A rod-shaped polycyclic polymer, its synthesis method and applications
By synthesizing rod-shaped polycyclic polymers (MCPs), the problems of ruthenium catalyst toxicity and insufficient types of lysosomal destructive drugs have been solved, achieving low-cost and high-efficiency lysosomal destructive effects, which are suitable for cancer treatment.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HUNAN ACAD OF CHINESE MEDICINE
- Filing Date
- 2026-03-20
- Publication Date
- 2026-06-30
AI Technical Summary
Rod-shaped polymers synthesized using transition metal catalysts such as ruthenium in existing technologies have toxicity issues, limiting their application in the biomedical field, and the types of drugs that are lysosomal destructive are limited.
Rod-shaped polycyclic polymers (MCPs) were synthesized under anhydrous conditions using compounds such as PCA, PEG-2Alkynyl, M-cPEG, DMAEMA, CPADB, and AIBN. Petal-shaped polymer micelles were then prepared as lysosomal disrupting drugs.
The synthesized rod-shaped polycyclic polymer MCP lowers the experimental equipment and technical barriers, is inexpensive, can effectively destroy lysosomes, and provides a wider range of lysosome-destroying drugs suitable for cancer treatment.
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Figure CN122302187A_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of medicine, and in particular relates to a rod-shaped polycyclic polymer, its synthesis method, and its application. Background Technology
[0002] Reported techniques for preparing polymers with rod-shaped molecular chains involve rare transition metal catalysts such as ruthenium. This is because only by using transition metal catalysts such as ruthenium can polymers with rod-shaped molecular chains be easily formed. However, the polymers obtained by this technique contain transition metals that accumulate over time and become toxic, which is not conducive to the biomedical applications of such polymers.
[0003] Lysosome disrupting drugs are a class of chemical substances that exert therapeutic effects by interfering with lysosomal function (such as disrupting their membrane integrity, altering their acid-base environment, or inducing the release of their contents). They have shown potential, especially in cancer treatment, but currently there are relatively few such drugs, so there is a need to develop more types of drugs.
[0004] Definitions: PCA: Polymerizable small molecule coupling agent.
[0005] MAA: Methacrylic acid.
[0006] DCC: N,N'-Dicyclohexylcarbodiimide.
[0007] DMAP: 4-Dimethylaminopyridine.
[0008] PEG: Polyethylene glycol.
[0009] PEG-2Alkynyl: A linear polyethylene glycol modified with diyne end groups.
[0010] M- c PEG: Cyclic polyethylene glycol monomer.
[0011] MCP: Polycyclic polymer.
[0012] DMF: N,N-dimethylformamide.
[0013] PMDETA: Pentamethyldivinyltriamine.
[0014] CuBr: Cuprous bromide.
[0015] DMAEMA: Dimethylaminoethyl methacrylate.
[0016] CPADB: 4-Cyano-4-(Thiobenzoyl)valerate.
[0017] AIBN: Azobisisobutyronitrile.
[0018] DMAc: N,N-dimethylacetamide. Summary of the Invention
[0019] To address the aforementioned problems, this invention discloses a rod-shaped polycyclic polymer, its synthesis method, and its applications. This invention is low-cost, requires simple experimental equipment, and is easy to operate, thus lowering the technical threshold for acceptance personnel.
[0020] To achieve the above objectives, the technical solution of the present invention is as follows: A rod-shaped polycyclic polymer, the structural formula of which is as follows:
[0021] A method for synthesizing a rod-shaped polycyclic polymer includes the following steps: Step 1: Synthesize the polymerizable small molecule coupling agent PCA; the chemical structural formula of PCA is as follows:
[0022] Step 2: Synthesis of diyne-terminated linear PEG: PEG-2Alkynyl; the chemical structure of PEG-2Alkynyl is as follows:
[0023] Step 3: Synthesize cyclic polyethylene glycol monomer M- via PCA and PEG-2Alkynyl. c PEG; M- c The chemical structure of PEG is as follows:
[0024] Step 4: Add DMAEMA and M- c The rod-shaped polycyclic polymer MCP of claim 1 was prepared by heating a mixture of PEG, CPADB, AIBN and DMAc.
