A traditional Chinese medicine composition for treating dysmenorrhea and its preparation method for a patch

Abstract

This invention belongs to the field of traditional Chinese medicine technology and discloses a traditional Chinese medicine composition for treating dysmenorrhea and its preparation method as a patch. Specifically, it relates to a traditional Chinese medicine composition for treating dysmenorrhea, comprising the following components in parts by weight: 10-14 parts of Ligusticum chuanxiong, 10-14 parts of Notopterygium incisum, 8-12 parts of processed myrrh, 2-6 parts of leech, 13-17 parts of processed Cyperus rotundus, 13-17 parts of Corydalis yanhusuo, 10-14 parts of earthworm, and 1-5 parts of dragon's blood. The traditional Chinese medicine composition for treating dysmenorrhea provided by this invention is based on the essence of the traditional Chinese medicine theory of "free flow prevents pain," with a rigorous combination of principal, assistant, and adjuvant herbs. The entire formula works synergistically to dispel wind and cold, invigorate blood circulation, remove blood stasis, regulate qi, and relieve pain, addressing both the symptoms and the root cause. After preparation as a patch, the medicine penetrates the skin and is absorbed through acupoints, resulting in rapid onset of action, convenient use, high safety, and good patient compliance. Clinical trials have shown that this invention has a good relieving effect on dysmenorrhea, with rapid onset and stable efficacy, overcoming many shortcomings of existing methods.

Description

Technical Field

[0001] This invention belongs to the field of traditional Chinese medicine technology, and in particular relates to a traditional Chinese medicine composition for treating dysmenorrhea and a method for preparing its patch. Background Technology

[0002] Dysmenorrhea is one of the most common gynecological symptoms, referring to lower abdominal pain and distension before, during, or after menstruation, accompanied by backache or other discomfort. Severe symptoms can significantly impact daily life and work. Dysmenorrhea is divided into two categories: primary dysmenorrhea and secondary dysmenorrhea. Primary dysmenorrhea, accounting for over 90% of dysmenorrhea cases, is functional dysmenorrhea without organic lesions in the reproductive organs; secondary dysmenorrhea is secondary to organic pelvic diseases such as endometriosis and adenomyosis. Dysmenorrhea not only causes physical pain for women but also seriously interferes with their work, study, and daily life quality, becoming a significant public health issue affecting women's physical and mental health.

[0003] Currently, Western medicine primarily treats dysmenorrhea with symptomatic medications, commonly including nonsteroidal anti-inflammatory drugs (NSAIDs, such as ibuprofen and naproxen) and oral contraceptives. NSAIDs relieve pain by inhibiting cyclooxygenase and reducing the synthesis and release of prostaglandins; oral contraceptives exert their analgesic effect by inhibiting ovulation and lowering prostaglandin levels. However, Western medicine treatment has certain limitations: NSAIDs may cause gastrointestinal adverse reactions, and long-term use carries the risk of liver and kidney damage; oral contraceptives may cause gastrointestinal reactions and abnormal liver function, and should be used with caution by those at risk of thrombosis. Furthermore, Western medicine treatments are mostly symptomatic, and relapse is common after discontinuation, making it difficult to achieve a complete cure.

[0004] Traditional Chinese medicine (TCM) has a long history of understanding dysmenorrhea. The earliest record of dysmenorrhea appears in Zhang Zhongjing's *Synopsis of Prescriptions of the Golden Chamber* (Jin Gui Yao Lue) from the Han Dynasty. The *Treatise on the Causes and Symptoms of Various Diseases* (Zhu Bing Yuan Hou Lun) from the Sui Dynasty first established the concept of "abdominal pain during menstruation," believing that dysmenorrhea is mostly caused by "excessive labor damaging blood and qi, leading to physical weakness, and exposure to wind and cold qi invading the uterus and damaging the Chong and Ren meridians." Later physicians continuously enriched the diagnostic and treatment methods for dysmenorrhea. The *Introduction to Medicine* (Yi Xue Ru Men) from the Ming Dynasty provided detailed discussions on different syndromes such as qi stagnation, blood stasis, and cold coagulation. The *Fu Qingzhu's Gynecology* (Fu Qingzhu's Gynecology) from the Qing Dynasty further supplemented the etiology, pathogenesis, and corresponding treatments for liver stagnation, cold dampness, and kidney deficiency. TCM believes that the main pathogenesis of dysmenorrhea is the obstruction of qi and blood in the Chong and Ren meridians and the uterus; stagnation leads to pain; or the Chong and Ren meridians and the uterus are not properly nourished, resulting in pain. Common clinical syndromes include qi stagnation and blood stasis syndrome, cold coagulation and blood stasis syndrome, damp-heat stagnation syndrome, qi and blood deficiency syndrome, and kidney qi deficiency syndrome, among which qi stagnation and blood stasis syndrome and cold coagulation and blood stasis syndrome are the most common. In terms of treatment, traditional Chinese medicine takes regulating qi and blood, promoting blood circulation and removing blood stasis, and warming the meridians and relieving pain as the basic principles, and often uses a variety of treatment methods such as oral Chinese medicine, acupuncture, and massage.

