Pharmaceutical composition for treating viral herpes skin diseases and method for preparing the same

Abstract

The application discloses a medicine composition for treating viral herpes skin diseases and a preparation method thereof, and belongs to the technical field of medicines. The medicine composition comprises 1 part of Myristica, 2 parts of Banlangen, 2 parts of Lianqiao, 1 part of Huangqin, 3 parts of Daqingye, 2 parts of Danzhuye, 3 parts of Zixueye, 1 part of Niu Douzi, 2 parts of Gegen, 1 part of Beiqiehu, 1 part of Guanghuoxiang, 1 part of Pailan, 1 part of Shichangpu and 1 part of Chuanqiong. The composition can effectively treat herpes skin diseases caused by different pathogens such as hand-foot-mouth disease, chickenpox and herpes zoster, and has a broad spectrum of prevention and treatment effects.

Description

Technical Field

[0001] This invention belongs to the field of pharmaceutical technology, and specifically relates to a pharmaceutical composition for treating viral herpetic skin diseases and its preparation method. Background Technology

[0002] Viral herpetic skin diseases, mainly including hand-foot-mouth disease, chickenpox, and shingles, are common skin and mucous membrane lesions caused by different viral infections. Hand-foot-mouth disease is mostly caused by Coxsackievirus A16 or Enterovirus 71, and is more common in children. In severe cases, it can lead to complications such as encephalitis and myocarditis. Chickenpox is caused by the varicella-zoster virus (VZV) and is highly contagious. Shingles is caused by the reactivation of latent VZV in the body, manifesting as severe pain and clustered blisters along the nerve distribution, often accompanied by postherpetic neuralgia.

[0003] Currently, clinical treatment for these viral herpes diseases mainly relies on antiviral drugs (such as acyclovir and ganciclovir) and symptomatic treatment. However, existing treatment options have the following limitations:

[0004] 1. Drug resistance and toxic side effects: Long-term or single use of chemically synthesized antiviral drugs can easily lead to drug resistance, and some drugs may cause liver and kidney damage, gastrointestinal reactions or allergic reactions, especially limiting their use in special groups such as children and the elderly.

[0005] 2. Lack of broad spectrum and specificity: Existing topical preparations are often developed for a single disease. They lack a systematic formula that can achieve the synergistic effect of clearing heat and detoxifying, drying dampness and resolving turbidity, and promoting qi and blood circulation, targeting the pathological characteristics of viral herpes diseases such as "internal accumulation of dampness and toxins and qi stagnation and blood stasis".

[0006] 3. Limited local repair and pain relief effects: Traditional treatments often focus on inhibiting viral replication, but they often lack highly effective Chinese medicine combinations in relieving local skin damage, improving microcirculation, and alleviating severe neuralgia or skin itching caused by viral herpes.

[0007] Therefore, developing a scientifically formulated, precisely proportioned drug composition that can be widely used to prevent and treat hand-foot-mouth disease, chickenpox, and shingles, in order to alleviate patient suffering, shorten the course of the disease, and reduce medication risks, has become an urgent technical challenge to be solved in the field of clinical medicine. Summary of the Invention

[0008] To address the above deficiencies, this invention provides a pharmaceutical composition for treating viral herpetic dermatitis, comprising 1 part cardamom, 2 parts isatis root, 2 parts forsythia, 1 part scutellaria, 3 parts indigo leaf, 2 parts lophatherum leaf, 3 parts perilla leaf, 1 part burdock fruit, 2 parts kudzu root, 1 part bupleurum root, 1 part patchouli, 1 part eupatorium, 1 part acorus, and 1 part chuanxiong.

[0009] Furthermore, the pharmaceutical composition is used to treat shingles.

[0010] Furthermore, the pharmaceutical composition is used to treat hand-foot-mouth disease.

[0011] Furthermore, the pharmaceutical composition is used to treat chickenpox.

