Preparation and application of extract containing gleditsia sinensis l. and antibacterial agent

CN122229932APending Publication Date: 2026-06-19BIJIE MEDICAL COLLEGE (BIJIE HEALTH SCHOOL) +1
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Patent Information

Authority / Receiving Office
CN Β· China
Patent Type
Applications(China)
Current Assignee / Owner
BIJIE MEDICAL COLLEGE (BIJIE HEALTH SCHOOL)
Filing Date
2026-01-30
Publication Date
2026-06-19

AI Technical Summary

Technical Problem

Existing chemically synthesized antibacterial agents have problems such as bioaccumulation, skin irritation, and endocrine disruption. Furthermore, the antibacterial spectrum of saponin thorn extract is narrow, the effective concentration is high, and the stability is poor when used alone, making it difficult to achieve industrial-scale promotion.

Method used

Multiple extraction methods and purification techniques were employed to prepare a compound extract of Gleditsia sinensis thorns, Sophora flavescens, Eucalyptus leaves-Cinnamomum camphora leaves, Cnidium monnieri, Gentiana scabra, Houttuynia cordata and Lygodium japonicum root. Antibacterial active substances were separated by ethanol extraction, ethyl acetate extraction, supercritical extraction and macroporous adsorption resin purification, and the compound was optimized to enhance the antibacterial effect.

Benefits of technology

It achieves broad-spectrum, high-efficiency, and stable antibacterial effects, reduces the risk of drug resistance, and improves safety and adaptability, making it suitable for medical, food preservation, and daily chemical fields.

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Abstract

This invention belongs to the technical fields of biomedicine and daily chemical care industries. It discloses the preparation and application of an antibacterial extract containing Gleditsia sinensis thorns and a formulated combination. Gleditsia sinensis thorns are extracted with 60%–75% ethanol via ultrasonic extraction followed by ethyl acetate extraction, and the extract is purified by column chromatography to obtain a Gleditsia sinensis thorn extract. Eucalyptus leaves and camphor leaves are extracted with supercritical CO2 and purified to obtain essential oils. Sophora flavescens, Gentiana scabra, Lygodium japonicum root, Houttuynia cordata, and Cnidium monnieri are extracted with 70%–85% ethanol via ultrasonic extraction, and the crude extracts are purified using macroporous adsorption resin to obtain extracts. By utilizing the natural antibacterial components of Gleditsia sinensis thorns and its formulated combination, the formulated antibacterial agent not only exhibits high efficiency in inhibiting common bacteria and fungi but also shows good effects against some microorganisms that are difficult to inhibit with traditional chemical antibacterial agents. Compared with traditional chemical antibacterial agents, Gleditsia sinensis thorns and the formulated antibacterial agent, based on natural plant extracts, significantly improve environmental friendliness and safety during use.
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