A composite hemostatic sponge, its preparation method and application

By combining biopolymer nanofibers with a sponge matrix, a composite hemostatic sponge is formed, consisting of a nanofiber barrier layer and a porous matrix. This solves the problem that traditional hemostatic sponges cannot simultaneously achieve efficient hemostasis and non-invasive removal, enabling rapid hemostasis and non-invasive removal, and reducing the risk of infection and delayed healing.

CN122297757APending Publication Date: 2026-06-30THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
Filing Date
2026-04-30
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Traditional hemostatic sponges cannot achieve both efficient hemostasis and non-invasive removal in emergency situations, which can easily lead to secondary bleeding and tissue damage, prolong the healing period and increase the risk of infection.

Method used

The method uses a combination of biopolymer nanofiber suspension and sponge matrix. A nanofiber barrier layer is formed through freezing treatment to prevent blood cells from embedding inside the sponge matrix. Combined with the porous sponge matrix, the blood can be quickly absorbed and concentrated to achieve rapid hemostasis, and can be directly and non-invasively removed.

Benefits of technology

It achieves rapid and efficient hemostasis, reducing bleeding by more than 40%, without tissue adhesion or secondary trauma, reducing the risk of infection and delayed healing, and has excellent biocompatibility and antibacterial properties, making it suitable for emergency treatment of deep trauma.

✦ Generated by Eureka AI based on patent content.

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Abstract

This invention belongs to the field of new materials technology, specifically disclosing a composite hemostatic sponge, its preparation method, and its application. The preparation method of the composite hemostatic sponge includes: adding tannic acid to a suspension of biopolymer nanofibers and mixing thoroughly to obtain a tannic acid-biopolymer nanofiber suspension; wherein the biopolymer contains carboxyl functional groups; impregnating a sponge matrix in a calcium chloride solution, and draining the liquid from the surface of the sponge matrix after impregnation; uniformly loading the tannic acid-biopolymer nanofiber suspension onto the surface of the sponge matrix; freezing the loaded sponge matrix for 12-24 hours, and then freeze-drying it to obtain the composite hemostatic sponge. The composite hemostatic sponge of this invention can achieve rapid and efficient hemostasis, significantly improving hemostasis efficiency, and can be removed non-invasively without secondary trauma.
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