[0012] The present invention also discloses a method for preparing the above-mentioned pharmaceutical composition, comprising the following steps:

[0013] S1. Prepare the raw material components according to the proportion and mix them. Pour in 6 liters of water and soak for 30 minutes.

[0014] S2. Bring the soaked raw material components to a boil over high heat, then simmer over low heat for 25 minutes. This is called the first liquid.

[0015] S3. Prepare the raw material components according to the proportion and mix them. Add 5 liters of water and bring to a boil over high heat. Then simmer over low heat for 20 minutes. This is called the second liquid.

[0016] S4. Mix the second liquid with the first liquid to obtain the external washing agent.

[0017] Compared with the prior art, the present invention has the following advantages:

[0018] 1. This formula, through the synergistic effects of clearing heat and detoxifying (such as Isatis root, Forsythia, Isatis leaf, and Scutellaria baicalensis), aromatically resolving dampness (such as Patchouli, Eupatorium fortunei, Cardamom, and Acorus tatarinowii), relieving exterior syndromes and dispelling pathogens (such as Perilla leaf, Pueraria lobata, and Bupleurum chinense), and promoting blood circulation and removing blood stasis (Ligusticum chuanxiong), breaks through the limitation of traditional drugs that can only target a single virus. This composition can effectively target herpetic lesions caused by different pathogens such as hand-foot-mouth disease, chickenpox, and shingles, and has a broad-spectrum preventive and therapeutic effect.

[0019] 2. Compared to the drug resistance and hepatotoxicity caused by long-term use of chemically synthesized antiviral drugs, the formulation of this invention uses carefully selected natural medicinal materials, has mild medicinal properties, and few toxic side effects. Experimental observations have shown that this composition did not produce significant systemic adverse reactions during treatment, and is especially suitable for children (patients with hand-foot-mouth disease and chickenpox) and elderly people with low immunity (patients with shingles), thus improving patient medication compliance. Attached Figure Description

[0020] Figure 1-5 This is a before-and-after comparison of a shingles patient using the external wash in Example 3 of the present invention.

[0021] Figure 6-8 This is a before-and-after comparison of the use of the external wash in patients with hand-foot-mouth disease in Example 4 of the present invention.

[0022] Figure 9-13 This is a before-and-after comparison of a chickenpox patient using the external wash in Example 5 of the present invention. Detailed Implementation

[0023] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0024] Example 1

[0025] This embodiment provides a pharmaceutical composition for treating viral herpetic dermatitis, comprising 10g of cardamom, 20g of isatis root, 20g of forsythia, 15g of scutellaria, 30g of indigo leaf, 15g of lophatherum leaf, 30g of perilla leaf, 10g of burdock fruit, 20g of kudzu root, 15g of bupleurum root, 10g of patchouli, 10g of agastache, 10g of calamus, and 10g of chuanxiong.

[0026] Example 2

[0027] This embodiment describes a method for preparing the pharmaceutical composition in Example 1, including the following steps:

[0028] S1. Prepare the raw material components according to the proportion and mix them. Pour in 6 liters of water and soak for 30 minutes.

[0029] S2. Bring the soaked raw material components to a boil over high heat, then simmer over low heat for 25 minutes. This is called the first liquid.

[0030] S3. Prepare the raw material components according to the proportion and mix them. Add 5 liters of water and bring to a boil over high heat. Then simmer over low heat for 20 minutes. This is called the second liquid.

[0031] S4. Mix the second liquid with the first liquid to obtain the external washing agent.

[0032] It should be noted that when using this product, the temperature of the external washing solution should be controlled at 37-40℃ before soaking the patient's affected area.

[0033] You can also use medical gauze / cotton wipes as a carrier, and control the temperature at around 37℃. If there is any discharge, you need to clean it first and then apply a wet compress to the affected area.

