Insecticidal composition containing fluorine-containing pyrrole ketone and application thereof

Abstract

The application belongs to the technical field of pesticide insecticide, and discloses a kind of fluorine pyrrole ketone-containing insecticide composition and application thereof, active ingredient of the insecticide composition includes active ingredient A and active ingredient B, active ingredient A is fluorine pyrrole ketone, active ingredient B is any one of benzpyrimoxan, flometoquin, indazapyroxamet, and the mass ratio of active ingredient A to active ingredient B is 1:50~50:1.The insecticide composition has excellent control effect on hemipterous pests, has remarkable synergistic effect, effectively reduces the use amount of pesticide, and slows down the environmental pressure.

Description

Technical Field

[0001] This invention belongs to the field of pesticide insecticide technology and discloses an insecticidal composition containing flupyrfuranone and its application. Background Technology

[0002] Hemiptera are a group of insects that feed on plant sap or animal blood using their piercing-sucking mouthparts. They include stink bugs, aphids, and planthoppers. Their distinguishing feature is that the basal half of their forewings (elytra) is leathery, while the distal half is membranous. Some species possess scent glands that secrete defensive volatiles. Hemiptera pests pose significant threats to agriculture and the ecosystem, including herbivorous species that directly suck plant sap, leading to reduced yields, and insects that act as vectors for viral diseases. These pests are highly prolific and adaptable, and their resistance to pesticides often increases the difficulty of control, necessitating integrated pest management using a combination of strategies.

[0003] Aphids (Aphidoidea) are a representative group of the superfamily Aphididae in the order Hemiptera. They are widely distributed in temperate and subtropical regions worldwide, feeding on the sap of plant phloem. They have an extremely high reproductive capacity, completing 20-30 generations per year, primarily through parthenogenesis, with a generation taking only 5 days. Aphids congregate on tender leaves and the base of stems to feed, causing leaves to curl, develop chlorotic spots, and in severe cases, stunt plant growth or even death. Besides direct damage, the honeydew secreted by aphids can induce sooty mold, hinder photosynthesis, and spread viruses such as cucumber mosaic virus and wheat yellow dwarf virus, causing even greater economic losses.

[0004] Rice planthoppers (Delphacidae) are migratory pests belonging to the family Delphacidae in the order Hemiptera. They primarily damage rice, with common species including the brown planthopper, white-backed planthopper, and gray planthopper. Brown planthoppers, both adults and nymphs, congregate at the base of rice plants, sucking sap and causing leaves to turn yellow and leaves to accumulate metabolic waste at the base of the stems. In severe cases, this can lead to leaf drop and sooty mold. Rice planthoppers can also transmit rice black-streaked dwarf virus (RSV) and southern rice black-streaked dwarf virus (SRBSDV), causing reduced rice yields or even total crop failure.

[0005] Compound pesticide formulations offer significant advantages for controlling hemipteran pests. Through the synergistic effect of different mechanisms of action, compound pesticides can broaden the insecticidal spectrum and improve control efficacy, while simultaneously delaying the development of resistance. Furthermore, compound formulations can reduce the dosage of single pesticides, thereby lowering pesticide residues and environmental pollution. Through scientific formulation and optimization, compound pesticides demonstrate higher economic efficiency and eco-friendliness in field applications, providing an effective means for the sustainable management of hemipteran pests. Summary of the Invention

[0006] Based on the above, the present invention provides an insecticidal composition containing flupyrfuranone, wherein the active ingredients of the insecticidal composition include active ingredient A and active ingredient B, wherein active ingredient A is flupyrfuranone, and active ingredient B is any one of benzpyrimoxan, frometoquin, and indazapyroxamet, and the mass ratio of active ingredient A to active ingredient B is 1:50 to 50:1.

[0007] Furthermore, the active ingredient B is benzpyrimoxan, and the mass ratio of active ingredient A to active ingredient B is 1:30 to 20:1; The active ingredient B is floctoquin, and the mass ratio of active ingredient A to active ingredient B is 1:40 to 20:1; The active ingredient B is indazapyroxamet, and the mass ratio of active ingredient A to active ingredient B is 1:40~36:1.

[0008] Furthermore, the active ingredient B is benzpyrimoxan, and the mass ratio of active ingredient A to active ingredient B is 1:20 to 10:1; The active ingredient B is floctoquin, and the mass ratio of active ingredient A to active ingredient B is 1:30 to 15:1; The active ingredient B is indazapyroxamet, and the mass ratio of active ingredient A to active ingredient B is 1:20~24:1; Preferably, the active ingredient B is benzpyrimoxan, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 10:1. The active ingredient B is floctoquin, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 5:1; The active ingredient B is indazapyroxamet, and the mass ratio of active ingredient A to active ingredient B is 1:10 to 6:1.

