Ganoderma lucidum peptide, preparation method thereof and application thereof in resisting skin photoaging

The method of extracting Ganoderma lucidum peptides from Ganoderma lucidum seed powder by alkaline extraction, acid precipitation and enzymatic hydrolysis and ultrafiltration solves the problems of complex extraction methods and insufficient bioavailability in existing technologies. It realizes the efficient preparation of small molecule Ganoderma lucidum peptides that are easily absorbed through the skin and are suitable for anti-skin photoaging products.

CN122405784APending Publication Date: 2026-07-17SHANGAO PHARMACY JIANGXI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGAO PHARMACY JIANGXI
Filing Date
2026-06-09
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies for extracting Ganoderma lucidum peptides are cumbersome, involve complex processes, and are not conducive to large-scale production. Furthermore, the bioavailability and transdermal absorption of existing anti-photoaging components are insufficient.

Method used

Ganoderma lucidum protein was extracted from Ganoderma lucidum seed powder using a combination of alkaline extraction, acid precipitation, and enzymatic hydrolysis. Small molecule Ganoderma lucidum peptides were then obtained by ultrafiltration membrane separation, avoiding the use of organic solvents, simplifying the purification process, and improving extraction efficiency and purity.

Benefits of technology

The prepared Ganoderma lucidum peptides have a high content of peptides with a molecular weight of less than 500, which can easily penetrate the skin barrier, significantly improve the bioavailability and cell activity of anti-photoaging ingredients, and are suitable for large-scale production.

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Abstract

本申请提出一种灵芝肽及其制备方法和在抗皮肤光老化中的应用，本申请以灵芝子实体为原料，通过天然提取及酶解工艺获得灵芝肽；提取过程通过碱溶酸沉以及酶解处理，不使用有机溶剂，确保无有害残留；提纯过程通过超滤膜超滤得到灵芝肽，纯化方法简单，适合进行大规模生产。本申请制备的灵芝肽小分子肽段占比高，可穿透角质层屏障，靶向作用于真皮层，显著提高抗光老化成分的生物利用度和提高光老化细胞存活率；因此本申请制备的灵芝肽在抗皮肤光老化中具有广泛的应用。
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Citation Information

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