[0034] Example 3

[0035] like Figure 1-5As shown (comparison charts for days 1, 3, 4, 5, and 6 respectively), this example demonstrates the treatment of shingles using the topical wash obtained in Example 2. The following is a before-and-after comparison of shingles patients using the topical wash:

[0036] Case 1: Ms. Long, 67 years old, presented with "pain, itching, and rash on the right side of her chest and back for 7 days." Numerous herpes lesions were observed on the right side of her chest and back, distributed in a band-like pattern, with clear fluid. She was diagnosed with shingles (herpes zoster). After using the traditional Chinese medicine external wash soaking agent from Example 2 of this invention for 6 days, all the above symptoms disappeared, and follow-up showed no recurrence, indicating a complete cure.

[0037] Example 4

[0038] like Figure 6-8 As shown (comparison images for days 1, 3, and 5 respectively), this embodiment uses the external wash obtained in Example 2 to treat hand-foot-mouth disease. The following is a comparison of hand-foot-mouth disease patients before and after using the external wash:

[0039] Case 2: Chen, male, 4 years old, presented with "fever and rash on hands and feet for 3 days," axillary temperature of 38.0℃, and scattered red maculopapular rashes and vesicles surrounded by erythema on his limbs and trunk. Some lesions ulcerated and had purulent spots. He was diagnosed with hand-foot-mouth disease. After using the traditional Chinese medicine external wash soaking agent of Example 2 of this invention for 5 days, all the above symptoms disappeared, and there was no recurrence during follow-up, indicating a complete cure.

[0040] Example 5

[0041] like Figure 9-13 As shown (comparison images for days 1, 2, 4, 5, and 6 respectively), this example uses the external wash obtained in Example 2 to treat chickenpox. The following is a comparison of chickenpox patients before and after using the external wash:

[0042] Case 3: Yuan, female, 6 years and 4 months old, presented with "rash and fever for more than 2 days," with an axillary temperature of 39.6℃. Symptoms included blisters, itchy skin, and fever. The blisters spread from the trunk to the face, behind the ears, and limbs. She was diagnosed with chickenpox. After using the traditional Chinese medicine external wash soaking agent from Example 2 of this invention for 6 days, all the above symptoms disappeared, and follow-up showed no recurrence, indicating a complete cure.

[0043] It should be noted that the structure described in this invention can be implemented in many different forms and is not limited to the embodiments described. Any equivalent transformations made by those skilled in the art based on the description and drawings of this invention, or direct or indirect applications in other related technical fields, such as the loading and unloading of other items, are included within the protection scope of this invention.

Claims

1. A pharmaceutical composition for treating viral herpetic skin diseases, characterized in that, The formula includes 1 part cardamom, 2 parts isatis root, 2 parts forsythia, 1 part scutellaria, 3 parts indigo leaf, 2 parts lophatherum leaf, 3 parts perilla leaf, 1 part burdock seed, 2 parts kudzu root, 1 part bupleurum root, 1 part patchouli, 1 part eupatorium, 1 part calamus, and 1 part chuanxiong.

2. The pharmaceutical composition according to claim 1, characterized in that: The pharmaceutical composition is used to treat shingles.

3. The pharmaceutical composition according to claim 1, characterized in that: The pharmaceutical composition is used to treat hand-foot-mouth disease.

4. The pharmaceutical composition according to claim 1, characterized in that: The pharmaceutical composition is used to treat chickenpox.

5. The method for preparing the pharmaceutical composition according to claim 1, characterized in that: Includes the following steps: S1. Prepare the raw material components according to the proportion and mix them. Pour in 6 liters of water and soak for 30 minutes. S2. Bring the soaked raw material components to a boil over high heat, then simmer over low heat for 25 minutes. This is called the first liquid. S3. Prepare the raw material components according to the proportion and mix them. Add 5 liters of water and bring to a boil over high heat. Then simmer over low heat for 20 minutes. This is called the second liquid. S4. Mix the second liquid with the first liquid to obtain the external washing agent.

Images