[0009] Furthermore, the active ingredient B is benzpyrimoxan, and the mass ratio of active ingredient A to active ingredient B is 1:30, 1:20, 1:15, 1:6, 1:3, 2:1, 10:1, or 20:1. The active ingredient B is floctoquin, and the mass ratio of active ingredient A to active ingredient B is 1:40, 1:30, 1:15, 1:5, 1:1, 5:1, 15:1, or 20:1. The active ingredient B is indazapyroxamet, and the mass ratio of active ingredient A to active ingredient B is 1:40, 1:20, 1:10, 1:5, 1:1, 6:1, 12:1, 24:1, or 36:1. Furthermore, the active ingredient B is benzpyrimoxan, and the mass ratio of active ingredient A to active ingredient B is 1:20, 1:15, 1:6, 1:3, 2:1, or 10:1. The active ingredient B is floctoquin, and the mass ratio of active ingredient A to active ingredient B is 1:30, 1:15, 1:5, 1:1, 5:1, or 15:1. The active ingredient B is indazapyroxamet, and the mass ratio of active ingredient A to active ingredient B is 1:20, 1:10, 1:5, 1:1, 6:1, 12:1, or 24:1. Furthermore, the active ingredient B is benzpyrimoxan, and the mass ratio of active ingredient A to active ingredient B is 1:15, 1:6, 1:3, 2:1, or 10:1. The active ingredient B is floctoquin, and the mass ratio of active ingredient A to active ingredient B is 1:15, 1:5, 1:1, or 5:1. The active ingredient B is indazapyroxamet, and the mass ratio of active ingredient A to active ingredient B is 1:10, 1:5, 1:1, or 6:1.

[0010] Furthermore, the insecticidal composition, in addition to the active ingredient, also contains auxiliary ingredients, which are selected from one or more of wetting agents, dispersants, emulsifiers, thickeners, disintegrants, antifreeze agents, defoamers, solvents, preservatives, stabilizers, synergists, or carriers.

[0011] Furthermore, based on a total weight of 100 wt%, the total weight of active ingredient A and active ingredient B accounts for 1% to 80% of the total weight of the insecticidal composition.

[0012] Furthermore, the insecticidal composition is prepared into a pesticide-permitted formulation, wherein the formulation is a solid or liquid formulation.

[0013] Furthermore, the solid formulation is a water-dispersible granule or a wettable powder; the liquid formulation is a suspension, microemulsion, water emulsion, microemulsion, emulsifiable concentrate, soluble concentrate, or dispersible oil suspension.

[0014] The present invention also discloses the application of the insecticidal composition described above for the control of agricultural, horticultural, and forestry pests.

[0015] Furthermore, the pests mentioned are hemiptera pests; the hemiptera pests are aphids or rice planthoppers.

[0016] The beneficial effects of this invention are as follows: (1) The insecticidal composition of the present invention combines compounds with different mechanisms of action in a reasonable manner, and has a significant synergistic effect on hemiptera pests under a certain mass ratio. (2) The insecticidal composition of the present invention has significant effects on the control of pests such as aphids and rice planthoppers, with rapid effect and long duration of action; (3) The insecticidal composition of the present invention reduces the dosage of pesticides and reduces agricultural production costs. Detailed Implementation

[0017] To make the technical solution, objectives and advantages of the present invention clearer, the present invention is described with reference to the following specific embodiments. However, the present invention can be implemented in various forms and should not be limited to the embodiments described herein.

[0018] Preparation method of formulation example.

[0019] 1. Preparation method of water-dispersible granules: According to the formula ratio, add the active ingredients to the carrier, and add surfactants and other functional additives to it. Mix, and after air jet milling, add 10-25% water. Then knead, granulate, dry and sieve to obtain water-dispersible granules; or spray water, granulate and dry the pulverized powder in a fluidized bed granulator, and then sieve to obtain the product.

[0020] 2. Preparation method of wettable powder: According to the formula ratio, the active ingredients, dispersant, wetting agent and filler are mixed and stirred evenly in a mixer. After being pulverized by an air jet mill, they are mixed evenly again to prepare the wettable powder of the composition of the present invention.

[0021] 3. Preparation method of emulsifiable concentrate: According to the formula ratio, add the measured active ingredients, solvent and co-solvent into the mixing tank and stir to dissolve them. Then add the emulsifier, and use the remaining solvent to make up the balance. Stir evenly in the mixing tank, and filter to obtain the emulsifiable concentrate required by the present invention.