[0025] Further improvements are made to step one as follows: Compound one is dissolved in anhydrous dichloromethane, DCC and DMAP are added sequentially under an ice bath and nitrogen atmosphere, stirred until homogeneous, then MAA is added, stirred until homogeneous under an ice bath, and then stirred at room temperature for 12 hours to obtain reaction product one. Reaction product one is separated and purified by column chromatography, and then PCA is obtained by rotary evaporation. The chemical structure of compound one is as follows:
[0026] In a further improvement, the molar ratio of compound I, DCC, DMAP and MAA is 6.94:7.63:0.76:7.63.
[0027] Further improvements are made, and the specific steps in step two are as follows: PEG with a number average molecular weight of 1.5 kDa was dissolved in anhydrous toluene. DCC and DMAP were then added sequentially under nitrogen protection and stirred until homogeneous. Anhydrous toluene solution of PCA was then added under ice bath conditions and the mixture was stirred for 0.5 h. The mixture was then stirred at room temperature for 48 h and centrifuged to obtain crude product 1. After purification, crude product 1 was obtained as PEG-2Alkynyl.
[0028] Further improvements were made, with the molar ratio of PEG, DCC, DMAP, and PCA being 0.50:2.25:0.23:2.25. The crude product was purified by redissolving it in toluene, then precipitating it in diethyl ether, followed by centrifugation, and this process was repeated three times.
[0029] Further improvements are made, and the specific steps of step three are as follows: 4-Nitroaniline was dissolved in DMF and heated to 40°C in an oil bath under a nitrogen atmosphere. o C, then PMDETA and CuBr were added. After 30 min, a mixed DMF solution containing PEG-2Alkynyl and PCA (with oxygen removed) was added at a rate of 1.0 mL / h. After the injection was completed, the reaction was carried out for 4 h to obtain reaction product two. Reaction product two was cooled to room temperature, and DMF was removed by rotary evaporation to obtain crude product two. Crude product two was purified: crude product two was dissolved in tetrahydrofuran and filtered through an alkaline alumina column to remove copper salts, and the filtrate was precipitated in cold diethyl ether and centrifuged. This process was repeated three times, and then dried under vacuum to obtain M- c PEG; wherein the molar ratio of 4-nitroaniline, PMDETA, CuBr, PEG-2Alkynyl and PCA is 2.60 μmol: 0.75 mol: 0.75 mol: 74.60 μmol: 0.261 mol.
[0030] Further improvements are made, and the specific steps of step four are as follows: DMAEMA, M- c PEG, CPADB, and AIBN were dissolved in DMAc. After complete dissolution, the solution underwent three freeze-pump-thaw cycles followed by degassing at 70°C. o The oil bath reaction of C was carried out for 24 h, then cooled to room temperature in air, diluted with tetrahydrofuran, and precipitated by adding cold n-hexane. The crude product was obtained by centrifugation. The crude product was dissolved in tetrahydrofuran, and precipitated again by adding cold n-hexane. The crude product was separated by centrifugation. After repeating this process three times, the product was dried under vacuum to obtain rod-shaped polycyclic polymer MCP. Among them, DMAEMA, M- cThe molar ratio of PEG, CPADB and AIBN was 0.50 mmol: 55.60 μmol: 5.56 μmol: 1.85 μmol.
[0031] One use of the above-mentioned rod-shaped polycyclic polymer, wherein the rod-shaped polycyclic polymer is used as a raw material for preparing lysosomal destructive drugs.
[0032] In a further improvement, the rod-shaped polycyclic polymer is dissolved in a sodium citrate buffer solution at pH 5.0 to prepare petal-shaped polymer micelles of 25.0 μg / mL to 50.0 μg / mL; the petal-shaped polymer micelles are used to prepare lysosomal destructive drugs.
[0033] Advantages of this invention: This invention discloses a polycyclic polymer that can be used as a lysosomal disrupting drug and its preparation method. The molecular chain of the polycyclic polymer has a rod-like structure with a length of about 100 nm. The invention also discloses a method for preparing the corresponding petal-shaped polymer micelles, providing a foundation for the further development of lysosomal disrupting drugs. Attached Figure Description
[0034] Figure 1 For PCA in DMSO- d The proton NMR spectrum in 6.
[0035] Figure 2 The image shows the 1H NMR spectrum of PEG-2Alkynyl in CDCl3.
[0036] Figure 3 PEG-2Alkynyl, M- c Size exclusion chromatograms of PEG and PEG.
[0037] Figure 4 For M- c The proton NMR spectrum of PEG in CDCl3.
