A preparation method and application of a tree-ring-shaped hemostatic sponge for non-accessible pressure wounds

By preparing a dendritic hemostatic sponge with a core-outer ring structure, the problems of excessive pressure and low hemostatic efficiency of existing hemostatic sponges on inaccessible wound surfaces are solved, achieving rapid hemostasis and biocompatibility, and possessing antibacterial properties.

CN122399088APending Publication Date: 2026-07-17NORTHWESTERN POLYTECHNICAL UNIV
View PDF 0 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
NORTHWESTERN POLYTECHNICAL UNIV
Filing Date
2026-05-11
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing hemostatic sponges suffer from problems such as excessive pressure on wounds that cannot be compressed, secondary damage due to their simple structure, and low hemostatic efficiency. They also lack morphological adaptability to the wound environment.

Method used

A biomimetic design was adopted to prepare a dendritic hemostatic sponge with a core-outer ring structure. The core is formed by the rigid support of carboxymethyl chitosan and sodium alginate cross-linked by calcium ions, while the outer ring is formed by the flexible sealing of a pre-gel made of Bletilla striata polysaccharide, mesoporous bioactive glass and carbomer 940. The hemostatic sponge with radial mechanical gradient was integrated through a step-by-step molding process.

Benefits of technology

It achieves rapid and moderate pressure hemostasis on wounds that are not easily compressible, reduces pressure damage to the wound, improves hemostasis efficiency, and has good biocompatibility and antibacterial properties.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN122399088A_ABST
    Figure CN122399088A_ABST
Patent Text Reader

Abstract

The application discloses a preparation method and application of a tree-ring-shaped hemostatic sponge for non-accessible pressure wounds, and relates to the technical field of medical biomaterials. The method adopts an ion crosslinking method to crosslink carboxymethyl chitosan, sodium alginate and calcium chloride to form a core pre-gel, and the core sponge is obtained through freeze-drying; a sol-gel method is adopted to prepare mesoporous bioactive glass, which is dispersed in a carbomer 940 solution together with bletilla striata polysaccharide, and an outer ring pre-gel is formed by adjusting pH; the core sponge is placed in the center of a mold, and the outer ring pre-gel is uniformly poured and cast on the outer periphery of the core, and a tree-ring-shaped hemostatic sponge with a core-ring structure is obtained after freeze-drying. The application constructs a biomimetic gradient structure of 'hard inside and soft outside', so that the hemostatic material has the functions of internal mechanical support and external rapid gel sealing, rapid and moderate compression hemostasis for non-accessible pressure wounds is realized, and the hemostatic material has good biocompatibility and antibacterial performance.
Need to check novelty before this filing date? Find Prior Art