A type of antibacterial and antiviral toothpaste
By using EGCG and coral grass extract combined with plant ingredients in toothpaste, the problem of oral microecological imbalance caused by toothpaste is solved, achieving antibacterial, antiviral, anti-inflammatory and teeth whitening effects, and improving the antibacterial and antiviral capabilities of toothpaste.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-05-20
- Publication Date
- 2026-06-30
AI Technical Summary
The chemical components in existing toothpastes can easily lead to oral microecological imbalance, bacterial resistance, and an inability to effectively prevent oral diseases. Furthermore, they lack antibacterial and antiviral functions.
Using EGCG and coral grass extract as the main ingredients, combined with plant extracts in a 1:2 mass ratio, along with moisturizers, abrasives, foaming agents, binders, and water, this toothpaste works synergistically to exert antioxidant, anti-inflammatory, antibacterial, and antiviral effects.
It significantly improves the oral environment, inhibits bacterial growth, reduces plaque formation, prevents tooth decay and periodontal disease, effectively kills viruses, enhances teeth whitening effects, and is safe with no side effects.
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Abstract
Description
Technical Field
[0001] This invention relates to the field of oral care technology, and in particular to a toothpaste with antibacterial and antiviral properties. Background Technology
[0002] Oral problems are mainly caused by bacteria. Helicobacter pylori infection can not only induce gastritis and gastric ulcers but also stomach cancer. Using effective toothpaste, mouthwash, and oral disease treatments can significantly reduce the number of pathogenic bacteria in the mouth, improving or even eliminating oral diseases. The reason why oral care products such as toothpaste and oral care solutions can achieve these functions is mainly due to the active or antibacterial ingredients in the products. However, frequent use of oral care products containing these ingredients can easily cause oral microecological imbalance or lead to antibiotic resistance in bacteria. This not only fails to prevent oral diseases but may also trigger other oral diseases.
[0003] EGCG is a polyphenol compound mainly found in green tea, with a variety of potential health benefits. When EGCG is added to toothpaste, it can exert the following effects and functions:
[0004] EGCG is a powerful antioxidant that can neutralize free radicals, reduce cellular oxidative stress, and protect cells from damage.
[0005] EGCG possesses anti-inflammatory properties, inhibiting inflammatory responses and the activity of inflammation-related enzymes, and reducing the release of inflammatory mediators. In terms of oral health, the anti-inflammatory effects of EGCG can help alleviate gingivitis and other oral inflammations.
[0006] EGCG has certain antibacterial and bacteriostatic effects, which can inhibit the growth of bacteria in the oral cavity, reduce the formation of dental plaque, and thus maintain oral health. EGCG in toothpaste can help prevent tooth decay and periodontal disease.
[0007] EGCG is highly effective in treating oral diseases such as periodontitis, gingivitis, toothache, and oral ulcers, and is safe with no side effects.
[0008] EGCG has the function of preventing and killing viruses. EGCG has antiviral activity against a variety of viruses, such as human papillomavirus (HPV), human immunodeficiency virus (HIV), influenza A virus (IAV), and hepatitis C virus (HCV). EGCG topical anti-HPV drugs have been certified by the US FDA and approved for marketing.
[0009] EGCG, as a natural compound and a disinfectant with good antibacterial properties, has an inactivating effect on various pathogenic microorganisms. In the field of oral care, it has demonstrated its powerful bactericidal and antibacterial capabilities, which have a positive impact on physical health.
[0010] Some compounds in *Sarcandra glabra* have anti-inflammatory effects, reducing the degree of tissue inflammation. It can also quickly stop gum bleeding, repair oral ulcers, improve swollen and painful gums, and eliminate bad breath. It also helps prevent gingivitis, periodontitis, and gum recession. *Sarcandra glabra* has a certain therapeutic effect on some inflammatory oral diseases caused by infection.