[0038] Figure 5 For M- c Infrared spectra of PEG and PEG-2Alkynyl.
[0039] Figure 6 MCP in CDCl3 1 H NMR spectrum.
[0040] Figure 7 This is a transmission electron microscope image of the rod-like structure of MCP.
[0041] Figure 8 An atomic force microscope image of the rod-shaped structure of MCP.
[0042] Figure 9 Transmission electron microscopy (TEM) image of petal-shaped polymer micelles formed by MCP.
[0043] Figure 10 Fluorescence imaging of lysosome-specific probes after 4T1 cells were co-incubated with different concentrations of MCP.
[0044] Figure 11 This is a semi-quantitative statistical graph of fluorescence intensity. Detailed Implementation
[0045] The present invention will be further described below with reference to the accompanying drawings and embodiments.
[0046] (a)
[0047] (b)
[0048] (c)
[0049] (d)
[0050] The specific synthesis steps are as follows: 1. Synthesis of polymerizable small molecule coupling agents (PCA):
[0051] Compound 1 (2.00 g, 6.94 mmol) was weighed into a round-bottom flask, and 10.0 mL of dry dichloromethane was added. After dissolution, the round-bottom flask was placed in an ice bath. Then, under nitrogen protection, DCC (1.57 g, 7.63 mmol) and DMAP (95.13 mg, 0.76 mmol) were added sequentially to the round-bottom flask. After stirring for 10 min, MAA (0.66 g, 7.63 mmol) was added. The mixture was stirred in an ice bath for 60 min, and then stirred for 12 h at room temperature. After the reaction was completed, the product PCA was purified by column chromatography using ethyl acetate / hexane (3 / 1 v / v) as the eluent. The purified product PCA was obtained by rotary evaporation, concentration, and drying. The molecular structure of the product was characterized by nuclear magnetic resonance spectroscopy. The 1H NMR spectrum of PCA in deuterated dimethyl sulfoxide is shown below. Figure 1 As shown. 2. Synthesis of diyne-terminated linear PEG (PEG-2Alkynyl):
[0052] In a round-bottom flask, PEG (0.75 g, 0.50 mmol) with a number-average molecular weight of 1.5 kDa was dissolved in 10.0 mL of dry toluene, and the flask was placed in an ice bath. Then, under nitrogen protection, DCC (0.46 g, 2.25 mmol) and DMAP (28.16 mg, 0.23 mmol) were added sequentially. After stirring for 10 min, a PCA solution (0.22 g, 2.25 mmol) dissolved in 5.0 mL of dry toluene was added to the round-bottom flask. The mixture was placed in an ice bath and stirred for 30 min, then stirred for another 48 h at room temperature. After the reaction was complete, the reaction mixture was filtered, and the filtrate was precipitated in cold diethyl ether. The crude product was obtained by centrifugation. The crude product was reconstituted with 3 mL of toluene and then precipitated again in diethyl ether. This dissolution-precipitation-centrifugation process was repeated three times. Finally, the product PEG-2Alkynyl was obtained by vacuum drying. The molecular structure of the product was characterized by nuclear magnetic resonance spectroscopy and size exclusion chromatography. The 1H NMR spectrum of PEG-2Alkynyl in deuterated chloroform is shown below. Figure 2 As shown, the size exclusion chromatographic elution curve of PEG-2Alkynyl is as follows: Figure 3 As shown. 3. Synthesis of cyclic polyethylene glycol monomer (M-cPEG):
[0053] In a 1 L three-necked flask, 0.40 mg (2.60 μmol) of 4-nitroaniline and 0.7 L of DMF were added sequentially. A continuous stream of nitrogen was introduced into the DMF solution in the flask. The flask was then placed in an oil bath and heated to 40 °C. o C. After nitrogen flow for 1 h, PMDETA (129.28 mg, 0.75 mol) and CuBr (107.01 mg, 0.75 mol) were added to the flask under nitrogen protection. After 30 min, another 50.0 mL solution of deoxygenated DMF, containing PEG-2Alkynyl (125.04 mg, 74.60 μmol) and PCA (93.02 mg, 0.261 mol), was added to the 1 L flask via a syringe pump at a rate of 1.0 mL / h. After