A novel dura mater repairing nanocomposite fiber membrane and a preparation method thereof
Nanocomposite fiber membranes were prepared by mixing decellularized dura mater matrix with nano-hydroxyapatite using electrospinning technology. This method overcomes the shortcomings of dura mater repair materials in terms of mechanical properties and bioactivity, achieving both structural support and neuroprotection, and promoting dura mater tissue regeneration and microenvironment regulation.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-04-23
- Publication Date
- 2026-07-17
AI Technical Summary
Existing dura mater repair materials cannot simultaneously meet the dual requirements of structural support and neuroprotection, and suffer from problems such as insufficient mechanical properties, uneven fiber distribution, unstable porosity, and lack of biomimetic design for the microenvironment of the skull-dura mater-brain junction area.
Electrospinning technology was used to uniformly mix decellularized dura mater matrix with nano-hydroxyapatite. By optimizing the solvent system and spinning parameters, nanocomposite fiber membranes were prepared to ensure uniform distribution of nHA and fiber continuity, thereby improving mechanical strength and bioactivity.
The prepared nanocomposite fiber membrane has excellent overall mechanical strength and structural stability, can promote the regeneration of dura mater tissue, construct a bioactive and regulatory neuro-immune microenvironment, and solve the single-function limitations of traditional materials.
Smart Images
Figure CN122399111A_ABST