[0022] 4. Preparation method of suspension: According to the formula ratio, place the active ingredients, surfactants and other functional additives in the reaction vessel in sequence, add water and mix evenly, then perform high-speed shearing, wet sand milling, and finally homogenization filtration to obtain the suspension product.

[0023] The following are examples of formulation preparation.

[0024] Preparation Example 1: 32% Flupyrrolidone·benzpyrimoxan water-dispersible granules (1:15) Formula composition: 2% flupyrrolidone, 30% benzpyrimoxan, 10% naphthalene sulfonate formaldehyde condensate, 5% BX (a type of succinate), 6% succinate sulfonate, 10% white sugar, and kaolin to make up the balance.

[0025] Preparation Example 2: 21% Flupyrrolidone·benzpyrimoxan wettable powder (1:6) Formula composition: 3% flupyrrolidone, 18% benzpyrimoxan, 10% sodium lignosulfonate, 4% vinyl phenol polyoxyethylene ether sulfate, 4% bleaching powder BX, 10% silica, and kaolin to make up the balance.

[0026] Preparation Example 3: 8% Flupyrrolidone·benzpyrimoxan emulsifiable concentrate (1:3) Formula composition: 2% fluopyrfuranone, 6% benzpyrimoxan, 20% N-methylpyrrolidone, 10% alkyl aryl polyoxyethylene ether polyoxypropylene ether, 3% succinate sulfonate, 12% DMF, methyl oleate to make up the balance.

[0027] Preparation Example 4: 22% Flupyrrolidone·benzpyrimoxan suspension (10:1) Formula composition: 20% flupyrrolidone, 2% benzpyrimoxan, 4% castor oil polyoxyethylene ether, 1.5% castor oil polyoxyethylene ether phosphate, 1% succinate sulfonate, 0.25% xanthan gum, 5% glycerol, 0.3% magnesium aluminum silicate, 0.1% sodium benzoate, 0.5% silicone oil, deionized water to make up the balance.

[0028] Preparation Example 5: 32% flupyrfuranone·flometoquin water-dispersible granules (15:1) Formula composition: 30% flupyrrolidone, 2% flometoquin, 4% sodium dodecyl sulfate, 10% fatty alcohol polyoxyethylene ether sulfate, 3% sodium lignosulfonate, 10% ammonium sulfate, starch to make up the balance.

[0029] Preparation Example 6: 30% Flupyrrolidone·Flocetoquin Wettable Powder (1:1) Formula composition: 15% flupyrrolidone, 15% flometoquin, 10% calcium dodecylbenzenesulfonate, 4% succinate sulfonate, 3% fatty alcohol polyoxyethylene ether sulfate, 5% silica, 20% starch, and kaolin to make up the balance.

[0030] Preparation Example 7: 16% flupyrfuranone·flometoquin emulsifiable concentrate (1:15) Formulation composition: 1% flupyrrolidone, 15% flometoquin, 10% EO / PO block copolymer, 10% acetophenone, 5% propylene glycol methyl ether, 3% sodium alkyl polyoxyethylene ether sulfonate, and tricresyl to make up the balance.

[0031] Preparation Example 8: 18% flupyrfuranone·flometoquin suspension (1:5) Formula composition: 3% flupyrrolidone, 15% flometoquin, 2% triphenylethylphenol polyoxyethylene ether, 2% phenylethylphenol polyoxyethylene polyoxypropylene ether, 2% fatty alcohol polyoxyethylene ether sulfate, 3% fatty alcohol polyoxyethylene ether phosphate, 0.25% magnesium aluminum silicate, 0.15% carboxyethyl cellulose, 0.25% sodium sorbate, 5% ethylene glycol, 0.5% silicone oil, deionized water to make up the balance.

[0032] Preparation Example 9: 30% flupyrrolidone·indazapyroxamet water-dispersible granules (1:5) Formula composition: 5% flupyrrolidone, 25% indazapyroxamet, 10% sodium lignosulfonate, 2.5% BX (a type of lignosulfonate), 2% naphthalene sulfonate formaldehyde condensate, 10% ammonium sulfate, and kaolin to make up the balance.

[0033] Preparation Example 10: 22% Flupyrrolidone·Indazapyroxamet Wettable Powder (1:10) Formula composition: 2% flupyrrolidone, 20% indazapyroxamet, 3% sodium alkyl polyoxyethylene ether sulfonate, 5% succinate sulfonate, 4% sodium polynaphthalene sulfonate, 8% kaolin, 10% silica, and bentonite to make up the balance.

