A method for biosynthesis of a syringolin compound

CN122303348APending Publication Date: 2026-06-30SHANGHAI OCEAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI OCEAN UNIV
Filing Date
2024-12-27
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Under traditional culture conditions, the yield of Alternaria solani (AOH) is low, which cannot meet the needs of biomedical development. Existing methods have failed to effectively activate silent secondary metabolic gene clusters, limiting their application and research in the biomedical field.

Method used

A co-culture strategy was adopted, in which Alternaria hainanensis and Irbisporus were co-cultured in contact or non-contact. The chemical signal exchange between the microorganisms was used to activate the silent gene cluster, and the culture conditions were optimized to increase the biosynthesis of Alternaria hainanensis. The high-purity compound was obtained by ethyl acetate extraction and column chromatography purification.

Benefits of technology

It significantly increased the yield of cross-linked spores, broadened its application prospects in the biomedical field, enhanced the antibacterial and anti-cellular activities of the compound, reduced experimental costs, and is suitable for omics analysis.

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Abstract

This invention belongs to the field of microbiology, specifically relating to a method for the biosynthesis of Alternaria alternata compounds. This method involves co-culturing Alternaria alternata and Ulva nigricans, followed by extraction with ethyl acetate to obtain high-yield Alternaria alternata compounds. This biosynthetic method is green, environmentally friendly, and sustainable, effectively increasing the biosynthetic yield of Alternaria alternata compounds and providing a new pathway for the research and industrial development of these compounds, showing great promise.
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