Magnetic graphene material without external blocking and synthesis method and application thereof
By coating the surface of magnetic graphene with SiO2 and modifying it with bifunctional PEG, the problems of non-specific adsorption and low utilization of active sites in magnetic graphene materials were solved, achieving highly selective and high-capacity purification of biological samples.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHANGHAI UNIV OF MEDICINE & HEALTH SCI
- Filing Date
- 2026-05-14
- Publication Date
- 2026-07-17
AI Technical Summary
Existing magnetic graphene materials suffer from problems in the purification of biological samples, such as strong non-specific adsorption, the need for external sealing leading to the introduction of impurities, low utilization of active sites, and insufficient structural stability.
By coating SiO2 onto the surface of magnetic graphene materials and modifying it with bifunctional PEG, PEG molecular hairs are formed, achieving a self-sealing effect without the need for external sealing. At the same time, the active groups are retained for covalent fixation of affinity ligands, thereby improving the selectivity and stability of the material.
A magnetic graphene material with high selectivity, high loading capacity, and stable structure has been developed for the efficient purification of bioactive substances, avoiding additional sealing steps and the introduction of impurities, thus improving separation and purification efficiency.
Smart Images
Figure CN122403435A_ABST
Abstract
Citation Information
Patent Citations
Synthetic method and application of metal organic skeleton-modified magnetic grapheme composite material
CN106140094A
Hydrophilic magnetic graphene material for fixing FcRn receptor and synthesis method
CN120900597A