[0034] Preparation Example 11: 7% Flupyrrolidone·indazapyroxamet EC (6:1) Formula composition: 6% flupyrrolidone, 1% indazapyroxamet, 15% N-methylpyrrolidone, 12% tristyrene-phenylphenol polyoxyethylene ether polyoxypropylene ether, 2% sodium dodecyl sulfate, 10% DMF, methyl oleate to make up the balance.

[0035] Preparation Example 12: 26% flupyrfuranone·indazapyroxamet suspension (12:1) Formula composition: 24% flupyrrolidone, 2% indazapyroxamet, 1% sodium lignosulfonate, 2% fatty alcohol polyoxyethylene ether sulfate, 2.5% castor oil polyoxyethylene ether phosphate, 0.25% xanthan gum, 1.2% magnesium aluminum silicate, 5% glycerol, 0.05% potassium benzoate, 0.5% silicone oil, deionized water to make up the balance.

[0036] Example 1: Indoor bioactivity assay.

[0037] Test reagents: Flupyrifuranone, Benzpyrimoxan, Flometoquin, and Indazapyroxamet technical grade. Based on the preliminary test results, five series concentrations were set up using a proportional method in the formal test. The technical grade was dissolved and diluted with a suitable solvent to prepare a stock solution of a certain concentration. Before the test, the stock solution was further diluted proportionally with a 0.1% (v / v) Tween-80 aqueous solution.

[0038] The insect sources tested were: peach aphid (nymph) and rice planthopper (nymph).

[0039] Aphid activity assay: Indoor toxicity was determined using the leaf-disc spray method. Fresh, non-toxic cabbage leaves were perforated to form leaf discs. A damp sponge was placed on a petri dish, followed by filter paper, and then the leaf discs were placed on the filter paper, with two leaf discs per dish. Indoor-raised aphids were inoculated onto the leaf discs, with 30 aphids per disc. The spray pressure of the Potter spray tower was adjusted to 1.47 × 10⁻⁶. 5 To ensure the stability of Pa, the cleaned spray head was first rinsed twice with acetone, then twice with distilled water. The culture dish was placed on the bottom of the Potter spray tower and sprayed with 1 mL of solution. After the solution settled for 1 minute, it was removed. The control was treated with the same amount of water. The culture dishes were incubated at (25±1)℃, 70%±5% relative humidity, and a 16h:8h light-dark cycle. The mortality rate was checked after 48 hours. The insects were gently touched with the tip of a brush; those that did not move or were stiff were considered dead.

[0040] Rice planthopper activity assay: The pressure of the Potter spray tower was stabilized at 1.47 × 10⁻⁶. 5 Pa, the spray nozzle was first cleaned twice with acetone, then twice with distilled water. Forty test insects of uniform physiological condition were selected using a brush and placed in a culture dish. The dish was then placed on the bottom of the Potter spray tower for quantitative spraying, with a spray volume of 1 mL. After the solution settled for 1 minute, it was removed. Each treatment was repeated four times, with a 0.1% Tween-80 aqueous solution used as a blank control. The treated insects were then placed in an intelligent artificial climate chamber with a temperature of (25±1)℃, a relative humidity of 60%~80%, and a photoperiod of 16L:8D. Mortality was checked after 48 hours; insects that did not move at all when gently touched with a size 0 brush were considered dead.

[0041] Calculate the mortality rate for each treatment based on the survey data. Use the following formula:

[0042] In the formula: P — Mortality rate, expressed as a percentage (%); K —This indicates the number of dead insects, expressed in heads; N — This indicates the total number of insects treated, in units of heads.

[0043]

[0044] In the formula: P 1 —Adjusted mortality rate, in percentages (%); P t —The mortality rate is expressed as a percentage (%). P 0 — Mortality rate in blank control group, expressed as a percentage (%).

[0045] If the control mortality rate is <5%, no correction is needed; if the control mortality rate is between 5% and 20%, correction should be performed according to the corrected mortality rate formula; if the control mortality rate is >20%, the trial needs to be repeated.

[0046] The toxicity regression equation, correlation coefficient, and LC were obtained using a statistical analysis system. 50 The value is used to evaluate the activity of the test reagent on the biological sample.

[0047] The co-toxicity coefficient (CTC value) of the mixture is calculated using the following formula:

[0048] In the formula: ATI —Measured toxicity index of the mixture; S LC of standard insecticides 50 The unit is milligrams per liter (mg / L); M LC of the mixture 50 The unit is milligrams per liter (mg / L).

