Preparation method and application of double-sided hard mask sealing adhesive capable of regulating and controlling fibroblast activity

By designing a double-sided dural sealant, side A promotes the activity of fibroblasts in the dural layer, while side B inhibits the activity of fibroblasts in the muscle layer. This solves the problem that dural sealant materials cannot simultaneously seal cerebrospinal fluid leakage and prevent epidural fibrosis, thus achieving simultaneous treatment of dural injury repair and fibrosis.

CN122351561AActive Publication Date: 2026-07-10JILIN UNIVERSITY
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Patent Information

Application Number
CN202610820998.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-06-09
Publication Date
2026-07-10
Estimated Expiration
2046-06-09

AI Technical Summary

Technical Problem

Existing dural sealing materials cannot simultaneously and effectively seal cerebrospinal fluid leakage and prevent epidural fibrosis, and existing strategies cannot simultaneously promote dural injury repair and prevent epidural fibrosis.

Method used

A double-sided hard membrane sealing adhesive is designed, with A facing the central part of the hard membrane layer to promote fibroblast activity and the surrounding part to provide good adhesion properties, and B facing the muscle layer to inhibit fibroblast activity. A double-sided structure with regulatory capabilities is formed by combining cross-linking agents and biomaterials.

Benefits of technology

It achieves the sealing of cerebrospinal fluid leakage and the prevention of epidural fibrosis, promotes the repair of dural injury and inhibits the excessive activation of fibroblasts, resolves the contradiction between dural injury and fibrosis, and provides reliable advantages for clinical application.

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Abstract

The invention relates to a preparation method and application of a double-sided dura mater sealing adhesive capable of regulating and controlling the activity of fibroblasts, and belongs to the field of medical biological materials, the double-sided dura mater sealing adhesive is composed of an A-facing dura mater layer and a B-facing muscle layer, and the A-facing dura mater layer is composed of a central part and a peripheral part; comprising the following steps: preparing an A-face hard mask layer; preparing a B-facing muscle layer; assembling a double-sided hard film sealing adhesive; the invention has the performance of bidirectionally regulating the activity of fibroblasts, not only improves the activity of epidural fibroblasts, but also inhibits the activity of epidural fibroblasts, solves the contradiction of regulating and controlling the activity of fibroblasts in the processes of repairing epidural injury and preventing epidural fibrosis, and can provide reliable cerebrospinal fluid leakage sealing performance at the same time. The problem that it is difficult to achieve dural damage repair and epidural fibrosis prevention at the same time is solved.
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