[0005] Traditional Chinese medicine (TCM) external therapies for dysmenorrhea have a long history, with acupoint application therapy being particularly popular. Acupoint application involves applying TCM pastes or powders directly to specific acupoints. Through the dual effects of drug penetration and acupoint stimulation, it aims to unblock meridians, regulate Qi and blood, and relieve pain. This therapy is simple to perform, highly safe, has few side effects, and avoids the first-pass effect and gastrointestinal irritation of oral medications, resulting in good patient compliance. In recent years, clinical research on TCM acupoint application for primary dysmenorrhea has increased, achieving remarkable efficacy. Multiple meta-analyses have shown that TCM acupoint application is superior to nonsteroidal anti-inflammatory drugs (NSAIDs) in terms of overall effectiveness, reduction of dysmenorrhea symptom scores, and visual analog scale (VAS) pain scores, and also has a significant advantage in reducing plasma prostaglandin levels. Studies have also found that among eight commonly used methods for treating primary dysmenorrhea, acupoint application ranks better than conventional treatments such as acupuncture, moxibustion, and ibuprofen in improving dysmenorrhea symptom scores. Acupoint application combined with oral Chinese medicine therapy is also superior to oral Chinese medicine alone in reducing VAS scores, showing a good synergistic effect.

[0006] Although traditional Chinese medicine external therapies for dysmenorrhea have made some progress, there is currently a lack of topical preparations on the market that are specifically designed for dysmenorrhea, have a rapid onset of action, and are easy to use. Therefore, developing a traditional Chinese medicine treatment for dysmenorrhea that is rationally formulated, easy to use, has a definite curative effect, and has few side effects is of great significance for meeting the clinical needs of a large number of dysmenorrhea patients. Summary of the Invention

[0007] To address the aforementioned technical problems, this invention proposes a traditional Chinese medicine composition for treating dysmenorrhea and a method for preparing its patch. The traditional Chinese medicine composition for treating dysmenorrhea described in this invention has good therapeutic effects on primary and secondary dysmenorrhea, as well as abdominal pain symptoms such as endometriosis, with rapid onset and good efficacy.

[0008] To achieve the above objectives, the present invention provides a traditional Chinese medicine composition for treating dysmenorrhea, comprising the following components in parts by weight: 10-14 parts of Ligusticum chuanxiong, 10-14 parts of Notopterygium incisum, 8-12 parts of processed myrrh, 2-6 parts of leech, 13-17 parts of processed Cyperus rotundus, 13-17 parts of Corydalis yanhusuo, 10-14 parts of earthworm, and 1-5 parts of dragon's blood.

[0009] Chuanxiong (Ligusticum striatum): It is warm in nature and pungent in taste, and enters the liver, gallbladder, and pericardium meridians. Its main functions are to invigorate blood circulation, promote qi circulation, dispel wind, and relieve pain. It is mainly used to treat blood stasis and qi stagnation, headache, rheumatic pain, and irregular menstruation. Its mechanism of action is related to improving blood circulation and inhibiting inflammatory responses.

[0010] Notopterygium root: It is pungent, bitter and warm in nature, and enters the bladder and kidney meridians. It has the effects of dispelling cold and relieving exterior syndrome, dispelling wind and dampness, and relieving pain. It is mainly used to treat diseases such as exogenous wind-cold, rheumatic pain, and headache and body pain.

