A traditional Chinese medicine nasal wash and its preparation method

Abstract

This invention discloses a traditional Chinese medicine nasal wash and its preparation method. The nasal wash is composed of traditional Chinese medicine components, yeast, and purified water in a specific ratio. The traditional Chinese medicine components include 21 herbs such as Bupleurum chinense and Cinnamomum cassia. The preparation method includes S1 decoction of traditional Chinese medicine, S2 filtration and fermentation, S3 fermentation and filtration, and S4 filling. The process employs low-temperature extraction, multi-stage filtration, and segmented constant temperature negative pressure settling, combined with ultrasonic disturbance, low-frequency electromagnetic treatment, and gradient osmotic pressure adjustment. This nasal wash is gentle and non-irritating, and can cleanse, reduce inflammation, and repair the nasal mucosa, overcoming the shortcomings of traditional saline nasal washes. The preparation process can fully retain the effective components of traditional Chinese medicine, improve the stability of efficacy, ensure uniform product quality, and is suitable for long-term use.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine preparation technology, specifically to a traditional Chinese medicine nasal wash and its preparation method. Background Technology

[0002] As the gateway to the human respiratory tract, the nasal cavity is easily irritated by the external environment and invaded by pathogens, leading to nasal diseases such as rhinitis and sinusitis, manifested as symptoms such as nasal congestion, runny nose, and nasal itching, seriously affecting human health and quality of life. Currently, the mainstream nasal wash products on the market are mainly saline-based, including physiological saline, hypertonic saline, and concentrated seawater. Although these products are widely used to relieve nasal discomfort, they have obvious "hidden harms" and are difficult to meet long-term nasal care needs.

[0003] The nasal mucosa is covered by a mucociliary system, which is the first line of defense for nasal health and plays a core role in cleaning and defense. However, nasal irrigation with saline solution continuously damages this defense: Although physiological saline (0.9%) has the same concentration as human body fluids and theoretically does not absorb or dehydrate, salt residue remains on the surface of mucosal cells after nasal irrigation. Long-term accumulation can cause chronic irritation and potential harm to the nasal cavity. Hypertonic saline and concentrated seawater have a higher concentration than human body fluids and will forcibly draw water out of the mucosal cells through osmosis, directly leading to mucosal dehydration. In the short term, this may achieve the effect of reducing swelling and clearing the nose, but long-term or frequent use will make the mucosa drier and more fragile, eventually leading to a vicious cycle of more stubborn and sensitive rhinitis.

[0004] More importantly, saline solution itself does not have antibacterial or anti-inflammatory effects. It can only physically flush away allergens, mucus, dust, and other dirt, or use its hypertonicity to temporarily reduce swelling. It cannot treat rhinitis from the root cause, which is the core reason why many people report that "the more you wash your rhinitis, the drier it gets, the more painful it becomes, and the more dependent you become."

[0005] Nasal irrigation with saline solution is not entirely unacceptable; the key is short-term and moderate use. It can be used for short-term nasal congestion during a cold or acute rhinitis attack to temporarily clean and relieve symptoms, or to quickly rinse the nasal cavity after exposure to large amounts of allergens such as pollen and dust. However, it is not recommended for long-term or frequent use, especially for those who choose hypertonic saline or concentrated seawater products, wash their noses multiple times a day or year-round without interruption, or have nasal dryness, pain, crusting, or bleeding problems. Use of saline solution in these individuals will further damage the mucous membrane.

[0006] Besides saline nasal wash products, other commonly used nasal wash products in clinical practice include chemical preparations and traditional Chinese medicine preparations. Although chemical preparations have a faster onset of action, long-term use can easily lead to drug resistance and can irritate the nasal mucosa. Traditional Chinese medicine nasal wash solutions are mostly made by decocting single Chinese herbs, resulting in insufficient dissolution of active ingredients, slow efficacy, and poor stability. They are prone to precipitation and deterioration during storage, making it difficult to meet clinical needs.

[0007] True nasal care is never about simply rinsing; it's about reducing irritation, repairing the mucosal barrier, and avoiding the flawed logic of "cleaning = dehydration." Given the limitations of saline nasal irrigation, there is an urgent need to develop a safe, long-term, gentle, and non-irritating nasal irrigation product that integrates cleansing, repair, and maintenance. Traditional Chinese medicine, with its gentle properties, few side effects, and long-lasting conditioning effects, has become an ideal direction for rhinitis care. Therefore, this invention aims to overcome the shortcomings of existing saline nasal irrigation solutions, such as easily causing mucosal dehydration and damage, and only providing physical cleaning without effective treatment, by providing a traditional Chinese medicine nasal irrigation solution and its preparation method, filling a market gap. Summary of the Invention

[0008] The purpose of this invention is to provide a traditional Chinese medicine nasal wash solution and its preparation method. This nasal wash solution eliminates saline components, has a scientifically proportioned composition, fully dissolves the effective ingredients, has stable efficacy, and is gentle and non-irritating to the nasal mucosa.

