A composition for soothing dry, itchy, red baby skin and uses thereof

Abstract

This invention provides a composition for soothing dry, itchy, and red skin in infants and children, and its application. The composition comprises 1-8% plant oil, 5-12% moisturizer, and 0.1-0.5% soothing ingredients. The plant oil contains ≥1% shea butter. Through the synergistic effect of the compound plant oil, moisturizer, and soothing ingredients, and with oat β-glucan modified by acetylation, the permeability and skin affinity are improved. The preparation employs a segmented emulsification and homogenization process, controlling the oil droplet size to 0.2-0.4 μm, and low-temperature compounding preserves the active ingredients. This composition achieves multiple benefits, including rapid soothing of dryness, itching, and redness, repair of the skin barrier structure, and balance of the skin microecology. Experimental verification shows that this composition has a significant inhibitory effect on inflammatory factors, is gentle and non-irritating, and can provide comprehensive protection for the delicate skin of infants and children.

Description

Technical Field

[0001] This invention relates to the field of infant and toddler care products technology, and in particular to a composition for relieving dry, itchy, and red skin in infants and children and its application. Background Technology

[0002] Infant skin, especially that of infants and children, is still developing in terms of structure and function, exhibiting significant differences from adult skin. The skin barrier of infants is not yet fully developed, the stratum corneum is thin and has low water content, making it susceptible to external stimuli such as dryness, itching, and redness. These physiological characteristics make infant skin more vulnerable to external physical, chemical, and biological stimuli. The rapid rate of transepidermal water loss makes it difficult to effectively maintain skin hydration, leading to a series of skin problems, among which dryness, itching, and redness are the most common and prominent, seriously affecting the quality of life and physical and mental health of infants and children.

[0003] Existing products often focus on a single moisturizing or soothing function, relying heavily on single ingredients like bisabolol or allantoin. These products can only temporarily relieve symptoms and cannot address the root causes of skin barrier damage and microecological imbalance. They lack barrier repair capabilities, are deficient in targeted lipid-replenishing ingredients, and struggle to repair damaged skin lipid gaps. Furthermore, they lack microecological regulation mechanisms and fail to address the balance of beneficial bacteria on the surface of infants' skin, leading to a high recurrence rate of dryness, itching, and redness. In addition, some products contain irritating ingredients, which may exacerbate skin problems with long-term use. Summary of the Invention

[0004] In view of this, the present invention proposes a composition for relieving dry, itchy, and red skin in infants and children and its application, thereby solving the above-mentioned problems.

[0005] The technical solution of the present invention is as follows: a composition for relieving dry, itchy and red skin of infants and children, comprising the following components by weight percentage: 1-8% plant oil, 5-12% moisturizer, and 0.1-0.5% soothing ingredient.

[0006] Preferably, the vegetable oil contains more than 1% shea butter and at least one vegetable oil selected from Inca Inchi seed oil, European hazelnut oil, avocado oil, camellia seed oil, oat kernel oil, and macadamia nut oil.

[0007] Preferably, the moisturizer is selected from one or a combination of glycerin, 1,3-propanediol, 1,3-butanediol, 1,2-hexanediol, and D-panthenol.

[0008] Preferably, the soothing ingredient is selected from one or a combination of several of bisabolol, allantoin, and gentian root extract.

[0009] Preferably, the composition further comprises the following components by weight percentage: 0.01-3% skin barrier repair lipids, 0.1-0.5% anti-allergy complex, and 0.5-2% skin microecological regulator. Preferably, the skin barrier repair lipids are selected from one or a combination of ceramide NP, ceramide AP, ceramide EOP, and phytosterols.

[0010] Preferably, the anti-allergy complex is composed of hydroxyphenylpropionamide benzoic acid and asiaticoside in a weight ratio of (1-3):(1-2).