[0011] Prepared myrrh: It has the effects of promoting blood circulation, relieving pain, reducing swelling and promoting tissue regeneration. It is mainly used to treat pain due to blood stasis, traumatic injuries, and non-healing sores.

[0012] Leeches: Their main effects are promoting blood circulation, removing blood stasis, anticoagulation, reducing swelling and relieving pain. They are mainly used to treat stroke, thrombosis, amenorrhea, and traumatic injuries. Their active ingredients (such as hirudin) can improve blood circulation and inhibit thrombus formation.

[0013] Prepared Cyperus rotundus has the effects of soothing the liver and relieving depression, regulating menstruation and relieving pain, regulating qi and relieving chest tightness. It is mainly used to treat liver qi stagnation, irregular menstruation, and spleen and stomach qi stagnation.

[0014] Corydalis: It has the effects of promoting blood circulation, removing blood stasis, regulating qi and relieving pain. It is often used for symptoms such as chest, rib and abdominal pain, dysmenorrhea, and traumatic injuries caused by qi stagnation and blood stasis.

[0015] Earthworm: Salty and cold in nature, it enters the liver, spleen, and bladder meridians. Its core functions are clearing heat and calming the mind, unblocking the meridians and relieving pain, relieving asthma, and promoting diuresis. It is mainly used to treat high fever convulsions, hemiplegia due to stroke, rheumatic pain, asthma, edema, and other symptoms.

[0016] Dragon's Blood: It is a commonly used Chinese medicine for promoting blood circulation and removing blood stasis. It is sweet, salty and neutral in nature, and enters the heart and liver meridians. It has the effects of promoting blood circulation and relieving pain, removing blood stasis and stopping bleeding, and promoting tissue regeneration. It is mainly used to treat injuries from falls and blows, external bleeding, and non-healing sores and ulcers.

[0017] Preferably, the ingredients include the following components by weight: 12 parts of Ligusticum chuanxiong, 12 parts of Notopterygium incisum, 10 parts of processed myrrh, 4 parts of leech, 15 parts of processed Cyperus rotundus, 15 parts of Corydalis yanhusuo, 12 parts of earthworm, and 3 parts of dragon's blood.

[0018] Preferably, the traditional Chinese medicine composition is a topical patch.

[0019] The present invention also provides a method for preparing a topical patch using the aforementioned traditional Chinese medicine composition, comprising the following steps: 1) Weigh out the following ingredients according to weight: Ligusticum chuanxiong, Notopterygium incisum, processed myrrh, leech, processed Cyperus rotundus, Corydalis yanhusuo, earthworm, and dragon's blood. Mix them, dry and pulverize them to obtain mixed Chinese medicine powder. 2) Mix the mixed Chinese herbal powder obtained in step 1) with hot water to obtain a mixed Chinese herbal paste; 3) Adjust the mixed Chinese herbal paste obtained in step 2) into a round medicine block, and place the round medicine block on the acupoint patch to obtain the external patch.

[0020] Preferably, the particle size of the mixed Chinese herbal powder in step 1) is 60-100 mesh.

[0021] Preferably, the ratio of the mixed Chinese herbal powder to hot water in step 2) is such that the mixture can form a fixed shape; the temperature of the hot water in step 2) is 40~80℃.

[0022] Preferably, the diameter of the circular drug block in step 3) is 1.5~2.5cm and the thickness of the circular drug block is 0.5~1.5cm.