[0009] The above-mentioned technical objective of the present invention is achieved through the following technical solution: A traditional Chinese medicine nasal wash comprises herbal components, a bio-repairing component, and a solvent. The herbal components include Bupleurum chinense, Cinnamomum cassia, Paeonia lactiflora, Acorus tatarinowii, Schizonepeta tenuifolia, Notopterygium incisum, Atractylodes lancea, Centipeda minima, Asarum heterotropoides, Xanthium sibiricum, Pogostemon cablin, Mentha haplocalyx, Ligusticum chuanxiong, Lonicera japonica, Saposhnikovia divaricata, Magnolia biondii, Elsholtzia ciliata, Carthamus tinctorius, Perilla frutescens, Eriobotrya japonica, and Taraxacum mongolicum. The bio-repairing component is yeast, and the solvent is purified water. The components are expressed in the following proportions by weight: Bupleurum chinense 0.1-5 parts by weight, Cinnamomum cassia 0.1-5 parts by weight, Paeonia lactiflora 0.1-5 parts by weight, Acorus tatarinowii 0.1-5 parts by weight, Schizonepeta tenuifolia 0.1-5 parts by weight, and Notopterygium incisum 0.1-5 parts by weight. Ingredients: Atractylodes lancea 0.1-5 parts by weight, Centipeda minima 0.1-5 parts by weight, Asarum sieboldii 0.1-5 parts by weight, Xanthium sibiricum 0.1-5 parts by weight, Pogostemon cablin 0.1-5 parts by weight, Mentha haplocalyx 0.1-5 parts by weight, Ligusticum chuanxiong 0.1-5 parts by weight, Lonicera japonica 0.1-5 parts by weight, Saposhnikovia divaricata 0.1-5 parts by weight, Magnolia biondii 0.1-5 parts by weight, Elsholtzia ciliata 0.1-5 parts by weight, Carthamus tinctorius 0.1-5 parts by weight, Perilla frutescens leaf 0.1-5 parts by weight, Eriobotrya japonica leaf 0.1-5 parts by weight, Taraxacum mongolicum 0.1-5 parts by weight, Yeast 0.001-1 parts by weight, Purified water 10-90 parts by weight.

[0010] A method for preparing a traditional Chinese medicine nasal wash, wherein the nasal wash comprises traditional Chinese medicine components, a biological repair component, and a solvent. The traditional Chinese medicine components include Bupleurum chinense, Cinnamomum cassia, Paeonia lactiflora, Acorus tatarinowii, Schizonepeta tenuifolia, Notopterygium incisum, Atractylodes lancea, Centipeda minima, Asarum heterotropoides, Xanthium sibiricum, Pogostemon cablin, Mentha haplocalyx, Ligusticum chuanxiong, Lonicera japonica, Saposhnikovia divaricata, Magnolia biondii, Elsholtzia ciliata, Carthamus tinctorius, Perilla frutescens, Eriobotrya japonica, and Taraxacum mongolicum. The biological repair component is yeast, and the solvent is purified water. The components, by weight, are: Bupleurum chinense 0.1-5 parts, Cinnamomum cassia 0.1-5 parts, Paeonia lactiflora 0.1-5 parts, Acorus tatarinowii 0.1-5 parts, Schizonepeta tenuifolia 0.1-5 parts, and Notopterygium incisum 0.1-5 parts. The ingredients are: Atractylodes lancea (0.1-5 parts by weight), Centipeda minima (0.1-5 parts by weight), Asarum heterotropoides (0.1-5 parts by weight), Xanthium sibiricum (0.1-5 parts by weight), Pogostemon cablin (0.1-5 parts by weight), Mentha haplocalyx (0.1-5 parts by weight), Ligusticum chuanxiong (0.1-5 parts by weight), Lonicera japonica (0.1-5 parts by weight), Saposhnikovia divaricata (0.1-5 parts by weight), Magnolia biondii (0.1-5 parts by weight), Elsholtzia ciliata (0.1-5 parts by weight), Carthamus tinctorius (0.1-5 parts by weight), Perilla frutescens (0.1-5 parts by weight), Eriobotrya japonica (0.1-5 parts by weight), Taraxacum mongolicum (0.1-5 parts by weight), yeast (0.001-1 parts by weight), and purified water (10-90 parts by weight). The preparation method includes the following steps: S1. Select the Chinese herbal medicine components, wash them, mix them, decoct them, and collect the liquid. S2. Filter and clarify the liquid collected in step S1, add yeast and seal for fermentation; S3. Control the fermentation conditions to carry out fermentation, and filter after fermentation to obtain a clear liquid. S4. Fill the clarified medicinal solution obtained in step S3 into a container to obtain the Chinese herbal nasal wash solution.

[0011] In a preferred embodiment, the decoction in step S1 adopts a low-temperature extraction process, specifically: the washed and mixed Chinese herbal components are placed in an extraction tank, 8-10 times the total mass of the Chinese herbal components are added with purified water, the extraction temperature is controlled at 50-60℃, and the decoction is carried out 2-3 times, with each decoction time being 60-90 minutes. The decoction liquids from each decoction are combined to obtain a mixed decoction and collected.

[0012] In a preferred embodiment, the filtration in steps S1 and S3 both adopt a multi-stage filtration process, specifically: the filtration in step S1 adopts a 200-mesh filter for coarse filtration, followed by a 0.45μm filter membrane for fine filtration; the filtration in step S3 adopts a 300-mesh filter for coarse filtration, followed by a 0.22μm filter membrane for fine filtration.

[0013] In a preferred embodiment, the sealed fermentation in step S2 uses a sterile ceramic jar as the container. The specific operation is as follows: the filtered and clarified liquid from step S1 is poured into the sterile ceramic jar, yeast is added in proportion, and after stirring evenly, the ceramic jar is sealed with a sterile sealing cap and placed in a dark and ventilated environment at 25-30°C for sealed fermentation.

[0014] In a preferred embodiment, the fermentation time in step S3 is controlled to be 3 months. Specifically, during the sealed fermentation period, the state of the liquid in the ceramic jar is observed every 7 days to ensure that the fermentation environment temperature is stable at 25-30℃ and that it is kept away from light and ventilated. After 3 months of fermentation, the filtration process specified in step S3 is immediately used to perform the filtration operation to obtain the clarified liquid.

[0015] In a preferred embodiment, after fermentation is completed in step S3 and before filtration, the fermented liquid is placed in a low-temperature environment of 10-15°C and left to stand for 24-36 hours. During this period, the liquid is stirred once every 8 hours for 5-8 minutes each time. After the activation is completed, the filtration operation specified in step S3 is performed.

[0016] In a preferred embodiment, after collecting the decoction in step S1 and before filtering and clarifying in step S2, the decocted mixed decoction is placed in a constant temperature environment of 35-40℃, while the negative pressure of the environment is controlled at -0.03 to -0.04 MPa, and left to stand for 12-18 hours; then the temperature is lowered to a constant temperature environment of 20-25℃, and the same negative pressure conditions are maintained, and it is left to stand for another 8-10 hours. After completion, the environmental pressure is restored to normal pressure, and then the filtering and clarification operation in step S2 is performed.