[0011] Although there are numerous types and functions of toothpaste on the market, there is no precedent for using EGCG combined with Cordyceps militaris to prepare toothpaste, especially oral care products with antibacterial and antiviral effects. Therefore, how to utilize EGCG and Cordyceps militaris to provide an antibacterial and antiviral toothpaste is a technical solution that urgently needs to be solved by those skilled in the art. In view of this, in-depth research was conducted on the above-mentioned problems, resulting in this case. Summary of the Invention
[0012] The purpose of this invention is to solve the above-mentioned problems by designing a bactericidal and antiviral toothpaste. This solves the problem that existing oral care products that frequently use chemical ingredients are prone to causing oral bacterial ecological imbalance, leading to bacterial resistance and failing to achieve the effect of preventing oral diseases.
[0013] The technical solution of the present invention to achieve the above objectives is as follows: a bactericidal and antiviral toothpaste, comprising the following components: EGCG, *Sarcandra glabra* extract, and plant extracts;
[0014] The plant extract is composed of EGCG and the herbaceous coral extract.
[0015] Preferably, the components should be in the following weight proportions: 1-3 parts EGCG, 2-6 parts Coralberry extract;
[0016] The plant extract is composed of 1-3 parts of EGCG and 2-6 parts of *Sarcandra glabra* extract in a 1:2 mass ratio.
[0017] Preferably, it also includes the following components in parts by weight: 30-40 parts of humectant, 20-25 parts of abrasive, 0.5-2 parts of foaming agent, 0.5-1 part of adhesive and 15-20 parts of water.
[0018] Preferably, the moisturizer is selected from one or more of glycerin, sorbitol, and polyethylene glycol.
[0019] Preferably, the friction agent is selected from one or more of silicon dioxide, calcium hydrogen phosphate dihydrate, anhydrous calcium pyrophosphate, and aluminum hydroxide.
[0020] Preferably, the foaming agent is selected from either sodium lauryl sulfate or sodium lauroyl sarcosinate.
[0021] Preferably, the adhesive is selected from one or more of xanthan gum, carrageenan, and sodium carboxymethyl cellulose.
[0022] This invention discloses a bactericidal and antiviral toothpaste made using the technical solution of this invention. The toothpaste uses EGCG and *Sarcandra glabra* as its main active ingredients. The synergistic effect of these ingredients effectively combats Helicobacter pylori, enhances antibacterial and antiviral activity, and removes odors. Simultaneously, the added plant extracts can improve the antibacterial and anti-inflammatory effects of the toothpaste to a certain extent and also have a certain teeth-whitening ability. EGCG and *Sarcandra glabra* extracts contain active compounds with significant antiviral, bactericidal, and anti-inflammatory effects. When applied to toothpaste, they can effectively improve the oral environment. EGCG and *Sarcandra glabra* extracts are both derived from natural plants, are widely used, and are readily available. EGCG and *Sarcandra glabra* extracts are dissolved separately in purified water at 45-55°C to maximize the solubility of the active ingredients. Traditionally, EGCG and *Sarcandra glabra* are used individually, but this invention combines them to achieve significant antibacterial and antiviral bactericidal effects. Detailed Implementation
[0023] The present invention will now be described in detail: a toothpaste with antibacterial and antiviral properties.
[0024] Example 1: A bactericidal and antiviral toothpaste comprising the following components: EGCG, *Gnaphalium affine* extract, and plant extracts;
[0025] One of the antibacterial and antiviral toothpaste plant extracts consists of an antibacterial and antiviral toothpaste EGCG and an antibacterial and antiviral toothpaste herb coral extract.
[0026] Specifically, the weight parts of a bactericidal and antiviral toothpaste component should be: 1-3 parts EGCG, 2-6 parts Coralgranatum extract;
[0027] One of the antibacterial and antiviral toothpaste plant extracts consists of 1-3 parts EGCG and 2-6 parts of coral grass extract in a 1:2 mass ratio.
[0028] Specifically, it also includes the following components by weight: 30-40 parts humectant, 20-25 parts abrasive, 0.5-2 parts foaming agent, 0.5-1 part adhesive, and 15-20 parts water.
[0029] Specifically, a bactericidal and antiviral toothpaste moisturizer is selected from one or more of glycerin, sorbitol, and polyethylene glycol.
