long-term safe electromagnetic modulation of the glial scar layer, maintains the stability of the electrode-tissue interface, extends the lifespan of the electrode, and improves the quality of nerve signal recording.

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Abstract

The invention discloses an electromagnetic regulation and control method for improving formation of a glial scar layer around an implanted electrode. According to the method, at least two electrode channels are selected from an implantable brain-computer interface electrode array to serve as stimulation channels, the stimulation channels are connected with an in-vitro stimulation drive circuit, low-frequency pulse stimulation current is balanced by outputting charges, and staged regulation and control are carried out on local tissue around electrodes at different stages after implantation; meanwhile, electrode-tissue interface impedance and / or a neural signal to noise ratio are continuously monitored, and closed-loop switching is carried out among different stimulation parameters according to a monitoring result. The method does not depend on drug release, can utilize bipolar or tripolar current to guide a stimulation configuration to adjust local electric field space distribution, and performs electromagnetic parameter dependent long-term regulation and control on inflammatory response of microglia and astroglia at an implantation interface in combination with an accompanying near-field electromagnetic effect; the long-term electrical stability of an implanted interface is improved, and the service life of the implanted electrode is prolonged.
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