Reaction control system for automatic NGS library construction

By designing an automated reaction control system for NGS library construction, the problem of reliance on manual operation in the NGS library construction process was solved, realizing an automated and efficient library construction process and improving the reliability and efficiency of experimental results.

CN122303026APending Publication Date: 2026-06-30HUNAN JIMAI MEDICAL TECHNOLOGY CO LTD
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Patent Information

Application Number
CN202610264257.0
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-03-05
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

In the current technology, the NGS library construction process is still carried out in a semi-automatic manner, which consumes a lot of manpower and time, and manual operation can easily affect the experimental results.

Method used

Design an automated NGS library construction reaction control system, including a base plate, motion module, nucleic acid extraction module, nucleic acid fragmentation module and library amplification module. The automated movement and temperature control of the modules are achieved through drive components and processors, and the reaction conditions are optimized by combining ultrasonic components and heat dissipation components.

Benefits of technology

It automates the construction of NGS libraries, reduces manual operations, improves the reliability and efficiency of experimental results, shortens reaction time, and reduces system costs.

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Abstract

The invention belongs to the technical field of molecular diagnosis, and particularly relates to a reaction control system for automatic NGS library construction, which comprises a bottom plate, a motion module, an upper plate, a nucleic acid extraction module, a nucleic acid fragmentation module, a first driving assembly, a library amplification module and a processor, the upper plate is directly or indirectly connected with the moving end of the moving module; the plurality of first driving assemblies are arranged on the upper plate; the motion module and the first driving assembly can move the nucleic acid extraction module and the nucleic acid fragmentation module in different directions relative to the bottom plate so as to drive the nucleic acid extraction module and the nucleic acid fragmentation module to be in butt joint with the corresponding reaction holes; and the library amplification module is arranged on the bottom plate and provides the temperature required by the amplification reaction for the corresponding reaction holes. The device is matched with a reaction device to realize the automation of NGS library construction, the modular design is convenient to adjust, and the library amplification module can accelerate the cooling speed and shorten the reaction time through heat dissipation.
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