Resmetirom solvates and methods of making and using the same
The preparation process of Resmetirom crystal form I was simplified by crystallizing a mixture of Resmetirom with N,N-dimethylacetamide and 2-butanone, which solved the problems of low yield and poor stability in the prior art and achieved the preparation of Resmetirom crystal form I with high purity and high yield.
CN122404296APending Publication Date: 2026-07-17JIANGSU DEYUAN PHARMA +1
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- JIANGSU DEYUAN PHARMA
- Filing Date
- 2025-01-15
- Publication Date
- 2026-07-17
AI Technical Summary
Technical Problem
The existing methods for preparing Resmetirom crystal form I have low yields, poor process repeatability, and are cumbersome to operate, making it difficult to obtain high-purity and stable pharmaceutical crystal forms.
Method used
Resmetirom was crystallized from a mixture of N,N-dimethylacetamide and 2-butanone. Compound A was precipitated by cooling, and then mixed with isopropanol to prepare Resmetirom crystal form I. This simplified the preparation process and improved the yield and stability.
Benefits of technology
It achieves high yield and good stability of Resmetirom crystal form I, simplifies the preparation process, improves purification effect, and is suitable for industrial production.
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Smart Images
Figure CN122404296A_ABST
Abstract
The application discloses a Resmetirom solvent compound and a preparation method and application thereof. Specifically provided is a preparation method of a compound shown in formula A, which comprises the following steps: subjecting a mixture containing Resmetirom, N,N-dimethylacetamide and 2-butanone to crystallization to obtain the compound shown in formula A, wherein x is 1 / 2 and y is 1 / 2. The Resmetirom solvent compound has good physical and chemical properties and good stability, and when Resmetirom crystal form I is prepared from the Resmetirom solvent compound, the yield is excellent.
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