Alcohol-relieving and liver-protecting compositions, beverages, preparation methods, and applications

Abstract

A composition for relieving hangovers and protecting the liver, made from the following raw materials in the indicated weight ratios: 3-20 parts of kudzu root extract, 2-20 parts of Japanese raisin tree fruit extract, 1-12 parts of N-acetylcysteine, 1-12 parts of L-ornithine, 1-15 parts of L-glutamine, 0.2-8 parts of glycyrrhetinic acid glycyrrhiza extract, 0.05-5 parts of curcumin, 0.005-0.5 parts of piperine, 0.5-10 parts of vitamin C, 0.01-2 parts of B vitamins complex, 0.1-8 parts of electrolyte salts, and 1-25 parts of honey or oligosaccharides.

Description

Technical Field

[0001] This invention relates to the field of functional foods, and more particularly to a composition for relieving hangovers and protecting the liver, a beverage, its preparation method, and its application. Background Technology

[0002] Alcoholic beverages have long been widely used in human society, business activities, banquets, and daily social interactions. Moderate drinking can have social and cultural significance in certain situations, but excessive drinking or drinking large amounts of alcohol in a short period can have many adverse effects on the body. After ethanol enters the body, it is mainly converted into acetaldehyde in the liver by alcohol dehydrogenase, and then further converted into acetic acid by acetaldehyde dehydrogenase, participating in subsequent metabolism. Acetaldehyde has strong reactivity; its accumulation in the body can easily cause adverse reactions after drinking, such as facial flushing, dizziness, nausea, vomiting, palpitations, fatigue, and decreased concentration, and may increase oxidative stress and inflammatory burden on liver cells.

[0003] Existing hangover remedies typically include plant extract-based, vitamin supplement-based, amino acid supplement-based, electrolyte-replenishing, and traditional Chinese medicine compound-based products. Some products primarily rely on plant-derived ingredients such as kudzu root, Japanese raisin tree fruit, turmeric, and licorice, while others supplement with B vitamins, vitamin C, N-acetylcysteine, ornithine, and electrolytes to support alcohol metabolism, provide antioxidant effects, replenish fluids, and aid in post-drinking recovery. CN120285127A discloses a hangover remedy and liver-protecting composition, beverage, preparation method, and application. The composition is made from turmeric, kudzu root, nutmeg, dendrobium officinale, camphor wood, black-striped snake, and licorice in a specific weight ratio and is used for hangover remedies and liver protection.

[0004] However, existing technologies still have the following shortcomings: First, some products have relatively simple ingredient structures, focusing only on relieving post-drinking symptoms, without simultaneously covering multiple aspects such as alcohol metabolism, acetaldehyde burden, hepatocyte oxidative stress, gastric mucosal irritation, dehydration, and the following day's fatigue; Second, some traditional compound products mainly rely on decoctions of animal and plant medicinal materials, making it difficult to standardize the preparation process and the content of effective ingredients, and there is still room for improvement in taste, portability, and food application; Third, some products lack clear functional ingredient ratios and experimental verification systems, making it difficult to stably evaluate their comprehensive effects in pre-drinking prevention, post-drinking recovery, and liver protection.

[0005] Therefore, it is necessary to develop a hangover-relieving and liver-protecting composition based on a multi-component synergistic approach. This composition should work through multiple pathways, including plant extracts, amino acids, antioxidants, vitamins, and electrolytes, and can be used both before and after drinking alcohol. It should also promote alcohol metabolism, alleviate post-drinking discomfort, reduce hepatocyte oxidative stress, and improve post-drinking recovery to a certain extent. Furthermore, this composition should be suitable for preparation into food or functional food forms such as beverages, solid drinks, concentrates, capsules, tablets, or jellies to improve product stability, palatability, and ease of use. Summary of the Invention

[0006] One of the objectives of this invention is to provide a hangover relief and liver protection composition, beverage, preparation method, and application. It can be used before and after drinking alcohol through the combined action of plant extracts, amino acid components, antioxidants, vitamins, and electrolytes. It can promote alcohol metabolism, alleviate post-drinking discomfort, reduce oxidative stress in liver cells, and improve post-drinking recovery to a certain extent.