[0030] Specifically, an antibacterial and antiviral toothpaste abrasive is selected from one or more of silica, dicalcium phosphate dihydrate, anhydrous calcium pyrophosphate, and aluminum hydroxide.
[0031] Specifically, a bactericidal and antiviral toothpaste foaming agent is selected from either sodium lauryl sulfate or sodium lauroyl sarcosinate.
[0032] Specifically, an antibacterial and antiviral toothpaste binder is selected from one or more of xanthan gum, carrageenan, and sodium carboxymethyl cellulose.
[0033] It should be noted that the combined use of EGCG and *Gynostemma pentaphyllum* generally exhibits synergistic effects in antioxidation, anti-inflammation, antibacterial, and antitumor properties, which can reduce the dosage of one ingredient, enhance efficacy, and reduce potential side effects.
[0034] EGCG: The core polyphenol of green tea, with strong antioxidant, anti-inflammatory, tumor proliferation and metastasis inhibition, and immune regulation properties.
[0035] Coralwort: Contains isopyridine, rosmarinic acid, flavonoids, etc., with broad-spectrum antibacterial, anti-inflammatory, antiviral, healing-promoting, and anti-tumor effects.
[0036] Both are polyphenols and phenolic acids, with complementary targets and superimposed mechanisms, which form the material basis for their synergy.
[0037] The main synergistic effects of the two are:
[0038] 1. Synergistic antioxidant effects
[0039] Combined use significantly enhances the ability to scavenge free radicals and superoxide anions compared to using them alone, resulting in improved overall antioxidant activity and a more pronounced reduction in lipid peroxidation. They also complement each other in scavenging different types of free radicals (EGCG is more lipophilic and membrane-protective, while *Sarcandra glabra* is more hydrophilic and intracellular). *Sarcandra glabra* polyphenols can stabilize EGCG, reduce oxidative degradation, and improve bioavailability.
[0040] 2. Anti-inflammatory synergy
[0041] For skin and mucous membrane inflammation, the anti-inflammatory index is higher than that of single and combined use.
[0042] 3. Synergistic effect of antibacterial and antiviral properties
[0043] Antibacterial: It kills Staphylococcus aureus, Escherichia coli, Candida albicans and Helicobacter pylori faster and inhibits biofilm formation more strongly.
[0044] Antiviral: It works synergistically to block viral adsorption and invasion, inhibit replication, and reduce viral load against influenza, herpes, enteroviruses, and HPV.
[0045] 4. It works synergistically to repair skin and mucous membranes, jointly promoting fibroblast proliferation and collagen synthesis, and degrading collagen; accelerating wound healing and improving sensitive inflammation.
[0046] The synergistic effect of EGCG and herbal toothpaste can fight bacteria, viruses, inflammation, prevent tooth decay, relieve periodontitis and oral ulcers, and reduce the bitterness of EGCG.
[0047] Since both are naturally derived, their combined toxicology makes them safer; given that EGCG is easily degraded by light, heat, and alkali, the addition of *Gynostemma pentaphyllum* can provide partial protection and improve the stability of the product.
[0048] EGCG + Coral Gynostemma pentaphyllum is a classic combination of natural polyphenols. Through target complementarity, mechanism superposition, and stability enhancement, it achieves synergistic effects and reduced toxicity in the fields of anti-oxidation, anti-inflammation, antibacterial, antiviral, antitumor, and repair, and has broad application prospects in the fields of daily chemicals, food, and medicine.
[0049] Example 2:
[0050] Formula 1: A bactericidal and antiviral toothpaste comprising the following components in parts by weight: 2 parts EGCG, 4 parts Coralberry extract, 15 parts glycerin, 30 parts sorbitol, 28 parts dicalcium phosphate dihydrate, 0.5 parts sodium lauryl sulfate, 0.5 parts sodium carboxymethyl cellulose, and 20 parts water.
