Edible mushroom polysaccharide multi-component membrane separation process

By integrating multi-level gradient membrane separation and precision concentration technology, the problems of low purity and inaccurate membrane fouling control in the separation of polysaccharides from edible fungi have been solved. This has enabled the efficient co-production of polysaccharides, oligosaccharides and monosaccharides, improving product purity and separation rate, and making it suitable for the high-value utilization of various edible fungi.

CN122404583APending Publication Date: 2026-07-17YANGTZE DELTA REGION INST OF TSINGHUA UNIV ZHEJIANG

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
YANGTZE DELTA REGION INST OF TSINGHUA UNIV ZHEJIANG
Filing Date
2026-03-11
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies for separating polysaccharides from edible fungi suffer from problems such as low efficiency of simultaneous multi-component fractionation, low purity, and inaccurate membrane fouling control, resulting in poor product purity and recovery rate, and failing to achieve efficient co-production of polysaccharides, oligosaccharides, and monosaccharides in the same process flow.

Method used

By employing multi-stage gradient membrane separation and precision concentration integration technology, and utilizing the synergistic cooperation of membrane modules with different retention characteristics, combined with specific hydrodynamic control parameters and physicochemical cleaning strategies, a multi-component membrane separation process for edible fungal sugars is constructed. This process includes microfiltration, two-stage ultrafiltration, and reverse osmosis, achieving refined separation of sugar components with different molecular weight ranges through precise control.

Benefits of technology

It achieves high-purity acquisition of polysaccharides, oligosaccharides and monosaccharides from edible fungi, improves the bioactivity and separation rate of the products, reduces operating costs, and significantly improves process stability and purity, making it suitable for the high-value utilization of various edible fungi.

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Abstract

本申请涉及一种食用菌菌糖多组分膜分离工艺技术领域,公开了一种食用菌菌糖多组分膜分离工艺,旨在解决食用菌多糖分离纯度低、分级效率不高及活性组分易失活的问题。该工艺其特征在于,包括:制备特定浓度的粗提液;利用1.0‑1.2μm微滤膜除杂;采用10KDa超滤膜分级多糖;采用1KDa超滤膜切分寡糖与单糖;利用反渗透膜在1.5‑3.0MPa下浓缩;最后通过真空冷冻干燥制粉。工艺全程控温40℃以下,并配合压力梯度策略与膜污染在线恢复。通过采用上述技术方案,本申请能够实现多糖、寡糖与单糖的高效联产,在提升产物纯度的同时,最大限度保障了生物活性。
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