[0007] One of the objectives of this invention is to provide an application of a hangover relief and liver protection composition, beverage, and preparation method that can improve product stability, palatability, and ease of use.

[0008] To achieve at least one objective of this invention, the present invention provides a hangover relief and liver protection composition, characterized in that the hangover relief and liver protection composition is made from the following raw materials in the indicated weight ratios: 3-20 parts of kudzu root extract, 2-20 parts of Japanese raisin tree fruit extract, 1-12 parts of N-acetylcysteine, 1-12 parts of L-ornithine, 1-15 parts of L-glutamine, 0.2-8 parts of glycyrrhetinic acid glycyrrhiza extract, 0.05-5 parts of curcumin, 0.005-0.5 parts of piperine, 0.5-10 parts of vitamin C, 0.01-2 parts of B vitamins complex, 0.1-8 parts of electrolyte salts, and 1-25 parts of honey or oligosaccharides.

[0009] According to another aspect of the present invention, the present invention also provides a hangover relief and liver protection composition, characterized in that the hangover relief and liver protection composition is made from the following raw materials in the indicated weight ratios: 5-15 parts of kudzu root extract, 4-12 parts of Japanese raisin tree fruit extract, 2-8 parts of N-acetylcysteine, 2-8 parts of L-ornithine, 2-10 parts of L-glutamine, 1-5 parts of glycyrrhetinic acid glycyrrhizin extract, 0.1-2 parts of curcumin, 0.01-0.2 parts of piperine, 1-5 parts of vitamin C, 0.05-0.8 parts of vitamin B complex, 0.5-4 parts of electrolyte salts, and 3-15 parts of honey or oligosaccharides.

[0010] In some embodiments, a food-acceptable acidulant, sweetener, flavoring, thickener, preservative, or purified water is added, along with a pharmaceutically acceptable excipient or carrier, to formulate the hangover-relieving and liver-protecting composition into granules, capsules, tablets, or oral liquid.

[0011] In some embodiments, the hangover relief and liver protection composition further includes taurine, glycine, L-theanine, nicotinamide, citric acid, trehalose, erythritol, xylitol, pectin, xanthan gum, or other food-acceptable adjuvants.

[0012] In some embodiments, the preparation method of the hangover relief and liver protection composition includes the following steps:

[0013] S10: Weigh each raw material according to the above weight proportions and sieve them separately for later use;

[0014] S20: Add kudzu root extract, Japanese raisin tree fruit extract, N-acetylcysteine, L-ornithine, L-glutamine, vitamin C, vitamin B complex and electrolyte salts to a portion of purified water and stir until fully dissolved;

[0015] S30: Mix curcumin, piperine and glycyrrhetinic acid glycyrrhizin extract with a small amount of food-grade solubilizing excipients or honey before adding them to the above solution and continue stirring to form a homogeneous system.

[0016] S40: Add honey, citric acid and appropriate amount of food flavoring to adjust the taste and pH value, so that the pH value is controlled within the range of 3.2-4.5;

[0017] S50: Add purified water to the target volume, stir well, and then filter. The filter pore size is 0.45-5μm.

[0018] S60: The filtered liquid is pasteurized or subjected to other sterilization treatments acceptable in the food industry.

[0019] S70: After cooling, the mixture is filled to obtain the hangover relief and liver protection composition.

[0020] In some embodiments, the preparation method of the hangover relief and liver protection composition includes the following steps: weighing 12 parts by weight of kudzu root extract, 10 parts by weight of Japanese raisin tree extract, 6 parts by weight of N-acetylcysteine, 6 parts by weight of L-ornithine, 8 parts by weight of L-glutamine, 5 parts by weight of taurine, 3 parts by weight of glycyrrhetinic acid glycyrrhizin extract, 1 part by weight of curcumin, 0.08 parts by weight of piperine, 4 parts by weight of vitamin C, 0.3 parts by weight of vitamin B complex, 2 parts by weight of electrolyte salts, 20 parts by weight of erythritol, 20 parts by weight of maltodextrin, and 1 part by weight of citric acid.

