Blue-green algae extract with photo-thermal damage repairing effect as well as preparation method and application of blue-green algae extract

The cyanobacteria extract prepared through a specific process synergistically regulates TLR4, NF-κB, and HSP90 signals in photothermal damage of the skin, overcoming the shortcomings of existing products in the dynamic balance between inflammation and repair, achieving immediate soothing and long-term repair effects, and is suitable for various skin damage scenarios.

CN122297357APending Publication Date: 2026-06-30青岛中科蓝智生物科技发展有限公司
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Patent Information

Application Number
CN202610287565.5
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-10
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Existing skincare products lack systematic regulation of the complex cellular signaling network following photothermal damage to the skin, especially the synergistic regulation of the three key nodes TLR4, NF-κB, and HSP90. They cannot achieve a dynamic balance between inflammation and repair. Furthermore, physical cooling ingredients may irritate sensitive skin, barrier repair ingredients are inefficient, and efficacy claims lack systematic biological basis.

Method used

Using a specific method for preparing cyanobacterial extracts, through repeated freeze-thaw cycles to break cell walls, cellulase extraction, and short-term low-temperature cycling, cyanobacterial active substances in the range of 10-30 kDa are enriched to achieve synergistic regulation of TLR4, NF-κB, and HSP90, thereby modulating inflammation and repair signaling pathways.

Benefits of technology

It provides immediate relief and long-term repair for photothermal damage to the skin, gently regulates TLR4 receptor activity, precisely modulates NF-κB signaling, stabilizes HSP90 molecular chaperone function, regulates TRPV1 channel activity, reduces excessive inflammation, and enhances the cell's self-repair ability. It is suitable for various scenarios such as sunburn and post-laser treatment.

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Abstract

The invention relates to a blue algae extract with a photo-thermal damage repairing effect and a preparation method and application thereof, and belongs to the technical field of cosmetic raw materials. The blue-green algae extract provided by the invention can be used for balancing inflammation of skin cells after photo-thermal injury and repairing a signal channel, and is used for preparing a skin care product with the effects of relieving, resisting inflammation and promoting barrier repair; the composition can synergistically balance a pro-inflammatory injury signal channel TLR4 / NF-kB axis and a survival-promoting repair signal channel HSP90 / PI3K-Akt axis which are simultaneously activated after photo-thermal injury of skin cells at multiple targets, can more effectively control excessive inflammation, reduce secondary injury and enhance the self-repair ability of the cells, is suitable for various scenes such as sunburn, laser postoperation and thermal environment injury, and has wide application prospects. Compared with products in the prior art, the method has obvious technical advantages and has wide application prospects and huge market value.
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