[0011] Preferably, the skin microecological regulator is composed of oat β-glucan and meadowsweet extract in a weight ratio of 0.3-0.9:1; the oat β-glucan is prepared by the following modification method: (1) Raw material purification: Take natural oat β-glucan powder, add it to deionized water at 50-60℃ to prepare an aqueous solution with a mass concentration of 5-8%, centrifuge at 3000r / min for 10-20min to remove insoluble impurities, then filter and purify, and collect the filtrate; (2) Modification: Cool the filtrate to 25-30℃ and add acetic anhydride. The weight ratio of oat β-glucan to acetic anhydride is 1:0.8-1.2. Add 5-8% of the weight of oat β-glucan with pyridine, stir and react for 2-4 hours, and control the degree of acetylation substitution to 0.3-0.8. (3) Neutralization and purification: Slowly add 1 mol / L sodium hydroxide solution to the reaction solution to adjust the pH to 6.5-7.0, and then use an ultrafiltration membrane with a molecular weight cutoff of 10 kDa to dialyze and purify the solution to remove unreacted reagents and small molecule impurities until no acetate ions are detected in the dialysate. Freeze-dry and pulverize to a particle size ≤20 μm to obtain the final product.

[0012] This invention provides the application of the composition described above for relieving dry, itchy, and red skin in infants in the preparation of infant skin care products.

[0013] This invention provides a face cream for soothing dry, itchy, and red skin in infants and young children, the face cream comprising the composition described in the above-mentioned technical solution.

[0014] Compared with the prior art, the beneficial effects of the present invention are: Through the synergistic effect of compound plant oils, moisturizers, and soothing ingredients, this product achieves three benefits: First, it quickly soothes dry, itchy, and red skin in infants and children, inhibiting the release of inflammatory factors; second, it repairs the skin barrier structure, with barrier components such as ceramides and phytosterols mimicking the natural lipid structure of infant skin, and oat β-glucan, after acetylation modification, increasing its permeability and enhancing its water-locking ability; third, it balances the skin microecology, reducing the adhesion of irritants. Compared to single-function products, the ingredients in this invention are natural and non-irritating. Experimental verification shows significant inhibitory effects on interleukin-1α and tumor necrosis factor-α, and the scientifically formulated ratio of ≥1% shea butter ensures a synergistic effect of repair and moisturizing, providing comprehensive protection for the delicate skin of infants and children. Detailed Implementation

[0015] To better understand the technical content of this invention, specific embodiments are provided below to further illustrate the invention.

[0016] Unless otherwise specified, the experimental methods used in the embodiments of this invention are all conventional methods.

[0017] Unless otherwise specified, all materials and reagents used in the embodiments of this invention are commercially available.

[0018] In this invention, Gentian root extract is obtained from gentian ( Gentiana scabra Bunge The dried roots of the plant were pulverized and extracted three times by reflux with eight times the volume of 60% ethanol aqueous solution, each time for 1.5 hours. The extracts were combined, filtered, and concentrated under reduced pressure (temperature ≤60℃) until no alcohol odor remained, yielding an extract.

[0019] Furthermore, the extract can be diluted with water, purified by passing it through a macroporous adsorption resin column, concentrated, and dried to obtain a high-purity gentian root extract.

[0020] Spiraea Ulmariia extract is an extract of Spiraea Ulmariia.

[0021] Examples 1-6

[0022] Please supplement the data for each component in the table above according to the actual process, and adjust the content to comply with regulations and not exceed the limits, with the total amount not exceeding 100%. The modification method of oat β-glucan includes the following steps: (1) Raw material purification: Take natural oat β-glucan powder, add 55℃ deionized water to prepare an aqueous solution with a mass concentration of 7%, centrifuge at 3000r / min for 15min to remove insoluble impurities, then filter and purify, and collect the filtrate; (2) Modification: Cool the filtrate to 30°C and add acetic anhydride. The weight ratio of oat β-glucan to acetic anhydride is 1:1. Add pyridine at 7% of the weight of oat β-glucan and stir for 3 hours to control the degree of acetylation to 0.5. (3) Neutralization and purification: Slowly add 1 mol / L sodium hydroxide solution to the reaction solution to adjust the pH to 6.5, and then use an ultrafiltration membrane with a molecular weight cutoff of 10 kDa to dialyze and purify the solution to remove unreacted reagents and small molecule impurities until no acetate ions are detected in the dialysate. Freeze-dry and pulverize to a particle size ≤20 μm to obtain white powdered acetylated oat β-glucan.