[0021] In some embodiments, the preparation method of the hangover relief and liver protection composition includes the following steps: S100: drying and pulverizing kudzu root extract, Japanese raisin tree extract, glycyrrhetinic acid glycyrrhizin extract, curcumin and piperine respectively, and passing them through an 80-mesh sieve; S200: mixing N-acetylcysteine, L-ornithine, L-glutamine, taurine, vitamin C, vitamin B complex and electrolyte salts to obtain water-soluble functional components; S300: adding plant extract components, water-soluble functional components, erythritol, maltodextrin and citric acid into a mixer, premixing at low speed for 5-10 minutes, and then mixing at high speed for 10-20 minutes; S400: granulating the mixture by dry granulation or wet granulation to obtain granules; S500: drying the granules until the moisture content is not higher than 5%, sieving and packaging to obtain the hangover relief and liver protection solid beverage.

[0022] According to another aspect of the present invention, the present invention also provides a food or medicine for relieving hangovers and protecting the liver, the food or medicine for relieving hangovers and protecting the liver includes the hangover-relieving and liver-protecting composition as described above.

[0023] According to another aspect of the present invention, the present invention also provides a bursting bead prepared using the aforementioned hangover-relieving and liver-protecting composition.

[0024] According to another aspect of the present invention, the present invention also provides the application of the aforementioned hangover-relieving and liver-protecting composition in the preparation of products having liver-protecting and hangover-relieving effects.

[0025] The beneficial effects of this invention are as follows:

[0026] The hangover relief and liver protection composition comprises plant extracts, amino acids, antioxidants, vitamins, electrolytes, and food-grade excipients. Specifically, the plant extracts are primarily used to help alleviate post-drinking discomfort and support liver metabolism; the amino acids are primarily used to support detoxification and nitrogen metabolism; the antioxidants are primarily used to reduce oxidative stress generated during ethanol metabolism; the vitamins are primarily used to support enzyme reactions related to alcohol metabolism and energy metabolism; and the electrolytes are primarily used to improve dehydration and mineral loss after drinking. Attached Figure Description

[0027] Figure 1 This is a flowchart of a method for preparing a hangover-relieving and liver-protecting composition according to an embodiment of the present invention. Detailed Implementation

[0028] The following description is intended to disclose the present invention and enable those skilled in the art to implement it. The preferred embodiments described below are merely examples, and other obvious variations will occur to those skilled in the art. The basic principles of the invention defined in the following description can be applied to other embodiments, modifications, improvements, equivalents, and other technical solutions that do not depart from the spirit and scope of the invention.

[0029] It is understood that the term "a" should be understood as "at least one" or "one or more", that is, in one embodiment, the number of an element can be one, while in another embodiment, the number of the element can be multiple, and the term "a" should not be understood as a limitation on the number.

[0030] In the embodiments of the present invention, the quantities mentioned are all parts by mass or weight ratios.

[0031] In this invention, the hangover relief and liver protection composition comprises plant extracts, amino acids, antioxidants, vitamins, electrolytes, and food-grade excipients. The plant extracts help alleviate post-drinking discomfort and support liver metabolism; the amino acids support detoxification and nitrogen metabolism; the antioxidants reduce oxidative stress during ethanol metabolism; the vitamins support alcohol-related enzymatic reactions and energy metabolism; and the electrolytes improve dehydration and mineral loss after drinking.

[0032] In a preferred embodiment of the present invention, the hangover relief and liver protection composition comprises, by weight, at least six of the following components: 3-20 parts of kudzu root extract, 2-20 parts of Japanese raisin tree fruit extract, 1-12 parts of N-acetylcysteine, 1-12 parts of L-ornithine, 1-15 parts of L-glutamine, 0.2-8 parts of glycyrrhetinic acid glycyrrhiza extract, 0.05-5 parts of curcumin, 0.005-0.5 parts of piperine, 0.5-10 parts of vitamin C, 0.01-2 parts of B vitamins complex, 0.1-8 parts of electrolyte salts, 1-25 parts of honey or oligosaccharides, and food-acceptable acidulants, sweeteners, flavorings, thickeners, preservatives, or purified water.

