Sulfonamide derivative sustained-release granule and preparation method thereof

By preparing small-particle-size sulfonamide derivative sustained-release particles and employing a double-layer sustained-release coating technology, the problems of swallowing difficulties and dosage fractionation difficulties in pediatric patients were solved, achieving good palatability and smooth drug release.

CN122320918APending Publication Date: 2026-07-03CHANGSHA JINGYI PHARM TECH CO LTD
0 Cites 0 Cited by

Patent Information

Application Number
CN202610401707.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Priority Date
2025-04-30
Filing Date
2026-03-30
Publication Date
2026-07-03

AI Technical Summary

Technical Problem

Existing sulfonamide derivative formulations, such as immediate-release tablets and sustained-release capsules, present problems such as difficulty in swallowing, difficulty in dose division, and inconvenience in administration in pediatric patients. In particular, the large particle diameter of sustained-release capsules leads to a noticeable gritty sensation.

Method used

Sulfonamide derivatives were prepared into small-particle-size sustained-release granules. A double-layer sustained-release coating technology was used, and by controlling the type and amount of excipients in each layer and combining flavoring excipients, a palatable and easy-to-swallow oral formulation for children was prepared.

Benefits of technology

It solves the problems of swallowing difficulties and dosage fractionation for pediatric patients. The particles have no gritty feel, are palatable, support dosage-based administration, and improve the convenience of medication and the smoothness of drug release.

✦ Generated by Eureka AI based on patent content.
Patent Text Reader

Abstract

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to sulfonamide derivative sustained-release granules and a preparation method thereof. The sulfonamide derivative sustained-release particle comprises a drug-loading layer, a sustained-release layer I and a sustained-release layer II, the drug-loading layer comprises a blank pellet core and an active ingredient layer, and the active ingredient is a compound shown in the formula I. The invention further discloses a preparation method of the sulfonamide derivative sustained-release particle. According to the invention, medicines are prepared into sustained-release particles with uniform particle size, the particle size distribution of blank pellet cores and the sustained-release particles is accurately controlled, sustained-release layer coating is sequentially carried out twice outside a medicine carrying layer, and the variety and dosage of auxiliary materials in each layer are regulated and controlled, so that the sustained-release particles which are free of gravel feeling, good in palatability and easy to swallow are obtained; dosages of the sustained-release granules can be flexibly divided according to clinical requirements, administration requirements of patients with different weights or ages can be met by measuring different volumes of the sustained-release granules, the sustained-release granules only need to be taken once every day, accurate and convenient oral administration of children is realized, and meanwhile, proper sustained-release characteristics of stable drug release rate and no burst release are obtained.
Need to check novelty before this filing date? Find Prior Art