Process for efficiently catalyzing synthesis of nicosulfuron nicotinamide intermediate
By combining a lanthanum-doped composite metal fluoride-diatomite supported catalyst with a 4A molecular sieve catalytic system, the problems of lengthy steps and high waste in the synthesis of dichloro-N,N-dimethylnicotinamide were solved, realizing a highly efficient and environmentally friendly catalytic synthesis of nicosulfuron-nicotinamide intermediates, which is suitable for industrial production.
Patent Information
- Application Number
- CN202610610106.6
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-05-06
- Publication Date
- 2026-06-30
AI Technical Summary
The existing synthetic route for dichloro-N,N-dimethylnicotinamide is lengthy, generates a large amount of wastewater and waste, has high catalyst costs and insufficient stability, and has limited reaction equilibrium, making it difficult to achieve the target product with high conversion rate and high purity.
A lanthanum-doped composite metal fluoride-diatomite supported catalyst is used, combined with in-situ dehydration of 4A molecular sieve and pressurized excess dimethylamine gas, to achieve efficient catalysis in a liquid phase environment through amidation reaction. By utilizing the multi-metal active centers of the catalyst and the pore structure of the molecular sieve, combined with precise thermodynamic and kinetic control, the reaction is ensured to move towards the product, and high-purity products are obtained through post-processing refining.
A simple and efficient synthesis of dichloro-N,N-dimethylnicotinamide was achieved, reducing catalyst consumption and waste generation, improving reaction conversion rate and product purity, making it suitable for industrial production and meeting the requirements of green chemistry.