[0033] In a more preferred embodiment, the hangover relief and liver protection composition, by weight, comprises 5-15 parts of kudzu root extract, 4-12 parts of Japanese raisin tree fruit extract, 2-8 parts of N-acetylcysteine, 2-8 parts of L-ornithine, 2-10 parts of L-glutamine, 1-5 parts of glycyrrhetinic acid glycyrrhiza extract, 0.1-2 parts of curcumin, 0.01-0.2 parts of piperine, 1-5 parts of vitamin C, 0.05-0.8 parts of B vitamins, 0.5-4 parts of electrolyte salts, and 3-15 parts of honey or oligosaccharides.

[0034] Furthermore, the kudzu root extract is derived from the dried root of the legume *Pueraria lobata*, and contains flavonoids such as puerarin, daidzein, and daidzeinogen. The *Hovenia dulcis* seed extract is derived from the seeds, pedicels, or related medicinal parts of the rhamnaceae plant *Hovenia dulcis*, and contains dihydromyricetin, flavonoids, or polysaccharides. The glycyrrhetinic acid-free licorice extract is derived from extracts of licorice *Glycyrrhiza uralensis*, and is used to improve stomach irritation and taste before and after drinking alcohol. The electrolyte salts include one or more of sodium citrate, potassium citrate, sodium chloride, potassium chloride, magnesium salts, or zinc salts.

[0035] In other preferred embodiments of the present invention, the hangover-relieving and liver-protecting composition further includes taurine, glycine, L-theanine, nicotinamide, citric acid, trehalose, erythritol, xylitol, pectin, xanthan gum, or other food-acceptable auxiliary ingredients. Not all of the above auxiliary ingredients need to be added simultaneously; they can be selected according to different product forms such as beverages, solid beverages, capsules, tablets, or jellies.

[0036] Furthermore, in a preferred embodiment, the hangover-relieving and liver-protecting composition is implemented as a beverage, and the preparation method is as follows:

[0037] This embodiment provides a method for preparing a hangover-relieving and liver-protecting beverage. By weight, the following ingredients are weighed: 10 parts kudzu root extract, 8 parts Japanese raisin tree fruit extract, 4 parts N-acetylcysteine, 4 parts L-ornithine, 5 parts L-glutamine, 2 parts glycyrrhetinic acid glycyrrhizic acid extract, 0.8 parts curcumin, 0.05 parts piperine, 2.5 parts vitamin C, 0.2 parts B vitamins, 1.5 parts electrolyte salts, 10 parts honey, 0.5 parts citric acid, with the remainder being purified water.

[0038] The specific preparation steps are as follows:

[0039] S10: Weigh each raw material according to the above weight proportions and sieve them separately for later use;

[0040] S20: Add kudzu root extract, Japanese raisin tree fruit extract, N-acetylcysteine, L-ornithine, L-glutamine, vitamin C, vitamin B complex and electrolyte salts to a portion of purified water and stir until fully dissolved;

[0041] S30: Mix curcumin, piperine and glycyrrhetinic acid glycyrrhizin extract with a small amount of food-grade solubilizing excipients or honey before adding them to the above solution and continue stirring to form a homogeneous system.

[0042] S40: Add honey, citric acid and appropriate amount of food flavoring to adjust the taste and pH value, so that the pH value is controlled within the range of 3.2-4.5;

[0043] S50: Add purified water to the target volume, stir well and then filter. The filter pore size can be 0.45-5μm.

[0044] S60: The filtered liquid is pasteurized or subjected to other sterilization treatments acceptable in the food industry.

[0045] S70: After cooling, it is bottled to obtain the hangover relief and liver protection beverage.