[0023] Comparative Example 1 The difference between this comparative example and Example 1 is that the composition does not contain any soothing ingredients, while the other components and preparation methods are the same as in Example 1.

[0024] Comparative Example 2 The difference between this comparative example and Example 1 is that the composition does not contain shea butter, but only an equal amount of Inca Inchi seed oil is added. The other components and preparation methods are the same as in Example 1.

[0025] Comparative Example 3 The difference between this comparative example and Example 1 is that the shea butter content in the composition is 0.8%, and the missing content is made up by Inca Inchi seed oil. The other components and preparation methods are the same as in Example 1.

[0026] Comparative Example 4 The difference between this comparative example and Example 1 is that the composition does not contain skin barrier repair lipids, while the other components and preparation methods are the same as in Example 1.

[0027] Comparative Example 5 The difference between this comparative example and Example 1 is that the composition does not contain the anti-allergic complex, while the other components and preparation methods are the same as in Example 1.

[0028] Comparative Example 6 The difference between this comparative example and Example 1 is that the composition does not contain skin microecological regulators, while the other components and preparation methods are the same as in Example 1.

[0029] Efficacy test 1. Human patch test In accordance with the "Cosmetic Safety Technical Specifications" (2015 edition), the compositions prepared in the examples and comparative examples were subjected to human skin occlusive patch tests. 0.020 g to 0.025 g of the test substance was placed in the patch tester, and a hypoallergenic adhesive tape was applied to the back of the subject. The test substance was removed after 24 hours, and the skin reaction was observed at 0.5, 24, and 48 hours after removal. The results were recorded according to the skin reaction grading standards in the currently effective technical specifications.

[0030] The results showed that none of the subjects experienced adverse reactions, and the composition had a skin irritation level of 0, indicating it was safe and mild.

[0031] 2. Moisturizing efficacy test 2.1 Following the evaluation methods outlined in the "Laboratory Test Operation Manual for Evaluating the Moisturizing Efficacy of Cosmetics," the test samples (compositions of Examples 1-6 and Comparative Example 4, all prepared as face creams) and the positive control (glycerin) were tested: The preparation method of the above face cream is as follows: S1. Preparation of aqueous phase: Add thickener to pure water, disperse evenly, heat to 80℃-85℃, keep warm for 10 minutes to obtain aqueous phase; S2. Preparation of oil phase: After adding emulsifier, emollient and vegetable oil in sequence, stir and heat to 80-85℃, keep warm and stir for 10-15 minutes to obtain oil phase; S3. Under stirring conditions, slowly pour the materials in the oil phase pot into the water phase and homogenize at high speed for 5-8 minutes. After homogenization, keep warm for 20-30 minutes, cool to 70-65℃ and add the skin conditioning agent. Cool to 42-40℃ and add soothing ingredients, moisturizers, skin barrier repair lipids, anti-allergy complex, skin microecological regulators, fragrance, and antioxidants. Stir well to obtain the face cream.

[0032] 2.2 Test Method: Samples were weighed, and the sample and positive control group were placed in constant temperature and humidity equipment at 25±1℃ and 43±2% respectively. The test samples were weighed after 1.5h and 3h, and the data were recorded. The moisture retention rate was calculated. Moisturizing rate (%) = (Sample mass after test / Sample mass before test) × 100% 2.3 Test Results Table 1:

[0033] The moisturizing effects of Examples 1-6 were all better than the glycerin control, with Example 1 showing the best moisturizing performance, reaching 99.2% after 1.5 hours and 98.3% after 3 hours. The differences in moisturizing rate data among the examples were small, and the overall moisturizing stability was good.