[0049]

[0050] In the formula: TTI —Theoretical toxicity index of the mixture; TI A —A. Toxicity index of drug A; P A —The percentage content of drug A in the mixture, expressed as a percentage (%). TI B—Toxicity index of drug B; P B —Percentage content of agent B in the mixture, expressed as percentage (%).

[0051]

[0052] In the formula: CTC —Cotoxicity coefficient; ATI —Measured toxicity index of the mixture; TTI —Theoretical toxicity index of mixed preparations.

[0053] Co-toxicity coefficient of compound CTC ≥120 exhibits a synergistic effect; CTC≤80 It exhibits antagonistic effects; 80 < CTC <120 exhibits an additive effect.

[0054] Table 1. Results of indoor bioactivity tests of flupyrfuranone and benzpyrimoxan on peach aphids. Test reagents Proportion Proportion virulence regression equation Correlation coefficient <![CDATA[LC 50 (mg·L -1 )]]> Cotoxicity coefficient (CTC) Flupyrrolidone (A) / / y = 4.7697 + 1.5095x 0.9975 1.4208 / benzpyrimoxan (B) / / y = 3.7557 + 1.5141x 0.9976 6.6341 / A:B 1 50 y = 3.9991 + 1.257x 0.9983 6.2555 98.934 A:B 1 30 y = 4.1577 + 1.2343x 0.9961 4.8133 123.241 A:B 1 20 y = 4.2331 + 1.2205x 0.9935 4.2498 132.885 A:B 1 15 y = 4.3554 + 1.279x 0.9944 3.1913 169.101 A:B 1 6 y = 4.5878 + 1.1927x 0.9997 2.2162 196.398 A:B 1 3 y = 4.7205 + 1.3317x 0.9906 1.6215 213.388 A:B 2 1 y = 4.9521 + 1.4126x 0.9953 1.0811 178.065 A:B 10 1 y = 4.9928 + 1.2049x 0.9877 1.0139 150.913 A:B 20 1 y = 4.9193 + 1.2969x 0.9986 1.1539 127.917 A:B 30 1 y = 4.8424 + 1.3341x 0.9887 1.3126 111.058 A:B 40 1 y = 4.7963 + 1.3826x 0.9954 1.4038 103.189 Indoor experiments showed that the combination of flupyrrolidone and benzpyrimoxan, under appropriate mass ratios, exhibited good biological activity against peach aphids, demonstrating a synergistic effect. A mass ratio of flupyrrolidone to benzpyrimoxan of 1:30–20:1 resulted in a co-toxicity coefficient greater than 120, indicating a synergistic effect; a mass ratio of 1:20–10:1 resulted in a co-toxicity coefficient greater than 130, showing a significant synergistic effect; and a mass ratio of 1:15–10:1 resulted in a co-toxicity coefficient greater than 140, showing a remarkable synergistic effect.

[0055] Among them, the mass ratios of flupyrfuranone to benzpyrimoxan of 1:30, 1:20, 1:15, 1:6, 1:3, 2:1, 10:1, and 20:1 showed a co-toxicity coefficient greater than 120, indicating a synergistic effect; the mass ratios of 1:20, 1:15, 1:6, 1:3, 2:1, and 10:1 showed a co-toxicity coefficient greater than 130, indicating a significant synergistic effect; and the mass ratios of 1:15, 1:6, 1:3, 2:1, and 10:1 showed a co-toxicity coefficient greater than 140, indicating a significant synergistic effect.

[0056] Table 2. Results of indoor bioactivity tests of flupyrrolidone and frometoquin in rice planthoppers. Test reagents Proportion Proportion virulence regression equation Correlation coefficient <![CDATA[LC 50 (mg·L -1 )]]> Cotoxicity coefficient (CTC) Flupyrrolidone (A) / / y = 3.8543 + 1.4205x 0.9980 6.4056 / flometoquin (B) / / y = 3.7221 + 0.8651x 0.9999 30.0000 / A:B 1 50 y = 3.3850 + 1.1425x 0.9985 25.9207 107.942 A:B 1 40 y = 3.4197 + 1.1653x 0.9983 22.7083 121.220 A:B 1 30 y = 3.5179 + 1.1301x 0.9925 20.4865 130.886 A:B 1 15 y = 3.6514 + 1.1659x 0.9947 14.3437 170.012 A:B 1 5 y = 3.7046 + 1.2639x 0.9885 10.5913 175.507 A:B 1 1 y = 4.1038 + 1.1197x 0.9958 6.3156 167.158 A:B 5 1 y = 4.1403 + 1.3038x 0.9994 4.5646 161.502 A:B 15 1 y = 4.1324 + 1.2287x 0.9955 5.0828 132.540 A:B 20 1 y = 4.1157 + 1.2060x 0.9956 5.4104 123.001 A:B 35 1 y = 3.9983 + 1.3095x 0.9964 5.8201 112.518 A:B 50 1 y = 3.9856 + 1.3095x 0.9938 5.9514 109.318 Indoor experiments showed that the combination of flupyrrolidone and flocetoquin, under appropriate mass ratios, exhibited good biological activity against rice planthoppers, demonstrating a synergistic effect. A mass ratio of flupyrrolidone to flocetoquin of 1:40–20:1 resulted in a co-toxicity coefficient greater than 120, indicating a synergistic effect; a mass ratio of 1:30–15:1 resulted in a co-toxicity coefficient greater than 130, showing a significant synergistic effect; and a mass ratio of 1:15–5:1 resulted in a co-toxicity coefficient greater than 140, also indicating a remarkable synergistic effect.