[0046] Furthermore, in a preferred embodiment, the hangover-relieving and liver-protecting composition is implemented as a beverage, specifically a solid beverage for hangover relief and liver protection, prepared as follows:

[0047] A method for preparing a solid beverage for relieving hangovers and protecting the liver, comprising, by weight, 12 parts of kudzu root extract, 10 parts of Japanese raisin tree extract, 6 parts of N-acetylcysteine, 6 parts of L-ornithine, 8 parts of L-glutamine, 5 parts of taurine, 3 parts of glycyrrhetinic acid glycyrrhizic acid extract, 1 part of curcumin, 0.08 parts of piperine, 4 parts of vitamin C, 0.3 parts of B vitamins complex, 2 parts of electrolyte salts, 20 parts of erythritol, 20 parts of maltodextrin, and 1 part of citric acid.

[0048] The specific preparation steps are as follows:

[0049] S100: The kudzu root extract, Japanese raisin tree extract, glycyrrhetinic acid glycyrrhizic acid extract, curcumin and piperine are dried and pulverized separately, and then passed through an 80-mesh sieve.

[0050] S200: N-acetylcysteine, L-ornithine, L-glutamine, taurine, vitamin C, vitamin B complex and electrolyte salts are mixed to obtain water-soluble functional components;

[0051] S300: Add the plant extract components, water-soluble functional components, erythritol, maltodextrin and citric acid to the mixer, premix at low speed for 5-10 minutes, and then mix at high speed for 10-20 minutes.

[0052] S400: Dry or wet granulation of a mixture to obtain granules;

[0053] S500: Dry the granules until the moisture content is no more than 5%, sieve and package them to obtain the hangover relief and liver protection solid beverage.

[0054] When using, dissolve each packet of solid beverage in 100-300mL of water before drinking.

[0055] Further, in a preferred embodiment, the hangover relief and liver protection composition is implemented as a hangover relief and liver protection capsule or tablet, and the preparation method is as follows: by weight, weigh 8 parts of kudzu root extract, 8 parts of Japanese raisin tree extract, 5 parts of N-acetylcysteine, 5 parts of L-ornithine, 5 parts of L-glutamine, 2 parts of glycyrrhetinic acid glycyrrhizin extract, 0.5 parts of curcumin, 0.03 parts of piperine, 2 parts of vitamin C, 0.2 parts of vitamin B complex, 1 part of electrolyte salt, 10 parts of microcrystalline cellulose, 2 parts of sodium carboxymethyl starch, and 0.5 parts of magnesium stearate.

[0056] The specific preparation steps are as follows:

[0057] S1000: Dry, pulverize and sieve each functional component separately;

[0058] S2000: Mix kudzu root extract, Japanese raisin tree extract, N-acetylcysteine, L-ornithine, L-glutamine, glycyrrhetinic acid glycyrrhizin extract, curcumin, piperine, vitamin C, vitamin B complex and electrolyte salts evenly.

[0059] S3000: Add microcrystalline cellulose and sodium carboxymethyl starch, and continue mixing to ensure uniform dispersion of the functional components;

[0060] S4000: Add magnesium stearate, mix at low speed, and then fill capsules or compress tablets;

[0061] S5000: After metal detection, weight difference detection and packaging, the hangover relief and liver protection capsules or tablets are obtained.

[0062] Example 1: Establishing a cell model for detecting alcohol metabolism

[0063] To evaluate the effect of the composition of the present invention on ethanol metabolism, an in vitro validation was performed using a HepG2 cell ethanol metabolism model.

[0064] Experimental materials: HepG2 cells, DMEM culture medium, fetal bovine serum, ethanol, ethanol content detection kit, alcohol dehydrogenase activity detection kit, and the hangover relief and liver protection composition prepared in Example 1.

[0065] Experimental Methods: HepG2 cells were seeded in 24-well plates and cultured until cell confluence reached approximately 70%-80%. The experiment was divided into a model group, a low-dose group, a medium-dose group, and a high-dose group. Ethanol was added to each group to a final concentration of 50 mmol / L. The low-dose, medium-dose, and high-dose groups were added with 50 μg / mL, 100 μg / mL, and 200 μg / mL of the composition of this invention, respectively. After 24 hours of culture, the residual ethanol concentration in the culture medium was measured, and the intracellular alcohol dehydrogenase activity was also detected. Each group was repeated three times.