[0023] Compared with the prior art, the present invention has the following advantages and technical effects: This invention proposes a traditional Chinese medicine composition for treating dysmenorrhea and a method for preparing its patch. The composition uses *Notopterygium incisum* as the principal ingredient, whose effects are to relieve exterior syndromes, dispel cold, eliminate wind and dampness, and relieve pain. *Ligusticum chuanxiong* is used as the assistant ingredient, which enhances the analgesic effect of *Notopterygium incisum*, and its effects are to invigorate blood circulation, promote qi circulation, dispel wind, and relieve pain. *Myrrha*, leeches, earthworms, and dragon's blood are used as adjuvant ingredients, which invigorate blood circulation and promote menstruation, thus enhancing the analgesic effect. *Myrrha* invigorates blood circulation, relieves pain, reduces swelling, and promotes tissue regeneration. Leeches break up blood stasis, promote menstruation, and eliminate masses. Earthworms clear heat, calm the nerves, unblock collaterals, and promote urination. Dragon's blood invigorates blood circulation and removes blood stasis. *Cyperus rotundus* and *Corydalis yanhusuo* are used as guiding ingredients, which regulate qi and relieve pain, and are essential for regulating menstruation and relieving pain. *Cyperus rotundus* invigorates the liver, regulates qi, and relieves menstruation and pain. *Corydalis yanhusuo* invigorates blood circulation, promotes qi circulation, and has strong analgesic properties. In summary, the traditional Chinese medicine composition for treating dysmenorrhea provided by this invention is based on the essence of the traditional Chinese medicine theory of "free flow prevents pain," with a scientifically formulated composition and a rigorous combination of principal, assistant, and adjuvant herbs. The entire formula works synergistically to dispel wind and cold, invigorate blood circulation, remove blood stasis, regulate qi, and relieve pain, addressing both the symptoms and the root cause, and is particularly effective in regulating qi and blood stagnation in the Chong and Ren meridians and the uterus. After preparation as a patch, the medicine penetrates the skin and is absorbed through acupoints, resulting in rapid onset of action and convenient use. It avoids the first-pass effect and gastrointestinal irritation associated with oral medications, ensuring high safety and good patient compliance. Clinical trials have shown that this invention not only has significant efficacy for primary and secondary dysmenorrhea but also provides good relief for abdominal pain symptoms caused by endometriosis, exhibiting rapid onset and stable efficacy, overcoming many shortcomings of existing dosage forms. Therefore, this invention provides a safe, effective, and convenient new external application solution for dysmenorrhea patients, with broad market application prospects and clinical promotion value. Detailed Implementation

[0024] Various exemplary embodiments of the present invention are now described in detail. This detailed description should not be considered as a limitation of the invention, but rather as a more detailed description of certain aspects, features, and embodiments of the invention. Furthermore, regarding numerical ranges in the present invention, it should be understood that each intermediate value between the upper and lower limits of the range is also specifically disclosed. Every smaller range between any stated value or intermediate value within a stated range, and any other stated value or intermediate value within said range, is also included within the present invention. The upper and lower limits of these smaller ranges may be independently included or excluded from the range.

[0025] The specification and embodiments of this invention are merely exemplary.

[0026] The terms “include,” “including,” “have,” “contain,” etc., used in this article are all open-ended terms, meaning that they include but are not limited to.

[0027] Unless otherwise specified, the term "parts" in this invention refers to parts by weight.

[0028] Example 1 12 parts of Ligusticum chuanxiong, 12 parts of Notopterygium incisum, 10 parts of processed myrrh, 4 parts of leech, 15 parts of processed Cyperus rotundus, 15 parts of Corydalis yanhusuo, 12 parts of earthworm, and 3 parts of dragon's blood.

[0029] A method for preparing a topical patch includes the following steps: 1) Weigh out the following ingredients according to weight: Ligusticum chuanxiong, Notopterygium incisum, processed myrrh, leech, processed Cyperus rotundus, Corydalis yanhusuo, earthworm and dragon's blood. Mix them, dry and pulverize them, and pass them through an 80-mesh sieve to obtain mixed Chinese medicine powder. 2) Mix the mixed Chinese herbal powder and 65℃ hot water in a proportion that allows it to be kneaded into a fixed shape to obtain a mixed Chinese herbal paste; 3) Adjust the mixed Chinese herbal paste into a round piece with a diameter of 2cm and a thickness of 1cm. Place the round piece on a round acupoint patch with a diameter of 5cm to obtain the external patch.

[0030] Example 2 10 parts of Ligusticum chuanxiong, 10 parts of Notopterygium incisum, 8 parts of processed myrrh, 2 parts of leech, 13 parts of processed Cyperus rotundus, 13 parts of Corydalis yanhusuo, 10 parts of earthworm, and 1 part of dragon's blood.