[0017] In a preferred embodiment, during the constant temperature and negative pressure settling stage at 35-40℃, a 20-30Hz ultrasonic low-frequency disturbance is performed every 4 hours, with each disturbance lasting 3-5 minutes; during the constant temperature and negative pressure settling stage at 20-25℃, a 15-20Hz ultrasonic low-frequency disturbance is performed every 5 hours, with each disturbance lasting 2-3 minutes.

[0018] In a preferred embodiment, before filling in step S4, purified water is added to the clarified drug solution obtained by filtration in step S3 to adjust the osmotic pressure so that the osmotic pressure of the drug solution is controlled at 280-320 mOsm / kg. After adjustment, the solution is allowed to stand for 5-10 minutes before filling.

[0019] Compared with the prior art, the present invention has the following beneficial effects: 1. This invention's herbal nasal wash eliminates the need for saline solution, thus avoiding problems such as mucosal dehydration and salt residue caused by saline nasal washes, meeting the needs of long-term nasal care. The scientifically formulated composition selects multiple herbs with diaphoretic, nasal-clearing, heat-clearing, detoxifying, wind-dispelling, cold-dispersing, lung-moistening, and throat-soothing effects. Their synergistic effect quickly relieves nasal discomfort such as congestion, runny nose, and itchy nose, making it suitable as an adjunct treatment for various nasal diseases with no significant toxic side effects. The addition of yeast as a biological repair component promotes the conversion and dissolution of the effective components of the herbs, enhancing efficacy while repairing the nasal mucosa and reducing irritation, achieving a three-in-one approach of cleansing, repairing, and nourishing. 2. The preparation method of this invention adopts processes such as low-temperature extraction, multi-stage filtration, and sterile fermentation, which can effectively retain the active ingredients in traditional Chinese medicine, remove impurities, improve the purity and stability of the medicinal solution, and avoid problems such as precipitation and deterioration during storage. The parameters of each process step are clear, simple and controllable, suitable for large-scale production, and can stably produce high-quality pure traditional Chinese medicine nasal wash solution. 3. This invention further optimizes the quality of the drug solution by incorporating low-temperature settling, segmented constant-temperature negative-pressure settling, low-frequency ultrasonic disturbance, and osmotic pressure adjustment during the preparation process. This improves the retention rate and efficacy of the active ingredients while reducing the irritation of the drug solution to the nasal mucosa, enhancing user comfort. It is non-addictive and non-irritating, suitable for long-term use by rhinitis patients, truly achieving "no harm to the nose and no dehydration," providing a sustainable solution for nasal health. Attached Figure Description

[0020] Figure 1 This invention relates to a flowchart of a method for preparing a traditional Chinese medicine nasal wash. Detailed Implementation

[0021] The present invention will be further described in detail below with reference to the accompanying drawings.

[0022] This specific embodiment is merely an explanation of the present invention and is not intended to limit the invention. After reading this specification, those skilled in the art can make modifications to this embodiment without contributing any inventive step, but such modifications are protected by patent law as long as they are within the scope of the claims of the present invention.

[0023] Example 1: This example relates to a traditional Chinese medicine nasal wash solution, which is composed of traditional Chinese medicine components, biological repair components, and a solvent. The traditional Chinese medicine components include Bupleurum chinense, Cinnamomum cassia, Paeonia lactiflora, Acorus tatarinowii, Schizonepeta tenuifolia, Notopterygium incisum, Atractylodes lancea, Centipeda minima, Asarum heterotropoides, Xanthium sibiricum, Pogostemon cablin, Mentha haplocalyx, Ligusticum chuanxiong, Lonicera japonica, Saposhnikovia divaricata, Magnolia biondii, Elsholtzia ciliata, Carthamus tinctorius, Perilla frutescens, Eriobotrya japonica, and Taraxacum mongolicum. The biological repair component is yeast, and the solvent is purified water. The specific proportions of each component by weight are: Bupleurum chinense 0.1-5 parts by weight, Cinnamomum cassia 0.1-5 parts by weight, Paeonia lactiflora 0.1-5 parts by weight, Acorus tatarinowii 0.1-5 parts by weight, Schizonepeta tenuifolia 0.1-5 parts by weight. 0.1-5 parts by weight of Notopterygium incisum, 0.1-5 parts by weight of Atractylodes lancea, 0.1-5 parts by weight of Centipeda minima, 0.1-5 parts by weight of Asarum heterotropoides, 0.1-5 parts by weight of Xanthium sibiricum, 0.1-5 parts by weight of Pogostemon cablin, 0.1-5 parts by weight of Mentha haplocalyx, 0.1-5 parts by weight of Ligusticum chuanxiong, 0.1-5 parts by weight of Lonicera japonica, 0.1-5 parts by weight of Saposhnikovia divaricata, 0.1-5 parts by weight of Magnolia biondii, 0.1-5 parts by weight of Elsholtzia ciliata, 0.1-5 parts by weight of Carthamus tinctorius, 0.1-5 parts by weight of Perilla frutescens, 0.1-5 parts by weight of Eriobotrya japonica, 0.1-5 parts by weight of Taraxacum mongolicum, 0.001-1 parts by weight of yeast, and 10-90 parts by weight of purified water.