[0057] Among them, the mass ratios of flupyrrolidone to frometoquin of 1:40, 1:30, 1:15, 1:5, 1:1, 5:1, 15:1, and 20:1 showed a co-toxicity coefficient greater than 120, indicating a synergistic effect; the mass ratios of 1:30, 1:15, 1:5, 1:1, 5:1, and 15:1 showed a co-toxicity coefficient greater than 130, indicating a significant synergistic effect; and the mass ratios of 1:15, 1:5, 1:1, and 5:1 showed a co-toxicity coefficient greater than 140, indicating a significant synergistic effect.

[0058] Table 3. Results of indoor bioactivity tests of flupyrrolidone and indazapyroxamet on peach aphids. Test reagents Proportion Proportion virulence regression equation Correlation coefficient <![CDATA[LC 50 (mg·L -1 )]]> Cotoxicity coefficient (CTC) Flupyrrolidone (A) / / y = 4.7813 + 1.4779x 0.9976 1.4061 / indazapyroxamet(B) / / y = 3.7834 + 1.5169x 0.9970 6.3390 / A:B 1 50 y = 4.1639 + 1.1081x 0.9975 5.6821 104.381 A:B 1 40 y = 4.1745 + 1.2127x 0.9936 4.7942 121.800 A:B 1 20 y = 4.2643 + 1.2180x 0.9950 4.0177 135.192 A:B 1 10 y = 4.3780 + 1.2882x 0.9992 3.0399 158.103 A:B 1 5 y = 4.6352 + 1.2536x 0.9964 1.9545 204.662 A:B 1 1 y = 4.9727 + 1.3367x 0.9979 1.0482 219.582 A:B 6 1 y = 4.9747 + 1.388x 0.9976 1.0429 151.689 A:B 12 1 y = 4.9402 + 1.2635x 0.9993 1.1152 134.113 A:B 24 1 y = 4.9592 + 1.2991x 0.9993 1.0749 135.015 A:B 36 1 y = 4.9002 + 1.4740x 0.9975 1.1686 122.908 A:B 48 1 y = 4.7800 + 1.3935x 0.9962 1.4384 99.332 Indoor experiments showed that the combination of flupyrrolidone and indazapyroxamet, under appropriate mass ratios, exhibited good biological activity against peach aphids, demonstrating a synergistic effect. When the mass ratio of flupyrrolidone to indazapyroxamet was 1:40–36:1, the co-toxicity coefficient was greater than 120, indicating a synergistic effect; when the mass ratio was 1:20–24:1, the co-toxicity coefficient was greater than 130, showing a significant synergistic effect; and when the mass ratio was 1:10–6:1, the co-toxicity coefficient was greater than 140, showing a remarkable synergistic effect.

[0059] Among them, the mass ratios of flupyrrolidone and indazapyroxamet of 1:40, 1:20, 1:10, 1:5, 1:1, 6:1, 12:1, 24:1, and 36:1 showed a co-toxicity coefficient greater than 120, indicating a synergistic effect; the mass ratios of 1:20, 1:10, 1:5, 1:1, 6:1, 12:1, and 24:1 showed a co-toxicity coefficient greater than 130, indicating a significant synergistic effect; and the mass ratios of 1:10, 1:5, 1:1, and 6:1 showed a co-toxicity coefficient greater than 140, indicating a significant synergistic effect.

[0060] Example 2: Field efficacy test for controlling peach aphids on Chinese cabbage.

[0061] Experimental location: The experiment was conducted in a cabbage plantation in Yifengdian Town, Jimo District, Qingdao City, Shandong Province, where the water and fertilizer conditions were moderate.

[0062] Experimental target: Peach aphid.