the injection was completed, the reaction was continued for 4 h. After the reaction was completed, the reaction mixture was cooled to room temperature, and DMF was removed by rotary evaporation to obtain the crude product. The crude product was dissolved in tetrahydrofuran and filtered through an alkaline alumina column to remove copper salts. The filtrate was precipitated in cold diethyl ether and centrifuged to obtain the precipitate. The precipitate was dissolved again in tetrahydrofuran, and the dissolution-precipitation-centrifugation process was repeated three times. The precipitate obtained by centrifugation was dried under vacuum to obtain product M-. c PEG. The molecular structure of the product was characterized by nuclear magnetic resonance spectroscopy, infrared spectroscopy, and size exclusion chromatography. M-c The 1H NMR spectrum of PEG in deuterated chloroform is as follows: Figure 4 As shown, M- c The infrared spectrum of PEG is as follows Figure 5 As shown, M- c Size exclusion chromatography elution curve of PEG as follows Figure 3 As shown. 4. Synthesis of polycyclic polymers (MCPs):
[0054] Accurately weigh DMAEMA (78.60 mg, 0.50 mmol), M- c PEG (113.01 mg, 55.60 μmol), CPADB (1.55 mg, 5.56 μmol), and AIBN (0.30 mg, 1.85 μmol) were added to a 1.5 mL centrifuge tube, followed by the addition of 0.20 mL of DMAc. After complete dissolution, the resulting solution was transferred to a 10 mL polymerization tube and degassed using a three-cycle freeze-pump-thaw cycle. The polymerization tube was then sealed and placed at 70°C. o The reaction was carried out in an oil bath at C. After 24 h of reaction, the polymerization tube was exposed to air and rapidly cooled to room temperature. 4.0 μL of the reaction mixture was used for monomer conversion determination by 1H NMR spectroscopy. The remaining reaction solution was diluted with 1 mL of tetrahydrofuran. The resulting tetrahydrofuran solution was added to excess cold n-hexane to precipitate the crude product. The crude product was obtained by centrifugation, and then redissolved in tetrahydrofuran. Unpolymerized DMAEMA was removed by a three-stage dissolution-precipitation-centrifugation process. Ultrafiltration was then performed using centrifuge tubes with a molecular cutoff of 5 kDa to remove unpolymerized macromonomers. Finally, the monomer with the composition P(DMAEMA) was obtained by freeze-drying. 59 - st -(M- c PEG-6) polycyclic polymers, abbreviated as MCP. The molecular structure of the product was characterized by nuclear magnetic resonance spectroscopy and size exclusion chromatography. The 1H NMR spectrum of MCP in deuterated chloroform is shown below. Figure 6 As shown, M- c Size exclusion chromatography elution curve of PEG as follows Figure 3 As shown. 5. Characterization methods for the rod-shaped molecular chain structure of polycyclic polymers:
[0055] The transmission electron microscopy (TEM) method for characterizing the rod-shaped molecular chain structure of polycyclic polymers is as follows: 0.5 mg of MCP was dissolved in 2.0 mL of DMF to obtain a polymer DMF solution with a concentration of 0.25 mg / mL. 10 μL of the polymer solution was dropped onto the surface of a carbon-coated copper mesh. After the polymer settled for 15 min, the remaining polymer solution was gently removed with filter paper. 10 μL of an aqueous solution of phosphotungstic acid (1% by mass, pH 7.4) was dropped onto the same copper mesh surface containing the polymer. After 5 min, the remaining phosphotungstic acid solution was gently removed with filter paper. The polymer sample on the copper mesh was dried in the dark at room temperature for several hours, and then the molecular chain structure of MCP was observed using a TEM. The TEM image of MCP is shown below. Figure 7 As shown, it visually demonstrates the rod-like structure of MCP, with a length of approximately 100 nm.