[0024] The selected herbal components have a synergistic effect. Bupleurum, Schizonepeta, Saposhnikovia, and Notopterygium can relieve exterior wind and alleviate nasal congestion and edema. Cinnamon twig and white peony root can harmonize qi and blood and nourish the mucous membrane. Acorus tatarinowii, Magnolia biondii, Centipeda minima, and Xanthium sibiricum can clear the nasal passages and dispel cold, improving nasal congestion. Honeysuckle, dandelion, and peppermint can clear heat and detoxify, inhibit bacteria and reduce inflammation. Patchouli and Atractylodes lancea can dispel dampness and turbidity. Safflower invigorates blood and removes blood stasis. Perilla leaf and loquat leaf moisten the lungs and soothe the throat. This combination of herbs can comprehensively target nasal cavity lesions. Yeast, as a biological repair component, can decompose... The large molecules in the drug components promote the dissolution of active ingredients and regulate the microenvironment of the solution, enhancing the stability of the drug's efficacy. Purified water, as a solvent, avoids the irritation of the nasal mucosa by other impurities. The components are formulated according to the specified mass ratio, which not only ensures the concentration of the active ingredients of traditional Chinese medicine and achieves the effects of cleansing, anti-inflammation, and repair, but also avoids problems such as poor efficacy and mucosal irritation caused by excessive or insufficient components. This ensures that the nasal wash is gentle and non-irritating, can be used for a long time, improves nasal discomfort, and solves the shortcomings of traditional saline nasal wash, which can only physically clean and easily damage the mucosa.

[0025] Example 2: This example also provides a method for preparing the traditional Chinese medicine nasal wash solution from Example 1. This preparation method is designed with the full dissolution of the effective components of the traditional Chinese medicine, stable efficacy, and safe use as its core. The specific preparation steps are as follows: First, in step S1, select the traditional Chinese medicine components in the above-mentioned limited proportions, wash each component, mix them evenly, and collect the decoction by decoction. Next, in step S2, filter and clarify the decoction collected in step S1, remove impurities, add yeast according to the proportions, and seal for fermentation. Then, in step S3, control the appropriate fermentation conditions to complete the fermentation process. After fermentation, filter again to obtain a clear decoction. Finally, in step S4, fill the clear decoction obtained in step S3 to obtain the finished traditional Chinese medicine nasal wash solution.

[0026] Step S1 involves decocting the herbs at high temperatures to rupture the cell walls, allowing active ingredients such as saikosaponins from Bupleurum, menthol from Mentha, and chlorogenic acid from Lonicera japonica to be fully released into the decoction. This lays the material foundation for the subsequent efficacy of the medicine. Purified water is used as a solvent during the decoction process to fully wet the herbal components and prevent the effective ingredients from failing to dissolve due to insufficient solvent. Step S2 first removes herbal residues, suspended particles, and other impurities from the decoction through filtration and clarification. If these impurities enter the subsequent fermentation process, they will adsorb yeast, affecting fermentation efficiency and potentially irritating the nasal mucosa during use. After filtration, yeast is added and the decoction is sealed. The yeast can metabolize the sugars and other substances in the herbal components, breaking down the large molecular effective ingredients into smaller molecules that are more easily absorbed by the nasal mucosa. At the same time, the organic acids produced by yeast metabolism can regulate the pH value of the decoction, enhance the stability of the effective ingredients, and extend the shelf life of the decoction. Step S3 controls fermentation temperature and environmental conditions to ensure the yeast is in optimal activity, fully converting the active ingredients. After fermentation, filtration removes yeast cells and small amounts of metabolic precipitates, further improving the purity of the solution and preventing these substances from causing turbidity or irritating the mucous membranes. Step S4, the filling process, must be performed in a sterile environment to prevent external microorganisms from entering the solution, avoiding contamination during storage and use, and ensuring the solution's efficacy remains stable and unspoiled within its shelf life. Through the orderly connection of these steps, the full dissolution and utilization of the effective components of the traditional Chinese medicine are guaranteed, while the purity and safety of the solution are ensured, achieving a gentle, non-irritating, and long-term usability effect. This precisely addresses the shortcomings of traditional saline nasal irrigation, which only provides physical cleaning and can easily damage the mucous membranes.

[0027] In step S1, a low-temperature extraction process is used to improve the quality of the medicinal liquid. The specific procedure is as follows: The washed and mixed Chinese herbal components are placed in an extraction tank, and 8-10 times the total mass of purified water is added. The extraction temperature is controlled at 50-60℃, and the mixture is decocted 2-3 times, each time for 60-90 minutes. The decoctions from each decoction are combined to obtain a mixed medicinal liquid, which is then collected. Volatile active ingredients in the Chinese herbal components (such as volatile oils in peppermint and patchouli) are easily volatilized and lost at high temperatures, leading to a decrease in efficacy. The low-temperature extraction process effectively avoids this problem. The extraction temperature of 50-60℃ ensures that the active ingredients in the Chinese herbal components are fully dissolved while reducing the loss of volatile components, thus improving the efficacy of the medicinal liquid. Adding 8-10 times the total mass of purified water to the herbal components ensures thorough wetting and allows the active ingredients to fully dissolve, preventing insufficient dissolution due to insufficient water volume. Decoction 2-3 times, 60-90 minutes each time, gradually extracts different active ingredients from the herbal components. The first decoction primarily extracts easily soluble components such as menthol and chlorogenic acid, while subsequent decoctions further extract less soluble components such as saikosaponins and atractylones. Combining the decoctions from multiple decoctions maximizes the retention of active ingredients and increases the efficacy concentration of the liquid. This process is simple to operate, with mild extraction conditions. Precise control of extraction temperature, water volume, and the number of decoctions ensures consistent efficacy in each preparation, preventing significant variations in active ingredient content due to fluctuations in extraction conditions, which could affect the overall therapeutic effect.

