A method for enrichment and detection of ghrp-2 and ghrp-6 based on covalent organic framework materials
By using functionalized covalent organic framework materials for the enrichment and detection of peptide stimulants in urine, the problems of poor selectivity and insufficient detection limit in existing technologies have been solved, and a highly sensitive, simple and efficient detection method has been achieved.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HARBIN INST OF TECH
- Filing Date
- 2026-04-27
- Publication Date
- 2026-07-17
AI Technical Summary
Existing methods for detecting peptide stimulants suffer from poor selectivity, low recovery rates, cumbersome operation, long processing times, high solvent consumption, and detection limits that fail to meet WADA requirements.
Functionalized covalent organic framework materials containing dimethylamino were used as adsorbents to enrich GHRP-2 and GHRP-6 in urine using dispersion solid-phase extraction technology. High-selectivity enrichment was achieved by utilizing multiple interaction mechanisms, and high-sensitivity detection was achieved by combining liquid chromatography-tandem mass spectrometry.
It significantly improves detection sensitivity, reduces matrix effect, simplifies operation procedures, reduces solvent consumption, and meets WADA's detection requirements.
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