[0063] Experimental methods: The experiment included five treatments and one blank control. Each treatment was replicated four times. All experimental plots were arranged in a randomized block design, with a plot area of ​​40 m². 2 On October 20, 2025, foliar spraying was carried out using a backpack sprayer.

[0064] Survey method: Five points were selected within the experimental plot, with two plants marked at each point, and the survey was conducted at fixed points and with fixed plants. The initial insect population was surveyed before pesticide application, and the number of surviving insects was surveyed at 1 day, 3 days, and 7 days after pesticide application, and the insect population reduction rate was calculated.

[0065] Methods for calculating drug efficacy:

[0066] The results of the field efficacy trials are shown in the table below: Table 4. Results of field efficacy trials of flupyrrolidone combined with benzpyrimoxan for controlling aphids on Chinese cabbage.

[0067] Field efficacy trials showed that the combination of flupyrrolidone and benzpyrimoxan had a good control effect on cabbage aphids.

[0068] Example 3: Field efficacy test for controlling strawberry peach aphid.

[0069] The experiment was conducted in a strawberry greenhouse in Da'ao Village, Hengxi Town, Yinzhou District, Ningbo City, Zhejiang Province. The soil at the experimental site was sandy loam with moderate fertility.

[0070] Experimental crop: strawberry.

[0071] The experiment involved five treatments, each repeated four times, with each test plot measuring 20m². 2 All test cells were randomly assigned to blocks.

[0072] Experimental Methods: The experiment was conducted on April 12, 2025. A PB-16 sprayer was used, with a spray pressure of 0.2–0.4 MPa, a nozzle diameter of 1 mm, and a flow rate of 920 mL / min. An equal volume of water was sprayed in the water control area. Different dosages of the same pesticide were sprayed in ascending order of dosage. The method for switching between different pesticides was to rinse the sprayer with water after each pesticide application before applying the next pesticide.

[0073] Survey methods: The experimental population was surveyed before the experiment, and the number of aphids was surveyed again at 3 and 10 days after the application of the pesticide. During the survey, 5 points were selected in each plot, and the number of aphids on 6 leaves was surveyed at each point.

[0074] Methods for calculating drug efficacy:

[0075] The results of the field efficacy trials are shown in the table below: Table 5. Results of field efficacy trials of flupyrrolidone combined with indazapyroxamet against strawberry aphids.

[0076] Field efficacy trials showed that the combination of flupyrrolidone and indazapyroxamet had a good control effect on strawberry aphids. Three days after application, the corrected control efficacy of the combined formulation was above 84%. Ten days after application, the corrected control efficacy of the combined formulation remained above 86%.

[0077] Example 4: Field efficacy test for controlling rice planthoppers.

[0078] Experimental site: The experiment was conducted in a rice paddy in Chahe Town, Hongze District, Huai'an City, Jiangsu Province. The experimental site has convenient irrigation and drainage and moderate fertility.

[0079] Experimental crop: rice.

[0080] Experimental target: rice planthopper.

[0081] Experimental Design: The experiment consisted of 6 treatments, each repeated 4 times, for a total of 24 treatments. All experimental plots were randomly assigned to blocks.

[0082] Experimental method: The pesticide was applied once on the morning of September 5, 2025. A backpack electric sprayer was used to evenly spray the base of the rice stems and leaves once, using 675 L / hm² of water. 2 Before applying the pesticide, the initial population of planthoppers was investigated. After application, the number of surviving planthoppers was investigated once at 1, 3, and 7 days. Ten samples were taken from each plot using the parallel skipping method. At each sample, two rice clumps were sampled, meaning that the planthopper population on 20 rice clumps was investigated in each plot.

[0083] Methods for calculating drug efficacy:

[0084] The results of the field efficacy trials are shown in the table below: Table 6. Results of field efficacy trials of flupyrrolidone combined with frometoquin against rice planthoppers.

[0085] Field efficacy trials showed that the combination of flupyrrolidone and floctoquin had excellent control effects on rice planthoppers. Among the five agents, 18% flupyrrolidone•flometoquin suspension (1:5) showed the best control efficacy against rice planthoppers, with a control efficacy of 97.35% 7 days after application. The control effect of the combination was significantly higher than that of the single-agent control.

[0086] Indoor toxicity tests and field efficacy tests show that the insecticidal composition of the present invention exhibits good control effects against aphids and rice planthoppers, and is safe for crops, reducing the dosage of pesticides and pesticide residues in agricultural products.

[0087] Although the present invention has been described in detail above with general description and specific embodiments, some modifications or improvements can be made to it, which will be obvious to those skilled in the art. Therefore, all such modifications or improvements made without departing from the spirit of the present invention are within the scope of protection claimed by the present invention.