[0028] In the preparation process, the filtration in steps S1 and S3 employs a multi-stage filtration process to ensure the clarity and purity of the medicinal solution. The specific operations are as follows: Step S1 involves coarse filtration through a 200-mesh filter followed by fine filtration through a 0.45μm membrane; Step S3 involves coarse filtration through a 300-mesh filter followed by fine filtration through a 0.22μm membrane. The medicinal solution after decoction in step S1 contains a significant amount of medicinal residue, suspended particles, and other impurities. Directly introducing these into subsequent processes would affect the clarity and purity of the solution and may irritate the nasal mucosa. The multi-stage filtration process removes impurities of different particle sizes in stages. The 200-mesh filter removes larger medicinal residue and suspended particles first, preventing membrane clogging during subsequent fine filtration and improving filtration efficiency. The 0.45μm membrane further removes finer impurities and microorganisms, ensuring a clear and transparent solution and reducing irritation to the nasal mucosa. The fermented liquid after step S3 may contain impurities such as yeast metabolites and a small amount of precipitate. Coarse filtration with a 300-mesh filter removes larger particulate impurities generated during fermentation, while fine filtration with a 0.22μm membrane removes tiny impurities and residual yeast, ensuring the liquid's purity meets usage standards. Simultaneously, the 0.22μm membrane ensures aseptic filtration, preventing contamination during subsequent storage and use. This staged filtration method, combining coarse and fine filtration, gradually improves the clarity and purity of the liquid, reduces irritation to the nasal mucosa from impurities, prevents membrane clogging, improves filtration efficiency, ensures stable liquid quality, and meets the safety requirements for long-term use.

[0029] Step S2, the sealed fermentation, uses a sterile ceramic jar as the container. The specific procedure is as follows: Pour the filtered and clarified medicinal liquid from step S1 into the sterile ceramic jar, add yeast in the specified proportion, stir well, seal the jar with a sterile sealing cap, and place it in a dark, well-ventilated environment at 25-30℃ for sealed fermentation. The sterile ceramic jar has good air permeability and stability. Air permeability allows the small amount of gas produced during yeast fermentation to slowly escape, preventing excessive pressure inside the jar from causing damage. It also maintains the stability of the microenvironment inside the jar, which is conducive to yeast growth and reproduction. Aseptic treatment prevents contamination of the medicinal liquid by microorganisms carried by the container itself, ensuring the safety of the fermentation process. Adding yeast in the specified proportion and stirring well ensures that the yeast is evenly dispersed in the medicinal liquid, ensuring sufficient contact between the yeast and the effective components of the traditional Chinese medicine, promoting the transformation of macromolecular components and the dissolution of effective ingredients. 25-30℃ is the optimal temperature for yeast growth and reproduction. Within this temperature range, yeast activity is at its peak, allowing for efficient fermentation. A light-protected environment prevents light from damaging the active ingredients in the medicinal solution and reduces efficacy. A well-ventilated environment maintains air circulation from the outside, preventing the growth of unwanted microorganisms in a damp environment that could affect fermentation. Sealing prevents external microorganisms from entering the tank and maintains the stability of the fermentation environment, ensuring the orderly progress of the fermentation process. By controlling the fermentation container, temperature, and environmental conditions, stable fermentation results can be guaranteed, allowing for the full transformation of the effective components of the traditional Chinese medicine and enhancing the efficacy and stability of the medicinal solution.

[0030] The fermentation time in step S3 is controlled at 3 months. Specifically, during sealed fermentation, the state of the liquid in the ceramic jar is observed every 7 days to ensure the fermentation temperature remains stable at 25-30℃ and that the jar is kept dark and well-ventilated. After 3 months of fermentation, the filtration process specified in step S3 is immediately applied to obtain a clear liquid. Yeast fermentation of the herbal components requires a certain amount of time. If the fermentation time is too short, the yeast cannot fully transform the macromolecular components of the herbal medicine, resulting in insufficient dissolution of the effective components and poor efficacy. If the fermentation time is too long, it will lead to over-fermentation by the yeast, producing excessive metabolites, which may affect the taste and safety of the liquid, and may even cause it to spoil. A 3-month fermentation time allows the yeast to fully exert its function, achieving full transformation and dissolution of the effective components of the herbal medicine, while avoiding the problems caused by over-fermentation. During sealed fermentation, the liquid condition should be observed every 7 days to promptly detect any abnormalities such as turbidity, off-odors, or sedimentation. This allows for timely adjustments to fermentation conditions, ensuring the normal progress of the fermentation process. Maintaining a stable fermentation temperature of 25-30℃, along with protection from light and proper ventilation, helps preserve yeast activity and prevents environmental changes from affecting fermentation results. Filtering immediately after 3 months of fermentation removes yeast and its metabolites, preventing further alterations to the liquid's composition and ensuring stable efficacy and quality. Precise control of fermentation time and environmental conditions ensures the controllability of the fermentation process and guarantees consistent quality across batches.

[0031] After fermentation in step S3 and before filtration, the fermented liquid needs to be subjected to a low-temperature settling treatment. Specifically, the fermented liquid should be placed in a 10-15℃ environment and allowed to stand for 24-36 hours, stirring every 8 hours for 5-8 minutes each time. After settling, proceed with the filtration operation specified in step S3. The fermented liquid contains small amounts of yeast metabolites and tiny precipitates. Direct filtration may not completely remove these impurities, affecting the clarity and purity of the liquid. The 10-15℃ low-temperature environment reduces the fluidity of the liquid, allowing tiny impurities and metabolites to settle slowly, facilitating subsequent filtration. Simultaneously, the low temperature stabilizes the active ingredients in the liquid, preventing degradation and ensuring no loss of efficacy. Allow the solution to stand for 24-36 hours to allow sufficient time for impurities to settle, ensuring that most impurities reach the bottom. Stir every 8 hours for 5-8 minutes each time to prevent the settled impurities from re-suspension and to ensure even distribution of the components, preventing excessively high local concentrations that could affect efficacy. Gentle stirring avoids damaging the active ingredients. Filtering after the initial settling period significantly improves filtration efficiency, thoroughly removing settled impurities and ensuring a clear, transparent solution that meets purity standards. This reduces irritation to the nasal mucosa. By controlling the ambient temperature, settling time, and stirring frequency, the quality of the solution can be effectively improved, ensuring its gentleness and safety during use.