[0066] The following are exemplary preliminary experimental results:

[0067] Group | Composition Concentration | Ethanol Concentration (mmol / L) after 24 hours | Relative Decrease Rate to Model Group | ADH Activity (U / mg protein)

[0068] Model group | 0 μg / mL | 42.6±3.1 | — | 0.82±0.10

[0069] Low-dose group | 50 μg / mL | 38.9±2.8 | 8.7% | 0.96±0.11

[0070] Medium-dose group | 100 μg / mL | 34.1±2.5 | 20.0% | 1.12±0.13

[0071] High-dose group | 200 μg / mL | 33.0±2.7 | 22.5% | 1.18±0.15

[0072] The results showed that, compared with the model group, the residual ethanol concentration in the culture medium of each dosage group containing the composition of the present invention showed a decreasing trend, while the intracellular alcohol dehydrogenase activity showed an increasing trend. The medium-dose and high-dose groups showed more significant effects. These results indicate that the composition of the present invention has the potential to promote ethanol metabolism in in vitro cell models.

[0073] Effects of prophylactic administration on righting reflex in mice

[0074] Experimental materials: Thirty-two C57BL / 6 mice, half male and half female, were randomly divided into a model group, a low-dose group, a medium-dose group, and a high-dose group, with eight mice in each group. The composition used in the experiment was the hangover relief and liver protection beverage prepared in Example 1.

[0075] Experimental Methods: Mice were fasted for 12 hours before the experiment, but had free access to water. The low-dose, medium-dose, and high-dose groups were administered the composition of this invention at doses of 0.5 g / kg, 1.0 g / kg, and 2.0 g / kg, respectively, while the model group received an equal volume of purified water. Thirty minutes after administration, mice in each group were administered an ethanol solution by gavage at a dose of 5.0 g / kg. The time of disappearance and recovery of the righting reflex were recorded. A longer righting reflex disappearance time indicates stronger tolerance to the central inhibitory effects of ethanol; a shorter righting reflex duration indicates faster recovery after alcohol consumption.

[0076] The following are exemplary preliminary experimental results:

[0077] Group | Number of animals | Time to disappearance of righting reflex (min) | Duration of righting reflex (min)

[0078] Model group | 8 | 12.4±4.8 | 182.6±34.5

[0079] Low-dose group | 8 | 15.3±5.2 | 159.8±30.6

[0080] Medium-dose group | 8 | 19.1±5.5 | 132.4±28.1

[0081] High-dose group | 8 | 20.8±6.2 | 124.7±25.9

[0082] The results showed that, compared with the model group, the time for the disappearance of the righting reflex in mice was prolonged and the time for the righting reflex to be maintained was shortened after pre-administration of the composition of the present invention. This indicates that the composition of the present invention helps to improve the tolerance of mice to the central inhibitory effect of ethanol and promotes recovery after drinking when used before alcohol consumption.

[0083] Effects of therapeutic administration on righting reflex in mice

[0084] Experimental materials: Thirty-two C57BL / 6 mice, half male and half female, were randomly divided into a model group, a low-dose group, a medium-dose group, and a high-dose group, with eight mice in each group. The composition used in the experiment was the hangover relief and liver protection beverage prepared in Example 1.

[0085] Experimental Methods: Mice were fasted for 12 hours before the experiment, but had free access to water. All groups of mice were administered an ethanol solution by gavage at a dose of 5.0 g / kg. Fifteen minutes after ethanol gavage, the low-dose, medium-dose, and high-dose groups were given the composition of this invention at doses of 0.5 g / kg, 1.0 g / kg, and 2.0 g / kg, respectively. The model group was given an equal volume of purified water. The duration of the righting reflex in the mice was recorded.

