A method for establishing a naked mole rat immune intervention radiation damage model
By eliminating macrophages in naked mole rats and establishing an immune intervention radiation damage model using chlorophosphate liposome solution, the limitations of traditional radiation protection agents are overcome, achieving efficient and simple radiation damage simulation, which is suitable for radiation damage mechanism research and drug screening.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- THE NAVAL MEDICAL UNIV OF PLA
- Filing Date
- 2026-03-11
- Publication Date
- 2026-07-17
AI Technical Summary
Existing radiation protection agents have short durations of action and significant toxic side effects, limiting traditional protection strategies. There is a need to develop highly effective and low-toxicity immune-mediated radiation protection drugs or strategies. The unique immune system of naked mole rats provides an ideal template for novel protection research.
Before subjecting naked mole rats to gamma ray irradiation, macrophages were removed, and the rats were injected with chlorophosphate liposome solution at a radiation dose of 6 Gy, with periodic injections, to establish an immune intervention radiation injury model in naked mole rats.
The established model has a short cycle, is easy to operate, has good reproducibility, and significantly demonstrates radiation damage, making it suitable for studying the mechanism of radiation damage and drug screening.
Smart Images
Figure CN122399259A_ABST