Full-process cell culture environment control system

By combining a central controller with a multi-module dynamic balance model and dynamic weight matrix optimization, the problem of parameter coupling effects not being considered in existing technologies is solved. This enables multi-parameter collaborative optimization and precise control of the cell culture environment, improving culture stability and product quality consistency, and supporting intelligent system management.

CN122405910APending Publication Date: 2026-07-17HUAMEI HAIBO (ZHEJIANG) BIO-INTELLIGENT TECHNOLOGY CO LTD

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
HUAMEI HAIBO (ZHEJIANG) BIO-INTELLIGENT TECHNOLOGY CO LTD
Filing Date
2026-03-10
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing cell culture environment control systems do not fully consider the mutual coupling effects between environmental parameters such as temperature, pH, and gas concentration. The control strategies lack specificity, making it difficult to adapt to the needs of different cell growth stages. The control precision is insufficient, fault diagnosis is easily interfered with, and model parameters cannot be optimized, resulting in poor culture stability and product quality consistency.

Method used

The system employs a central controller that integrates environmental data sensing, control execution, data storage and communication, and fault diagnosis and emergency response modules. It optimizes the coupling effects between various parameters through a dynamic balance model and dynamic weight matrix, achieving multi-parameter collaborative optimization. It also features fault diagnosis and emergency response functions, a self-learning model to optimize parameters, and provides a comprehensive stability index for the cell culture environment.

Benefits of technology

It achieves multi-parameter collaborative optimization and precise control, improves the overall stability and consistency of the culture environment, enhances system reliability, reduces the risk of batch failure, and supports the digital and intelligent management of the process.

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Abstract

本发明公开了全流程细胞培养环境控制系统,包括:中央控制器、环境数据感知模块、环境调控执行模块、数据存储与通信模块以及故障诊断与应急模块;环境数据感知模块部署于培养容器内部及关键管路,用于实时采集细胞培养全流程的多种环境参数数据,并将采集的数据传输至中央控制器;环境调控执行模块包括温度控制单元、气体混配与供给单元、液体添加与循环单元,用于接收中央控制器发送的调控指令,并对培养环境进行相应的物理干预;本发明能够更好的进行全流程细胞培养环境控制。
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