[0086] The following are exemplary preliminary experimental results:

[0087] Group | Number of animals | Duration of righting reflex (min)

[0088] Model group | 8 | 178.4±36.0

[0089] Low-dose group | 8 | 162.0±31.5

[0090] Medium-dose group | 8 | 145.3±28.7

[0091] High-dose group | 8 | 137.6±24.9

[0092] The results showed that, compared with the model group, the duration of the righting reflex in mice was shortened after administration of the composition of the present invention following ethanol ingestion. This indicates that the composition of the present invention may also promote recovery and shorten the duration of central nervous system depression caused by ethanol when used after alcohol consumption.

[0093] Effects on liver alcohol dehydrogenase levels

[0094] Experimental materials: Forty C57BL / 6 mice, half male and half female, were randomly divided into four groups: blank group, model group, low-dose group, medium-dose group, and high-dose group, with eight mice in each group. The composition used in the experiment was the hangover relief and liver protection beverage prepared in Example 1.

[0095] Experimental methods: The low-dose, medium-dose, and high-dose groups were administered the composition of this invention at doses of 0.5 g / kg, 1.0 g / kg, and 2.0 g / kg, respectively, for 7 consecutive days. The blank group and model group received an equal volume of purified water. Thirty minutes after administration on day 7, the model group and each dose group were administered an ethanol solution by gavage at a dose of 5.0 g / kg, while the blank group received an equal volume of purified water. Six hours after ethanol gavage, the mice were sacrificed, and liver tissue was collected to prepare homogenates for detecting liver alcohol dehydrogenase activity.

[0096] The following are exemplary preliminary experimental results:

[0097] Group | Number of animals | Hepatic ADH activity (U / mg protein)

[0098] Blank group | 8 | 1.08±0.12

[0099] Model group | 8 | 0.71±0.09

[0100] Low-dose group | 8 | 0.82±0.11

[0101] Medium-dose group | 8 | 0.94±0.10

[0102] High-dose group | 8 | 0.98±0.13

[0103] The results showed that the liver ADH activity of mice in the model group was lower than that in the blank group after ethanol treatment; after administration of the composition of the present invention, the liver ADH activity of mice showed a recovery trend. Among them, the recovery trend was more obvious in the medium-dose group and the high-dose group. This result indicates that the composition of the present invention may exert an auxiliary effect in detoxification and liver protection by improving the activity of enzymes related to liver ethanol metabolism.

[0104] Those skilled in the art should understand that the embodiments of the present invention described above and shown in the accompanying drawings are merely examples and do not limit the present invention. The objectives of the present invention have been fully and effectively achieved. The functional and structural principles of the present invention have been demonstrated and explained in the embodiments, and any modifications or variations of the embodiments of the present invention may be made without departing from these principles.

Claims

1. A composition for relieving hangovers and protecting the liver, characterized in that, The hangover relief and liver protection composition is made from the following raw materials in the indicated weight ratios: 3-20 parts of kudzu root extract, 2-20 parts of Japanese raisin tree fruit extract, 1-12 parts of N-acetylcysteine, 1-12 parts of L-ornithine, 1-15 parts of L-glutamine, 0.2-8 parts of glycyrrhetinic acid glycyrrhiza extract, 0.05-5 parts of curcumin, 0.005-0.5 parts of piperine, 0.5-10 parts of vitamin C, 0.01-2 parts of B vitamins complex, 0.1-8 parts of electrolyte salts, and 1-25 parts of honey or oligosaccharides.

2. A composition for relieving hangovers and protecting the liver, characterized in that, The hangover relief and liver protection composition is made from the following raw materials in the indicated weight ratios: 5-15 parts kudzu root extract, 4-12 parts Japanese raisin tree fruit extract, 2-8 parts N-acetylcysteine, 2-8 parts L-ornithine, 2-10 parts L-glutamine, 1-5 parts glycyrrhetinic acid glycyrrhizic acid extract, 0.1-2 parts curcumin, 0.01-0.2 parts piperine, 1-5 parts vitamin C, 0.05-0.8 parts B vitamins, 0.5-4 parts electrolyte salts, and 3-15 parts honey or oligosaccharides.

