Lactobacillus paragasseri ccfm1525 preparation promoting vitamin b 12 Postbiotic that absorbs and enhances neuro-repair improving cognition

The postbiotic prepared by Lactobacillus paragerens CCFM1525 solved the problem of insufficient intestinal VB12 absorption, promoted VB12 absorption and enhanced nerve repair and cognitive function, and achieved effective absorption and neuroprotective effect of VB12 in mice.

CN122405481APending Publication Date: 2026-07-17WUXI INSTITUTE FOR SPECIALIZED NUTRITION & HEALTH CO LTD
View PDF 2 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
WUXI INSTITUTE FOR SPECIALIZED NUTRITION & HEALTH CO LTD
Filing Date
2026-04-10
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

In cases of gut microbiota disorder, age-related degenerative changes, or post-gastrointestinal surgery, the gut's ability to absorb vitamin B12 is significantly reduced, leading to functional deficiency. Direct supplementation with exogenous VB12 has limited effect, and there is a lack of scientific probiotic strategies to promote VB12 absorption.

Method used

The postbiotic prepared using Lactobacillus paragasseri CCFM1525 promotes VB12 absorption and enhances neural repair and cognitive function by upregulating the expression of Cubilin and Amnionless proteins in intestinal cells.

Benefits of technology

It significantly upregulated the expression of Cubilin and Amnionless proteins in intestinal cells, improved the absorption of VB12 in mice, alleviated symptoms related to nerve damage, enhanced myelin regeneration and synaptic plasticity in the brain, and improved cognitive abilities.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure CN122405481A_ABST
    Figure CN122405481A_ABST
Patent Text Reader

Abstract

The application discloses a strain capable of promoting vitamin B 12 absorption and improving cognitive function, and application thereof, and belongs to the technical field of biotechnology. The application provides a Paraglactobacillus paracus CCFA1525, which is preserved in the Guangdong Microbial Culture Collection Center, and has a preservation number of GDMCC No: 67380 and a preservation date of November 18, 2025. The Paraglactobacillus paracus CCFA1525 can up-regulate the expression of key proteins in the ileum, promote the absorption of vitamin B 12 , relieve nerve damage and cognitive impairment caused by sleep deprivation, and thus plays a significant neuroprotective role. Therefore, the Paraglactobacillus paracus CCFA1525 can be used for developing products with anti-nerve damage function, and is suitable for improving cognitive impairment caused by vitamin B 12 absorption disorder, and has good functional application prospect and industrial production potential. 12 ​
Need to check novelty before this filing date? Find Prior Art