Porous structure rapid hemostatic gel dressing and method of making same

By designing a dual-chamber syringe and Schiff base crosslinking reaction, a porous gel dressing was prepared, which solved the operational difficulties of traditional hemostatic materials in rapid bleeding scenarios, achieving rapid hemostasis and high liquid absorption capacity, and is suitable for deep or irregular wounds.

CN122399096APending Publication Date: 2026-07-17SUZHOU QINGLAN BIOMEDICAL TECH CO LTD
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Patent Information

Application Number
CN202610862157.8
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-06-15
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing hemostatic materials are difficult to effectively fill deep, narrow or irregular wounds, and are difficult to operate with one hand in rapid bleeding scenarios. Traditional gel dressings have a slow curing speed and limited liquid absorption capacity, which may lead to incomplete hemostasis or tissue damage.

Method used

Employing a dual-chamber syringe design, the system mixes modified gelatin and oxidized sodium alginate components, utilizes the reaction of sodium bicarbonate and citric acid to generate carbon dioxide gas, and combines it with Schiff base crosslinking to form a porous gel structure, achieving rapid in-situ curing and high-capacity blood absorption.

Benefits of technology

It achieves a porous gel that solidifies within seconds, absorbs 5-10 times its own weight in blood, stops bleeding in no more than 30 seconds, has good biocompatibility, no risk of thermal damage, and is suitable for emergency one-handed operation.

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Abstract

本发明公开了一种多孔结构快速止血凝胶敷料及其制备方法,该敷料为双组分液体体系,第一组分含改性明胶和碳酸氢钠,第二组分含氧化海藻酸钠和柠檬酸,通过单手操作的双室注射器同时挤出混合,原位发生席夫碱交联与二氧化碳发泡协同反应,形成具有连通多孔结构的凝胶;本发明通过将发泡反应与交联反应集成于同一双组分体系中,配合双室注射器实现单手挤出与混合,在5‑15秒内固化,吸水倍率5‑10倍,止血时间≤30秒,且无热损伤、可降解、可复合止血或抗菌成分,解决了现有止血敷料难以单手操作、固化慢且缺乏快速吸液多孔结构的问题。
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