[0056] The atomic force microscopy (AFM) method for characterizing the rod-shaped molecular chain structure of polycyclic polymers is as follows: 0.5 mg of MCP was dissolved in 2.0 mL of DMF to obtain a polymer DMF solution with a concentration of 0.25 mg / mL. 10 μL of the polymer solution was deposited onto the surface of a freshly cleaved mica substrate. After standing at room temperature for 2 minutes, the structure of the polymer molecular chains was examined using an AFM. The AFM image of MCP is shown below. Figure 8 As shown, it visually demonstrates the rod-like structure of MCP, with a length of approximately 100 nm. 6. Preparation method of petal-shaped polymer micelles:
[0057] Weigh 1 mg of MCP and dissolve it in 4 mL of sodium citrate buffer solution with a pH of 5.0 (ionic strength of 150 mM to simulate the acidic conditions of lysosomes). After standing at room temperature for 10 h, a petal-shaped polymer micelle solution with a concentration of 0.25 mg / mL is obtained and stored under cold conditions. 7. Transmission electron microscopy characterization of petal-shaped polymer micelles:
[0058] A 10 μL solution of petal-shaped polymer micelles was dropped onto a carbon-coated copper mesh surface. After the polymer micelles settled for 15 min, the remaining solution was gently aspirated with filter paper. A 10 μL aqueous solution of phosphotungstic acid (1% by mass, pH 7.4) was then dropped onto the same copper mesh surface containing the polymer micelles. After 5 min, the remaining phosphotungstic acid solution was gently aspirated with filter paper. The polymer micelle sample on the copper mesh was dried in the dark at room temperature for several hours, and then the petal-shaped structure of the micelles was observed using a transmission electron microscope (TEM). The TEM image of the petal-shaped MCP micelles is shown below. Figure 9As shown, under simulated acidic conditions of lysosomes (pH=5.0), MCP micelles exhibit a visually visible branched structure, presenting an overall petal-like structure. 8. Application technology of petal-shaped polymer micelles as lysosomal destructive drugs:
[0059] 4T1 cells were seeded at a density of 100,000 cells per well in 24-well plates and incubated at 37°C. o Cells were cultured at 0.5% CO2 for 24 h. Subsequently, they were co-incubated with petal-shaped polymer micelles at concentrations of 25.0 μg / mL and 50.0 μg / mL for 4 h. After washing the cells three times with PBS, they were co-incubated with lysosomal probes for 30 min according to the Lysotracker kit from KGI Biotech. Cells were then washed three times with PBS. Next, cell nuclei were labeled with Hoechst for 15 min. Finally, the cells were washed three times with PBS, imaged using a fluorescence inverted microscope, and the semi-quantitative intensity analysis of the lysosomal-specific red fluorescent probes was performed using ImageJ software. The red fluorescence images of lysosomal-specific probes after co-incubation of 4T1 cells with different concentrations of petal-shaped polymer micelles are shown below. Figure 10 ), and the corresponding semi-quantitative statistical results of the average red fluorescence intensity of lysosomes, as follows: Figure 11 As shown. Results ( Figure 10 and Figure 11 The results showed that, compared with cells treated with physiological saline, the mean fluorescence intensity of lysosome-specific probes decreased by 1.3-fold in cells treated with petal-shaped polymer micelles (MCP) at a polymer micelle concentration of 25 μg / mL. In contrast, the mean fluorescence intensity of lysosome-specific probes did not change significantly in cells treated with polymeric control (LCP). When the concentration of MCP micelles increased to 50 μg / mL, the mean red fluorescence intensity of the treated cells further decreased by 1.8-fold. This is mainly because petal-shaped MCP micelles can disrupt lysosomes, causing the lysosome-specific red probes to be expelled from the lysosomes, thus leading to a decrease in the mean red fluorescence signal. These results indicate that rod-shaped polycyclic polymers can be used as lysosome-disrupting agents by forming petal-shaped polymer micelles.
[0060] Although embodiments of the present invention have been disclosed above, they are not limited to the applications listed in the specification and embodiments. They can be applied to various fields suitable for the present invention. Other modifications can be easily made by those skilled in the art. Therefore, without departing from the general concept defined by the claims and their equivalents, the present invention is not limited to the specific details and the illustrations shown and described herein.
Claims
1. A rod-shaped polycyclic polymer, characterized in that, The structural formula of the rod-shaped polycyclic polymer is as follows:
2. A method for synthesizing a rod-shaped polycyclic polymer, characterized in that, Includes the following steps: Step 1: Synthesize the polymerizable small molecule coupling agent PCA; the chemical structural formula of PCA is as follows: Step 2: Synthesis of diyne-terminated linear PEG: PEG-2Alkynyl; the chemical structure of PEG-2Alkynyl is as follows: Step 3: Synthesize cyclic polyethylene glycol monomer M- via PCA and PEG-2Alkynyl. c PEG; M- c The chemical structure of PEG is as follows: Step 4: Add DMAEMA and M- c The rod-shaped polycyclic polymer MCP of claim 1 was prepared by heating a mixture of PEG, CPADB, AIBN and DMAc.