[0031] A method for preparing a topical patch includes the following steps: 1) Weigh out the following ingredients according to weight: Ligusticum chuanxiong, Notopterygium incisum, processed myrrh, leech, processed Cyperus rotundus, Corydalis yanhusuo, earthworm and dragon's blood. Mix them, dry and pulverize them, and pass them through a 60-mesh sieve to obtain mixed Chinese medicine powder. 2) Mix the mixed Chinese herbal powder and 50℃ hot water in a proportion that allows it to be kneaded into a fixed shape after mixing to obtain a mixed Chinese herbal paste; 3) Adjust the mixed Chinese herbal paste into a round piece with a diameter of 1.5cm and a thickness of 0.5cm. Place the round piece on a round acupoint patch with a diameter of 5cm to obtain the external patch.

[0032] Example 3 14 parts of Ligusticum chuanxiong, 14 parts of Notopterygium incisum, 12 parts of processed myrrh, 6 parts of leech, 17 parts of processed Cyperus rotundus, 17 parts of Corydalis yanhusuo, 14 parts of earthworm, and 5 parts of dragon's blood.

[0033] A method for preparing a topical patch includes the following steps: 1) Weigh out the following ingredients according to weight: Ligusticum chuanxiong, Notopterygium incisum, processed myrrh, leech, processed Cyperus rotundus, Corydalis yanhusuo, earthworm and dragon's blood. Mix them, dry and pulverize them, and pass them through a 100-mesh sieve to obtain mixed Chinese medicine powder. 2) Mix the mixed Chinese herbal powder and 80℃ hot water in a proportion that allows it to be kneaded into a fixed shape to obtain a mixed Chinese herbal paste; 3) Adjust the mixed Chinese herbal paste into a round piece with a diameter of 2.5cm and a thickness of 1.5cm. Place the round piece on a round acupoint patch with a diameter of 5cm to obtain the external patch.

[0034] Example 4 11 parts of Ligusticum chuanxiong, 11 parts of Notopterygium incisum, 9 parts of processed myrrh, 3 parts of leech, 14 parts of processed Cyperus rotundus, 14 parts of Corydalis yanhusuo, 11 parts of earthworm, and 2 parts of dragon's blood.

[0035] A method for preparing a topical patch includes the following steps: 1) Weigh out the following ingredients according to weight: Ligusticum chuanxiong, Notopterygium incisum, processed myrrh, leech, processed Cyperus rotundus, Corydalis yanhusuo, earthworm and dragon's blood. Mix them, dry and pulverize them, and pass them through a 70-mesh sieve to obtain mixed Chinese medicine powder. 2) Mix the mixed Chinese herbal powder and 60℃ hot water in a proportion that allows it to be kneaded into a fixed shape to obtain a mixed Chinese herbal paste; 3) Adjust the mixed Chinese herbal paste into a round piece with a diameter of 2cm and a thickness of 1cm. Place the round piece on a round acupoint patch with a diameter of 5cm to obtain the external patch.

[0036] Example 5 13 parts of Ligusticum chuanxiong, 13 parts of Notopterygium incisum, 11 parts of processed myrrh, 5 parts of leech, 16 parts of processed Cyperus rotundus, 16 parts of Corydalis yanhusuo, 13 parts of earthworm, and 4 parts of dragon's blood.

[0037] A method for preparing a topical patch includes the following steps: 1) Weigh out the following ingredients according to weight: Ligusticum chuanxiong, Notopterygium incisum, processed myrrh, leech, processed Cyperus rotundus, Corydalis yanhusuo, earthworm and dragon's blood. Mix them, dry and pulverize them, and pass them through a 90-mesh sieve to obtain mixed Chinese medicine powder. 2) Mix the mixed Chinese herbal powder and 70℃ hot water in a proportion that allows it to be kneaded into a fixed shape to obtain a mixed Chinese herbal paste; 3) Adjust the mixed Chinese herbal paste into a round piece with a diameter of 2cm and a thickness of 1cm. Place the round piece on a round acupoint patch with a diameter of 5cm to obtain the external patch.

[0038] Example 6 One hundred patients diagnosed with abdominal pain symptoms caused by primary dysmenorrhea, secondary dysmenorrhea, and endometriosis during outpatient visits were selected (patients allergic to the patch material are prohibited from using it, and patients with allergies should use it with caution). The external patch prepared in Example 1 of this invention was used during menstruation, twice a day, once in the morning and once in the evening, for 12 hours each time, for three consecutive menstrual periods.