[0034] 3. Soothing efficacy test The determination was performed according to the "Hyaluronase Inhibition Experiment Operating Instructions": 3.1 Sample pretreatment: Prepare homogeneous mixed solutions of Examples 1-6, Comparative Examples 1 and 5, and control samples for later use; 3.2 Construction of the reaction system: The sample solution, hyaluronidase solution and hyaluronic acid substrate were added sequentially, and the mixture was incubated in a water bath at 37°C; 3.3 Termination and Detection: Add pH adjuster, boil in water for 10 minutes to terminate the reaction, and measure the OD value after cooling; 3.4 Calculation: The absorbance (OD value) was measured at a specific wavelength (585nm) using an ELISA reader. The hyaluronidase inhibition rate was calculated based on the OD value, and the P value was determined through statistical analysis.

[0035] Hyaluronidase inhibition rate (%) = [1 - (Sample A - Sample A blank) / (Control A - Control A blank)] × 100% In the formula, Sample A: OD value of the sample group (including test substance, hyaluronidase, and substrate); A. Sample Blank: OD value of the sample blank group (containing the test substance and substrate, but without hyaluronidase); A. Control: OD value of the control group (containing hyaluronidase and substrate, but not the test substance); A. Control blank: The OD value of the control blank group (containing only the substrate, without the test substance and hyaluronidase).

[0036] 3.5 Test Results Table 2:

[0037] The hyaluronidase inhibition rates of Examples 1-6 all reached over 85%, with Example 1 showing the best inhibition rate. All examples showed highly significant differences compared to the blank control group (P < 0.05). All examples effectively inhibited hyaluronidase activity, exhibiting significant soothing effects, and the differences in inhibition effects among examples were small, demonstrating good stability.

[0038] 4. Anti-inflammatory and antipruritic efficacy test A lipopolysaccharide (LPS)-induced inflammation model of human keratinocytes (HaCaT) was used. 4.1 Basic cell culture conditions: HaCaT cells were cultured in DMEM high glucose medium containing 10% fetal bovine serum (FBS) and 1% penicillin-streptomycin in a humidified incubator at 37°C and 5% CO2 using standard methods.

[0039] 4.2 Experimental Groups: The following groups were set up (n≥3): Blank control group: Normally cultured cells without any treatment.

[0040] Model control group (LPS): Only LPS stimulation was used, without sample intervention.

[0041] Example 1 group: Pretreatment with 25 μg / mL culture medium.

[0042] Comparative Examples 1-6: Pretreated with culture medium containing 25 μg / mL of each comparative example sample.

[0043] After 24 hours of stimulation culture in a 37°C, 5% CO2 incubator, the cell supernatant was collected.

[0044] 4.3 Detection indicators: Enzyme-linked immunosorbent assay (ELISA) was used to detect the levels of key inflammatory factors: interleukin-1α (IL-1α) and tumor necrosis factor-α (TNF-α), and the inhibition rate of inflammatory factors in each sample group was calculated.

[0045] 4.4 Antipruritic test: HaCaT cells were incubated with 10 μmol / L histamine precursor for 12 h, the test sample was added, and the cells were cultured for another 12 h. The histamine content in the cell supernatant was detected by fluorescence spectrophotometry. Histamine release inhibition rate = (histamine content in blank group - histamine content in sample group) / histamine content in blank group × 100%.

