A method for the preparation of a transmucosal barrier and immune inducing carrier based on amphoteric mannans

By coupling amphoteric mannan with PLGA copolymer to form a nanoparticle carrier, the problems of penetration of the intestinal mucus layer and immune activation in mucosal delivery systems are solved, achieving efficient mucosal vaccine delivery and immune enhancement effects.

CN122167750APending Publication Date: 2026-06-09DALIAN UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
DALIAN UNIV OF TECH
Filing Date
2026-01-27
Publication Date
2026-06-09

AI Technical Summary

Technical Problem

In the existing technology, oral vaccine mucosal delivery systems have difficulty effectively penetrating the intestinal mucus layer and have immunogenicity risks and delivery stability issues. PLGA has a strong hydrophobic surface and lacks immunostimulatory properties, while PEG-mediated cellular uptake capacity is limited.

Method used

Amphoteric mannan was coupled with PLGA copolymer and formed into a nanoparticle carrier by ultrasonic self-assembly. The amphoteric mannan on the carrier surface has excellent mucus penetration and cell uptake capabilities, promoting immune activation.

Benefits of technology

It achieves efficient cross-mucosal delivery, significantly improves mucus penetration ability, promotes cellular uptake and induces mucosal immune enhancement, and has good application prospects.

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Abstract

The application discloses a preparation method of a trans-mucosal barrier and immune induction carrier based on amphoteric mannans, and belongs to the technical field of biological medicines. The application is based on a novel adjuvant mannans (MN) and a biodegradable polylactic acid-glycolic acid copolymer (PLGA). First, the mannans are modified to be amphoteric, and then the PLGA is chemically coupled by means of acyl chloride to form an amphiphilic copolymer. The copolymer is self-assembled into nanoparticles by means of ultrasonic method. The amphoteric mannans on the surface of the nanoparticle carrier can penetrate mucus, be taken up by cells and then stimulate immunity.
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