[0039] Efficacy evaluation criteria: Cured: Menstrual cramps will not recur for three months after application; Significant effect: Pain is significantly reduced after application, but pain may still occur from time to time within three months; Ineffective: If the pain remains severe after application and there is no effect, other treatment methods are needed.

[0040] Table 1. Therapeutic effects of the topical patch prepared in Example 1 of the present invention

[0041] As shown in Table 1, the external patch prepared in Example 1 of this invention has a cure rate of 75%, a significant efficacy rate of 20%, an ineffective rate of 5%, and a total effective rate of 95%.

[0042] Case 1: Ms. He, 35 years old, from Qinzhuang Village, Wangji Town, Jieshou City, first visit on July 15, 2025. Chief complaint: Secondary dysmenorrhea for 3 years. Present illness: 5-7 days / 30 days, moderate flow, dark color, clots, severe lower abdominal pain, accompanied by rectal tenesmus. Breast tenderness before menstruation. For the past three years, the patient has needed to take ibuprofen to relieve pain during dysmenorrhea. LMP: July 14, 2025. Multiple pelvic ultrasound examinations showed no obvious abnormalities. Pale tongue with thin white coating, wiry and hesitant pulse. Traditional Chinese medicine diagnosis: Dysmenorrhea, Qi stagnation and blood stasis syndrome; Western medicine diagnosis: Dysmenorrhea. Prescribed the herbal patch prepared in Example 1 of this invention, twice a day (replace every 10-12 hours). Instructions: Maintain emotional well-being and avoid raw, cold, and spicy foods.

[0043] Second visit, August 22, 2025: Chief complaint and present illness as before. LMP: Lower abdominal pain and anal tenesmus significantly disappeared on August 13, 2025. Continue to apply the Chinese herbal acupoint patch prepared in Example 1 of this invention, once in the morning and once in the evening (replace every 10-12 hours). Instructions: Maintain emotional well-being and avoid raw, cold, and spicy foods.

[0044] Third visit, November 15, 2025: Secondary dysmenorrhea for 3 years. Four months after treatment with the acupoint herbal patch prepared in Example 1 of this invention, LMP: 2025.11.13 No dysmenorrhea or anal tenesmus.

[0045] Case 2: Ms. Liu, 55 years old, from Shuangyang Village, Damiao Town, Taihe County, first visit on June 10, 2025. Chief complaint: secondary dysmenorrhea for 10 years. Present illness: 7 / 28-30 days, heavy flow, dark color, clots, severe dysmenorrhea, lower back pain, occasional diarrhea during menstruation. LMP: June 10, 2025, history of cesarean section. Multiple gynecological ultrasound examinations showed no obvious abnormalities. Pale tongue, thin coating, choppy pulse. Traditional Chinese medicine diagnosis: dysmenorrhea, blood stasis syndrome; Western medicine diagnosis: dysmenorrhea. Prescribed the acupoint herbal patch prepared in Example 1 of this invention, twice a day (replace every 10-12 hours). Instructions: maintain emotional well-being, avoid raw, cold, and spicy foods.

[0046] Second visit, July 14, 2025. Chief complaint and present illness history were the same as on June 10, 2025. LMP: July 10, 2025. Moderate flow, red color, with a few blood clots. Dysmenorrhea significantly improved, and lower back pain disappeared. Continue to apply the acupoint herbal patch prepared in Example 1 of this invention, once in the morning and once in the evening (replace every 10-12 hours). Instructions: Maintain emotional well-being and avoid raw, cold, and spicy foods.

[0047] On August 4, 2025, the patient had experienced secondary dysmenorrhea for 10 years. After treatment with the acupoint-based herbal patch prepared according to Example 1 of this invention, the dysmenorrhea disappeared, and there were no other discomforts. LMP: July 10, 2025. The patient continued to receive the acupoint-based herbal patch prepared according to Example 1 of this invention to consolidate the therapeutic effect.

[0048] On October 20, 2025, a telephone follow-up with the patient revealed no dysmenorrhea or other discomfort during menstruation.