[0032] After collecting the decoction in step S1 and before filtration and clarification in step S2, the decocted mixed decoction needs to undergo a segmented constant-temperature settling-negative-pressure slow-release treatment. The specific procedure is as follows: First, place the decocted mixed decoction in a constant-temperature environment of 35-40℃, while controlling the ambient negative pressure to -0.03 to -0.04 MPa, and let it stand for 12-18 hours. Then, cool it to a constant-temperature environment of 20-25℃, maintaining the same negative pressure conditions, and continue to let it stand for 8-10 hours. After completion, restore the ambient pressure to normal pressure, and then proceed with the filtration and clarification operation in step S2. The decocted mixed decoction contains a small amount of volatile active ingredients. If filtered directly, some of these volatile ingredients will be lost with the air, leading to a decrease in efficacy. Additionally, the decoction may contain a small amount of minute impurities that are not easily settled. A constant temperature environment of 35-40℃ allows volatile components in the medicinal solution to slowly evaporate. Combined with a negative pressure of -0.03 to -0.04 MPa, this accelerates the removal of volatile impurities and promotes the sedimentation of minute impurities. The negative pressure environment also lowers the boiling point of the medicinal solution, allowing volatile components to evaporate at a lower temperature and preventing high temperatures from damaging the effective components of the traditional Chinese medicine. Letting the solution stand for 12-18 hours allows for the full removal of volatile impurities and the initial sedimentation of minute impurities. Subsequently, cooling to 20-25℃ and maintaining the same negative pressure for another 8-10 hours further promotes the sedimentation of remaining impurities and stabilizes the active ingredients in the solution, preventing degradation due to excessively high temperatures. After settling, the pressure is restored to normal to avoid the negative pressure environment from affecting subsequent filtration operations and ensure the smooth progress of the filtration process. This operation can effectively remove volatile and minute impurities from the medicine solution, improving the purity and efficacy of the medicine solution. By precisely controlling the constant temperature, negative pressure value and settling time, the dual effects of impurity removal and efficacy retention can be achieved.

[0033] During the segmented constant temperature and negative pressure slow release combined treatment process, it is necessary to use ultrasonic low-frequency disturbance operation. The specific operation method is as follows: during the constant temperature and negative pressure static stage at 35-40℃, perform ultrasonic low-frequency disturbance at 20-30Hz every 4 hours, with each disturbance lasting 3-5 minutes; during the constant temperature and negative pressure static stage at 20-25℃, perform ultrasonic low-frequency disturbance at 15-20Hz every 5 hours, with each disturbance lasting 2-3 minutes. Low-frequency ultrasonic perturbation can generate gentle mechanical vibrations that act on the medicinal liquid. During the constant temperature and negative pressure settling stage at 35-40℃, an ultrasonic frequency of 20-30Hz can promote thorough mixing of the medicinal liquid, prevent volatile components from accumulating locally, accelerate the discharge of volatile impurities, and break up the agglomeration of tiny impurities in the medicinal liquid, promoting impurity sedimentation. Each perturbation lasts 3-5 minutes, once every 4 hours, to ensure the perturbation effect while avoiding excessive perturbation that could damage the effective components of the traditional Chinese medicine. During the constant temperature and negative pressure settling stage at 20-25℃, a relatively low ultrasonic frequency of 15-20Hz can further promote the sedimentation of remaining tiny impurities, while avoiding excessive perturbation that could cause the settled impurities to resuspend. Each perturbation lasts 2-3 minutes, once every 5 hours, to balance the impurity sedimentation effect and the stability of the medicinal liquid. By adjusting the ultrasonic frequency, disturbance time, and interval in stages, the efficiency of impurity removal and the removal of volatile components can be significantly improved, further enhancing the purity of the medicinal solution. At the same time, the effective components of traditional Chinese medicine are not damaged, ensuring the stability of the medicinal effect and achieving a balance between impurity removal and efficacy retention, thereby improving the overall quality of the medicinal solution.

[0034] Before filling in step S4, the osmotic pressure of the clarified medication obtained from filtering in step S3 needs to be adjusted. Specifically, purified water is added to the clarified medication to adjust the osmotic pressure to 280-320 mOsm / kg. After adjustment, the solution is allowed to stand for 5-10 minutes before filling. The normal osmotic pressure of human nasal mucosal cells is approximately 280-320 mOsm / kg. If the osmotic pressure of the medication is too high, it will draw water from the mucosal cells through osmosis, leading to dehydration, dryness, and even damage to the mucosa. If the osmotic pressure is too low, the mucosal cells will absorb water and swell, causing nasal discomfort and affecting the user experience. Adding purified water to adjust the osmotic pressure ensures that the osmotic pressure of the medication matches that of the human nasal mucosa, preventing irritation and improving user comfort. It also promotes the absorption of the active ingredients in the medication by the nasal mucosa, enhancing efficacy. After adjustment, allow the solution to stand for 5-10 minutes to stabilize the osmotic pressure, preventing fluctuations caused by uneven local concentrations. This ensures consistent osmotic pressure in each bottle after filling, guaranteeing product quality stability. By monitoring the osmotic pressure and gradually adding purified water, the osmotic pressure can be precisely controlled within the specified range. This effectively improves the safety and comfort of using the herbal nasal wash, meeting the needs of long-term nasal care and preventing mucosal damage caused by improper osmotic pressure.

[0035] Osmotic pressure adjustment employs a gradient adjustment method to ensure accuracy. The specific procedure is as follows: First, add 5-8% purified water (by weight of the total medicinal solution) to the clarified medicinal solution. Let it stand for 3-5 minutes and measure the osmotic pressure. If the osmotic pressure is higher than 320 mOsm / kg, continue adding purified water for adjustment. If the osmotic pressure is lower than 280 mOsm / kg, add the concentrated medicinal solution obtained from step S1 until the osmotic pressure reaches 280-320 mOsm / kg. After adjustment, let it stand for 5-10 minutes. This gradient adjustment method avoids a sudden drop in osmotic pressure due to adding too much purified water at once, or adding too little water to achieve the desired adjustment effect, ensuring accurate and stable osmotic pressure adjustment. Adding 5-8% purified water initially lowers the osmotic pressure, preventing excessive adjustment difficulty due to an initially high osmotic pressure. Letting it stand for 3-5 minutes allows the purified water and medicinal solution to mix thoroughly, ensuring accurate osmotic pressure test results and avoiding errors caused by uneven mixing. If the osmotic pressure remains above 320 mOsm / kg, continue adding purified water to gradually reduce it to the specified range. If the osmotic pressure is below 280 mOsm / kg, add the concentrated medicinal solution obtained from step S1 to increase the concentration of active ingredients and thus raise the osmotic pressure, avoiding dilution of the medicinal effect due to simply adding purified water. After adjustment, let it stand for 5-10 minutes to stabilize the osmotic pressure, ensuring consistent osmotic pressure in each bottle of product subsequently filled. This adjustment method, through step-by-step operation and precise testing, effectively avoids osmotic pressure adjustment deviations, guarantees product quality, ensures that the osmotic pressure of each batch of medicinal solution meets the physiological needs of the human nasal cavity, and improves safety and efficacy.

