Anti-wrinkle polypeptide combination and its use in skin care products
By modifying acetyl hexapeptide-8 and dipeptide diaminobutyryl benzylamide diacetate with citronellol, their transdermal permeability and stability are improved, solving the problem that anti-wrinkle ingredients in skin care products are difficult to penetrate the skin barrier and are decomposed, thus achieving better anti-wrinkle effects.
CN122404483APending Publication Date: 2026-07-17GUANGZHOU JISHENGYUAN BIOTECH CO LTD
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- GUANGZHOU JISHENGYUAN BIOTECH CO LTD
- Filing Date
- 2026-04-27
- Publication Date
- 2026-07-17
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Figure CN122404483A_ABST
Abstract
本发明公开了一种抗皱多肽组合及其在护肤品中的应用，属于生物技术领域。该抗皱多肽组合主要成分为香茅酰六肽‑8、香茅酰二肽二氨基丁酰苄基酰胺二乙酸盐，能抑制神经突触囊泡中的递质释放和竞争性抑制乙酰胆碱与受体结合，阻断面部肌纤维收缩，本申请通过Franz体外透皮实验证实该组合物无需额外促渗剂即可高效穿透表皮，经CCK‑8细胞实验验证其安全性良好，无细胞毒性。该组合物可直接应用于各类抗皱护肤品制备，原料易得、适配现有规模化生产，兼具优异抗皱活性与应用安全性。
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