3. The hangover relief and liver protection composition as described in claim 1 or 2, characterized in that, The composition for relieving hangovers and protecting the liver is formulated into granules, capsules, tablets, or oral liquid by adding food-acceptable acidulants, sweeteners, flavorings, thickeners, preservatives, or purified water, and pharmaceutically acceptable excipients or carriers.

4. The hangover relief and liver protection composition as described in claim 1 or 2, characterized in that, The hangover relief and liver protection composition also includes taurine, glycine, L-theanine, nicotinamide, citric acid, trehalose, erythritol, xylitol, pectin, xanthan gum, or other food-acceptable auxiliary ingredients.

5. The hangover relief and liver protection composition as described in claim 1 or 2, characterized in that, The preparation method of the hangover relief and liver protection composition includes the following steps: S10: Weigh each raw material according to the above weight proportions and sieve them separately for later use; S20: Add kudzu root extract, Japanese raisin tree fruit extract, N-acetylcysteine, L-ornithine, L-glutamine, vitamin C, vitamin B complex and electrolyte salts to a portion of purified water and stir until fully dissolved; S30: Mix curcumin, piperine and glycyrrhetinic acid glycyrrhizin extract with a small amount of food-grade solubilizing excipients or honey before adding them to the above solution and continue stirring to form a homogeneous system. S40: Add honey, citric acid and appropriate amount of food flavoring to adjust the taste and pH value, so that the pH value is controlled within the range of 3.2-4.5; S50: Add purified water to the target volume, stir well, and then filter. The filter pore size is 0.45-5μm. S60: The filtered liquid is pasteurized or subjected to other sterilization treatments acceptable in the food industry. S70: After cooling, the mixture is filled to obtain the hangover relief and liver protection composition.

6. The hangover-relieving and liver-protecting composition as described in claim 1, characterized in that, The preparation method of the hangover relief and liver protection composition includes the following steps: weigh out 12 parts by weight of kudzu root extract, 10 parts by weight of Japanese raisin tree extract, 6 parts by weight of N-acetylcysteine, 6 parts by weight of L-ornithine, 8 parts by weight of L-glutamine, 5 parts by weight of taurine, 3 parts by weight of glycyrrhetinic acid glycyrrhizin extract, 1 part by weight of curcumin, 0.08 parts by weight of piperine, 4 parts by weight of vitamin C, 0.3 parts by weight of vitamin B complex, 2 parts by weight of electrolyte salt, 20 parts by weight of erythritol, 20 parts by weight of maltodextrin, and 1 part by weight of citric acid.

7. The hangover-relieving and liver-protecting composition as described in claim 6, characterized in that, Preparation method of the hangover relief and liver protection composition The process includes the following steps: S100: Dry and pulverize kudzu root extract, Japanese raisin tree extract, glycyrrhetinic acid glycyrrhiza extract, curcumin, and piperine separately, and pass them through an 80-mesh sieve; S200: Mix N-acetylcysteine, L-ornithine, L-glutamine, taurine, vitamin C, vitamin B complex, and electrolyte salts to obtain water-soluble functional components; S300: Add the plant extract components, water-soluble functional components, erythritol, maltodextrin, and citric acid to a mixer, premix at low speed for 5-10 minutes, and then mix at high speed for 10-20 minutes; S400: Perform dry granulation or wet granulation on the mixture to obtain granules; S500: Dry the granules until the moisture content is no higher than 5%, sieve, and package to obtain the hangover-relieving and liver-protecting solid beverage.

8. A food or medicine for relieving hangovers and protecting the liver, characterized in that: The sobering and liver-protecting food or medicine includes the sobering and liver-protecting composition as described in any one of claims 1 to 7.

9. A type of burst bead, characterized in that, It is prepared using the composition for hangover relief and liver protection as described in any one of claims 1 to 7.

10. The use of the hangover-relieving and liver-protecting composition according to any one of claims 1 to 7 in the preparation of a product having liver-protecting and hangover-relieving effects.

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