Claims

1. An insecticidal composition containing flupyrfuranone, characterized in that, The insecticidal composition comprises active ingredient A and active ingredient B, wherein active ingredient A is flupyrrolidone, and active ingredient B is any one of benzpyrimoxan, frometoquin, and indazapyroxamet, and the mass ratio of active ingredient A to active ingredient B is 1:50 to 50:

1.

2. The insecticidal composition according to claim 1, characterized in that, The active ingredient B is benzpyrimoxan, and the mass ratio of active ingredient A to active ingredient B is 1:30~20:1; The active ingredient B is floctoquin, and the mass ratio of active ingredient A to active ingredient B is 1:40 to 20:1; The active ingredient B is indazapyroxamet, and the mass ratio of active ingredient A to active ingredient B is 1:40 to 36:

1.

3. The insecticidal composition according to claim 2, characterized in that, The active ingredient B is benzpyrimoxan, and the mass ratio of active ingredient A to active ingredient B is 1:20 to 10:

1. The active ingredient B is floctoquin, and the mass ratio of active ingredient A to active ingredient B is 1:30 to 15:1; The active ingredient B is indazapyroxamet, and the mass ratio of active ingredient A to active ingredient B is 1:20~24:1; Preferably, the active ingredient B is benzpyrimoxan, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 10:

1. The active ingredient B is floctoquin, and the mass ratio of active ingredient A to active ingredient B is 1:15 to 5:1; The active ingredient B is indazapyroxamet, and the mass ratio of active ingredient A to active ingredient B is 1:10 to 6:

1.

4. The insecticidal composition according to claim 1, characterized in that, The active ingredient B is benzpyrimoxan, and the mass ratio of active ingredient A to active ingredient B is 1:30, 1:20, 1:15, 1:6, 1:3, 2:1, 10:1, or 20:

1. The active ingredient B is floctoquin, and the mass ratio of active ingredient A to active ingredient B is 1:40, 1:30, 1:15, 1:5, 1:1, 5:1, 15:1, or 20:

1. The active ingredient B is indazapyroxamet, and the mass ratio of active ingredient A to active ingredient B is 1:40, 1:20, 1:10, 1:5, 1:1, 6:1, 12:1, 24:1, or 36:

1. Preferably, the active ingredient B is benzpyrimoxan, and the mass ratio of active ingredient A to active ingredient B is 1:20, 1:15, 1:6, 1:3, 2:1, or 10:

1. The active ingredient B is floctoquin, and the mass ratio of active ingredient A to active ingredient B is 1:30, 1:15, 1:5, 1:1, 5:1, or 15:

1. The active ingredient B is indazapyroxamet, and the mass ratio of active ingredient A to active ingredient B is 1:20, 1:10, 1:5, 1:1, 6:1, 12:1, or 24:

1. More preferably, the active ingredient B is benzpyrimoxan, and the mass ratio of the active ingredient A to the active ingredient B is 1:15, 1:6, 1:3, 2:1, or 10:

1. The active ingredient B is floctoquin, and the mass ratio of active ingredient A to active ingredient B is 1:15, 1:5, 1:1, or 5:

1. The active ingredient B is indazapyroxamet, and the mass ratio of active ingredient A to active ingredient B is 1:10, 1:5, 1:1, or 6:

1.

5. The insecticidal composition according to claim 1, characterized in that, The insecticidal composition contains, in addition to the active ingredient, an auxiliary ingredient selected from one or more of the following: wetting agent, dispersant, emulsifier, thickener, disintegrant, antifreeze, defoamer, solvent, preservative, stabilizer, synergist, or carrier.

6. The insecticidal composition according to claim 1, characterized in that, The total weight of the insecticidal composition is 100 wt%, and the total weight of active ingredient A and active ingredient B accounts for 1% to 80% of the total weight of the insecticidal composition.

7. The insecticidal composition according to claim 1, characterized in that, The insecticidal composition is prepared into a pesticide formulation that is permitted in pesticides, wherein the formulation is a solid or liquid formulation.

8. The insecticidal composition according to claim 7, characterized in that, The solid formulation is a water-dispersible granule or a wettable powder; the liquid formulation is a suspension, microemulsion, water-in-oil emulsion, microemulsion, emulsifiable concentrate, soluble concentrate, or dispersible oil suspension.

9. The application of the insecticidal composition according to any one of claims 1-8 for the control of agricultural, horticultural, and forestry pests.

10. The application according to claim 9, characterized in that, The pests mentioned are hemiptera pests; the hemiptera pests mentioned are aphids or rice planthoppers.

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