A rapid screening method for promoting bone repair surface structure

By preparing gradient titanium dioxide nanotube arrays on the surface of titanium sheets and combining them with cytokine analysis, we can quickly screen out the surface structures of bone repair materials that are suitable for different individuals or groups. This solves the problems of low screening efficiency and poor adaptability in traditional methods, and realizes the development of highly efficient and personalized bone repair materials.

CN122306774APending Publication Date: 2026-06-30CHONGQING UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CHONGQING UNIV
Filing Date
2026-04-13
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

In the current research and development of bone repair materials, the screening efficiency is low and the individual/group adaptability is poor. Traditional methods are difficult to quickly achieve targeted optimization of the material surface topology, resulting in significant differences in repair effects.

Method used

A titanium dioxide nanotube array with a continuous gradient of 0-200 nm was prepared on the surface of a titanium sheet using a four-electrode bipolar electrochemical device. Combined with immunofluorescence staining of bone marrow mesenchymal stem cells and calculation of the comprehensive osteogenic coefficient, the optimal surface structure suitable for different ages or pathological conditions was quickly screened.

Benefits of technology

Significantly improves screening efficiency, shortens the R&D cycle, enables precise design for individuals/groups, ensures the compatibility and repeatability of repair materials, and is suitable for different bone repair needs.

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Abstract

This invention relates to a rapid screening method for bone-repairing surface structures, belonging to the field of bone repair materials technology. It aims to solve the technical problems of low efficiency and low individual / group adaptability of traditional screening methods. This invention constructs a titanium dioxide nanotube array with a continuous gradient diameter of 0-200 nm using a four-electrode bipolar electrochemical method. Immunofluorescence staining of key bone repair factors BMP-2, RUNX2, OPN, and OCN, combined with panoramic scanning analysis, is used to normalize the average fluorescence intensity of each of the four factors and then sum them to obtain a comprehensive osteogenic coefficient. Based on this coefficient, the optimal bone-repairing surface structure corresponding to bone marrow mesenchymal stem cells (BMSCs) from different age groups or different pathological conditions (such as osteoporosis, osteoarthritis, etc.) can be precisely located. This invention achieves high-throughput screening covering multiple surface structures in a single experiment, providing an efficient technical path for the precise and personalized design of bone repair materials, and has significant clinical translational value.
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