[0049] Case 3: Ms. Yan, 54 years old, from Lane 4, Jieguang Road, Jieshou City, first visit on June 10, 2025. Chief complaint: Dysmenorrhea with increased menstrual flow for 7 years, worsening for 1 year. Present illness: For the past 7 years, the patient has experienced heavy, dark-colored menstrual flow with clots every 7 / 30 days, with severe dysmenorrhea requiring oral analgesics for relief. In the past year, the lower abdominal distension and pain have significantly worsened, and the pain symptoms are still not relieved by analgesics. She is also irritable and easily angered. LMP: June 10, 2025, CA125 11.40 U / mL, CA1993.11 U / mL at this hospital. Multiple ultrasound examinations showed an enlarged uterus and uneven myometrial echoes. Dark tongue, choppy pulse. Gynecological examination: Enlarged uterus, tender nodules on the posterior uterine wall, slightly tender to palpation. Traditional Chinese Medicine diagnosis: Dysmenorrhea, Qi stagnation and blood stasis syndrome; Western medicine diagnosis: 1. Dysmenorrhea; 2. Endometriosis; The acupoint herbal patch prepared in Example 1 of this invention was applied twice a day, morning and evening (replaced every 10-12 hours). Instructions: Maintain emotional well-being and avoid raw, cold and spicy foods.

[0050] Second visit: June 18, 2025. Chief complaint: Dysmenorrhea with increased menstrual flow for 7 years, worsening for 1 year. Medical history: Same as June 10, 2025. After treatment with the acupoint herbal patch prepared according to Example 1 of this invention, the dysmenorrhea symptoms significantly improved and the menstrual flow decreased. The patient requested to continue the acupoint herbal patch treatment prepared according to Example 1 of this invention with medication in advance. Instructions: Maintain emotional well-being and avoid raw, cold, and spicy foods.

[0051] Third visit: Chief complaint: Dysmenorrhea with increased menstrual flow for 7 years, worsening for 1 year. Present illness (LMP): After receiving acupoint herbal patch treatment prepared according to Example 1 of this invention on November 8, 2025, the dysmenorrhea disappeared for more than 3 months, and the menstrual flow is normal. The patient requests to continue acupoint herbal patch treatment prepared according to Example 1 of this invention with medication in advance. Instructions: Maintain emotional well-being and avoid raw, cold, and spicy foods.

[0052] Case 4: Ms. Yang, 37 years old, from Tianying Town, Jieshou City. Initial visit: July 25, 2025. Chief complaint: Dysmenorrhea with increased menstrual flow for 3 years. Present illness: 7-8 / 28-30 days, heavy flow, dark color, clots, dysmenorrhea accompanied by rectal tenesmus and fatigue. LMP: July 25, 2025. The patient required pain medication when experiencing severe lower abdominal pain. Ultrasound at our hospital showed: Uterus 59×60×62mm, thickened anterior wall myometrium, heterogeneous echo (suggestive of uterine gland disease). CA125: 47.99U / mL. Dark tongue, choppy pulse. Traditional Chinese medicine diagnosis: Dysmenorrhea, Qi stagnation and blood stasis syndrome; Western medicine diagnosis: 1. Dysmenorrhea; 2. Endometriosis; Prescribed the acupoint herbal patch prepared in Example 1 of this invention, applied twice daily (replaced every 10-12 hours). Instructions: Maintain emotional well-being and avoid raw, cold, and spicy foods.

[0053] Second visit: August 25, 2025. Chief complaint and medical history same as July 25, 2025. LMP: August 24, 2025. After treatment with the acupoint herbal patch prepared in Example 1 of this invention, the dysmenorrhea symptoms have significantly improved, the menstrual flow has decreased, and there are no special discomforts. Continue to apply the acupoint herbal patch prepared in Example 1 of this invention twice a day, morning and evening (replace every 10-12 hours). Instructions: Maintain emotional well-being and avoid raw, cold, and spicy foods.

[0054] Third visit: On September 28, 2025, the patient's dysmenorrhea disappeared after two courses of treatment with the acupoint herbal patch prepared according to Example 1 of this invention. LMP: September 25, 2025, menstrual flow was normal, with no special discomfort. Continue to apply the acupoint herbal patch prepared according to Example 1 of this invention twice a day, morning and evening (replace every 10-12 hours). Instructions: Maintain emotional well-being and avoid raw, cold, and spicy foods.