[0051] Formula 2: A bactericidal and antiviral toothpaste comprising the following components in parts by weight: 3 parts EGCG, 3 parts coral grass extract, 3 parts plant extract, 10 parts propolis, 36 parts polyethylene glycol, 25 parts anhydrous calcium pyrophosphate, 1.5 parts sodium lauroyl sarcosinate, 0.5 parts xanthan gum, 0.3 parts carrageenan, and 18 parts water.
[0052] Formula 3: A bactericidal and antiviral toothpaste comprising the following components in parts by weight: 5 parts EGCG, 5 parts coral grass extract, 5 parts plant extract, 12 parts propolis, 42 parts sorbitol, 28 parts aluminum hydroxide, 2 parts sodium lauryl sulfate, 1 part sodium carboxymethyl cellulose, and 20 parts water.
[0053] Comparative Example 1: The antibacterial and antiviral toothpaste of Comparative Example 1 is the same as that of Example 2, except that the toothpaste does not contain EGCG.
[0054] Comparative Example 2: The antibacterial and antiviral toothpaste of Comparative Example 2 is the same as that of Example 2, except that the toothpaste does not contain coral grass extract.
[0055] Referring to the People's Republic of China National Standard for Disposable Sanitary Products, Hygienic Standard GB 15979-2002C4, Test Method for Antibacterial Performance of Dissolving Antibacterial (Inhibitory) Products, the inhibitory effects of toothpastes corresponding to formulations 1-3 and comparative formulations 1-2 on Escherichia coli, Staphylococcus aureus, Porphyromonas gingivalis, Streptococcus mutans, and Candida albicans were determined. The test results are shown in Table 1.
[0056] Table 1 Results of antibacterial rate determination
[0057] The results in Figure 1 show that the toothpaste of the present invention has excellent antibacterial and antimicrobial effects, and the combination of EGCG and coral grass extract has a synergistic effect on sterilization and antiviral activity, with a significant inhibitory effect on Helicobacter pylori, which can better improve the oral environment.
[0058] In addition, this invention also conducted detection of the compound in HPV pseudoviruses, as follows:
[0059] This experiment used the PBNA standard method recommended by the World Health Organization (WHO) to detect neutralizing antibodies using pseudoviruses (DIFF-HPV). The results are shown in Table 2.
[0060] Table 2 Test Results (Unit: Person)
[0061] The above test data demonstrate that this product has a significant inhibitory effect on HPV. EGCG and Coralberry extract work synergistically to achieve remarkable results and improve the oral environment.
[0062] The above technical solutions only embody the preferred technical solutions of the present invention. Any modifications that may be made by those skilled in the art to certain parts thereof embody the principles of the present invention and fall within the protection scope of the present invention.
Claims
1. A toothpaste with antibacterial and antiviral properties, characterized in that, It includes the following components: EGCG, coral grass extract, and plant extracts; The plant extract is composed of EGCG and the herbaceous coral extract.
2. The antibacterial and antiviral toothpaste according to claim 1, characterized in that, The weight parts of the components should be: 1-3 parts of EGCG and 2-6 parts of Coralgranatum extract; The plant extract is composed of 1-3 parts of EGCG and 2-6 parts of *Sarcandra glabra* extract in a 1:2 mass ratio.
3. The antibacterial and antiviral toothpaste according to claim 1, characterized in that, It also includes the following components by weight: 30-40 parts moisturizer, 20-25 parts abrasive, 0.5-2 parts foaming agent, 0.5-1 part binder, and 15-20 parts water.
4. The antibacterial and antiviral toothpaste according to claim 3, characterized in that, The moisturizer is selected from one or more of glycerin, sorbitol, and polyethylene glycol.
5. The antibacterial and antiviral toothpaste according to claim 3, characterized in that, The friction agent is selected from one or more of silicon dioxide, dicalcium phosphate dihydrate, anhydrous calcium pyrophosphate, and aluminum hydroxide.
6. The antibacterial and antiviral toothpaste according to claim 3, characterized in that, The foaming agent is selected from either sodium lauryl sulfate or sodium lauroyl sarcosinate.
7. The antibacterial and antiviral toothpaste according to claim 3, characterized in that, The adhesive is selected from one or more of xanthan gum, carrageenan, and sodium carboxymethyl cellulose.