[0036] In the segmented constant-temperature settling-negative-pressure sustained-release combined process, low-frequency electromagnetic treatment is also required. The specific procedure is as follows: Under a constant temperature environment of 20-25℃, the mixed medicinal solution is subjected to low-frequency electromagnetic treatment at 10-15 Hz for 10-15 minutes each time, repeated every 6 hours until filling is complete. The 10-15 Hz low-frequency electromagnetic treatment generates a gentle electromagnetic field that acts on the mixed medicinal solution, further breaking down the agglomeration of tiny impurities and promoting rapid sedimentation. Simultaneously, it accelerates the dissolution and dispersion of the effective components of the traditional Chinese medicine, improving the uniformity of the medicinal solution composition and preventing excessively high local component concentrations from affecting efficacy. Processing at a constant temperature of 20-25℃ avoids damage to the active ingredients of the medication due to temperature fluctuations, ensuring stable efficacy. Each treatment lasts 10-15 minutes to guarantee the effectiveness of the electromagnetic treatment while preventing over-treatment that could alter the medication composition. Treatment is repeated every 6 hours until filling is complete, continuously maintaining the homogeneity of the medication, preventing the re-suspension of settled impurities, and ensuring uniform distribution of the active ingredients, thus improving the stability and consistency of the medication's efficacy. By controlling the electromagnetic frequency, treatment time, and intervals, the purity and homogeneity of the medication can be further improved, guaranteeing product quality and ensuring that the medication remains homogeneous and stable in efficacy throughout storage and use, meeting the needs of long-term nasal care.

[0037] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or terminal device that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or terminal device. Unless otherwise specified, an element defined by the phrase "comprising..." or "including..." does not exclude the presence of additional elements in the process, method, article, or terminal device that includes said element. Additionally, in this document, "greater than," "less than," "exceeding," etc., are understood to exclude the stated number; "above," "below," "within," etc., are understood to include the stated number.

[0038] The above description of the embodiments is provided to facilitate understanding and use of the present invention by those skilled in the art. It is obvious to those skilled in the art that various modifications can be easily made to the embodiments, and the general principles described herein can be applied to other embodiments without creative effort. Therefore, the present invention is not limited to the above embodiments. Improvements and modifications made by those skilled in the art based on the disclosure of the present invention without departing from the scope of the present invention should be within the protection scope of the present invention.

Claims

1. A traditional Chinese medicine nasal wash solution, characterized in that, The product is composed of traditional Chinese medicine components, bio-repair components, and a solvent. The traditional Chinese medicine components include Bupleurum chinense, Cinnamomum cassia, Paeonia lactiflora, Acorus tatarinowii, Schizonepeta tenuifolia, Notopterygium incisum, Atractylodes lancea, Centipeda minima, Asarum heterotropoides, Xanthium sibiricum, Pogostemon cablin, Mentha haplocalyx, Ligusticum chuanxiong, Lonicera japonica, Saposhnikovia divaricata, Magnolia biondii, Elsholtzia ciliata, Carthamus tinctorius, Perilla frutescens, Eriobotrya japonica, and Taraxacum mongolicum. The bio-repair component is yeast, and the solvent is purified water. The components are expressed in the following proportions by weight: Bupleurum chinense 0.1-5 parts by weight, Cinnamomum cassia 0.1-5 parts by weight, Paeonia lactiflora 0.1-5 parts by weight, Acorus tatarinowii 0.1-5 parts by weight, Schizonepeta tenuifolia 0.1-5 parts by weight, Notopterygium incisum 0.1-5 parts by weight, Atractylodes lancea, Centipeda minima, Asarum heterotropoides, Xanthium sibiricum, Pogostemon cablin, Mentha haplocalyx, Ligusticum chuanxiong, Lonicera japonica, Saposhnikovia divaricata, Magnolia biondii, Elsholtzia ciliata, Carthamus tinctorius, Perilla frutescens, Eriobotrya japonica, and Taraxacum mongolicum. 0.1-5 parts by weight of Atractylodes macrocephala, 0.1-5 parts by weight of Centipeda minima, 0.1-5 parts by weight of Asarum heterotropoides, 0.1-5 parts by weight of Xanthium sibiricum, 0.1-5 parts by weight of Pogostemon cablin, 0.1-5 parts by weight of Mentha haplocalyx, 0.1-5 parts by weight of Ligusticum chuanxiong, 0.1-5 parts by weight of Lonicera japonica, 0.1-5 parts by weight of Saposhnikovia divaricata, 0.1-5 parts by weight of Magnolia biondii, 0.1-5 parts by weight of Elsholtzia ciliata, 0.1-5 parts by weight of Carthamus tinctorius, 0.1-5 parts by weight of Perilla frutescens leaf, 0.1-5 parts by weight of Eriobotrya japonica leaf, 0.1-5 parts by weight of Taraxacum mongolicum, 0.001-1 parts by weight of yeast, and 10-90 parts by weight of purified water.