[0046] 4.5 Test Results

[0047] In Example 1 of this invention, the inhibition rate of interleukin-1α and tumor necrosis factor-α was significantly higher than that of all comparative examples. Compared with Comparative Example 1, this indicates that the soothing component is the key to directly inhibiting the inflammatory response and relieving dryness and itching; its absence significantly reduces the anti-inflammatory and soothing ability. Compared with Comparative Examples 2 and 3, shea butter is rich in unsaturated fatty acids and natural phytosterols, which can synergistically fill the skin lipid gap and repair the damaged barrier with barrier components such as ceramides, reduce the release of inflammatory factors and histamine, and enhance the skin penetration rate of active ingredients such as soothing and repairing agents and anti-allergy complexes, thereby strengthening the synergistic anti-inflammatory and antipruritic effect. However, since the shea butter did not reach the minimum effective concentration of >1%, its lipid replenishment and synergistic effect could not be fully released.

[0048] Compared to Comparative Example 4, the skin barrier repair lipids filled lipid gaps and restored water-locking ability, reducing irritant invasion and inflammation triggering from the source. Compared to Comparative Example 5, the anti-allergy complex synergistically inhibited histamine release and reduced inflammation with the soothing ingredients; without it, the synergistic effect of anti-allergy and anti-inflammation disappeared, and the soothing effect was significantly weakened. Compared to Comparative Example 6, the skin microecological regulator, together with other ingredients, constituted a comprehensive antipruritic support system, indirectly relieving itching by repairing the barrier and reducing inflammation.

[0049] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A composition for soothing dry, itchy, red skin of an infant or child, characterized in that, By weight percentage, it includes the following components: 1-8% plant oils, 5-12% moisturizers, and 0.1-0.5% soothing ingredients.

2. The composition of claim 1, wherein The plant oil contains ≥1% shea butter and at least one plant oil selected from Inca Inchi seed oil, European hazelnut oil, avocado oil, camellia seed oil, oat kernel oil, and macadamia nut oil.

3. The composition of claim 1, wherein The moisturizer is selected from one or more combinations of glycerin, 1,3-propanediol, 1,3-butanediol, 1,2-hexanediol, and D-panthenol.

4. The composition of claim 1, wherein The soothing ingredients are selected from one or more of bisabolol, allantoin, and gentian root extract.

5. The composition of claim 1, wherein It also includes the following components by weight percentage: skin barrier repair lipids 0.01-3%, anti-allergy complex 0.1-0.5%, and skin microecological regulators 0.5-2%.

6. The composition of claim 5, wherein The skin barrier repair lipids are selected from one or more combinations of ceramide NP, ceramide AP, ceramide EOP, and phytosterols.

7. The composition of claim 5, wherein The anti-allergy complex is composed of hydroxyphenylpropionamide benzoic acid and asiaticoside in a weight ratio of (1-3):(1-2).

8. The composition of claim 5, wherein The skin microecological regulator is composed of oat β-glucan and meadowsweet extract in a weight ratio of 0.3-0.9:1; the oat β-glucan is prepared by the following modification method: (1) Raw material purification: Take natural oat β-glucan powder, add it to deionized water at 50-60℃ to prepare an aqueous solution with a mass concentration of 5-8%, centrifuge at 3000r / min for 10-20min to remove insoluble impurities, then filter and purify, and collect the filtrate; (2) Modification: Cool the filtrate to 25-30℃ and add acetic anhydride. The weight ratio of oat β-glucan to acetic anhydride is 1:0.8-1.

2. Add 5-8% of the weight of oat β-glucan with pyridine, stir and react for 2-4 hours, and control the degree of acetylation substitution to 0.3-0.

8. (3) Neutralization and purification: Slowly add 1 mol / L sodium hydroxide solution to the reaction solution to adjust the pH to 6.5-7.0, and then use an ultrafiltration membrane with a molecular weight cutoff of 10 kDa to dialyze and purify the solution to remove unreacted reagents and small molecule impurities until no acetate ions are detected in the dialysate. Freeze-dry and pulverize to a particle size ≤20 μm to obtain the final product.

9. The use of the composition for relieving dry, itchy, and red skin of infants according to any one of claims 1-8 in the preparation of infant skin care products.

10. A cream for soothing dry, itchy, red baby skin, characterized by, The face cream comprises the composition according to any one of claims 1-8.

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