A pH and near-infrared light dual-responsive photocaged compound and application thereof
By designing a pH- and near-infrared dual-responsive photosensitive protective group based on a silicon-xanthones framework, the problem of insufficient biological endogenous signal response in existing NIR-PPGs is solved, enabling precise controlled release of the encapsulated molecules and improving safety.
CN122167467APending Publication Date: 2026-06-09SHENZHEN SECOND PEOPLES HOSPITAL (SHENZHEN INST OF TRANSLATIONAL MEDICINE)
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHENZHEN SECOND PEOPLES HOSPITAL (SHENZHEN INST OF TRANSLATIONAL MEDICINE)
- Filing Date
- 2026-03-23
- Publication Date
- 2026-06-09
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Figure CN122167467A_ABST
Abstract
The application provides a pH and near-infrared light dual-response photocage compound and application thereof. The photocage compound comprises a silicon-xanthene ion skeleton and a molecular residue Cargo, and the silicon-xanthene ion skeleton is connected with the Cargo through a Linker. The PPG core skeleton of the application not only responds to near-infrared light irradiation, but also introduces a response mechanism to pH conditions. Compared with the existing PPG which only depends on light triggering, the dual-gating of 'environment (tumor acidity) + external triggering (NIR light)' is realized, the spatiotemporal accuracy and targeting selectivity of active molecule release are significantly improved, and the non-specific release in non-target tissues is reduced, thereby reducing systemic toxicity.
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