3. The method for synthesizing the rod-shaped polycyclic polymer as described in claim 2, characterized in that, Step 1 is as follows: Compound 1 is dissolved in anhydrous dichloromethane, DCC and DMAP are added sequentially under an ice bath and nitrogen atmosphere, and after stirring evenly, MAA is added. After stirring evenly under an ice bath, the reaction is stirred at room temperature for 12 h to obtain reaction product 1. Reaction product 1 is separated and purified by column chromatography, and then PCA is obtained by rotary evaporation. The chemical structure of compound one is as follows:
4. The method for synthesizing the rod-shaped polycyclic polymer as described in claim 3, characterized in that, The molar ratio of compound I, DCC, DMAP and MAA is 6.94:7.63:0.76:7.
63.
5. The method for synthesizing the rod-shaped polycyclic polymer as described in claim 2, characterized in that, The specific steps in step two are as follows: PEG with a number average molecular weight of 1.5 kDa was dissolved in anhydrous toluene. DCC and DMAP were then added sequentially under nitrogen protection and stirred until homogeneous. Anhydrous toluene solution of PCA was then added under ice bath conditions and the mixture was stirred for 0.5 h. The mixture was then stirred at room temperature for 48 h and centrifuged to obtain crude product 1. After purification, crude product 1 was obtained as PEG-2Alkynyl.
6. The method for synthesizing the rod-shaped polycyclic polymer as described in claim 5, characterized in that, The molar ratio of PEG, DCC, DMAP and PCA was 0.50:2.25:0.23:2.
25. The crude product was purified by redissolving it in toluene, precipitating it in diethyl ether, and then centrifuging it. This process was repeated three times.
7. The method for synthesizing the rod-shaped polycyclic polymer as described in claim 2, characterized in that, The specific steps of step three are as follows: 4-Nitroaniline was dissolved in DMF and heated to 40°C in an oil bath under a nitrogen atmosphere. o C, then PMDETA and CuBr were added. After 30 min, a mixed DMF solution containing PEG-2Alkynyl and PCA (with oxygen removed) was added at a rate of 1.0 mL / h. After the injection was completed, the reaction was carried out for 4 h to obtain reaction product two. Reaction product two was cooled to room temperature, and DMF was removed by rotary evaporation to obtain crude product two. Crude product two was purified: crude product two was dissolved in tetrahydrofuran and filtered through an alkaline alumina column to remove copper salts, and the filtrate was precipitated in cold diethyl ether and centrifuged. This process was repeated three times, and then dried under vacuum to obtain M- c PEG; wherein the molar ratio of 4-nitroaniline, PMDETA, CuBr, PEG-2Alkynyl and PCA is 2.60 μmol: 0.75 mol: 0.75 mol: 74.60 μmol: 0.261 mol.
8. The method for synthesizing the rod-shaped polycyclic polymer as described in claim 2, characterized in that, The specific steps of step four are as follows: DMAEMA, M- c PEG, CPADB, and AIBN were dissolved in DMAc. After complete dissolution, the solution underwent three freeze-pump-thaw cycles followed by degassing at 70°C. o The oil bath reaction of C was carried out for 24 h, then cooled to room temperature in air, diluted with tetrahydrofuran, and precipitated by adding cold n-hexane. The crude product was obtained by centrifugation. The crude product was dissolved in tetrahydrofuran, and precipitated again by adding cold n-hexane. The crude product was separated by centrifugation. After repeating this process three times, the product was dried under vacuum to obtain rod-shaped polycyclic polymer MCP. Among them, DMAEMA, M- c The molar ratio of PEG, CPADB and AIBN was 0.50 mmol: 55.60 μmol: 5.56 μmol: 1.85 μmol.
9. Use of the rod-shaped polycyclic polymer according to claim 1, characterized in that, The rod-shaped polycyclic polymer is used as a raw material for preparing lysosomal destructive drugs.
10. Use of the rod-shaped polycyclic polymer as described in claim 9, characterized in that, The rod-shaped polycyclic polymer was dissolved in a sodium citrate buffer solution at pH 5.0 to prepare petal-shaped polymer micelles with a concentration of 25.0 μg / mL to 50.0 μg / mL; the petal-shaped polymer micelles are used to prepare lysosomal destructive drugs.