[0055] Four diagnostic methods: On October 25, 2025, the patient's LMP: On September 25, 2025, the menstrual flow was normal, with no lower abdominal pain or other discomfort. Continue to apply the acupoint herbal patch prepared in Example 1 of this invention twice a day (replace every 10-12 hours). Instructions: Maintain emotional well-being and avoid raw, cold, and spicy foods.

[0056] Fifth consultation: December 2, 2025. The patient's menstrual flow has been normal for the past 3 months, with no dysmenorrhea or other discomfort.

[0057] Case 5: Ms. Zhao, 22 years old, from Zhaoda Administrative Village, Bingji Township, Jieshou City. Initial visit: September 25, 2025. Chief complaint: Dysmenorrhea for 1+ years. Present illness: 5-6 / 26 days, moderate flow, dark color, clots, dysmenorrhea. LMP: Multiple ultrasound examinations on September 23, 2025, showed no obvious abnormalities in the pelvic cavity; CA125 in this hospital: 14.29 U / mL, pale tongue, choppy pulse. Traditional Chinese medicine diagnosis: Dysmenorrhea, blood stasis syndrome; Western medicine diagnosis: Dysmenorrhea. Prescribed the acupoint herbal patch prepared in Example 1 of this invention, applied twice daily (replaced every 10-12 hours). Instructions: Maintain emotional well-being, avoid raw, cold, and spicy foods.

[0058] Second visit: December 15, 2025. Patient's LMP: 2025.12.13. Menstrual flow was normal, with no lower abdominal pain or other discomfort. Continue applying the acupoint herbal patch prepared in Example 1 of this invention, twice a day (changing it every 10-12 hours) to consolidate the therapeutic effect. Instructions: Maintain emotional well-being and avoid raw, cold, and spicy foods.

[0059] The embodiments described above are merely preferred embodiments of the present invention and are not intended to limit the scope of the present invention. Various modifications and improvements made by those skilled in the art to the technical solutions of the present invention without departing from the spirit of the present invention should fall within the protection scope defined by the claims of the present invention.

Claims

1. A traditional Chinese medicine composition for treating dysmenorrhea, characterized in that, It includes the following components by weight: 10-14 parts of Ligusticum chuanxiong, 10-14 parts of Notopterygium incisum, 8-12 parts of processed Myrrh, 2-6 parts of Hirudo medicinalis, 13-17 parts of processed Cyperus rotundus, 13-17 parts of Corydalis yanhusuo, 10-14 parts of Pheretima aspergillum, and 1-5 parts of Dragon's Blood.

2. The traditional Chinese medicine composition according to claim 1, characterized in that, It includes the following components by weight: 12 parts of Ligusticum chuanxiong, 12 parts of Notopterygium incisum, 10 parts of processed myrrh, 4 parts of leech, 15 parts of processed Cyperus rotundus, 15 parts of Corydalis yanhusuo, 12 parts of earthworm, and 3 parts of dragon's blood.

3. The traditional Chinese medicine composition according to claim 1, characterized in that, The traditional Chinese medicine composition is a topical patch.

4. A method for preparing a topical patch using the traditional Chinese medicine composition as described in claim 1, characterized in that, Includes the following steps: 1) Weigh out the following ingredients according to weight: Ligusticum chuanxiong, Notopterygium incisum, processed myrrh, leech, processed Cyperus rotundus, Corydalis yanhusuo, earthworm, and dragon's blood. Mix them, dry and pulverize them to obtain mixed Chinese medicine powder. 2) Mix the mixed Chinese herbal powder obtained in step 1) with hot water to obtain a mixed Chinese herbal paste; 3) Adjust the mixed Chinese herbal paste obtained in step 2) into a round medicine block, and place the round medicine block on the acupoint patch to obtain the external patch.

5. The method for preparing a topical patch according to claim 4, characterized in that, The particle size of the mixed Chinese herbal powder mentioned in step 1) is 60~100 mesh.

6. The method for preparing a topical patch according to claim 4, characterized in that, The ratio of the mixed Chinese herbal powder to hot water in step 2) is such that the mixture can form a fixed shape; the temperature of the hot water in step 2) is 40~80℃.

7. The method for preparing a topical patch according to claim 4, characterized in that, The diameter of the circular medicine block mentioned in step 3) is 1.5~2.5cm, and the thickness of the circular medicine block is 0.5~1.5cm.

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