2. A preparation method of a traditional Chinese medicine nasal wash solution, characterized in that, The herbal nasal wash solution is composed of herbal ingredients, a bio-repairing component, and a solvent. The herbal ingredients include Bupleurum chinense, Cinnamomum cassia, Paeonia lactiflora, Acorus tatarinowii, Schizonepeta tenuifolia, Notopterygium incisum, Atractylodes lancea, Centipeda minima, Asarum heterotropoides, Xanthium sibiricum, Pogostemon cablin, Mentha haplocalyx, Ligusticum chuanxiong, Lonicera japonica, Saposhnikovia divaricata, Magnolia biondii, Elsholtzia ciliata, Carthamus tinctorius, Perilla frutescens, Eriobotrya japonica, and Taraxacum mongolicum. The bio-repairing component is yeast, and the solvent is purified water. The components are expressed in the following proportions by weight: Bupleurum chinense 0.1-5 parts by weight, Cinnamomum cassia 0.1-5 parts by weight, Paeonia lactiflora 0.1-5 parts by weight, Acorus tatarinowii 0.1-5 parts by weight, Schizonepeta tenuifolia 0.1-5 parts by weight, and Notopterygium incisum 0.1-5 parts by weight. Ingredients: Atractylodes lancea 0.1-5 parts by weight, Centipeda minima 0.1-5 parts by weight, Asarum sieboldii 0.1-5 parts by weight, Xanthium sibiricum 0.1-5 parts by weight, Pogostemon cablin 0.1-5 parts by weight, Mentha haplocalyx 0.1-5 parts by weight, Ligusticum chuanxiong 0.1-5 parts by weight, Lonicera japonica 0.1-5 parts by weight, Saposhnikovia divaricata 0.1-5 parts by weight, Magnolia biondii 0.1-5 parts by weight, Elsholtzia ciliata 0.1-5 parts by weight, Carthamus tinctorius 0.1-5 parts by weight, Perilla frutescens leaf 0.1-5 parts by weight, Eriobotrya japonica leaf 0.1-5 parts by weight, Taraxacum mongolicum 0.1-5 parts by weight, Yeast 0.001-1 parts by weight, Purified water 10-90 parts by weight; The preparation method includes the following steps: S1. Select the Chinese herbal medicine components, wash them, mix them, decoct them, and collect the liquid. S2. Filter and clarify the liquid collected in step S1, add yeast and seal for fermentation; S3. Control the fermentation conditions to carry out fermentation, and filter after fermentation to obtain a clear liquid. S4. Fill the clarified medicinal solution obtained in step S3 into a container to obtain the Chinese herbal nasal wash solution.

3. The method for preparing a traditional Chinese medicine nasal wash according to claim 2, characterized in that, The decoction in step S1 adopts a low-temperature extraction process, specifically: the washed and mixed Chinese herbal components are placed in an extraction tank, and 8-10 times the total mass of the Chinese herbal components are added with purified water. The extraction temperature is controlled at 50-60℃, and the decoction is carried out 2-3 times, with each decoction time being 60-90 minutes. The decoction liquids from each decoction are combined to obtain a mixed decoction and collected.

4. The method for preparing a traditional Chinese medicine nasal wash according to claim 2, characterized in that, The filtration in steps S1 and S3 both adopt a multi-stage filtration process, specifically: the filtration in step S1 adopts a 200-mesh filter for coarse filtration, followed by a 0.45μm filter membrane for fine filtration; the filtration in step S3 adopts a 300-mesh filter for coarse filtration, followed by a 0.22μm filter membrane for fine filtration.

5. The method for preparing a traditional Chinese medicine nasal wash according to claim 2, characterized in that, The sealed fermentation in step S2 uses a sterile ceramic jar as a container. The specific operation is as follows: Pour the filtered and clarified liquid from step S1 into the sterile ceramic jar, add yeast in proportion, stir evenly, seal the ceramic jar with a sterile sealing lid, and place it in a dark and ventilated environment at 25-30℃ for sealed fermentation.

6. The method for preparing a traditional Chinese medicine nasal wash according to claim 2, characterized in that, The fermentation time in step S3 is controlled to be 3 months. The specific control method is as follows: during the sealed fermentation period, the state of the medicinal liquid in the ceramic jar is observed every 7 days to ensure that the fermentation environment temperature is stable at 25-30℃ and to keep it away from light and ventilated. After fermentation for 3 months, the filtration process specified in step S3 is immediately used to filter the liquid to obtain a clear medicinal liquid.

7. The method for preparing a traditional Chinese medicine nasal wash according to claim 2, characterized in that, After fermentation is completed in step S3 and before filtration, place the fermented liquid in a low-temperature environment of 10-15℃ and let it stand for 24-36 hours. Stir it once every 8 hours during this period, and each stirring time is 5-8 minutes. After the standing activation is completed, perform the filtration operation specified in step S3.

8. The method for preparing a traditional Chinese medicine nasal wash according to claim 2, characterized in that, After collecting the decoction in step S1 and before filtering and clarifying in step S2, place the decocted mixed decoction in a constant temperature environment of 35-40℃, while controlling the negative pressure of the environment to -0.03 to -0.04MPa, and let it stand for 12-18 hours; then cool it down to a constant temperature environment of 20-25℃, maintain the same negative pressure conditions, and continue to stand for 8-10 hours. After completion, restore the environmental pressure to normal pressure, and then perform the filtering and clarification operation in step S2.

9. The method for preparing a traditional Chinese medicine nasal wash according to claim 8, characterized in that, During the constant temperature and negative pressure settling stage at 35-40℃, a 20-30Hz ultrasonic low-frequency disturbance is performed every 4 hours, with each disturbance lasting 3-5 minutes; during the constant temperature and negative pressure settling stage at 20-25℃, a 15-20Hz ultrasonic low-frequency disturbance is performed every 5 hours, with each disturbance lasting 2-3 minutes.

10. The method for preparing a traditional Chinese medicine nasal wash according to claim 2, characterized in that, Before filling in step S4, add purified water to the clarified drug solution obtained by filtration in step S3 to adjust the osmotic pressure so that the osmotic pressure of the drug solution is controlled at 280-320 mOsm / kg. After adjustment, let it stand for 5-10 minutes before filling.

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