An experimental apparatus and method for testing photodamage to retinal pigment epithelial cells.

By designing a retinal pigment epithelial cell photodamage experimental device that includes an experimental chamber, a base, a heating and light source mechanism, the problems of uneven illumination and temperature control in existing devices have been solved, achieving efficient and accurate photodamage simulation and improving the reliability and efficiency of experimental data.

CN122303023APending Publication Date: 2026-06-30SHANGHAI FIRST PEOPLES HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI FIRST PEOPLES HOSPITAL
Filing Date
2026-04-13
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Existing experimental devices for photodamage to retinal pigment epithelial cells suffer from uncontrollable irradiation areas, lack of spatial resolution, temperature control and photothermal interference issues, batch errors introduced by multiple experiments, and a lack of multi-parameter coordinated control capabilities.

Method used

A device was designed that includes a test chamber, a test base, a heating mechanism, a light source mechanism, and a test light-assisted adjustment mechanism. The light spot diameter can be continuously adjusted through the light source control head and the adjustment lens module to ensure consistent illumination of each hole. Combined with the light sensor and the heating device, it provides precise photothermal control.

Benefits of technology

It significantly improves the reliability and comparability of experimental data between groups, reduces human error, and increases experimental efficiency, making it suitable for various disease research needs in universities, hospitals, and pharmaceutical companies.

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Abstract

This invention provides an experimental apparatus and method for testing photodamage to retinal pigment epithelial cells. The apparatus comprises an experimental chamber, an experimental platform, a heating mechanism, a light source mechanism, and a photodamage adjustment mechanism. Multiple cell culture dishes are mounted on the experimental platform. The heating mechanism is located below the cell culture dishes within a bottom heating chamber. The light source mechanism includes a light source control head for generating and adjusting the experimental light source, with the control head facing the experimental platform. The photodamage adjustment mechanism is installed on the experimental platform at a position corresponding to the cell culture dishes, and assists in adjusting the experimental light irradiating the cell culture dishes. This invention utilizes the combined operation of the light source mechanism and the photodamage adjustment mechanism to achieve continuous adjustment of the light spot diameter, flexibly simulating photodamage lesions of different scales from microfocal to diffuse, meeting the needs of various disease research.
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